Article
Behavioral Sciences
Takashi Ohira, Fuminori Kawano, Katsumasa Goto, Hiroshi Kaji, Yoshinobu Ohira
Summary: Sensory nervous activity plays an important role in regulating muscle properties through passive shortening and/or active contraction. Remodeling of sarcomeres in the soleus can help restore sarcomere length, but lower sarcomere number leads to decreased overall tension and muscle atrophy. Rear-foot strike landing during walking or running and periodic stretching can be effective in stimulating soleus mobilization and recovery.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Nutrition & Dietetics
Sean Paul Kilroe, Jonathan Fulford, Sarah Jackman, Andrew Holwerda, Annemie Gijsen, Luc van Loon, Benjamin Toby Wall
Summary: The study found that three days of muscle disuse leads to significant declines in muscle mass and daily myofibrillar protein synthesis rates. However, daily protein intake does not modulate these muscle deconditioning responses.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Marta Murgia, Lorenza Brocca, Elena Monti, Martino V. V. Franchi, Maximilian Zwiebel, Sophia Steigerwald, Emiliana Giacomello, Roberta Sartori, Sandra Zampieri, Giovanni Capovilla, Mladen Gasparini, Gianni Biolo, Marco Sandri, Matthias Mann, Marco V. V. Narici
Summary: This study used mass spectrometry-based proteomics to analyze the changes in plasma protein abundance after 10 days of bed rest. The results showed that inactivity affected the concentration of complement cascade proteins, lipid carriers, and proteins derived from tissue leakage. Additionally, the study identified several proteins that could potentially serve as biomarkers to distinguish individuals prone to muscle atrophy from those resistant to it.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Anand Kumar, Chaitany Jayprakash Raorane, Deepak Rawat, Priyanka Prajapati, Ritu Raj, Dinesh Kumar, Seong-Cheol Kim, Vinit Raj, Sapana Kushwaha
Summary: This study aimed to investigate the effect of atenolol on cast immobilization-induced skeletal muscle loss. The results demonstrated that atenolol can effectively prevent muscle loss caused by cast immobilization and protect against the deleterious effects of prolonged bed rest.
Review
Geriatrics & Gerontology
Nicholas Preobrazenski, Joel Seigel, Sandra Halliday, Ian Janssen, Chris McGlory
Summary: This study aimed to assess the declines in leg muscle size and strength of uninjured adults following single-leg disuse. The systematic review and meta-analysis revealed that leg extensor strength and size decreased significantly after more than 14 days of single-leg disuse. The use of different fixation devices (cast or brace) did not affect the extent of decline. However, there is a lack of studies involving females, males, and adults over 40 years of age.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biology
Emanuela Abiusi, Paola Infante, Cinzia Cagnoli, Ludovica Lospinoso Severini, Marika Pane, Giorgia Coratti, Maria Carmela Pera, Adele D'Amico, Federica Diano, Agnese Novelli, Serena Spartano, Stefania Fiori, Giovanni Baranello, Isabella Moroni, Marina Mora, Maria Barbara Pasanisi, Krizia Pocino, Loredana Le Pera, Davide D'Amico, Lorena Travaglini, Francesco Ria, Claudio Bruno, Denise Locatelli, Enrico Silvio Bertini, Lucia Ovidia Morandi, Eugenio Mercuri, Lucia Di Marcotullio, Francesco Danilo Tiziano
Summary: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the degeneration of the second motor neuron. miRNome analysis suggests the primary involvement of skeletal muscle in SMA pathogenesis. Three specific miRs were found to be significantly upregulated in the serum of patients, and the severity predicted by the SMA-score showed a high correlation with clinical classification.
Article
Biochemistry & Molecular Biology
Taro Umezu, Satoshi Nakamura, Yuiko Sato, Tami Kobayashi, Eri Ito, Takaya Abe, Mari Kaneko, Masatoshi Nomura, Akihiko Yoshimura, Akihito Oya, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto
Summary: The study suggests that skeletal muscle cell-intrinsic Smad2/3 play important roles in immobilization-induced muscle atrophy and bone loss. Smad2/3 may represent potential therapeutic targets for preventing immobilization-induced bone and muscle atrophy through muscle-bone interaction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Kuan-Hung Lin, Gary M. Wilson, Rocky Blanco, Nathaniel D. Steinert, Wenyuan G. Zhu, Joshua J. Coon, Troy A. Hornberger
Summary: This study highlights the role of decreased protein synthesis in the loss of muscle mass during immobilization and questions the current belief that changes in protein kinase activity mediate this effect. Deep proteomic analyses revealed that the decrease in protein synthesis cannot be explained by changes in the abundance or phosphorylation state of proteins implicated in translation regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Geriatrics & Gerontology
Ji Hee Yu, Regina E. Y. Kim, Jin-Man Jung, So Young Park, Da Young Lee, Hyun Joo Cho, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Chol Shin, Nan Hee Kim
Summary: This study found that sarcopenia is associated with brain volume atrophy, especially in the parietal gray matter. Maintaining good muscle mass is important for brain health in middle-aged population.
