Article
Clinical Neurology
Anatilde Trindade, Catarina Custodio, Jorge Cabral, Telma Lopes, Vera Martins, Margarida Aguiar, Ines Goncalves, Sofia Furtado
Summary: This study aimed to compare the adherence to positive airway pressure (PAP) therapy between patients with or without excessive daytime sleepiness (EDS) in different severities of obstructive sleep apnea (OSA). The results showed that there were differences in adherence between patients with different severities of OSA but without EDS. However, there was no difference in adherence between patients with or without EDS, regardless of the severity.
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Review
Pharmacology & Pharmacy
Jiahe Wang, Xiang Li, Siyuan Yang, Tianyi Wang, Zhongmou Xu, Jianguo Xu, Heng Gao, Gang Chen
Summary: Pitolisant demonstrated efficacy and controllable safety in treating excessive daytime sleepiness in patients with narcolepsy and OSA, showing reductions in ESS score, increased sleep latency, and improved quality of life. However, treatment with pitolisant may lead to insomnia as a treatment-emergent adverse event, emphasizing the importance of monitoring and management.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Psychiatry
Danwei Zhang, Zhen Zhang, Huihua Li, Kaimo Ding
Summary: The study indicates a significant relationship between excessive daytime sleepiness (EDS), depression, and obstructive sleep apnea (OSA). Continuous Positive Airway Pressure (CPAP) has been proven to be an effective therapy for improving EDS and depression in patients with OSA.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Yezhou Li, Jing Wang, Lirong Ji, Chaohong Cheng, Tong Su, Shuqing Wu, Fei Han, Daniel J. Cox, Erlei Wang, Rui Chen
Summary: This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. It was found that the cortical thickness was significantly thinner in the sleepiness group, particularly in the left temporal, frontal, and parietal lobe, and bilateral pre- and postcentral gyri. There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score.
FRONTIERS IN NEUROLOGY
(2023)
Article
Otorhinolaryngology
Sang Hoo Park, Woo Yong Bae, Sangjun Kim, Young Gun Kim, Young Bin Yun, Hyung Geun Lee, Bok Joo Kim, Jung-han Kim
Summary: This study aimed to compare the improvement and non-improvement groups of excessive daytime sleepiness in patients with obstructive sleep apnea (OSA). The results showed significant differences between the groups in Social Avoidance and Distress Scale (SADS), Fear of Negative Evaluation (FNE), apnea index (AI), apnea-hypopnea index (AHI), percentage of stage 2 non-REM sleep (N2%), and frequency of 3% oxygen desaturation (ODI3).
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Sang-Ahm Lee, Kayeong Im, Ha-Rin Yang, Hyo Jae Kim
Summary: There are significant sex differences in subjective daytime sleepiness in subjects with severe OSA and PLMS. Severe OSA may influence daytime sleepiness more in males, while PLMS may have a greater impact on daytime sleepiness in females.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Article
Clinical Neurology
Phoebe K. Yu, Jerilynn Radcliffe, H. Gerry Taylor, Raouf S. Amin, Cristina M. Baldassari, Thomas Boswick, Ronald D. Chervin, Lisa M. Elden, Susan L. Furth, Susan L. Garetz, Alisha George, Stacey L. Ishman, Erin M. Kirkham, Christopher Liu, Ron B. Mitchell, S. Kamal Naqvi, Carol L. Rosen, Kristie R. Ross, Jay Shah, Ignacio E. Tapia, Lisa R. Young, David A. Zopf, Rui Wang, Susan Redline
Summary: The relationship between the severity of obstructive sleep apnea and neurobehavioral morbidity is unclear. This study compares the neurobehavioral symptoms of mild sleep-disordered breathing and obstructive sleep apnea, finding that children with mild sleep-disordered breathing have more abnormal executive function scores and higher rates of inattention and hyperactivity compared to children with obstructive sleep apnea.
Review
Clinical Neurology
Reena Mehra, Raphael Heinzer, Pablo Castillo
Summary: While residual EDS can be difficult to treat, reversible issues may contribute to some cases, and wake-promoting medications may be helpful for others. Multidisciplinary management of patients with EDS is often recommended.
