Review
Environmental Sciences
Jutti Levita, Gofarana Wilar, Ika Wahyuni, Lidya Cahyo Bawono, Tiara Ramadaini, Rohani Rohani, Ajeng Diantini
Summary: Intoxication of vitamin D is not commonly seen in pediatrics. This review provides insights into the clinical toxicology of vitamin D in pediatrics, including the mechanism, case reports, and management of vitamin D poisoning.
Article
Nutrition & Dietetics
Mario Flores-Aldana, Marta Rivera-Pasquel, Armando Garcia-Guerra, Jesus Giovanni Perez-Cortes, Juan E. Barcena-Echegollen
Summary: This study aimed to assess the effect of vitamin D supplementation at different doses on serum 25(OH)D concentrations in preschool children. After three months, there was a significant increase in serum concentrations of 25(OH)D and a decrease in the prevalence of vitamin D deficiency. No adverse effects were observed.
Review
Nutrition & Dietetics
Rakesh Balachandar, Raghu Pullakhandam, Bharati Kulkarni, Harshpal Singh Sachdev
Summary: This study found that cholecalciferol was more effective than ergocalciferol in improving vitamin D status and regulating PTH levels, regardless of participant demographics, dosage, and vehicle of supplementation.
Review
Medicine, General & Internal
Riccardo Nocini, Brandon M. M. Henry, Camilla Mattiuzzi, Giuseppe Lippi
Summary: This review examined the relationship between vitamin D and tinnitus, and found a link between lower serum vitamin D levels and tinnitus. Further research is needed to explore whether vitamin D supplementation can help prevent and/or improve tinnitus.
Review
Health Care Sciences & Services
Michael Wakeman
Summary: The potential effects of medications on vitamin D status are varied and may require more research to better understand the interactions between vitamin D and drugs. Healthcare providers should be aware of the potential for vitamin D depletions induced by medications, especially in elderly patients on multiple-drug therapy, and consider supplementation if necessary.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2021)
Article
Endocrinology & Metabolism
Stefano Ciardullo, Emanuele Muraca, Rosa Cannistraci, Silvia Perra, Guido Lattuada, Gianluca Perseghin
Summary: This study analyzes data from a national survey and finds an association between 25(OH)D levels and NAFLD and liver fibrosis, suggesting a potential role of vitamin D in the occurrence and progression of NAFLD.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Spectroscopy
Ojars Balcers, Ulises Miranda, Rita Veilande
Summary: The study aims to explore the feasibility of developing non-invasive optical sensors for Vitamin D2 and D3 by calculating their optical properties and comparing them with traditional mass spectroscopy and immunoassay methods. The findings are significant for the convenience and accuracy of measuring the concentrations of these substances in medical applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Food Science & Technology
Joel B. Johnson, C. P. Ekanayake, Federico Caravani, Janice S. Mani, Pawan Lal, Sarah J. Calgaro, Shirtika S. Prasad, Robyn D. Warner, Mani Naiker
Summary: Vitamin D plays crucial roles in various bodily functions, and meat products appear to be a significant source of vitamin D for much of the global population.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Agriculture, Dairy & Animal Science
Miranda C. M. Dosi, Chris M. Riggs, Jessica May, Adele Lee, Eugenio Cillan-Garcia, Joe Pagan, Bruce C. McGorum
Summary: Hong Kong racehorses have low serum vitamin D-2 and total vitamin D concentrations and rely on D-3 supplementation to maintain adequate vitamin D status.
Article
Nutrition & Dietetics
Bridget A. Baxter, Michaela G. Ryan, Stephanie M. LaVergne, Sophia Stromberg, Kailey Berry, Madison Tipton, Nicole Natter, Nikiah Nudell, Kim McFann, Julie Dunn, Tracy L. Webb, Michael Armstrong, Nichole Reisdorph, Elizabeth P. Ryan
Summary: This study investigates the association between vitamin D deficiency and COVID-19 severity among survivors. The findings show a correlation between vitamin D deficiency and severe cases, as well as the presence of post-acute sequelae of COVID-19 (PASC) among survivors. Gender and BMI are also found to be related to vitamin D levels, but not to the presence of PASC.
Article
Endocrinology & Metabolism
Carl Jenkinson, Reena Desai, Malcolm D. McLeod, Jonathan Wolf Mueller, Martin Hewison, David J. Handelsman
Summary: This study analyzed the contribution of sulfate and glucuronide vitamin D metabolites relative to unconjugated levels in human serum. The results showed that sulfate conjugates formed a higher proportion of circulating vitamin D metabolites compared to glucuronide conjugates. The findings suggest that a combination of both conjugated and unconjugated measurements may provide a more accurate assessment of vitamin D status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Nutrition & Dietetics
Eva Pal, Zoltan Ungvari, Zoltan Benyo, Szabolcs Varbiro
Summary: Deficiency in vitamin D affects a significant portion of the Western population and plays a crucial role in cardiovascular health. This deficiency leads to adverse vascular remodeling, endothelial dysfunction, vascular inflammation, and increased risk for cardiovascular and cerebrovascular diseases. Understanding the complex role of vitamin D deficiency is important for intervention and prevention among cardiologists, dietitians, and geriatricians.
