☆ 4.5 Article

Endoplasmic reticulum stress is induced in the human placenta during labour

PLACENTA (2015)

期刊

PLACENTA

卷 36, 期 1, 页码 88-92

出版社

W B SAUNDERS CO LTD

DOI: 10.1016/j.placenta.2014.11.005

关键词

Endoplasmic reticulum stress; Labour; Placenta

类别

Developmental Biology Obstetrics & Gynecology Reproductive Biology

资金

Wellcome Trust in UK [084804/2/08/Z]
Ter Meulen Fund, Royal Netherlands Academy of Arts and Sciences in Netherlands

向作者/读者索取更多资源

Protocol

Reagent

摘要

Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to labour represents an in vivo model for the study of acute placental ER stress. ER stress markers, GRP78, P-eIF2 alpha and XBP-1, were significantly higher in laboured placentas than in Caesareandelivered controls localised mainly in the syncytiotrophoblast. The similarities to changes observed in PE/IUGR placentas suggest exposure to labour can be used to investigate induction of ER stress in pathological placentas. (c) 2014 The Authors. Published by Elsevier Ltd.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Immunology

Etiological Value of Sterile Inflammation in Preeclampsia: Is It a Non-Infectious Pregnancy Complication?

Sayani Banerjee, Zheping Huang, Zhengke Wang, Akitoshi Nakashima, Shigeru Saito, Surendra Sharma, Shibin Cheng

Summary: The understanding of sterile inflammation and its effects on pregnancy complications such as preeclampsia is still in its early stages. Emerging evidence suggests that sterile inflammation regulated by pathways such as the inflammasome-gasdermins-caspase-1 axis may contribute to the development of preeclampsia. Further research is needed to elucidate the mechanisms underlying these inflammatory pathways and potential therapeutic strategies for treating these complications.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

添加到收藏夹

Article Peripheral Vascular Disease

Endoplasmic reticulum stress impairs trophoblast syncytialization through upregulation of HtrA4 and causes early-onset preeclampsia

Xi Yuan, Xiyao Liu, Fangyu Zhu, Biao Huang, Li Lin, Jiayu Huang, Li Wen, Mark D. Kilby, Philip N. Baker, Yong Fu, Weiwei Wu, Hongbo Qi, Jing Tang, Chao Tong

Summary: This study investigates the relationship among HtrA4, endoplasmic reticulum stress (ERS), and trophoblast syncytialization in the development of early-onset preeclampsia (EO-PE). The findings suggest that ERS enables syncytialization of placental development by upregulating HtrA4, but excessive HtrA4 expression and preexisting ERS impair syncytialization and cause EO-PE.

JOURNAL OF HYPERTENSION (2023)

添加到收藏夹

Article Food Science & Technology

Maternal exposure to a glyphosate-based herbicide impairs placental development through endoplasmic reticulum stress in mice

Mengling Liu, Siying Lu, Chuanzhen Yang, Dalei Zhang, Jun Zhu, Jiting Yin, Hongru Zhao, Bei Yang, Haibin Kuang

Summary: This study aimed to investigate the effects and mechanisms of glyphosate-based herbicides (GBHs) exposure on placental development in vivo during pregnancy in mice. The results showed that GBHs administration led to increased resorption of fetuses, decreased fetal and placental weight, inhibited placental growth, and altered expression of related proteins and genes. Further study revealed that GBHs exposure induced oxidative stress in placental tissue. In conclusion, maternal exposure to GBHs can impair placental development through the activation of endoplasmic reticulum stress-mediated signaling pathway.

FOOD AND CHEMICAL TOXICOLOGY (2023)

添加到收藏夹

Article Peripheral Vascular Disease

Evidence From Human Placenta, Endoplasmic Reticulum-Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia

Shibin Cheng, Zheping Huang, Sayani Banerjee, Sukanta Jash, Joel N. Buxbaum, Surendra Sharma

Summary: This study demonstrates the importance of protein aggregation in the pathophysiology of preeclampsia. The aggregation of TTR protein is found to be associated with endoplasmic reticulum stress and apoptosis. Furthermore, the use of transgenic mice provides further evidence of the link between TTR aggregation and preeclampsia-like features.

