Article
Pharmacology & Pharmacy
Abdullah A. Alamoudi, Osama A. A. Ahmed, Khalid M. El-Say
Summary: This study successfully enhanced the transdermal delivery and bioavailability of avanafil using optimized TPGS-based mixed micelle-loaded film design.
Article
Medicine, Research & Experimental
Jin Wang, Yan-li Wang, Yao He, Sen Li, You-peng Zhang, Yong-biao Cheng, Jia-lun Guo, Lin Sun, Yu Xin, Yong Tang, Zhao-hui Zhu, Han-qing Zeng
Summary: This study found that a history of drinking, spousal noncooperation, number of fixed sex partners, long duration of ED, and depression could be influencing factors for ED patients' non-response to PDE5 inhibitors.
CURRENT MEDICAL SCIENCE
(2021)
Article
Andrology
Ahmed S. Zaghloul, Abdelrahman M. El-Nashaar, Shady Z. Said, Ihab A. Osman, Taymour Mostafa
Summary: This study evaluated the effectiveness of platelet-rich plasma (PRP) combined with oral tadalafil in diabetic patients with erectile dysfunction (ED) who did not respond to PDE5 inhibitors. The results showed that PRP therapy significantly improved erectile function and erection hardness in these patients. Furthermore, the level of diabetic control was associated with treatment outcomes.
Article
Biochemistry & Molecular Biology
Abhinandan D. Hudwekar, Pankul Kotwal, Mohd. Ishaq Dar, Shilpi Balgotra, Ashish Dogra, Jaspreet Kour, Santosh S. Chobe, Utpal Nandi, Sajad Hussain Syed, Sanghapal D. Sawant
Summary: Continuing our research on sildenafil analogs as inhibitors of PDE5 for erectile dysfunction, we found that modifications at the N-methylpiperazine ring with hydrophobic region followed by hydrogen bond donor or acceptor region have potential. However, previously identified leads had limitations such as poor pharmacokinetic profile, low aqueous solubility, and poor bioavailability. Therefore, we designed, synthesized, and screened a new series of sildenafil based analogs. Compound 18 showed excellent in vitro activity with selectivity towards PDE5 isozyme, as well as excellent in vivo activity and pharmacokinetic profile. The compound also exhibited excellent cyp inhibition and CaCO2 permeability.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Endocrinology & Metabolism
Giuseppe Defeudis, Rossella Mazzilli, Marta Tenuta, Giovanni Rossini, Virginia Zamponi, Soraya Olana, Antongiulio Faggiano, Paolo Pozzilli, Andrea M. Isidori, Daniele Gianfrilli
Summary: This study reviews the definition and prevalence of erectile dysfunction in diabetes mellitus, the impact of diabetes complications and treatment on erectile dysfunction, and current and emerging therapies for erectile dysfunction in patients with diabetes mellitus.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Otorhinolaryngology
Lillian W. Dattilo, Alan D. Workman, Neil Bhattacharyya
Summary: The study shows a significant association between chronic rhinosinusitis and erectile dysfunction, which remains even when the interval between diagnosis and treatment is restricted. This adds to the literature demonstrating the link between chronic rhinosinusitis and sexual dysfunction.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Physiology
Pamela da Silva Pereira, Dalila Andrade Pereira, Fabiano Beraldi Calmasini, Leonardo O. Reis, Nathan Brinkman, Arthur L. Burnett, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: This study found that in sickle cell disease, decreased haptoglobin levels contribute to abnormal erectile function. Treatment with haptoglobin can improve erectile function by regulating the expression of key proteins involved in the control of penile erection. This suggests that haptoglobin treatment may be an additional strategy to prevent priapism in sickle cell disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Alberto Ongaro, Giuseppe Zagotto, Maurizio Memo, Alessandra Gianoncelli, Giovanni Ribaudo
Summary: In 1998, sildenafil was introduced as the first FDA-approved oral drug for treating erectile dysfunction (ED). Over the past two decades, the development of other synthetic PDE5 inhibitors has been accompanied by the increasing popularity of natural remedies from various chemical classes. In this study, in silico tools were used to evaluate the efficacy of 30 natural compounds claimed to be effective against ED, focusing on pharmacokinetic properties, binding energies for PDE5, and comparison with sildenafil's interaction pattern with PDE.
