Review
Psychiatry
Danwei Zhang, Zhen Zhang, Huihua Li, Kaimo Ding
Summary: The study indicates a significant relationship between excessive daytime sleepiness (EDS), depression, and obstructive sleep apnea (OSA). Continuous Positive Airway Pressure (CPAP) has been proven to be an effective therapy for improving EDS and depression in patients with OSA.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Critical Care Medicine
Ali Azarbarzin, Andrey Zinchuk, Andrew Wellman, Gonzalo Labarca, Daniel Vena, Laura Gell, Ludovico Messineo, David P. White, Daniel J. Gottlieb, Susan Redline, Yuksel Peker, Scott A. Sands
Summary: In this post hoc analysis, it was found that patients with higher Delta HR experience greater cardiovascular benefits from CPAP therapy, while those with lower Delta HR do not have significant risk reduction.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Karin Elisabeth Sundt Mjelle, Sverre Lehmann, Ingvild West Saxvig, Shashi Gulati, Bjorn Bjorvatn
Summary: This study investigates the possible associations between obstructive sleep apnea (OSA) and fatigue, as well as the associations with excessive sleepiness, depression, and anxiety. The study finds that pathological fatigue, anxiety, and depression do not increase with the severity of OSA, while excessive sleepiness does.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Otorhinolaryngology
Sang Hoo Park, Woo Yong Bae, Sangjun Kim, Young Gun Kim, Young Bin Yun, Hyung Geun Lee, Bok Joo Kim, Jung-han Kim
Summary: This study aimed to compare the improvement and non-improvement groups of excessive daytime sleepiness in patients with obstructive sleep apnea (OSA). The results showed significant differences between the groups in Social Avoidance and Distress Scale (SADS), Fear of Negative Evaluation (FNE), apnea index (AI), apnea-hypopnea index (AHI), percentage of stage 2 non-REM sleep (N2%), and frequency of 3% oxygen desaturation (ODI3).
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Anne Walker, Matthew T. Naughton, Lachlan Shaw, Andrew T. Jeklin, Catherine Martin, Eli Dabscheck
Summary: The study aimed to evaluate changes in Hospital Anxiety and Depression Scale (HADS) scores after CPAP treatment in patients with obstructive sleep apnea. Results showed that CPAP therapy reduced depression scores, especially with high CPAP adherence. Anxiety scores also decreased, but there was no significant difference between high and low CPAP adherence groups.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Medicine, General & Internal
Jae Hyuk Choi, Eunkyu Lee, Sang Duk Hong, Seung Kyu Chung, Yong Gi Jung, Hyo Yeol Kim
Summary: A retrospective analysis of OSA patients undergoing CPAP therapy showed significant improvements in laryngopharyngeal reflux symptoms and examination findings, independent of body mass index or OSA severity.CPAP treatment has the potential to reduce laryngeal reflux symptoms and improve laryngeal examination results in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yoko Fujino, Yasunori Oka, Tomoko Wakamura
Summary: This study found that seasonal differences can impact the CPAP adherence of patients with obstructive sleep apnea. Patients in the adherent group had lower CPAP use rate and shorter duration in summer, while the non-adherent group showed significant differences between winter and summer.
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Article
Medicine, General & Internal
Baixin Chen, Miaolan Guo, Yueksel Peker, Neus Salord, Luciano F. Drager, Geraldo Lorenzi-Filho, Xiangdong Tang, Yun Li
Summary: CPAP treatment leads to a significant decrease in total cholesterol but has no effect on other lipid profiles in patients with obstructive sleep apnea. Factors such as age, gender, body mass index, daytime sleepiness, OSA severity, follow-up duration, CPAP compliance, and presence of cardiometabolic disease do not moderate the effects of CPAP treatment on lipid profiles.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Reena Mehra, Raphael Heinzer, Pablo Castillo
Summary: While residual EDS can be difficult to treat, reversible issues may contribute to some cases, and wake-promoting medications may be helpful for others. Multidisciplinary management of patients with EDS is often recommended.