Article
Biochemistry & Molecular Biology
Marie Bicikova, Ludmila Macova, Martin Hill
Summary: Vitamin D plays an important role in immunomodulation, brain development, and functioning. Its potential immunoprotective role in COVID-19 has been discussed. This study found that individuals who took vitamin D had a significantly lower risk of COVID-19 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Jiri Janousek, Veronika Pilarova, Katerina Macakova, Anderson Nomura, Jessica Veiga-Matos, Diana Dias da Silva, Fernando Remiao, Luciano Saso, Katerina Mala-Ladova, Josef Maly, Lucie Novakova, Premysl Mladenka
Summary: Vitamin D plays a crucial role in calcium homeostasis and has various non-calcemic functions. Over one billion people worldwide are deficient in vitamin D, which is associated with several diseases. Supplementation can be beneficial, but it should be done under the supervision of healthcare professionals to avoid overdosing.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Physics, Atomic, Molecular & Chemical
Andreas Lehner, Margaret Johnson, Alan Zimmerman, Justin Zyskowski, John Buchweitz
Summary: This study examined the feasibility of utilizing GC/MS/MS for the determination of Vitamin D3, D2, and their metabolites, finding it to operate reasonably well. The method allowed for detection of various vitamin D compounds and could be extended to 25-hydroxy compounds with improved accuracy through the inclusion of specific deuterated internal standards. The described method proved valuable in detecting ergocalciferol and cholecalciferol in animal feeds, highlighting its potential applicability in serum determination.
EUROPEAN JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Nutrition & Dietetics
Asher Y. Rosinger, Hilary J. Bethancourt, Abigail M. Pauley, Celine Latona, Jason John, Alysha Kelyman, Krista S. Leonard, Emily E. Hohman, Katherine McNitt, Alison D. Gernand, Danielle Symons Downs, Jennifer S. Savage
Summary: This study found that a multi-component behavioral intervention helped overweight/obese pregnant women maintain better hydration throughout pregnancy. Exploratory analyses showed that underhydration was associated with birth weight in opposite ways in the second and third trimesters. Future studies should confirm these results, as they have important implications for early life nutrition.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Pediatrics
Debmalya Nandy, Sarah J. C. Craig, Jingwei Cai, Yuan Tian, Ian M. Paul, Jennifer S. Savage, Michele E. Marini, Emily E. Hohman, Matthew L. Reimherr, Andrew D. Patterson, Kateryna D. Makova, Francesca Chiaromonte
Summary: Metabolomic analysis revealed a significant positive association between stool butyrate concentration and child weight outcomes, with consideration of covariates such as maternal smoking during pregnancy. Additionally, butyrate concentration was positively associated with the abundance of a bacterial genus.
Editorial Material
Pediatrics
Brandon T. McDaniel, Elizabeth L. Adams, Emily E. Hohman, Victor Cornet, Lauren Reining, Zachary Kaiser
Article
Biochemistry & Molecular Biology
James C. Fleet, Dennis Aldea, Lei Chen, Sylvia Christakos, Michael Verzi
Summary: This study identified the regulatory sites controlling intestine-specific Vdr gene expression using ATAC-Seq technology. The results showed that these sites vary during intestinal development and are associated with intestinal transcription factors. Comparison with DNAse-Seq data from other tissues revealed that these regulatory sites are highly conserved in humans as well.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Aurelie Bechoff, Apurba Shee, Brighton M. Mvumi, Patrick Ngwenyama, Hawi Debelo, Mario G. Ferruzzi, Loveness K. Nyanga, Sarah Mayanja, Keith I. Tomlins
Summary: Postharvest losses (PHLs) have a significant impact on food security and nutrient availability in low- and middle-income countries. This study developed a methodology and tool to estimate nutritional postharvest losses (NPHLs) for various food commodities in sub-Saharan Africa. The findings suggest that reducing PHLs along food value chains could greatly improve access to nutritious food for vulnerable populations.
Review
Agriculture, Multidisciplinary
Mary Ann Lila, Roberta Targino Hoskin, Mary H. Grace, Jia Xiong, Renee Strauch, Mario Ferruzzi, Massimo Iorizzo, Colin Kay
Summary: Protein-polyphenol aggregate particles can enhance the health effects of functional food products. Evidence suggests that the complexation of polyphenolic compounds can protect them during transit in the gastrointestinal tract, allowing them to exert their health benefits in the colon.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Emily E. Hohman, Joshua M. Smyth, Katherine M. McNitt, Abigail M. Pauley, Danielle Symons Downs, Jennifer S. Savage
Summary: Although women with obesity reported higher perceived stress, they had lower urinary cortisol than women with normal BMI, and gestation-related increases in cortisol were similar across weight groups and unrelated to perceived stress, suggesting that physiological factors that drive increases in cortisol as pregnancy may outweigh effects of stress and adiposity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
John R. N. Taylor, Mario G. Ferruzzi, Cheikh Ndiaye, Djibril Traor, Violet K. Mugalavai, Hugo De Groote, Cheryl O. ' Brien, Timothy J. Rendall, Bruce R. Hamaker
Summary: Small and micro food enterprises are important partners for fortification strategies to address micronutrient deficiencies in low-income countries. This paper discusses Entrepreneur-led Food Fortification (ElFF), which involves collaborations between US and African food and nutrition R&D organizations and African small-scale food processors. ElFF can overcome challenges faced by these enterprises and achieve business scale and nutritional impact through providing value propositions, product distribution and marketing. The example of entrepreneur-led production of fortified grain-based instant porridge flour illustrates a framework for successful implementation of ElFF in local markets and government nutrition strategies.