NATURAL PRODUCT RESEARCH
(2021)
Review
Plant Sciences
A. Anand Ganapathy, V. M. Hari Priya, Alaganandam Kumaran
Summary: This paper reviewed 97 medicinal plants with PDE5 inhibitory effect, of which 77 were selected based on their traditional use as aphrodisiacs. Isoflavones and biflavones were identified as the major active constituents responsible for action, while Icariin and Icariside II were found to be the most effective inhibitors from natural sources. Traditional medicines containing extracts of Ginkgo biloba, Kaempferia parviflora, Clerodendrum colebrookianum, Eurycoma longifolia, and Vitis vinifera were also found to inhibit the PDE5 enzyme.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zheng Wang, Yunyun Wang, Jiachao Xiong, Xinxin Gan, Yewei Bao, Aimin Jiang, Ye Zhou, Huangfu Zhao, Yiren Yang, Zhiyong Liu, Demeng Xia, Linhui Wang
Summary: A two-sample Mendelian randomization (MR) study revealed a positive causal link between hypertension and the risk of erectile dysfunction. Various MR methods consistently showed that hypertension is associated with an increased risk of erectile dysfunction. Therefore, more attention should be given to prevent or improve erectile function in the management of hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Urology & Nephrology
Taymour Mostafa, Moheiddin F. Alghobary
Summary: Oral phosphodiesterase type 5 inhibitors (PDE5Is) are widely used for the treatment of erectile dysfunction (ED). However, some men abuse these drugs for recreational use to enhance their sexual performance. This literature review reveals a high prevalence of recreational use of oral PDE5Is, highlighting the need for increased awareness and regulation to protect consumers from potential adverse effects.
SEXUAL MEDICINE REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Mattia Longoni, Alessandro Bertini, Nicolo Schifano, Emanuele Zaffuto, Paolo Maggio, Rossi Piercarlo, Sara Baldini, Giulio Carcano, Gabriele Antonini, Andrea Salonia, Francesco Montorsi, Federico Deho, Paolo Capogrosso
Summary: Erectile dysfunction (ED) affects a significant percentage of men worldwide, with a strong correlation to aging. Various pharmacological treatments, including oral, injection, and topical/intraurethral therapies, are available for ED. This study provides a comprehensive overview of these treatment options, including available drugs and formulations, their effectiveness, common adverse events, and prescription guidelines. Future directions in ED pharmacotherapy are also discussed.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Bingbing Zhu, Yangjiu Niu, Lipan Niu, Xijia Zhang, Fengxia Liu
Summary: Sildenafil improves erectile dysfunction by inhibiting inflammation. Intervention with sildenafil can alleviate IL-18-induced inflammation in high-fat diet-induced ED rats, enhancing erectile function through modulation of the NLRP3/caspase-1 pyroptosis pathway.
Article
Medicine, General & Internal
Virginia Zamponi, Giuseppe Defeudis, Francesca Federico, Antongiulio Faggiano, Rossella Mazzilli
Summary: This study evaluated the prevalence of diabetes mellitus (DM) among patients with erectile dysfunction (ED) and the impact of glycometabolic compensation and antihyperglycemic treatment on ED severity. The study found that DM patients had higher severity of ED and lower response to PDE5-i treatment. A better glycometabolic profile, as well as new antihyperglycemic drugs, seemed to have a positive effect on improving ED.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Anthony P. Nunes, John D. Seeger, Andrew Stewart, Alankar Gupta, Thomas McGraw
Summary: This real-world study found that co-possession of nitrate and PDE5i prescriptions is not associated with an increased risk of cardiovascular outcomes. Most cardiovascular outcome rates were not significantly different between co-possession and ED + PDE5i periods, although some outcomes were higher with co-possession. Many patients discussed the risks of co-possession with their physicians and received warnings or instructions.
JOURNAL OF SEXUAL MEDICINE
(2021)
Review
Andrology
Andrea Sansone, Tommaso B. Jannini, Susanna Dolci, Emmanuele A. Jannini
Summary: Peter Abelard is a renowned figure in philosophy, theology, and psychology, known for his mastery of dialectical debate. His relationship with Heloise d'Argenteuil is characterized by intense passion and documented through their correspondence, which has become a model for sentimental education and romantic love letters. Through analysis of Abelard's writings and historical context, we aim to explore whether he was castrated or subjected to an even more brutal punishment.
Article
Medicine, General & Internal
Lorenzo Spirito, Michele Morelli, Roberto La Rocca, Luigi Napolitano, Claudia Colla Ruvolo, Lorenzo Romano, Angelo di Giovanni, Carmine Sciorio, Sergio Concetti, Emanuele Montanari, Francesca Tripodi, Ferdinando Fusco, Marco Capece
Summary: In this longitudinal study, it was found that quarantine negatively impacted the sexual function of infected male patients. However, after 3 months of testing negative for SARS-CoV-2, a promising return to pre-infection sexual function levels was observed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychology, Clinical
Roberta Galizia, Francesca M. Tripodi, Roberta Rossi, Paolo M. Michetti, Chiara Simonelli, Filippo M. Nimbi
Summary: This study aimed to analyze the psychometric properties of the Italian versions of the 12-item Sexual Distress Scale (SDS) and the 5-item Sexual Distress Scale-Short Form (SDS-SF). The results support their adequacy, reliability, and validity, suggesting their usefulness for assessing sexual distress in clinical and research settings.