NEUROLOGY AND THERAPY
(2021)
Review
Clinical Neurology
Janna R. Raphelson, Kimberly Y. Kreitinger, Atul Malhotra
Summary: Obstructive sleep apnea (OSA) is a common condition with significant neurocognitive and cardiovascular effects. Positive airway pressure (PAP) therapy can help prevent airway collapse and improve oxygen levels, carbon dioxide levels, and sleep quality. While adherence to PAP therapy was once seen as a barrier, in reality, adherence rates are likely higher than commonly believed, with various strategies available to help improve patient adherence.
Article
Respiratory System
Peter A. Cistulli, Jeff P. Armitstead, Atul Malhotra, Yang Yan, Vy Vuong, Kimberly L. Sterling, Meredith A. Barrett, Carlos M. Nunez, Jean-Louis Pepin, Adam V. Benjafield
Summary: This study demonstrates the feasibility of capturing patient-reported outcomes via a digital platform. Patient-reported outcomes appear to be associated with PAP usage, especially self-reported sleepiness and its response to therapy. Capturing patient-reported outcomes using digital solutions during the course of treatment has the potential to enhance patient outcomes by providing actionable insights.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Review
Clinical Neurology
Zhiqiang Li, Sijie Cai, Jing Wang, Rui Chen
Summary: Continuous positive airway pressure therapy improves subjective and objective sleepiness in patients with obstructive sleep apnea. Age, baseline BMI, baseline ESS score, adherence, and duration of treatment may predict the effects of CPAP on excessive daytime sleepiness (EDS) in these patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Elisa Morrone, Alberto Braghiroli, Nadia D'artavilla Lupo, Sonia Carli, Pasquale Tondo, Rossella Trentin, Irene Risi, Simona Arcovio, Francesco Fanfulla
Summary: This study investigated the presence of anxiety and depressive symptoms in OSA patients and the link between these psychological symptoms and acceptance or adherence to CPAP treatment. The results suggested that anxiety and depression may negatively influence early acclimatization and adherence to treatment.
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cecile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Levy
Summary: This study investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA. The results showed that ASV did not effectively suppress sympathetic activation in heart failure patients and was associated with increased cardiovascular mortality.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Editorial Material
Respiratory System
Patrick Levy, Sophia Schiza
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Jean-Louis Pepin, Sebastien Bailly, Joelle B. B. Texereau, Emmanuel Sonnet, Sylvie Picard, Bruno Verges, Christine Coffin Boutreux, Gwenaelle Arnault Ouary, Laurence Kessler, Bruno Guerci, Brigitte Anton Kuchly, Salha Fendri Gaied, Alain Cuperlier, Christel Voinot, Christele Derrien, Severine Dubois, Florent Lavergne, Anne Laure Borel, Renaud Tamisier, Pierre-Yves Benhamou
Summary: This study investigated sleep apnoea prevalence, factors influencing severity, and associations between sleep apnoea severity and micro-/macrovascular complications in patients with type 1 diabetes. The findings highlight the significance of sleep apnoea as a comorbidity in these patients and emphasize the importance of screening and management.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Patrick Levy
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Clinical Neurology
Claire Denis, Isabelle Jaussent, Lily Guiraud, Caroline Mestejanot, Caroline Arquizan, Isabelle Mourand, Sofiene Chenini, Beatriz Abril, Anne Wacongne, Renaud Tamisier, Sebastien Baillieul, Jean-Louis Pepin, Lucie Barateau, Yves Dauvilliers
