Article
Health Care Sciences & Services
Nicole M. Vecin, David R. Gater
Summary: This manuscript reviews the risk of pressure injuries caused by spinal cord injury and discusses the multidisciplinary approach required to prevent and treat these injuries in the vulnerable population.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Critical Care Medicine
Kun-Ze Lee, Li-Min Liou, Stephane Vinit
Summary: Cervical magnetic stimulation can be used to assess post-injury excitability of phrenic motor outputs, with shorter latency and increased amplitude observed in response to acute injury. Placing the stimulation more laterally at the left spinal cord in subchronic and chronic injury stages generally leads to larger motor-evoked potentials of the diaphragm.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Thorsten Jentzsch, David W. Cadotte, Jefferson R. Wilson, Fan Jiang, Jetan H. Badhiwala, Muhammad A. Akbar, Brett Rocos, Robert G. Grossman, Bizhan Aarabi, James S. Harrop, Michael G. Fehlings
Summary: This study aimed to investigate if baseline MRI features predicted the clinical course of SCI, and found that patients with SC signal change were younger, more likely to experience adverse events, and had worse clinical outcomes after one year.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Kee D. D. Kim, K. Stuart Lee, Domagoj Coric, James S. S. Harrop, Nicholas Theodore, Richard M. M. Toselli
Summary: Based on 6-month data from the INSPIRE study, acute implantation of NSS appeared to be safe in patients with complete thoracic SCI and showed potential for neurological recovery. The study evaluated outcomes up to 24 months postimplantation.
Article
Pharmacology & Pharmacy
Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini Ravandi, Mahmoudreza Hadjighassem
Summary: This study found that early administration of bumetanide after spinal cord injury can promote recovery of locomotor function. The results showed that bumetanide can reduce the expression of NKCC1 gene and increase GAP protein levels, thereby having neuroprotective and regenerative effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fangliang Guo, Xiaolong Zheng, Ziyu He, Ruoying Zhang, Song Zhang, Minghuan Wang, Hong Chen, Wei Wang
Summary: The study found that long-term treatment with NMD helps to improve locomotion, pain-related behaviors, and spasticity-like symptoms in rats with SCI, but has less effect on open-field activity, hind limb grip strength, and bladder function. Additionally, NMD-treated rats showed greater tissue preservation, reduced lesion areas, and increased perilesional neuronal sparing, suggesting a potential therapeutic strategy for SCI treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Camila Marques Freria, Lori Graham, Ali Azimi, Paul Lu
Summary: We propose an updated model of moderately severe bilateral cervical level 6 contusive spinal cord injury (SCI) in the rat, which is more clinically relevant than previous models and allows animals to survive the lesion. This model closely mimics the most common cervical level of SCI in humans and provides a superior tool for assessing motor recovery interventions.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Clinical Neurology
Mahmoud Yousefifard, Arash Sarveazad, Asrin Babahajian, Seyedeh Niloufar Rafiei Alavi, Arian Madani Neishaboori, Alex R. Vaccaro, Mostafa Hosseini, Vafa Rahimi-Movaghar
Summary: This study conducted a systematic review and meta-analysis to evaluate the effects of administration of growth factor gene-modified cells on locomotion recovery after spinal cord injury (SCI) in animal studies. The results showed that transplantation of growth factor gene-modified cells significantly improved locomotion in SCI animal models. However, there are concerns regarding the safety of genetically modified cells before conducting translational and clinical studies.
WORLD NEUROSURGERY
(2022)
Review
Cell Biology
Minna Christiansen Lund, Bettina Hjelm Clausen, Roberta Brambilla, Kate Lykke Lambertsen
Summary: This systematic review provides an overview of the literature on the expression of tumor necrosis factor (TNF) after spinal cord injury (SCI) and highlights its therapeutic potential. The review concludes that TNF expression increases rapidly after SCI, primarily in resident cells during the acute phase and in macrophages during the chronic phase. Inhibition of TNF signaling is suggested as a promising therapeutic approach for SCI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Rehabilitation
Marc Possover
Summary: The study reported the long-term effects of low-frequency stimulation of pelvic somatic nerves in patients with chronic spinal cord injuries, showing that most patients experienced some degree of recovery after stimulation training. Many patients were able to stand and walk to some extent after long-term follow-up.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Clinical Neurology
Numaira Obaid, Kazuhito Morioka, Eleni Sinopoulou, Yvette-Nout Lomas, Ernesto Salegio, Jacqueline C. C. Bresnahan, Michael S. S. Beattie, Carolyn J. J. Sparrey
Summary: Large animal contusion models of spinal cord injury are crucial for developing and assessing treatment options for human spinal cord injury. This review examines the impact of head and neck positioning on the biomechanics and outcomes of a cervical contusion model of spinal cord injury. The results suggest that neck positioning is an important factor and standardizing it can improve inter-study consistency and comparability in cervical spinal cord injury models.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Laurence Ge, Ayodeji Jubril, Addisu Mesfin
Summary: The study evaluated functional outcomes and characteristics associated with gunshot wounds to the spine, finding that most patients did not have any clinical improvement in ambulatory status and the majority of injuries were ASIA A.
