Article
Plant Sciences
Gulnur Sevin, Elif Alan, Serdar Demir, Gokay Albayrak, Tugce Demiroz, Gunay Yetik-Anacak, Sura Baykan
Summary: This study aimed to investigate the effects of root extracts of Prangos sp. on erectile function, revealing that the extract of P. pabularia had the strongest relaxing effect on mouse corpus cavernosum, possibly through the formation of NO and H2S. The major compound, (+)-oxypeucedanin, may be responsible for the H2S-mediated relaxations of P. pabularia root extract in the mouse corpus cavernosum.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Bedoor Qabazard, Mariam Yousif, Alyaa Mousa, Oludotun Adebayo Phillips
Summary: The study investigates the potential protective role of hydrogen sulfide in diabetes-induced erectile dysfunction, with findings suggesting that H2S may reduce corporal contraction and fibromuscular changes in diabetic penile tissue, as well as having a link with plasma/urinary levels. These findings indicate that H2S could be a new strategy for preventing and treating diabetes-induced ED.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Xin Rui Lim, Eamonn Bradley, Caoimhin S. Griffin, Mark A. Hollywood, Gerard P. Sergeant, Keith D. Thornbury
Summary: This study revealed fast, voltage-dependent sodium currents in mouse CCSM and showed that stimulation of these currents increased contractility of CCSM in vitro, suggesting a potential role in erectile dysfunction. Further research is needed to define the exact involvement of these currents.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jorge Navarro-Dorado, Belen Climent, Maria Elvira Lopez-Oliva, Maria Pilar Martinez, Marina Hernandez-Martin, Angel Agis-Torres, Paz Recio, Maria Victoria Barahona, Sara Benedito, Vitor S. Fernandes, Medardo Hernandez
Summary: This study investigates the role of bitter taste receptors (TAS2R) in rat corpus cavernosum (CC). The results suggest that TAS2R10 is broadly expressed in the CC smooth muscle and plays a role in promoting smooth muscle relaxation and inhibitory neurotransmission mediated by H2S and NO. TAS2R10 may represent an important therapeutic target in the treatment of erectile dysfunction (ED).
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Hak Myong Choe, Kai Gao, Hyo Jin Paek, Xin-Yue Liu, Zhou-Yan Li, Biao-Hu Quan, Xi -Jun Yin
Summary: This study investigated the role of MSTN in pig penile smooth muscle and found that MSTN inhibition could promote smooth muscle growth and decrease fat deposition. This suggests that MSTN could be a potential target for treating smooth muscle dystrophy-related disorders such as erectile dysfunction.
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Chenchen Zhuang, Guozi Yi, Wenjuan Wang, Runmin Sun, Miaomiao Qi, Jing Yu
Summary: The study found that Sacubitril/valsartan (SAC/VAL) treatment has potential therapeutic effects on improving sexual dysfunction and genital fibrosis in female hypertensive patients. SAC/VAL treatment was more effective than VAL treatment alone, prolonging estrus phase, increasing sexual receptivity and proceptive behaviors, decreasing aggressive behaviors, and improving the fibrosis of vaginal and clitoral tissues.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ettore Lignelli, Francesco Palumbo, Selahattin Goerkem Bayindir, Noriyuki Nagahara, Istvan Vadasz, Susanne Herold, Werner Seeger, Rory E. Morty
Summary: Nitric oxide, carbon monoxide, and hydrogen sulfide gasotransmitters are playing important roles in newborn physiology, diseases, and therapies. Recent studies have highlighted the potential of hydrogen sulfide in animal models of bronchopulmonary dysplasia, where exogenous hydrogen sulfide was found to mitigate the impact of oxygen toxicity on lung development. Additionally, research has shown that hydrogen sulfide is directly generated by three enzymes, with potential therapeutic implications for lung development and pulmonary vascular physiology.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Andrology
Hao Cheng, Guo-Xiong Liu, Fei Wang, Ke Wang, Li-Tao Ruan, Lin Yang
Summary: The study found that shear wave elastography can be used to evaluate the aging degree of the corpus cavernosum. With increasing age, the Young's modulus of the corpus cavernosum increases and erectile function decreases. Histological investigation revealed an increase in collagen content and a decrease in smooth muscle content of the corpus cavernosum with age.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Urology & Nephrology
Peace Orji, Helen Sun, Ilaha Isali, Spencer Bell, Nicholas Zaorsky, Kirtishri Mishra, Shubham Gupta, Andres Correa, Marc Smaldone, Adam Calaway, Rosalia Viterbo, Laura Bukavina
Summary: Radical cystectomy has a significant negative impact on sexual function in both men and women. However, there has been limited research on female sexual function and organ preservation post cystectomy. This review aims to provide an overview of preoperative evaluation and available tools for sexual function assessment, as well as discuss various operative techniques for preserving or restoring sexual function in women after cystectomy.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Surgery
Adel M. Wilson, Amr A. Zaki
Summary: The study focused on the treatment of female genital mutilation through clitoral reconstruction and coverage with sensate labial flaps, showing significant improvements in sexual function, clitoral sensation, genital aesthetics, and self-esteem among patients.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Ismail Mert Vural, Gokce Sevim Ozturk Fincan, Derya Sebile Koc, Yagmur Okcay, Celil Ilker Askin, Ayse Kubra Kibar, Sevil Ozger Ilhan, Yusuf Sarioglu
Summary: This study demonstrated that nicotine can increase relaxation response in rabbit corpus cavernosum, suggesting a role of nicotinic acetylcholine receptors. Moreover, the research highlighted the significant role of the CB2 receptor in nicotine-induced enhancement, while the CB1 and VR1 receptors did not show significant effects.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Surgery
Enrico Tognazzo, Sarah Berndt, Jasmine Abdulcadir
Summary: This study assessed the effect of intraoperative administration of autologous platelet-rich plasma (A-PRP) on postoperative clitoral re-epithelialization time and pain. The results showed that all women achieved complete clitoral epithelialization within 80 days, with 3 women completing it between day 54 and 70. Only one woman was still taking painkillers at 2 months postoperative, but had stopped by the 3-month follow-up. All women reported improved clitoral access, stimulation, sexual arousal, lubrication, and pleasure, and were satisfied with their restored body image.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Engineering, Biomedical
Wenjia Lou, Fei Chen, Tao Xu, Qingbo Fan, Honghui Shi, Jia Kang, Xinwen Shi, Lan Zhu
Summary: The study demonstrates that vaginal fractional CO2 laser therapy can significantly improve sexual function in women, with sustained benefits for up to 1 year without any serious adverse events.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Psychology, Clinical
Malin Jordal, Linn Levin, Jessica Pafs, Gabriele Griffin, Anna Wahlberg
Summary: In relation to clitoral reconstruction surgery, gynecologists were found to position themselves in three different ways: outright negative, uncertain, or positive towards the surgery. This diversity in attitudes may impact cut women's access to CR surgery.
INTERNATIONAL JOURNAL OF SEXUAL HEALTH
(2021)
Article
Obstetrics & Gynecology
Sonia Angles-Acedo, Cristina Ros-Cerro, Silvia Escura-Sancho, M. Jose Palau-Pascual, Eduardo Bataller-Sanchez, Montserrat Espuna-Pons, Francisco Carmona-Herrera
Summary: This study demonstrated that LSC-Cx resulted in longer vaginal length compared to AVM, with higher rates of persistent dyspareunia after AVM. Having a partner for sexual activity and experiencing dyspareunia were found to have a greater impact on female sexual function than vaginal length pre- and postoperatively.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)