Summary: Sleep disturbances after ischaemic stroke, including alterations of sleep architecture, obstructive sleep apnea (OSA), restless legs syndrome (RLS), daytime sleepiness and insomnia, were explored in this study. The impact of these disturbances on functional outcomes was assessed at 3 months after stroke, and the effectiveness of continuous positive airway pressure (CPAP) in patients with severe OSA was evaluated. The results showed no significant differences in functional independence, disability, and stroke severity between different OSA groups or between CPAP-treated and sham-treated groups. Poorer outcomes at 3 months were associated with insomnia, RLS, depressive symptoms, and decreased total sleep time and rapid eye movement sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Respiratory System
Monique Mendelson, Jeremy Duval, Francois Bettega, Renaud Tamisier, Sebastien Baillieul, Sebastien Bailly, Jean-Louis Pepin
Summary: CPAP is the first-line therapy for OSA, but adherence is a major issue, with up to 50% discontinuing CPAP within 3 years. This article discusses the individual and societal costs of non-adherence, factors associated with non-adherence, and strategies for improving adherence, including telehealth and behavioral interventions. Challenges in visualization and analysis of CPAP remote monitoring platforms are also addressed. Expert opinion highlights the need for tailored strategies to improve CPAP adherence, as well as the importance of refining visualization dashboards and utilizing telehealth and innovative analytics.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Clinical Neurology
Ami-Marie Bocoum, Sebastien Bailly, Marie Joyeux-Faure, Sebastien Baillieul, Francois Arbib, Clara-Lou Kang, Van Ngo, Pierre Boutouyrie, Renaud Tamisier, Jean Louis Pepin
Summary: This observational study aimed to analyze the association between long-term continuous positive airway pressure (CPAP) adherence and cardiovascular outcomes. The study found that long-term CPAP adherence was positively associated with a reduction in all-cause mortality, but it did not significantly affect the occurrence of cardiovascular events.
Editorial Material
Clinical Neurology
Sebastien Baillieul, Renaud Tamisier, Millene Rodrigues Camilo, Octavio Marques Pontes-Neto
Article
Health Care Sciences & Services
Jean-Louis Pepin, Pauline Lemeille, Helene Denis, Anne Josseran, Florent Lavergne, Arnaud Panes, Sebastien Bailly, Alain Palot, Arnaud Prigent
Summary: This study investigated the health trajectories of individuals with COPD before initiating at-home NIV and compared mortality outcomes between different pre-NIV health trajectory groups. The findings revealed significant heterogeneity in clinical initiation of NIV, indicating the lack of strong evidence and guideline recommendations. Knowledge about these different clusters should be used to promote more consistent and personalized use of domiciliary NIV in COPD.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Health Care Sciences & Services
Francois Bughin, Monique Mendelson, Dany Jaffuel, Jean-Louis Pepin, Frederic Gagnadoux, Frederic Goutorbe, Beatriz Abril, Bronia Ayoub, Alexandre Aranda, Khuder Alagha, Pascal Pomies, Francois Roubille, Jacques Mercier, Nicolas Molinari, Yves Dauvilliers, Nelly Heraud, M. Hayot
Summary: This study aims to assess the potential benefits of a telerehabilitation program implemented at continuous positive airway pressure initiation compared to continuous positive airway pressure alone and usual care on symptoms and cardiometabolic risk factors of obstructive sleep apnea syndrome. The study is a 6-months multicenter randomized controlled trial including 180 obese patients with severe obstructive sleep apnea syndrome.
Article
Clinical Neurology
Jeremy Duval, Clementine Mouroux, Sophie Foury, Jean-Louis Pepin, Sebastien Bailly
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Kimberly L. Sterling, Naomi Alpert, Peter A. Cistulli, Jean-Louis Pepin, Suyog More, Kate V. Cole, Atul Malhotra
Summary: Obstructive sleep apnea (OSA) is a prevalent yet underdiagnosed disease that poses a significant economic burden on the US healthcare system. This retrospective study found that adherence to positive airway pressure (PAP) therapy is associated with reduced healthcare resource utilization and costs, providing additional evidence for the diagnosis and long-term treatment of OSA.
JOURNAL OF SLEEP RESEARCH
(2023)