GLOBAL SPINE JOURNAL
(2022)
Review
Cell Biology
Xinli Hu, Yu Xu, Hui Xu, Chenqiang Jin, Haojie Zhang, Haohan Su, Yao Li, Kailiang Zhou, Wenfei Ni
Summary: Ferroptosis, a novel type of programmed cell death, has been found to be associated with acute central nervous system (CNS) trauma. The processes that induce ferroptosis include iron overload, imbalanced glutathione metabolism, and lipid peroxidation. Understanding the mechanism of ferroptosis is important for studying the pathophysiological process of CNS trauma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Rehabilitation
Edelle C. Field-Fote, Catherine L. Furbish, Natalie E. Tripp, Jeanne M. Zanca, Trevor Dyson-Hudson, Steven Kirshblum, Allen W. Heinemann, David Chen, Elizabeth Roy Felix, Lynn Worobey, Mary Schmidt-Read, Ralph J. Marino, Matthew J. Hayat
Summary: The experience of spasticity after spinal cord injury is complex and multidimensional, affecting mobility, sleep, comfort, and quality of life. Stiffness appears to be the most problematic characteristic of spasticity. Physical therapeutic interventions deserve further investigation.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Oncology
J. -P. Obeid, R. Stoyanova, D. Kwon, M. Patel, K. Padgett, J. Slingerland, C. Takita, N. Alperin, M. Yepes, Y. H. Zeidan
CLINICAL & TRANSLATIONAL ONCOLOGY
(2017)
Article
Oncology
N. Andres Parra, Amber Orman, Kyle Padgett, Victor Casillas, Sanoj Punnen, Matthew Abramowitz, Alan Pollack, Radka Stoyanova
STRAHLENTHERAPIE UND ONKOLOGIE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kelin Wang, Michele S. Ferenci, Alberto de la Zerda, Kyle R. Padgett, Elizabeth L. Bossart, Ming Chao, Hua Shao, Mutain Zhang
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2017)
Article
Oncology
Radka Stoyanova, Felix Chinea, Deukwoo Kwon, Isildinha M. Reis, Yohann Tschudi, Nestor A. Parra, Adrian L. Breto, Kyle R. Padgett, Alan Dal Pra, Matthew C. Abramowitz, Oleksandr N. Kryvenko, Sanoj Punnen, Alan Pollack
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyle R. Padgett, Radka Stoyanova, Sara Pirozzi, Perry Johnson, Jon Piper, Nesrin Dogan, Alan Pollack
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2018)
Article
Oncology
Kyle R. Padgett, Amy Swallen, Sara Pirozzi, Jon Piper, Felix M. Chinea, Matthew C. Abramowitz, Aaron Nelson, Alan Pollack, Radka Stoyanova
STRAHLENTHERAPIE UND ONKOLOGIE
(2019)
Article
Critical Care Medicine
Andrea J. Santamaria, Francisco D. Benavides, Kyle R. Padgett, Luis G. Guada, Yohjan Nunez-Gomez, Juan P. Solano, James D. Guest
JOURNAL OF NEUROTRAUMA
(2019)
Article
Oncology
Nancy El-Bared, Lorraine Portelance, Benjamin O. Spieler, Deukwoo Kwon, Kyle R. Padgett, Karen M. Brown, Eric A. Mellon
PRACTICAL RADIATION ONCOLOGY
(2019)
Article
Medicine, General & Internal
David Asher, Kyle R. Padgett, Ricardo E. Llorente, Benjamin S. Farnia, John C. Ford, Shefali R. Gajjar, Shahil Mehta, Garrett N. Simpson, Nesrin Dogan, Lorraine Portelance
CUREUS JOURNAL OF MEDICAL SCIENCE
(2018)
Article
Medicine, General & Internal
Kyle R. Padgett, Garrett N. Simpson, Ricardo Llorente, Michael A. Samuels, Nesrin Dogan
CUREUS JOURNAL OF MEDICAL SCIENCE
(2018)
Article
Medicine, General & Internal
Adrian L. Breto, Kyle R. Padgett, John C. Ford, Deukwoo Kwon, Channing Chang, Martin Fuss, Radka Stoyanova, Eric A. Mellon
CUREUS JOURNAL OF MEDICAL SCIENCE
(2018)
Article
Medicine, General & Internal
Shahil Mehta, Shefali R. Gajjar, Kyle R. Padgett, David Asher, Radka Stoyanova, John C. Ford, Eric A. Mellon
CUREUS JOURNAL OF MEDICAL SCIENCE
(2018)
Article
Clinical Neurology
B. J. Hill, K. R. Padgett, V. Kalra, A. Marcillo, B. Bowen, P. Pattany, D. Dietrich, R. Quencer
AMERICAN JOURNAL OF NEURORADIOLOGY
(2018)
Article
Oncology
Stephen James Ramey, Kyle R. Padgett, Narottam Lamichhane, Hanmath J. Neboori, Deukwoo Kwon, Eric A. Mellon, Karen Brown, Melissa Duffy, James Victoria, Nesrin Dogan, Lorraine Portelance
PRACTICAL RADIATION ONCOLOGY
(2018)
Review
Andrology
Fei Yang, John C. Ford, Nesrin Dogan, Kyle R. Padgett, Adrian L. Breto, Matthew C. Abramowitz, Alan Dal Pra, Alan Pollack, Radka Stoyanova
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2018)