Article
Biochemical Research Methods
Min Yin, Yan Wang, Xuwen Gao, Shichao Du, Yan Cheng, Shuai Yu, Guizheng Zou, Fumin Xue
Summary: A near-infrared electrochemiluminescence immunosensor was developed using AgInS2/ZnS nanocrystals as environmentally-friendly tags for sensitive and selective detection of CA125. The platform showed efficient detection capabilities with a detection limit of 1 x 10(-6) U/mL, offering potential for early diagnosis and treatment of ovarian cancer.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Wuyi Zhang, Dong Han, Zejia Wu, Kui Yang, Shiguo Sun, Jia Wen
Summary: In this study, the authors designed a hybrid material AuNPs@Fe-Zr-MOL consisting of gold nanoparticles (AuNPs) and metal-organic layers (MOLs) for the amplification of electrochemiluminescence (ECL) signal. The addition of Fe-Zr-MOL, a novel metal-organic framework with peroxidase-like activity, effectively enhanced the ECL signal of luminol. The planar structure of Fe-Zr-MOL exposed more active sites for luminol catalysis, improving its conductivity. Furthermore, the integration of AuNPs not only improved electron transport efficiency but also allowed for antibody conjugation, enabling the construction of a sandwich immuno-sensor for alpha fetoprotein (AFP) detection. The results demonstrated the effective amplification of ECL signal and immunodetection of AFP.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Chemistry, Analytical
Qing Li, Jing-Tao Wu, Ying Liu, Xiao-Man Qi, Hong-Guang Jin, Chun Yang, Jun Liu, Guang-Li Li, Quan-Guo He
Summary: Black phosphorus has attracted significant attention due to its anisotropic electro-conductivity and tunable direct bandgap, making it suitable for various electrochemical sensing applications. Research efforts have explored synthesis methods, protection strategies, and sensing applications of BP and its derivatives, along with functionalization mechanisms, sensing strategies, and properties.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Dexin Du, Jue Wang, Mingquan Guo, Jiangnan Shu, Wei Nie, Zhiping Bian, Di Yang, Hua Cui
Summary: Label-free electrochemiluminescence (ECL) immunoassays (lf-ECLIA) have become an attractive method for biomarker detection due to their simplicity, speed, and cost-effectiveness. This study investigated the interaction between biomarkers and analytical interfaces constructed using a nanoluminophore and antibody-functionalized gold nanoparticles. The results showed that positively charged biomarkers increased the ECL intensity, while negatively charged biomarkers decreased the ECL intensity. A charge-dependent lf-ECLIA method was established based on the ECL signal changes, which exhibited different responses to positively charged and negatively charged biomarkers.
ANALYTICAL CHEMISTRY
(2022)
Article
Spectroscopy
Ying Bao, Kexin Han, Zhifang Ding, Yue Li, Ting Li, Ming Guan, Guixin Li
Summary: Polypyrrole-luminol-AuNPs nanocomposites were prepared and utilized for a label-free electrochemiluminescence (ECL) immunosensor for detecting carbohydrate antigen 153 (CA153). The nanocomposites exhibited excellent ECL activity and good film-forming property, allowing them to be fixed on electrode surface without the need for additional film-forming materials.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Lingya Ning, Yumin Bai, Zixiao Wang, Wenjun Wen, Junping Wang
Summary: A novel and rapid electro-chemiluminescence (ECL) immunosensor was successfully fabricated for ultrasensitive detection of 3-NT. The sensor utilized gold nanoparticles as the luminophore and electropolymerized polyaniline to promote the luminescence of the nanoparticles. It exhibited good analytical performance for 3-NT detection with a wide linear detection range and low detection limit, and had high recovery rate in practical sample applications.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Yujie Han, Yu Du, Kun Xu, Xiang Ren, Guanhui Zhao, Zhuangzhuang Ru, Yue Jia, Qin Wei