Article
Biochemistry & Molecular Biology
Zhihua Feng, Steven Lam, Elena-Marie Sandino Tenn, Arundhati Sengupta Ghosh, Sarah Cantor, Wei Zhang, Pei-Fen Yen, Karen S. Chen, Steven Burden, Sergey Paushkin, Gai Ayalon, Chien-Ping Ko
Summary: The research demonstrates that activating MuSK can improve neuromuscular junction innervation in patients with spinal muscular atrophy, reduce muscle atrophy, and increase muscle cross-sectional area and myofiber numbers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Dumitru Constantin-Teodosiu, Despina Constantin
Summary: Muscle fatigue can decrease the capacity of muscles to complete tasks over time, with short-lasting fatigue often caused by overtraining, undertraining, or physical injury, while persistent and severe fatigue may be associated with pathological states or chronic exposure to certain substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Wei Wang, Ming Li, Zehao Chen, Lai Xu, Mengyuan Chang, Kexin Wang, Chunyan Deng, Yun Gu, Songlin Zhou, Yuntian Shen, Feng Tao, Hualin Sun
Summary: Pathophysiological changes of skeletal muscle can cause muscle atrophy and dysfunction, greatly affecting quality of life. Extracellular vesicles (EVs) are involved in the pathophysiological processes of skeletal muscle. EVs play a role in skeletal muscle growth, regeneration, and atrophy by delivering bioactive molecules. EVs have potential as biomarkers and therapeutic carriers for skeletal muscle diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Akihiro Kosoku, Tomoaki Iwai, Takuma Ishihara, Kazuya Kabei, Shunji Nishide, Keiko Maeda, Yoshiko Hanayama, Eiji Ishimura, Junji Uchida
Summary: This study examined the association between protein intake and changes in skeletal muscle mass in kidney transplant recipients. The results showed that insufficient protein intake adversely affected the recovery of skeletal muscle mass after kidney transplantation. Therefore, a protein intake of at least 0.72 g/kg ideal body weight per day is recommended for kidney transplant recipients with skeletal muscle mass loss.
CLINICAL NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Elisa Duranti, Chiara Villa
Summary: ALS is a fatal disease characterized by the loss of motor neurons, leading to muscle damage and paralysis. Muscle research plays a crucial role in understanding the molecular mechanisms and developing treatments for this disease.
Review
Pharmacology & Pharmacy
Yan Yan, Ming Li, Jie Lin, Yanan Ji, Kexin Wang, Dajun Yan, Yuntian Shen, Wei Wang, Zhongwei Huang, Haiyan Jiang, Hualin Sun, Lei Qi
Summary: This review summarizes the role of AMPK in regulating mitochondrial function and its impact on skeletal muscle metabolism and health.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Takashi Nakagata, Yoshifumi Tamura, Hideyoshi Kaga, Motonori Sato, Nozomu Yamasaki, Yuki Someya, Satoshi Kadowaki, Daisuke Sugimoto, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study found that ingestion of KM can reduce the AUC of glucose during a 75-g OGTT in Japanese individuals with impaired glucose tolerance, and this mechanism may involve elevated levels of circulating early-phase insulin.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Nozomu Yamasaki, Yoshifumi Tamura, Hideyoshi Kaga, Motonori Sato, Mai Kiya, Satoshi Kadowaki, Ruriko Suzuki, Yasuhiko Furukawa, Daisuke Sugimoto, Takashi Funayama, Yuki Someya, Saori Kakehi, Shuko Nojiri, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study showed that the decrease in plasma glucose levels induced by the sodium-glucose co-transporter-2 inhibitor is essential for the increase in endogenous glucose production and the decrease in insulin secretion.
DIABETES OBESITY & METABOLISM
(2021)
Letter
Endocrinology & Metabolism
Hikaru Otsuka, Hiroki Tabata, Yuki Someya, Yoshifumi Tamura
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Endocrinology & Metabolism
Motonori Sato, Yoshifumi Tamura, Takashi Nakagata, Yuki Someya, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The prevalence of impaired glucose tolerance (IGT) was higher in young underweight Japanese women compared to normal weight women, with those with IGT showing impaired early-phase insulin secretion, lower fitness levels, and reduced whole-body and adipose tissue insulin sensitivity levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kageumi Takeno, Yoshifumi Tamura, Saori Kakehi, Hideyoshi Kaga, Ryuzo Kawamori, Hirotaka Watada
Summary: The study identified a relationship between ALDH2 rs671 G/G carriers and higher alcohol consumption, elevated fasting plasma glucose levels, and reduced hepatic insulin sensitivity. Alcohol intake was significantly correlated with hepatic insulin sensitivity, fasting glucose clearance, and fasting plasma glucose levels in the participants.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Motonori Sato, Yoshifumi Tamura, Hideyoshi Kaga, Nozomu Yamasaki, Mai Kiya, Satoshi Kadowaki, Daisuke Sugimoto, Takashi Funayama, Yuki Someya, Saori Kakehi, Shuko Nojiri, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study showed that SGLT2i tofogliflozin did not affect the metabolic clearance rate of insulin, but could improve glycated hemoglobin levels and reduce body weight.
