期刊
JOURNAL OF SEPARATION SCIENCE
卷 33, 期 3, 页码 410-421出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200900653
关键词
Chemometric application; Quality control; Traditional Chinese medicines; Trends of chromatographic fingerprint development
资金
- National Nature Foundation Committee of P R China [20875104]
- Ministry of Science and Technology of China [2007DFA40680]
Development of chromatographic fingerprint (CF) and related chemometric methods and their applications to quality control of traditional Chinese medicines (TCMs) were discussed CF is essentially a kind of quality control method for TCMs (or Chinese herbal medicines). Also, it is a quality-relevant-data high-throughput and integral tool to explore chemically the complexity of TCMs. With the help of chemometrics, some difficulties in evaluation and analysis of CFs, such as calculation of information content, peak alignment. pattern analysis, deconvolution of overlapping peaks, etc. could be well solved To further explore TCMs synergic quality, intensive study of CF coupled with chemometrics will create the possibility to achieve the aim to reveal the working mechanisms of TCMs and to further control and strengthen TCMs' intrinsic quality in a comprehensive manner
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