Summary: An electrochemiluminescence-electrochemistry (ECL-EC) dual-mode biosensing platform was developed to detect Microcystin-LR (MC-LR) with high sensitivity. The platform utilized sulfur quantum dots (SQDs) as an ECL cathode emitter and Ag+ as an ECL signal-amplifying molecule. The biosensor achieved detection in the range of 0.001-100 pg/mL MC-LR concentration with detection limits of 0.17 and 0.24 pg/mL for ECL and EC, respectively.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Tamara Guerrero-Esteban, Cristina Gutierrez-Sanchez, Emiliano Martinez-Perinan, Monica Revenga-Parra, Felix Pariente, Encarnacion Lorenzo
Summary: A novel ECL immunosensor based on electrografted CND was developed for sensitive determination of glyphosate in soy milk and tea. The sensor, in combination with magnetic nanoparticles, showed stable and reproducible response for glyphosate detection, with results matching those from ELISA kits.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Wuyi Zhang, Lanlan Chen, Kui Yang, Lijuan Wang, Baoquan Han, Shiguo Sun, Jia Wen
Summary: A sensitive electrochemiluminescence (ECL) immunosensor was developed using functionalized metal organic layers (MOLs) for the detection of carcinoembryonic antigen (CEA). The immunosensor utilized gold nanoparticles (AuNPs) grown on ultrathin two-dimensional MOLs, which acted as electron transfer accelerators and labels for antibody conjugation. The AuNPs@Ir-Zr-MOL nanocomposite exhibited high ECL efficiency and could detect CEA concentration in the range of 1.00 pg mL-1 to 100 ng mL-1 with a detection limit of 0.200 pg mL-1 (S/N = 3).
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Chemistry, Analytical
Longsheng Jin, Weishuai Liu, Ziying Xiao, Haijian Yang, Huihui Yu, Changxun Dong, Meisheng Wu
Summary: Rapid and efficient detection of mycotoxins is crucial in ensuring food safety. This review discusses various traditional and commercial methods of detection, including HPLC, LC/MS, ELISA, and test strips. ECL biosensors, known for their high sensitivity and specificity, have gained significant attention in mycotoxins detection. This article focuses on the recent advancements in the design of ECL biosensors for mycotoxins assay, particularly with regards to amplification strategies and working mechanisms.
Article
Chemistry, Analytical
Xinrong Shao, Xianzhen Song, Xin Liu, Liangguo Yan, Lei Liu, Dawei Fan, Qin Wei, Huangxian Ju
Summary: A dual signal-amplified sandwich electrochemiluminescence (ECL) immunosensor was successfully fabricated for highly sensitive detection of procalcitonin (PCT), demonstrating great potential for clinical applications.
Article
Electrochemistry
Xinya Jiang, Huijun Wang, Fang Yang, Li Cheng, Cai Nie, Wenbing Shi
Summary: In this study, an electrochemiluminescence (ECL) biosensor based on interparticle DNA walker and N-Ti3C2 QDs was developed for sensitive assay of MUC1. The interparticle DNA walker could improve the conversion efficiency of target MUC1 by enhancing its moving freedom and area. The synthesized N-Ti3C2 QDs showed higher ECL luminous efficiency compared to previous reported N-Ti3C2 QDs, providing a potential feasible method for other protein sensitive assay.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Ana M. Villa-Manso, Tamara Guerrero-Esteban, Felix Pariente, Celia Toyos-Rodriguez, Alfredo de la Escosura-Muniz, Monica Revenga-Parra, Cristina Gutierrez-Sanchez, Encarnacion Lorenzeo
Summary: A novel immunosensor based on electrochemiluminescence resonance energy transfer (ECL-RET) has been developed for the sensitive determination of N protein of the SARS-CoV-2 coronavirus. The immunosensor utilizes bifunctional core@shell nanoparticles as ECL acceptor and [Ru(bpy)(3)](2+) as ECL donor. It demonstrates a wide linear response to the concentration of N protein with a detection limit of 1.27 pg/mL, high stability, and specificity. The immunosensor has been successfully applied for quantification of N protein in saliva samples and showed consistent results with a commercial colorimetric ELISA kit.
