Article
Veterinary Sciences
Angela Martins, Debora Gouveia, Ana Cardoso, Ines Viegas, Oscar Gamboa, Antonio Ferreira
Summary: The study compared locomotor recovery in dogs post-surgery for incomplete SCI undergoing BWSTT or COGI training, finding that BWSTT led to faster and better recovery outcomes. 90% of dogs achieved functional recovery and 100% recovered bladder function after training.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Jian-Tao Liu, Shuo-Yu Wang, Han-Ping Xiao, Bing Gu, Hua-Nan Li
Summary: The study showed that the combination of methylprednisolone and treadmill training significantly improved hind limb function in rats with spinal cord injury compared to methylprednisolone treatment alone. This combined treatment strategy may represent a promising approach to cure spinal cord injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Veterinary Sciences
M. J. Lewis, S. A. Thomovsky, G. E. Moore
Summary: This study aimed to investigate whether gait analysis on a land treadmill could be applied to an underwater treadmill, and whether non-ambulatory dogs walking unassisted on the underwater treadmill at a standardized water level would generate gait scores. The results showed that gait scoring based on the land treadmill was feasible for dogs walking on the underwater treadmill and could complement other gait analysis methods, especially for non-ambulatory dogs.
VETERINARY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Xiangzhe Li, Xinjian Song, Lu Fang, Jie Ding, Longju Qi, Qinghua Wang, Chuanming Dong, Sheng Wang, Jiahuan Wu, Tong Wang, Qinfeng Wu
Summary: This study aimed to investigate the effects and mechanisms of exercise training on spasticity after spinal cord injury (SCI). The findings revealed that exercise training could increase the expression of GAD-65, GAD-67, and KCC2 in the spinal cord via the TrkB signaling pathway, reduce motoneuronal excitability, and improve spasticity symptoms.
NEUROCHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yoon Heo, Hyuk-Jae Choi, Seok-Jin Hwang, Jong-Won Lee, Chil-Yong Kwon, Hyeon-Seok Cho, Gyoo-Suk Kim
Summary: This study found that using a knee-actuated EGO can effectively reduce metabolic cost of transport and significantly improve gait performance in patients with incomplete paraplegia.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Alexander Echemendia del Valle, Juan Enrique Bender del Busto, Armando Sentmanat Belison, Juan Nicolas Cuenca-Zaldivar, Oliver Martinez-Pozas, Pedro Martinez-Lozano, Samuel Fernandez-Carnero, Norberto Valcarcel Izquierdo, Eleuterio A. Sanchez-Romero
Summary: Spinal cord injury is a pathological process that affects the spinal cord and can alter motor, sensory, and autonomic function. This study evaluated the effect of a gait training program on patients with spinal cord injuries and found that it produced significant improvements regardless of the level of injury, sex, or functional class.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Luo Bin, Xiaoping Wang, Hu Jiatong, Fan Donghua, Wang Qiang, Shen Yingchao, Miao Yiming, Ma Yong
Summary: Robot-assisted gait training may be helpful in improving functional abilities and TUG (Timed Up and Go test) in patients with spinal cord injuries. However, its impact on gait distance, gait speed, leg strength, 10 MWT, and 6 MWT may be limited.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Takahiro Kondo, Risa Saito, Yuta Sato, Kenta Sato, Akito Uchida, Kimika Yoshino-Saito, Munehisa Shinozaki, Syoichi Tashiro, Narihito Nagoshi, Masaya Nakamura, Junichi Ushiba, Hideyuki Okano
Summary: This study developed a rehabilitation model of severe traumatic spinal cord injury in nonhuman primates and found that locomotor recovery can be promoted through rehabilitation training, restoring the connection between supraspinal input and the lumbosacral network.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Yury Ivanenko, Elena Y. Shapkova, Daria A. Petrova, Daria F. Kleeva, Mikhail A. Lebedev
Summary: Neuromodulation through spinal cord electrical stimulation (SCES) is effective in restoring function, but its effectiveness can be enhanced by combining it with exoskeleton gait training (EGT) that promotes activity-dependent plasticity. Assessing individual characteristics of spinal cord function is important for developing personalized SCES and EGT therapies. Combining SCES and EGT can have a synergistic rehabilitative effect on restoring multiple functions in paralyzed individuals.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Review
Engineering, Biomedical
Rieko Yamamoto, Shun Sasaki, Wataru Kuwahara, Michiyuki Kawakami, Fuminari Kaneko
Summary: Exoskeleton-assisted Body Weight Supported Treadmill Training (BWSTT) may be effective in improving walking function in patients with chronic stroke, but further studies are needed to verify its efficacy and strengthen evidence on intervention protocols.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Behavioral Sciences
D. Nathan Neckel, Haining Dai, John Hanckel, Yichien Lee, Christopher Albanese, Olga Rodriguez
Summary: Rehabilitative training can improve motor function after spinal cord injury, with specific task training leading to improvements in only those tasks trained. However, combining robot-assisted gait training with skilled forelimb training can significantly enhance recovery of unassisted locomotion in rats with hemisection injuries. This combined training may lead to a more robust interneuronal relay network, as suggested by imaging studies.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Isabel Sinovas-Alonso, Diana Herrera-Valenzuela, Ana de-los-Reyes-Guzman, Roberto Cano-de-la-Cuerda, Antonio J. del-Ama, Angel Gil-Agudo
Summary: SCI-GDI demonstrated construct validity with the 10MWT, TUGT, LEMS, SCIM IIIIOMob, and SS WISCI II levels for independently walking adults with iSCI. Further research should be conducted with a more diverse sample, including the pediatric population, to assess the psychometric characteristics.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Chemistry, Analytical
Roushanak Haji Hassani, Romina Willi, Georg Rauter, Marc Bolliger, Thomas Seel
Summary: In this study, a new method for inertial gait analysis in clinical settings was proposed and validated. The method showed acceptable accuracy in determining joint range of motion and relative gait phases, providing potential for non-restrictive motion analysis in clinical environments.
Article
Engineering, Biomedical
Daniel Pinto, Allen W. Heinemann, Shuo-Hsiu Chang, Susan Charlifue, Edelle C. Field-Fote, Catherine L. Furbish, Arun Jayaraman, Candace Tefertiller, Heather B. Taylor, Dustin D. French
Summary: This study aimed to estimate the cost-effectiveness of locomotor training strategies following spinal cord injury (SCI) by injury status (complete versus incomplete). The results showed that conventional training was more cost-effective than overground robotic training for patients with incomplete SCI, while overground robotic training was more cost-effective than conventional training for patients with complete SCI.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Chemistry, Analytical
Seongmi Song, Nathaniel J. Fernandes, Andrew D. Nordin
Summary: This study investigates the feasibility of using wireless inertial measurement unit (IMU) sensors and machine learning methods for gait event detection. The results show that with IMU data and machine learning classification, we were able to effectively identify gait events during bodyweight-supported treadmill walking on land and underwater.