Article
Physiology
Isabella T. Wu, Michael C. Gibbons, Mary C. Esparza, Laura S. Vasquez-Bolanos, Sydnee A. Hyman, Shanelle N. Dorn, Anshuman Singh, John G. Lane, Donald C. Fithian, Severin Ruoss, Samuel R. Ward
Summary: This study characterized the progression of muscle and fat changes over time after the repair of a chronic rotator cuff tear in a rabbit model. The results showed that atrophy and muscle degeneration peaked around 2 weeks after repair, with no significant regeneration observed. Fat accumulation and fibrosis were increased at all time points compared to the contralateral side.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Cheng Wang, Xiaoyuan Ma, Qiaohui Liu, Guofeng Dai
Summary: Minimally invasive surgery for humeral fractures may have cosmetic benefits, but postoperative malrotation could increase the risk of rotator cuff and cartilage degeneration. Animal experiments showed that the malrotated group had higher scores for cartilage and rotator cuff pathology, as well as disrupted collagen alignment.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Dong Hyun Kim, Seung Gi Min, Ho Seok Lee, Hyun Joo Lee, Kyeong Hyeon Park, Seok Won Chung, Amir Dehdashtian, Jong Pil Yoon
Summary: The clinical outcomes improved after rotator cuff repair regardless of the presence of concomitant osteoarthritis. However, patients with large-to-massive rotator cuff tears and associated osteoarthritis had significantly inferior clinical results compared with those without osteoarthritis.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Multidisciplinary Sciences
Chul-Hyun Cho, Ki-Choer Bae, Du-Han Kim
Summary: This study investigated the incidence and risk factors of early postoperative stiffness in patients undergoing isolated ARCR without preoperative stiffness. The overall incidence of early postoperative stiffness was 14.2%, with diabetes mellitus and timing of rehabilitation identified as independent risk factors.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Liren Wang, Yuhao Kang, Guoming Xie, Jiangyu Cai, Chang'an Chen, Xiaoyu Yan, Jia Jiang, Jinzhong Zhao
Summary: Severe rotator cable tears do not significantly impair rotator cuff function, while tears involving all rotator cuff tissue above the humeral head rotation center result in obvious functional impairment.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Rehabilitation
Alan Z. Grusky, Amos Song, Peter Kim, Gregory D. Ayers, Laurence D. Higgins, John E. Kuhn, Keith M. Baumgarten, Elizabeth Matzkin, Nitin B. Jain
Summary: In a cohort of patients with shoulder pain, older age, involvement of the dominant shoulder, and a higher body mass index were found to be independently associated with rotator cuff tears. Further research is needed to understand the mechanisms behind these associations.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Medicine, General & Internal
Der-Sheng Han, Wei-Ting Wu, Po-Cheng Hsu, Hsiang-Chi Chang, Kuo-Chin Huang, Ke-Vin Chang
Summary: Sarcopenia is significantly associated with shoulder pain and consistent tendinopathic changes in the supraspinatus tendons in sarcopenic patients. However, sarcopenia is less likely to be associated with serious rotator cuff pathology, such as tendon tears.
FRONTIERS IN MEDICINE
(2021)
Article
Orthopedics
Filippo Familiari, Roberto Castricini, Olimpio Galasso, Giorgio Gasparini, Bruno Ianno, Francesco Ranuccio
Summary: The study identified the top 50 most cited articles on rotator cuff tears, mainly clinical articles with Level IV evidence as the most common.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Orthopedics
James Johnson, Devin von Stade, Ben Gadomski, Daniel Regan, Jeremiah Easley, Katie J. Sikes, Kevin Troyer, Tianjian Zhou, Ted Schlegel, Kirk McGilvray
Summary: The biomechanical and histopathological properties of human rotator cuff tendons vary with age, with younger tendons exhibiting different properties compared to older tendons. These findings provide important insights into the natural aging process and degenerative changes of tendons.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Yoshitsugu Takeda, Koji Fujii, Naoto Suzue, Katsutoshi Miyatake, Yoshiteru Kawasaki, Kenji Yokoyama
Summary: This study revealed that intraoperative repair tension is closely related to tear size in the mediolateral direction, and mediolateral tear size is an independent predictor of repair tension. Repair tension and geometric classification are significant factors influencing rotator cuff integrity after ARCR.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Orthopedics
Alejandro Pagan-Conesa, Maria Tiscar Garcia-Ortiz, Emilio Jose Salmeron-Martinez, Alejandro Moya-Martinez, Fernando Lopez-Prats
Summary: This study found that supraspinatus muscular atrophy changes can be reversed after repair and quantified using ultrasound imaging. Patte II cases showed the best results after repair, while Patte III cases showed minimal improvement in terms of atrophy but improvement clinically. Factors such as echogenicity and PA after surgery were related to symptom recurrence.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Medicine, General & Internal
Haifeng Liu, Tony Chieh-Ting Huang, Hanzhong Yu, Yicun Wang, Daping Wang, Zeling Long
Summary: A study compared the effects of TSA and RSA on OA patients with or without rotator cuff damage. The results showed that for patients with rotator cuff damage, the complication rates of RSA were comparable to TSA. However, for patients without rotator cuff damage, RSA had more and severer complications.