NEUROLOGY AND THERAPY
(2021)
Review
Clinical Neurology
Sarah Ronnebaum, Morgan Bron, Dipen Patel, Diane Menno, Shay Bujanover, David Kratochvil, Eleanor Lucas, Carl Stepnowsky
Summary: The study compared the efficacy and safety of medications (solriamfetol, modafinil, and armodafinil) used to treat excessive daytime sleepiness associated with obstructive sleep apnea. The results showed various levels of improvement in ESS, MWT20, and CGI-C after 12 weeks of treatment, with similar safety risks among participants.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Clinical Neurology
Riccardo A. Stoohs, Morris S. Gold
Summary: This study investigated the association between typical symptoms of obstructive sleep apnea, daytime somatic arousal, and the apnea-hypopnea index. The findings suggest that there is a relationship between sleepiness, fatigue, and somatic arousal in individuals with sleep apnea. The apnea-hypopnea index and the body sensation questionnaire (BSQ) both independently correlate with sleepiness, with the apnea-hypopnea index impacting sleepiness when it exceeds 50/h.
Article
Biology
Rosario Statello, Stefano Rossi, Francesco Pisani, Matteo Bonzini, Roberta Andreoli, Agnese Martini, Monica Puligheddu, Pierluigi Cocco, Michele Miragoli
Summary: This study found altered cardiac autonomic regulation in patients with obstructive sleep apnea (OSA) during nighttime and suggested that nighttime HRV could potentially be used as a predictor of sleep breathing disorders. These findings have important clinical implications for the diagnosis and prognosis of OSA.
Article
Clinical Neurology
Jeong Sik Kim, Do Eon Lee, Hyoeun Bae, Joo Yeon Song, Kwang Ik Yang, Seung Bong Hong
Summary: This study aimed to investigate the long-term effects of vagus nerve stimulation (VNS) on sleep-disordered breathing (SDB), daytime sleepiness, and sleep quality in patients with drug-resistant epilepsy (DRE), as well as the relationships among these effects, clinical characteristics, and VNS parameters. The findings showed that VNS improved seizure control in DRE patients but increased obstructive sleep apnea. Age and epilepsy duration were found to influence the increase in sleep-disordered breathing.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Karin Elisabeth Sundt Mjelle, Sverre Lehmann, Ingvild West Saxvig, Shashi Gulati, Bjorn Bjorvatn
Summary: This study investigates the possible associations between obstructive sleep apnea (OSA) and fatigue, as well as the associations with excessive sleepiness, depression, and anxiety. The study finds that pathological fatigue, anxiety, and depression do not increase with the severity of OSA, while excessive sleepiness does.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pediatrics
Eduardo Machado Rossi-Monteiro, Laura Rodrigues Sefair, Marcos Correia Lima, Maria Fernanda Lima Nascimento, Daniel Mendes-Pinto, Lukas Anschuetz, Maria Gloria Rodrigues-Machado
Summary: This study aimed to compare cardiovascular parameters between healthy children and those with obstructive sleep-disordered breathing (oSDB), as well as identify predictors of arterial stiffness indices in children with oSDB. Children with oSDB showed higher reflection coefficient and augmentation index compared to controls, indicating increased arterial stiffness. Multiple regression analysis revealed age, female sex, reflection coefficient, and systolic volume as independent predictors of augmentation index, while higher pulse wave velocity was associated with poorer quality of life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Katina Aleksovska, Claudio L. A. Bassetti, Thomas Berger, Vanessa Carvalho, Joao Costa, Guenther Deuschl, Kristian S. Frederiksen, Joke Jaarsma, Teia Kobulashvili, Maurizio Leone, Lucia Pavlakova, Michele Romoli, Luca Vignatelli
Summary: This paper aims to establish a set of criteria for prioritizing topics for future European Academy of Neurology (EAN) guidelines. Through literature review, a Delphi consensus procedure, and voting, a set of approved criteria were determined, and the first 30 topics were selected. The process involved both a bottom-up approach with community involvement and a top-down approach with board member selection.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Rocco Vergallo, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Massimo Volpe, Carlo Patrono
EUROPEAN HEART JOURNAL
(2023)
Review
Peripheral Vascular Disease
James E. Sharman, Pedro Ordunez, Tammy Brady, Gianfranco Parati, George Stergiou, Paul K. Whelton, Raj Padwal, Michael Hecht Olsen, Christian Delles, Aletta E. Schutte, Maciej Tomaszewski, Daniel T. Lackland, Nadia Khan, Richard J. McManus, Ross T. Tsuyuki, Xin-Hua Zhang, Lisa D. Murphy, Andrew E. Moran, Markus P. Schlaich, Norm R. C. Campbell
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Clinical Neurology
Sven Svedmyr, Jan Hedner, Maria Rosaria Bonsignore, Carolina Lombardi, Gianfranco Parati, Ondrej Ludka, Ding Zou, Ludger Grote
