Article
Multidisciplinary Sciences
Darshini Mahadevia, Rinki Saha, Alessia Manganaro, Nao Chuhma, Annette Ziolkowski-Blake, Ashlea A. Morgan, Dani Dumitriu, Stephen Rayport, Mark S. Ansorge
Summary: The authors demonstrate that terminal activity of dopaminergic neurons projecting from the ventral tegmental area to the lateral septum plays a key role in promoting aggression in mice. Dopamine acts on D2 receptors to inhibit GABAergic neurons within the lateral septum, and septal D2 signaling is essential for ventral tegmental area dopamine activity to promote aggression.
NATURE COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Marcos Antonio Lopez-Patino, Arleta Krystyna Skrzynska, Fatemeh Naderi, Juan Miguel Mancera, Jesus Manuel Miguez, Juan Antonio Martos-Sitcha
Summary: Chronic stress exposure, such as high stocking density and food deprivation, enhanced the stress response parameters in gilthead sea bream juveniles. The monoaminergic activities in different brain regions helped to reorganize the physiological response to the challenges applied, suggesting a role of brain monoaminergic activity in orchestrating the endocrine response to chronic stress in fish.
Review
Biochemistry & Molecular Biology
Andrea de Bartolomeis, Giuseppe De Simone, Mariateresa Ciccarelli, Alessia Castiello, Benedetta Mazza, Licia Vellucci, Annarita Barone
Summary: Schizophrenia is a severe mental illness characterized by alterations in synaptic plasticity and functional connectivity. Antipsychotics, the cornerstone of pharmacological treatment for schizophrenia, have been found to affect synaptic architecture and reshape neuronal functional units. Different antipsychotics may lead to different patterns of co-activation in brain regions.
Article
Anatomy & Morphology
Cheryl D. Stimpson, Jeroen B. Smaers, Mary Ann Raghanti, Kimberley A. Phillips, Bob Jacobs, William D. Hopkins, Patrick R. Hof, Chet C. Sherwood
Summary: Investigating evolutionary changes in frontal cortex microstructure is crucial to understanding cognition in different primate species. This study found that the rate of evolutionary change is similar across microstructural variables, except for neuropil fraction, which has a stronger correlation with brain size. The study also revealed that neuropil fraction in specific layers of the orbitofrontal cortex is associated with cross-species variation in self-control.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biochemistry & Molecular Biology
Natosha M. Mercado, Guanglin Zhang, Zhe Ying, Fernando Gomez-Pinilla
Summary: Most research on traumatic brain injury (TBI) has focused on the brain itself, overlooking the role of systemic physiology. This study highlights the significance of gut-derived serotonin and its downstream metabolic targets in the systemic pathogenesis of TBI. Researchers found that TBI temporarily downregulated enteric neuronal markers and altered colonic genes related to serotonin synthesis and degradation, leading to an overall decrease in serotonin levels. The study also revealed changes in gut microbiota and serotonin-associated gene expression in downstream tissues after TBI. These findings emphasize the importance of understanding the role of systemic physiology in TBI pathogenesis to develop effective treatments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Marlene Storm Andersen, Dilara Bedriye Guler, Jonas Larsen, Karen Kalhoj Rich, Asa Fex Svenningsen, Mengliang Zhang
Summary: This study investigated the effects of brain injury on limb postural changes and the expression of 5-HT2A and 2C receptors. The results showed that brain injury caused long-term motor deficits and postural asymmetry, but these deficits were not related to the expression of 5-HT2A and 2C receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Alison M. Luckey, Lauren S. McLeod, Yuefeng Huang, Anusha Mohan, Sven Vanneste
Summary: Non-invasive transcutaneous electrical stimulation of the greater occipital nerve (NITESGON) during learning elicited a long-term memory effect by enhancing memory consolidation via modulation of dopaminergic input. This finding may have significant implications for neurocognitive disorders that inhibit memory consolidation such as Alzheimer's disease.
Article
Neurosciences
Anders Nelson, Brenda Abdelmesih, Rui M. Costa
Summary: This study reveals the important role of corticospinal neuron collaterals in sensorimotor cortex and motor control, with the dorsolateral striatum identified as the main target of these collaterals. It also shows that different corticospinal neurons have biased targeting of spinal cord circuits and encode complex information related to movements and motor sequences. Furthermore, the research demonstrates a logic of coordinated connectivity between forebrain and spinal circuits through corticospinal neuron populations, suggesting that differences in postsynaptic connectivity determine motor specificity.