Article
Orthopedics
Elizabeth L. Yanik, Nancy L. Saccone, Alexander W. Aleem, Aaron M. Chamberlain, Benjamin Zmistowski, Julianne A. Sefko, Jay D. Keener
Summary: Genetic factors may influence the age at diagnosis for atraumatic rotator cuff tear patients. Specific single nucleotide polymorphisms (SNPs) are associated with younger diagnosis age, but not with bilateral tear prevalence or tear size. Further research is needed to determine if genetic markers can be used alongside patient characteristics to identify optimal surgical repair candidates.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Scott M. Bolam, Young-Eun Park, Subhajit Konar, Karen E. Callon, Josh Workman, A. Paul Monk, Brendan Coleman, Jillian Cornish, Mark H. Vickers, Jacob T. Munro, David S. Musson
Summary: In a rat model of RC repair, diet-induced obesity (DIO) resulted in inferior enthesis healing, with poor biomechanical and histological outcomes. Restoring a normal weight with dietary changes after surgery did not improve the healing outcomes.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Christos K. Yiannakopoulos, Iakovos Vlastos, Georgios Theotokatos, Nikiforos Galanis
Summary: Through a prospective study on 811 consecutive patients over the age of 55, the significance of untreated primary acromioclavicular joint osteoarthritis in arthroscopic rotator cuff repair was evaluated. The findings suggest that distal clavicle excision may not be necessary to alleviate pain symptoms related to ACJ osteoarthritis, whether symptomatic or asymptomatic.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Orthopedics
Samuel Rosas, Andrey Zuskov, Tianyi David Luo, Martin W. Roche, Cynthia L. Emory, Johannes F. Plate
Summary: This study evaluated the outcomes of patients with gout following total knee arthroplasty (TKA) through a case-control study. The study found that patients with gout had higher rates of postoperative complications and increased costs compared to controls.
JOURNAL OF KNEE SURGERY
(2022)
Article
Geriatrics & Gerontology
Brett M. Frye, Payton M. Valure, Suzanne Craft, Mark G. Baxter, Christie Scott, Shanna Wise-Walden, David W. Bissinger, Hannah M. Register, Carson Copeland, Matthew J. Jorgensen, Jamie N. Justice, Stephen B. Kritchevsky, Thomas C. Register, Carol A. Shively
Summary: The study showed that gait speed and cognitive performance decline in older vervet monkeys, there is a strong agreement in performance between the novel executive function task and the established working memory assessment, and slow gait is associated with poor cognitive performance in both domains.
Review
Zoology
Brett M. Frye, Suzanne Craft, Caitlin S. Latimer, C. Dirk Keene, Thomas J. Montine, Thomas C. Register, Miranda E. Orr, Kylie Kavanagh, Shannon L. Macauley, Carol A. Shively
Summary: The study highlights the vervet monkey as a suitable model for age-related Alzheimer's disease, with traits related to cognitive function, physical function, glucose handling, and more. Evidence suggests that aging vervets exhibit characteristics consistent with early AD, making them a valuable model for LOAD research. Studies show relationships between AD-like neuropathology in vervets and modifiable risk factors, shaping future research to understand mechanisms underlying divergent neurocognitive aging trajectories and develop interventions for LOAD.
AMERICAN JOURNAL OF PRIMATOLOGY
(2021)
Article
Clinical Neurology
Siobhan Hoscheidt, Ashley H. Sanderlin, Laura D. Baker, Youngkyoo Jung, Samuel Lockhart, Derek Kellar, Christopher Whitlow, Angela J. Hanson, Seth Friedman, Thomas Register, James B. Leverenz, Suzanne Craft
Summary: The study revealed that dietary patterns in mid-life are associated with Alzheimer's disease risk, and individuals with different cognitive statuses respond differently to different diets.
ALZHEIMERS & DEMENTIA
(2022)
Article
Orthopedics
Raveena M. Doshi, Monique Y. Reid, Nikhil N. Dixit, Emily B. Fawcett, Jacqueline H. Cole, Katherine R. Saul
Summary: The study compared functional movement outcomes in rats with brachial plexus birth injury (BPBI) after preganglionic and postganglionic neurectomy, finding that the preganglionic neurectomy group spent less time in stance and exhibited less elbow flexion and shoulder protraction in the affected limb. Results indicate the presence of compensatory motor control strategies during locomotion following BPBI.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Obstetrics & Gynecology
M. Nudy, R. Xie, D. M. O'Sullivan, X. Jiang, S. Appt, T. C. Register, J. R. Kaplan, T. B. Clarkson, P. F. Schnatz
Summary: Through an experiment conducted on female cynomolgus monkeys, it was found that coronary artery VDR expression was associated with systemic coronary artery atherosclerosis risk factors, with high VDR expression correlating with lower systemic inflammation markers.