HYPERTENSION (2022)

添加到收藏夹

Article Peripheral Vascular Disease

Chronic Hypoxia in Ovine Pregnancy Recapitulates Physiological and Molecular Markers of Preeclampsia in the Mother, Placenta, and Offspring

Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tessa A. Garrud, Peter F. B. Wooding, Caroline J. Shaw, Qiang Lyu, Lin Zhang, Jin Ma, Tereza Cindrova-Davies, Hong Wa Yung, Graham J. Burton, Dino A. Giussani

Summary: This study investigated the inter-relationship between chronic hypoxia during pregnancy and maternal, placental, and fetal outcomes, common in preeclampsia. The results showed that chronic hypoxia in ovine pregnancy promoted fetal growth restriction and activated placental stress response pathways. It also led to changes in maternal blood pressure and angiogenic balance. These findings demonstrate that chronic hypoxia recapitulates physiological and molecular features of preeclampsia in the mother, placenta, and offspring.

HYPERTENSION (2022)

添加到收藏夹

Article Cell Biology

Obesity impacts placental function through activation of p-IRE1a-XBP1s signaling

Wei-Bin Shen, Bingbing Wang, Ruofan Yao, Katherine R. Goetzinger, Sheng Wu, Haijun Gao, Peixin Yang

Summary: Maternal obesity is associated with adverse obstetrical outcomes and increased risk of congenital heart defects in fetuses. This study examines the activation of endoplasmic reticulum stress pathways in obese placenta.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

添加到收藏夹

Review Immunology

The endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy

Jana Messias Sandes, Regina Celia Bressan Queiroz de Figueiredo

Summary: The endoplasmic reticulum (ER) is an important organelle in higher eukaryotic cells responsible for protein folding and assembly. It undergoes strict quality control to ensure proper processing of proteins, with unfolded proteins being targeted for degradation through the ER-associated degradation (ERAD) complex. Additionally, the ER responds to stress through the unfolded protein response (UPR) to restore homeostasis or induce cell death. Protozoan parasites such as Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. also have similar ER structures and stress response mechanisms, making them attractive targets for chemotherapy.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

添加到收藏夹

Article Cell Biology

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway

Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao

Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.

CELL DEATH & DISEASE (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Regulation of liver subcellular architecture controls metabolic homeostasis

Gunes Parlakgul, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Guney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, Gokhan S. Hotamisligil

Summary: This study reveals the complex structural organization of organelles in liver tissue and highlights the significant alterations in obese mice. The functional importance of these structural changes on cellular and systemic metabolism is also demonstrated.

NATURE (2022)

添加到收藏夹

Article Developmental Biology

Stress regulation of WFS1 and PERK-p-eIF2 & alpha;-ATF4 signaling pathway in placental tissue cells of intrahepatic cholestasis of pregnancy

Daijuan Chen, Tingting Xu, Yaqian Li, Jinfeng Xu, Bing Peng, Wenming Xu, Xiaodong Wang

Summary: The expression levels of WFS1 and key factors of the PERK pathway were increased in severe ICP placental tissues. After silencing the WFS1 gene, the protein expression levels of PERK, P-eIF2α, and ATF4 were significantly increased, while CRH and UCN protein levels were significantly decreased.

PLACENTA (2023)

添加到收藏夹

Article Developmental Biology

Transcriptional profiles of genes related to mitochondrial aging in placental pathologies

Lucy A. Bartho, Daniel R. McKeating, Natalie J. Hannan, Tu'uhevaha J. Kaitu'u-Lino, Anthony Perkins

Summary: This study aimed to investigate the correlation between genes related to mitochondria, endoplasmic reticulum (ER), and cellular senescence in placentae affected by pregnancy complications. The findings suggest that genes associated with mitochondrial dynamics and aging undergo changes in placentae affected by pregnancy pathologies. The TOMM20/PARK2 ratio may be a promising marker for distinguishing between healthy and unhealthy placental tissue.