JOURNAL OF SEX & MARITAL THERAPY
(2023)
Letter
Andrology
Elena Colonnello, Andrea Sansone, Emmanuele A. A. Jannini
Review
Endocrinology & Metabolism
Bac Nguyen Hoai, Long Hoang, Thang Nguyen Cao, Quan Pham Minh, Emmanuele A. JanninI
Summary: Hypogonadism can have a significant impact on men's physical and psychological health, but diagnosing and treating it in developing countries can be challenging due to lack of awareness, limited resources, and high treatment costs. This review examines the potential benefits and risks of testosterone replacement therapy (TRT) from the perspective of a developing country.
Article
Urology & Nephrology
Giacomo Ciocca, Giulia Origlia, Erika Limoncin, Daniele Mollaioli, Annalisa Tanzilli, Vittorio Lingiardi, Emmanuele A. Jannini
Summary: This study aimed to investigate the role of the capacity to love in hypersexual behavior, considering distress and defense mechanisms as possible mediators. The findings revealed a significant negative relationship between the capacity to love and hypersexual behavior. Psychological distress and immature defense mechanisms were found to mediate this relationship. The results highlight the importance of the capacity to love in mental and sexual health.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Roberta Galizia, Annalisa Theodorou, Chiara Simonelli, Carlo Lai, Filippo Maria Nimbi
Summary: This study tested a mediation model and found that the quality of dyadic sexual communication plays a key role in decreasing the degree of perceived sexual desire discrepancy through increased sexual satisfaction.
Article
Health Care Sciences & Services
Filippo Maria Nimbi, Roberta Galizia, Erika Limoncin, Tom Levy, Emmanuele Angelo Jannini, Chiara Simonelli, Renata Tambelli
Summary: The present study aimed to develop and validate the Sexual Desire and Erotic Fantasies questionnaire-Part 2 (SDEF2), focusing on the use, experiences, attitudes, and sharing of sexual fantasies. The SDEF2 showed good psychometric properties, internal reliability, construct, and discriminant validity, being able to differentiate between sexually clinical and functional individuals. This study validates the usefulness of the SDEF2 in assessing different aspects related to fantasizing activity, which is associated with sexual functioning and satisfaction.
Letter
Psychology, Clinical
Hui Zhang, Elena Colonnello, Fu Wang, Emmanuele A. Jannini
ARCHIVES OF SEXUAL BEHAVIOR
(2023)
Article
Psychology, Multidisciplinary
Filippo Maria Nimbi, Roberto Baiocco, Guido Giovanardi, Annalisa Tanzilli, Vittorio Lingiardi
Summary: This study examined the psychological and social factors related to the fear of monkeypox. The findings showed that factors such as identity, education level, religious importance, COVID-19 vaccine doses, current quality of life, and the impact of the COVID-19 pandemic were associated with higher levels of monkeypox fear. These results can inform the development of targeted education and prevention programs to reduce fear and promote healthier behaviors.
BEHAVIORAL SCIENCES
(2023)
Article
Andrology
Hoai Bac Nguyen, Cao Thang Nguyen, Minh Quan Pham, Long Hoang, Andrea Sansone, Emmanuele A. Jannini
Summary: This study aimed to determine the validity and threshold value of self-estimated intravaginal ejaculation latency time (PIELT) in the diagnosis of premature ejaculation (PE). The results showed that a PIELT of <= 3.5 minutes predicts PE, indicating the need to revise the taxonomy and definition of PE.
Review
Medicine, General & Internal
Hui Zhang, Elena Colonnello, Andrea Sansone, Fu Wang, Jun Guo, Chunling Wang, Yan Zhang, Emmanuele A. Jannini
Summary: This study evaluated the efficacy of acupuncture in treating premature ejaculation (PE) and found that acupuncture has a significant effect on improving certain important indicators of PE. However, due to the low quality of the included studies, larger and well-designed randomized controlled trials are needed to confirm these findings.
Meeting Abstract
Psychology, Clinical
Roberta Galizia, Serena Petrocchi, Peter Johannes Schulz, Filippo Maria Nimbi, Chiara Simonelli
INTERNATIONAL JOURNAL OF SEXUAL HEALTH
(2022)
Meeting Abstract
Psychology, Clinical
Alain Giami, Stefano Eleuteri, Filippo Maria Nimbi, Brice Gouvernet, Joseph Tucker
INTERNATIONAL JOURNAL OF SEXUAL HEALTH
(2022)