NATURE NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Faisal Alosaimi, David Dominguez-Paredes, Rick Knoben, Faris Almasabi, Sarah Hescham, Kristen Kozielski, Yasin Temel, Ali Jahanshahi
Summary: This study investigates the effect of magnetoelectric nanoelectrodes on neurotransmitter systems and motor behavior in mice. The results show that magnetoelectric stimulation improves motor behavior and induces changes in relevant neurotransmitter systems. These findings suggest that magnetoelectric DBS could be a suitable alternative to conventional DBS.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biophysics
Isabel Galvez, Antonella Fioravanti, Eduardo Ortega
Summary: Spa therapy is a combination of techniques based on water's healing effects, including hydrotherapy, balneotherapy, and mud therapy. This study aimed to review the available evidence on the effect of spa therapy on serotonin and dopamine function. The findings highlight the lack of studies evaluating these neurotransmitters and hormones in the context of spa therapy, emphasizing the need for further research to evaluate the potential effects of these therapies on serotonin or dopamine function.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)
Article
Neurosciences
Zhifeng Zhong, Simin Zhou, Bin Xiang, Yu Wu, Jiaxin Xie, Peng Li
Summary: Living at high altitude can impair cognitive function, with significant associations found between peripheral plasma neurotransmitters and cognitive performance. Exposure to chronic hypobaric hypoxia can alter brain neurotransmitter levels, emphasizing a possible causal effect on cognitive performance.
Article
Gastroenterology & Hepatology
Madina Makhmutova, Jonathan Weitz, Alejandro Tamayo, Elizabeth Pereira, Maria Boulina, Joana Almaca, Rayner Rodriguez-Diaz, Alejandro Caicedo
Summary: The study revealed the presence of vagal sensory nerve terminals in pancreatic islets, which communicate with beta-cells via serotonin signaling. Serotonin may convey information about the secretory state of beta-cells to vagal afferent nerves.
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Neurosciences
Gael Villanueva-Charbonneau, Stephane Potvin, Serge Marchand, Alexander McIntyre, Diane McIntosh, Alain Bissonnette, Alain Gendron, Charles-edouard Giguere, Marie-eve Koue, Edouard Kouassi
Summary: This study found that mRNA expression of serotonin transporter (SERT) on the surface of peripheral blood mononuclear cells (PBMCs) was significantly reduced in subjects with major depression disorder (MDD), but not in those with fibromyalgia (FM) or FM + MDD. Although drug treatment improved symptoms, it had no significant effect on SERT mRNA expression.
Review
Neurosciences
Eugene E. Lin, Emily Scott-Solomon, Rejji Kuruvilla
Summary: Precision regulation of circulating glucose is crucial for human health, with peripheral nerves playing a key role in glucose homeostasis and metabolism. Studies have shown dynamic changes in peripheral innervation in obesity and diabetes animal models, highlighting the potential of peripheral nerves as a new therapeutic target for metabolic disorders.
TRENDS IN NEUROSCIENCES
(2021)
Article
Pharmacology & Pharmacy
Pierre Clement, Francois Giuliano
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2016)
Editorial Material
Urology & Nephrology
Francois Giuliano, Gerald Brock
JOURNAL OF SEXUAL MEDICINE
(2017)
Article
Urology & Nephrology
Konstantinos Hatzimouratidis, Edouard Amar, Ian Eardley, Francois Giuliano, Dimitrios Hatzichristou, Francesco Montorsi, Yoram Vardi, Eric Wespes
Article
Urology & Nephrology
Konstantinos Hatzimouratidis, Ian Eardley, Francois Giuliano, Dimitrios Hatzichristou, Ignacio Moncada, Andrea Salonia, Yoram Vardi, Eric Wespes
Article
Urology & Nephrology
Andrea Salonia, Ian Eardley, Francois Giuliano, Dimitrios Hatzichristou, Ignacio Moncada, Yoram Vardi, Eric Wespes, Konstantinos Hatzimouratidis
Article
Urology & Nephrology
R. Porto, F. Giuliano
PROGRES EN UROLOGIE
(2013)
Article
Urology & Nephrology
F. Giuliano, S. Droupy
PROGRES EN UROLOGIE
(2013)
Article
Urology & Nephrology
S. Droupy, F. Giuliano
PROGRES EN UROLOGIE
(2013)
Review
Psychology, Biological
F Giuliano, O Rampin
PHYSIOLOGY & BEHAVIOR
(2004)
Article
Urology & Nephrology
F Giuliano, J Allard
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2001)