GLOBAL FOOD SECURITY-AGRICULTURE POLICY ECONOMICS AND ENVIRONMENT
(2023)
Article
Endocrinology & Metabolism
Erika Hernandez, Emily E. Hohman, Mackenzie J. Ferrante, Stephanie Anzman-Frasca, Ian M. Paul, Jennifer S. Savage
Summary: The study found that mothers' structure-based feeding practices in infancy, as well as some control-based feeding practices, were associated with later healthier toddler dietary patterns.
Article
Biochemistry & Molecular Biology
Michael P. Dzakovich, Hawi Debelo, Marc C. Albertsen, Ping Che, Todd J. Jones, Marissa K. Simon, Zuo-Yu Zhao, Kimberly Glassman, Mario G. Ferruzzi
Summary: Vitamin A, iron, and zinc deficiencies are common in sub-Saharan Africa, particularly among women and children. Biotechnology has been used to enhance the content and bioaccessibility of provitamin A carotenoids and minerals in staple crops, but the simultaneous enhancement of both carotenoids and minerals has not been thoroughly studied. This research evaluated genetically engineered constructs containing heterologous genes to improve carotenoid stability and pathway flux, and phytase to increase mineral bioaccessibility. The results showed significant increases in carotenoid content and improved mineral bioaccessibility in the transgenic events compared to control groups. These findings suggest that combined approaches to enhance micronutrient content and bioaccessibility are feasible and should be further studied in human trials.
Article
Endocrinology & Metabolism
Heng Jiang, Krittikan Chanpaisaeng, Sylvia Christakos, James C. Fleet
Summary: This study investigated the role of vitamin D receptor-mediated 1,25(OH)(2)D-3 signaling in adult calcium absorption and bone health. The results showed that intestinal vitamin D receptor prevents bone loss under low calcium intake but is dispensable under adequate calcium intake.
Article
Biochemistry & Molecular Biology
Abigayle M. R. Simpson, Mary Jane De Souza, Janhavi Damani, Connie Rogers, Nancy I. Williams, Connie Weaver, Mario G. Ferruzzi, Sydney Chadwick-Corbin, Cindy H. Nakatsu
Summary: This study aims to characterize the effect of prune supplementation on the gut microbiome of postmenopausal women. The results show that prune consumption leads to a decrease in gut microbiome diversity, and different doses of prunes have different effects on the gut microbiome. In addition, prune consumption may enrich beneficial bacterial taxa and correlate with urinary phenolic metabolites and inflammatory markers. These findings suggest that prunes may exert health effects by modulating the gut microbiome.
Article
Endocrinology & Metabolism
Krittikan Chanpaisaeng, Perla C. Reyes-Fernandez, Brian Dilkes, James C. Fleet
Summary: Genetics and dietary calcium both play critical roles in regulating bone mass and microarchitecture, with genetics impacting bone traits significantly and influencing the physiological response of bone to dietary calcium restriction. The study identified novel genetic loci controlling bone mass/microarchitecture and their adaptation to inadequate dietary calcium intake.
Article
Biochemistry & Molecular Biology
Micaela Hayes, Zulfiqar Mohamedshah, Sydney Chadwick-Corbin, Roberta Hoskin, Massimo Iorizzo, Mary Ann Lila, Andrew P. Neilson, Mario G. Ferruzzi
Summary: Insights into the impact of food matrix factors on the bioavailability of bioactive carotenoids and chlorophylls from fruits and vegetables are crucial. In vitro models were used to assess the stability, bioaccessibility, and intestinal absorption of carotenoids and chlorophylls in different forms of spinach. The results showed that spinach forms created by various drying technologies deliver similar levels of bioaccessible bioactives, and the lower gastrointestinal tract may play a significant role in the absorption of these compounds.
Article
Biochemistry & Molecular Biology
Zulfiqar Mohamedshah, Micaela Hayes, Sydney Chadwick-Corbin, Andrew P. Neilson, Mario G. Ferruzzi
Summary: The study compared the bioavailability and metabolism of phenolics between grapes and grape juice. It found that phenolics in grape juice were more easily absorbed compared to whole grapes. However, overall, the absorbable phenolics from 100% grape juice were similar to those from whole grapes, suggesting that consuming whole fruit and juice may have similar health benefits.