Article
Multidisciplinary Sciences
Derek Kellar, Thomas Register, Samuel N. Lockhart, Paul Aisen, Rema Raman, Robert A. Rissman, James Brewer, Suzanne Craft
Summary: Intranasal insulin (INI) has shown promise in treating Alzheimer's disease (AD) by improving biomarker profiles and slowing symptom progression. In a phase 2 trial, participants with mild cognitive impairment or AD who received INI treatment showed increased immune/inflammatory/vascular markers in their Cerebral Spinal Fluid (CSF) compared to placebo. The insulin-treated group also exhibited different associations between these markers and cognitive changes, brain volume, and amyloid and tau concentrations, suggesting a compensatory immune response associated with therapeutic benefit.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Marnie G. Silverstein-Metzler, Brett M. Frye, Jamie N. Justice, Thomas B. Clarkson, Susan E. Appt, J. Jeffrey Carr, Thomas C. Register, Mays Albu-Shamah, Hossam A. Shaltout, Carol A. Shively
Summary: Chronic psychosocial stress is associated with an increased risk of type 2 diabetes. This study found that social subordination stress and a Western diet have significant effects on body composition and carbohydrate metabolism in middle-aged female primates.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Tina E. Brinkley, Iris Leng, Thomas C. Register, Bryan J. Neth, Henrik Zetterberg, Kaj Blennow, Suzanne Craft
Summary: This study compared the effects of a Modified Mediterranean Ketogenic (MMK) diet and an American Heart Association (AHA) diet on body weight, body composition, body fat distribution, and their association with cerebrospinal fluid (CSF) biomarkers in older adults. The results showed that the MMK diet led to favorable changes in body composition, body fat distribution, and CSF biomarkers.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Corbin S. C. Johnson, Brett M. Frye, Thomas C. Register, Noah Snyder-Mackler, Carol A. Shively
Summary: Dietary composition is associated with the prevalence of psychiatric disorders, with the Western diet increasing the risk while the Mediterranean diet reducing the risk. In nonhuman primates, diet composition may affect immune system function through its effects on behavior. A randomized preclinical trial on middle-aged female cynomolgus macaques showed that the Mediterranean diet improved social behavior, reduced social isolation and anxiety, potentially mitigating social isolation-associated disorders.
Article
Geriatrics & Gerontology
Jacob D. Negrey, Brett M. Frye, Suzanne Craft, Thomas C. Register, Mark G. Baxter, Matthew J. Jorgensen, Carol A. Shively
Summary: This study examined the age-related associations between social interactions, activity patterns, and cognitive function in female vervet monkeys. The results showed that time spent in affiliative behavior and grooming others decreased with age, while time spent alone increased. The number of social partners for grooming also decreased. Grooming patterns mirrored physical activity levels, and cognitive performance partially mediated the relationship between age and grooming time. These findings suggest that aging vervet monkeys engage less in social behavior, potentially due to cognitive deficits.
Article
Clinical Neurology
Brett M. M. Frye, Suzanne Craft, Thomas C. C. Register, Jeongchul Kim, Christopher T. T. Whitlow, Richard A. A. Barcus, Samuel N. N. Lockhart, Kiran Kumar Solingapuram Sai, Carol A. A. Shively
Summary: This study examined the relationship between age, cognitive performance, and neuroanatomy in vervet monkeys. The results showed that age was negatively associated with cortical gray matter volume and temporal-parietal cortical thickness. Additionally, cortical gray matter volumes predicted working memory performance. This study provides a foundation for future investigations into the early diagnosis and treatment of Alzheimer's disease.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Article
Clinical Neurology
Ashish Kumar, Mitu Sharma, Yixin Su, Sangeeta Singh, Fang-Chi Hsu, Bryan J. Neth, Thomas C. Register, Kaj Blennow, Henrik Zetterberg, Suzanne Craft, Gagan Deep
Summary: The study analyzed neuron-enriched extracellular vesicles to predict the response and molecular mechanisms of a modified Mediterranean-ketogenic diet in participants with mild cognitive impairment. The findings suggest that these small extracellular vesicles offer promise in assessing the efficacy of dietary interventions against mild cognitive impairment/Alzheimer's disease, showing reductions in amyloid beta and tau proteins with dietary intervention. Furthermore, the vesicles also demonstrated a differential targeting of glutamate receptors and strong correlation with clinical biomarkers.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Jacob D. Negrey, Dorothy L. Dobbins, Timothy D. Howard, Karin E. Borgmann-Winter, Chang-Gyu Hahn, Sergey Kalinin, Douglas L. Feinstein, Suzanne Craft, Carol A. Shively, Thomas C. Register
Summary: The study demonstrates age-related differential gene expression in the olfactory pathway, which is associated with neuropathological markers of Alzheimer's disease. These findings provide insights into the mechanisms underlying early AD pathogenesis and potential targets for therapeutic intervention.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Article
Veterinary Sciences
Sri Rahmatul Laila, Dewi Apri Astuti, Irma Herawati Suparto, Ekowati Handharyani, Thomas C. Register, Dondin Sajuthi
Summary: This study assessed carotid artery lesions in Indonesian cynomolgus monkeys exposed to an atherogenic diet. The results showed severe atherosclerosis and macrophage infiltration in monkeys with intermediate and hyper-responsive characteristics.
VETERINARY SCIENCES
(2022)