Article
Biophysics
Baha Ondes, Sinem Evli, Murat Uygun, Deniz Aktas Uygun
Summary: A new label-free electrochemical immunosensor modified with boron nitride nanosheets was developed for early detection of CA125 in this study. The immunosensor showed good detection properties and stability, successfully detecting CA125 in artificial serum samples. The prepared immunosensor has potential for point-of-care diagnosis in real cases.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Yixin Nie, Peilin Wang, Qiang Ma, Xingguang Su
Summary: Based on electronic metal-support interaction (EMSI), a gold single atom confined MXene (AuSA/MXene) heterostructure was developed as a highly efficient electrochemiluminescence (ECL) functional material, which improved the electrochemical properties and expanded the sensing application of MXenes. The AuSA/MXene heterostructure exhibited high catalytic activity and electrical activity, enabling the construction of a high-efficiency ECL sensor for specific substance detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Electrochemistry
Wenyuan Zhu, Xiaoya Li, Weihong Liu, Zuodong Chen, Jianping Li, Hongcheng Pan
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2017)
Article
Chemistry, Multidisciplinary
Shan Huang, Guangming Pang, Xiangkui Li, Jianping Li, Hongcheng Pan
JOURNAL OF NANOPARTICLE RESEARCH
(2017)
Article
Chemistry, Analytical
Zhong-Xia Wang, Fen-Ying Kong, Wen-Juan Wang, Rui Zhang, Wei-Xin Lv, Xian-He Yu, Hong-Cheng Pan, Wei Wang
SENSORS AND ACTUATORS B-CHEMICAL
(2017)
Article
Chemistry, Analytical
Xiaping Zhu, Yali Yuan, Yun Zhang, Jianping Li, Hongcheng Pan
Article
Electrochemistry
Shangwang Le, Qian Jiang, Hongcheng Pan
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2018)
Article
Electrochemistry
Guangming Pang, Jurui Zheng, Xiangkui Li, Jianping Li, Wenyuan Zhu, Hongcheng Pan
ELECTROCHEMISTRY COMMUNICATIONS
(2019)
Article
Electrochemistry
Fuyang Jiang, Hongyuan Tang, Jishun Li, Liaoming Yang, Hongcheng Pan
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2020)
Article
Chemistry, Analytical
Qilin Wen, Dandan Li, Guidan Huang, Huai Xi, Hongcheng Pan, Lianming Zhang, Ziyuan Li, Xiaofen Xiao, Wenyuan Zhu
Summary: In this study, a dual amplification fluorescence strategy was proposed for the ultrasensitive detection of DNA adenine methylation methyltransferase (Dam MTase) activity. The method showed a low detection limit, good selectivity, and can be extended to the detection of other types of DNA MTases.
Review
Chemistry, Analytical
Dan Li, Kui Luo, Lianming Zhang, Jingxia Gao, Jinlu Liang, Jianping Li, Hongcheng Pan
Summary: The text introduces the principle of chiral imprinting recognition and reviews various strategies in the past 10 years to improve the selectivity of chiral imprinting, such as using derivative functional monomers, supramolecular compounds, chiral assembly materials, and biomolecules.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mengmeng Li, Dandan Li, Guidan Huang, Linying Zhou, Qilin Wen, Wenyuan Zhu, Hongcheng Pan
Summary: A signal-on E-DNA sensor was developed for accurate quantification of RCA products, utilizing a restriction enzyme to cleave long tandem repeat sequences and successfully applied to the detection of miR-7a with a low detection limit of 0.59 fM, demonstrating high specificity and sensitivity.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Analytical
Haofan Wang, Yin Guo, Hongcheng Pan
Summary: A stripping voltammetric determination method using hierarchical dendritic gold nanostructure modified electrodes was developed for the sensitive determination of selenium and copper in water and food samples. The method showed good accuracy and high sensitivity, making it suitable for real sample analysis.
Article
Chemistry, Analytical
Qilin Wen, Xiaolin Liang, Hongcheng Pan, Jianping Li, Yun Zhang, Wenyuan Zhu, Zhixiang Long
Article
Materials Science, Multidisciplinary
Hongyuan Tang, Jurui Zheng, Jianping Li, Qin Xu, Hongcheng Pan
OPTOELECTRONICS AND ADVANCED MATERIALS-RAPID COMMUNICATIONS
(2017)
Article
Chemistry, Analytical
Shangwang Le, Hui Zhou, Jinfang Nie, Chaohong Cao, Jiani Yang, Hongcheng Pan, Jianping Li, Yun Zhang
Article
Electrochemistry
Hongcheng Pan, Shan Huang, Xuepeng Li, Ping Li, Wenyuan Zhu
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2016)