Summary: The study found that monotherapy with beta-blocker can lower systolic blood pressure in non-obese middle-aged males with hypertension. However, in patients with moderate-severe obstructive sleep apnea, the combination of a beta-blocker and a diuretic can lower both systolic and diastolic blood pressure.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Medicine, General & Internal
Greta Mainieri, Giuseppe Loddo, Luca Baldelli, Angelica Montini, Susanna Mondini, Federica Provini
Summary: Disorders of arousal (DoA) are a type of NREM parasomnia characterized by motor and emotional behaviors that arise from incomplete awakenings from deep sleep. While DoA are commonly seen in children, they can persist into adulthood with different features. Adults with DoA often experience excessive sleepiness and potentially harmful behaviors, which are rare in childhood.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Paola Faverio, Umberto Zanini, Anna Monzani, Gianfranco Parati, Fabrizio Luppi, Carolina Lombardi, Elisa Perger
Summary: The prevalence and impact of sleep-disordered breathing (SDB) in chronic respiratory infections, such as cystic fibrosis (CF), bronchiectasis, and mycobacterial infections, are reported in this narrative review. The common pathophysiological mechanisms underlying SDB onset in these infections include inflammation, nocturnal cough and pain, mucous plugs, ventilatory impairment, upper airway involvement, and comorbidities. SDB may affect approximately 50% of bronchiectasis patients and significantly impact the quality of life in both children and adults with CF. Routine assessment of SDB should be incorporated into the clinical evaluation of patients with CF from the early stages of the disease to avoid late diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Clinical Neurology
Federica Provini, Raffaele Ferri
Article
Multidisciplinary Sciences
Elisa Perger, Paolo Castiglioni, Andrea Faini, Davide Soranna, Antonella Zambon, Debora Rosa, Stefano Vicini, Paolo Meriggi, Laura Pini, Claudia Baratto, Sergio Caravita, Ali Azarbarzin, Gianfranco Parati, Carolina Lombardi
Summary: The combination of noradrenergic and antimuscarinic drugs can reduce the severity of obstructive sleep apnea. However, there is no data on its effects on cardiac autonomic modulation. This study aimed to evaluate the impact of 1-week treatment with this drug on cardiovascular autonomic control in OSA patients.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Andrea Zagaria, Scarpelli Serena, Alessandro Musetti, Giada Rapelli, Luigi De Gennaro, Giuseppe Plazzi, Christian Franceschini
Summary: This study investigated changes in sleep problems during the COVID-19 pandemic and found a link between sleep hygiene practices and sleep disruptions. Improving sleep hygiene practices may help mitigate the negative impact of the COVID-19 pandemic on sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Angelica Montini, Alex Iranzo, Pietro Cortelli, Carles Gaig, Amaia Munoz-Lopetegi, Federica Provini, Joan Santamaria
Summary: This study aimed to develop a scoring method that incorporates stages previously used in neurodegenerative diseases and test it in patients with alpha-synucleinopathies. The results showed that using this scoring system allowed an accurate description of the complex sleep-wake changes in patients with alpha-synucleinopathies.
Article
Computer Science, Information Systems
Matteo Rossi, Davide Sala, Dario Bovio, Caterina Salito, Giulia Alessandrelli, Carolina Lombardi, Luca Mainardi, Pietro Cerveri
Summary: There is growing evidence that the combination of wearable devices and deep learning for multifactorial nocturnal monitoring may disrupt the early diagnosis and assessment of sleep disorders. This study used optical, differential air-pressure, and acceleration signals from a chest-worn sensor to train a deep network to classify overall signal quality, breathing patterns, and sleep patterns. The developed architecture provided additional qualitative and quantitative data to improve the interpretation of predictions. The accuracy of the network varied across different classification sets, with higher accuracy for distinguishing normal from corrupted signals and breathing patterns compared to sleep patterns.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Correction
Cardiac & Cardiovascular Systems
Stephane Doutreleau, Mathilde Ulliel-Roche, Ivan Hancco, Sebastien Bailly, Laura Oberholzer, Paul Robach, Julien Brugniaux, Aurelien Pichon, Emeric Stauffer, Elisa Perger, Gianfranco Parati
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
Laura Maria Beatrice Belotti, Mirko Di Martino, Corrado Zenesini, Luca Vignatelli, Elisa Baldin, Flavia Baccari, Ben Ridley, Francesco Nonino
Summary: A cohort study conducted in Northern Italy found that highly adherent patients with multiple sclerosis (MS) had a 25% lower risk of experiencing moderate or severe relapses compared to non-adherent patients. The study highlights the importance of DMD adherence in reducing relapse rates and suggests that choosing the right DMD and promoting treatment adherence are crucial for physicians and patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)