期刊
JOURNAL OF SEPARATION SCIENCE
卷 32, 期 15-16, 页码 2592-2600出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200900168
关键词
In-tube solid-phase microextraction; Monolithic capillary; Poly(ethylene glycol); Poly(N-isopropylacrylamide-co-ethylene dimethacrylate)
资金
- National Science Fund for Distinguished Young Scholars [20625516]
- National Key Technologies RD Program [2006BAF07B03]
- Science Fund for Creative Research Groups, NSFC [20621502]
A poly(N-isopropylacrylamide-co-ethylene dimethacrylate) (poly(NIPAAm-co-EDMA)) monolith was in situ prepared in the capillary and was investigated for in-tube solid-phase microextraction (SPME). NIPAAm, an acrylamide monomer with isopropyl group, was crosslinked with EDMA. PEG of 400 - 20 000 Da molecular weight and methanol were selected as the binary porogens. The porous structures of the resulting monoliths have been assessed by SEM, nitrogen adsorption-desorption, and pressure drop measurements. To investigate the extraction mechanism, several groups of model analytes (including neutral, acidic, and basic) were examined. The result showed that this monolithic material exhibited high extraction efficiencies for compounds under highly acidic and basic conditions, which was due to the hydrophobic interactions and excellent pH stability of the monolith. The equilibrium extraction time profiles were also monitored for model compounds to evaluate the extraction capacity of monolithic capillary. Finally, the developed monolith in-tube SPME-HPLC method was applied to the determination of three tricyclic antidepressants from urine samples.
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