MOLECULAR HUMAN REPRODUCTION (2022)

添加到收藏夹

Article Cell Biology

Senescent Changes and Endoplasmic Reticulum Stress May Be Involved in the Pathogenesis of Missed Miscarriage

Yunhui Tang, Xinyan Zhang, Yi Zhang, Hua Feng, Jing Gao, Haiyan Liu, Fang Guo, Qi Chen

Summary: Increased levels of p16, p21, and gamma H2AX were found in missed miscarriage placentas, along with elevated levels of misfolded proteins and increased ROS production. Oxidative stress and accumulation of misfolded proteins in missed miscarriage placentas may contribute to the changes in senescence and endoplasmic reticulum stress observed.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

An ER-Horse Detonating Stress Cascade for Hepatocellular Carcinoma Nanotherapy

Xintong Bian, Ningke Fan, Meng Li, Daobin Han, Jia Li, Lu Fan, Xinyu Li, Liangsheng Kong, Hua Tang, Shijia Ding, Fangzhou Song, Siqiao Li, Wei Cheng

Summary: A hepatocellular carcinoma (HCC) cell-derived ER vesicle (ER-horse) has been developed for precise HCC nanotherapy by imitating the physiological function of endoplasmic reticulum (ER) and triggering excessive ER stress and apoptosis. The findings provide a new method for HCC nanotherapy via interference of ER stress signaling.

ACS NANO (2023)

添加到收藏夹

Article Environmental Sciences

TiO2 NPs induce the reproductive toxicity in mice with gestational diabetes mellitus through the effects on the endoplasmic reticulum stress signaling pathway

Ling Chen, Penghui Nie, LiYang Yao, YiZhou Tang, Wuding Hong, Wenting Liu, Fen Fu, Hengyi Xu

Summary: This study found that TiO2 nanoparticles have adverse effects on mice with gestational diabetes mellitus, potentially triggering oxidative stress and activating the ER stress pathway to induce cell apoptosis.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Endoplasmic reticulum stress in airway hyperresponsiveness

Qirui Duan, Ying Zhou, Dong Yang

Summary: Airway hyperresponsiveness is a major clinical phenomenon in lung diseases and can lead to severe complications during the perioperative period. This review focuses on the effects of endoplasmic reticulum stress on immune cells, inflammation, and remodeling in the airways, with the aim of understanding the mechanisms and finding prevention strategies.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cross talk between S-nitrosylation and S-glutathionylation in control of the Na,K-ATPase regulation in hypoxic heart

Sergej Yakushev, Mark Band, Martha C. Tissot van Patot, Max Gassmann, Aaron Avivi, Anna Bogdanova

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

添加到收藏夹

Article Physiology

Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioning

Martha C. Tissot van Patot, Andrew J. Murray, Virginia Beckey, Tereza Cindrova-Davies, Jemma Johns, Lisa Zwerdlinger, Eric Jauniaux, Graham J. Burton, Natalie J. Serkova

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mixed S-Nitrosylated Polymerized Bovine Hemoglobin Species Moderate Hemodynamic Effects in Acutely Hypoxic Rats

David Irwin, Paul W. Buehler, Abdu I. Alayash, Yiping Jia, Joe Bonventura, Ben Foreman, Molly White, Robert Jacobs, Brian Piteo, Martha C. TissotvanPatot, Karyn L. Hamilton, Robert W. Gotshall

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

Hong Wa Yung, Mathew Cox, Martha Tissot van Patot, Graham J. Burton

FASEB JOURNAL (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

A potential role for reactive oxygen species and the HIF-1α-VEGF pathway in hypoxia-induced pulmonary vascular leak

David C. Irwin, Joe. M. McCord, Eva Nozik-Grayck, Ginny Beckly, Ben Foreman, Tim Sullivan, Molly White, Joseph T. Crossno, Damian Bailey, Sonia C. Flores, Susan Majka, Dwight Klemm, Martha C. Tissot van Patot

FREE RADICAL BIOLOGY AND MEDICINE (2009)

添加到收藏夹

Article Biophysics

Hypoxia: Adapting to High Altitude by Mutating EPAS-1, the Gene Encoding HIF-2α

Martha C. Tissot van Patot, Max Gassmann

HIGH ALTITUDE MEDICINE & BIOLOGY (2011)

添加到收藏夹

Article Developmental Biology

Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development

T. Cindrova-Davies, M. Tissot van Patot, L. Gardner, E. Jauniaux, G. J. Burton, D. S. Charnock-Jones

MOLECULAR HUMAN REPRODUCTION (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Suppression of Mitochondrial Electron Transport Chain Function in the Hypoxic Human Placenta: A Role for miRNA-210 and Protein Synthesis Inhibition

Francesca Colleoni, Nisha Padmanabhan, Hong-wa Yung, Erica D. Watson, Irene Cetin, Martha C. Tissot van Patot, Graham J. Burton, Andrew J. Murray

PLOS ONE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Nobel Mabel. The woman who discovered that low oxygen stimulates hemoglobin production

Martha C. Tissot van Patot

FASEB JOURNAL (2020)

添加到收藏夹

Article Obstetrics & Gynecology

Protective Effects from the Ischemic/Hypoxic Stress Induced by Labor in the High-Altitude Tibetan Placenta

Wuren Tana, Tenzing Noryung, Graham J. Burton, Martha Tissot van Patot, Ge Ri-Li

Summary: The study found that high-altitude Tibetan population showed no stress response to acute hypoxia/ischemia in labor, while there were differences in gene expression between laboring and non-laboring placentas from high-altitude European descendants. This suggests adaptation to acute hypoxic ischemic insult caused by labor and vaginal birth in high-altitude native Tibetan population.

REPRODUCTIVE SCIENCES (2021)

添加到收藏夹

Article Physiology

Enhanced Placental Mitochondrial Respiration in Tibetan Women at High Altitude

Huifang Liu, Noryung Tenzing, Martha Tissot van Patot, Muge Qile, Ri-li Ge, Tana Wuren

Summary: The Tibetan population has adapted to the challenges of high-altitude living over thousands of years, with their placental mitochondria showing greater respiratory function compared to lower-altitude Tibetans and Han Chinese. This increased mitochondrial respiration in high-altitude Tibetans may represent an acute response that induces mitochondrial adaptations to protect against acute ischemic/hypoxic insult during labor.

FRONTIERS IN PHYSIOLOGY (2021)

添加到收藏夹

Meeting Abstract Developmental Biology

DOES HYPOXIA ALTER THE PLACENTAL RENIN ANGIOTENSIN SYSTEM (RAS)?

Lesia O. Kurlak, Hiten D. Mistry, Tereza Cindrova-Davies, Martha C. Tissot van Patot, Graham J. Burton, Fiona Broughton Pipkin

PLACENTA (2012)

添加到收藏夹

Meeting Abstract Obstetrics & Gynecology

Increase Phosphorylation of Eukaryotic Initiation Factor 2 Alpha and 4E Binding Protein 1 Expressions in High Altitude Placentas: The Role of Protein Synthesis Inhibition in Small for Gestational Age Babies

Hong Wa Yung, Mathew J. Cox, Martha C. Tissot van Patot, Graham J. Burton

REPRODUCTIVE SCIENCES (2012)

添加到收藏夹

Meeting Abstract Developmental Biology

HYPOXIA INDUCES ELECTRON TRANSPORT CHAIN DYSFUNCTION IN HUMAN PLACENTAL MITOCHONDRIA

Francesca Colleoni, Hong-wa Yung, Nisha Padmanabhan, Irene Cetin, Martha C. Tissot van Patot, Graham. Burton, Andrew J. Murray

PLACENTA (2011)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.