Article
Clinical Neurology
J. Kikuta, K. Kamagata, K. Takabayashi, T. Taoka, H. Yokota, C. Andica, A. Wada, Y. Someya, Y. Tamura, R. Kawamori, H. Watada, S. Naganawa, S. Aoki
Summary: The study found that alterations in the glymphatic system in the brain may be related to hypertension, as evidenced by a decrease in the analysis along the perivascular space index in elderly subjects with hypertension. Furthermore, the perivascular space index was negatively correlated with blood pressure and pulse pressure values.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Endocrinology & Metabolism
Saori Kakehi, Yoshifumi Tamura, Shin-Ichi Ikeda, Naoko Kaga, Hikari Taka, Noriko Ueno, Tetsuya Shiuchi, Atsushi Kubota, Keishoku Sakuraba, Ryuzo Kawamori, Hirotaka Watada
Summary: Physical inactivity impairs muscle insulin sensitivity, potentially through increased intramyocellular diacylglycerol and PKC ε activity, reduced phosphorylation of IR β and Akt, and enhanced activity of Lipin1.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Yuki Someya, Yoshifumi Tamura, Hideyoshi Kaga, Daisuke Sugimoto, Satoshi Kadowaki, Ruriko Suzuki, Shigeki Aoki, Nobutaka Hattori, Yumiko Motoi, Kazunori Shimada, Hiroyuki Daida, Muneaki Ishijima, Kazuo Kaneko, Shuko Nojiri, Ryuzo Kawamori, Hirotaka Watada
Summary: This study investigated the association between sarcopenic obesity and cognitive impairment in Japanese older adults. The results showed that sarcopenic obesity was independently associated with mild cognitive impairment and dementia.
CLINICAL NUTRITION
(2022)
Article
Geriatrics & Gerontology
Hideyoshi Kaga, Yoshifumi Tamura, Yuki Someya, Hitoshi Naito, Hiroki Tabata, Saori Kakehi, Nozomu Yamasaki, Motonori Sato, Satoshi Kadowaki, Ruriko Suzuki, Daisuke Sugimoto, Ryuzo Kawamori, Hirotaka Watada
Summary: In this cross-sectional study of older adults in Tokyo, Japan, it was found that prediabetes and diabetes are independent risk factors for sarcopenia in men, while only diabetes is an independent risk factor for sarcopenia in women. Additionally, age, higher body fat percentage, and lower body mass index were identified as independent risk factors for sarcopenia in both sexes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Physiology
Hiro Yamamoto, Hiroaki Eshima, Saori Kakehi, Ryuzo Kawamori, Hirotaka Watada, Yoshifumi Tamura
Summary: The study found that fatigue resistance in slow-twitch dominant muscle is impaired in mice with obesity-related type 2 diabetes, possibly due to decreased mitochondrial oxidative enzyme activity and impairment of Ca2+ uptake to the sarcoplasmic reticulum.
PHYSIOLOGICAL REPORTS
(2022)
Article
Endocrinology & Metabolism
Mika Kurita, Hiroaki Satoh, Hideyoshi Kaga, Satoshi Kadowaki, Yuki Someya, Yuka Tosaka, Yuya Nishida, Fuki Ikeda, Yoshifumi Tamura, Hirotaka Watada
Summary: To achieve long-term management of diabetes, patients with type 2 diabetes mellitus need high treatment adherence, which is associated with treatment satisfaction and quality of life. Patient education about diabetes self-management is essential. This study investigates the improvement of quality of life and post-discharge glycemic control in patients with type 2 diabetes mellitus through a diabetes education program.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Medicine, General & Internal
Satoshi Kadowaki, Yoshifumi Tamura, Daisuke Sugimoto, Hideyoshi Kaga, Ruriko Suzuki, Yuki Someya, Nozomu Yamasaki, Motonori Sato, Saori Kakehi, Akio Kanazawa, Ryuzo Kawamori, Hirotaka Watada
Summary: A short-term high-calorie high-fat diet impairs insulin sensitivity in non-obese Japanese men, leading to decreased insulin sensitivity in the muscle and liver, increased lipopolysaccharide binding protein levels, and ectopic fat accumulation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Saki Asano, Akitoshi Ogawa, Takahiro Osada, Satoshi Oka, Koji Nakajima, Yasushi Oshima, Sakae Tanaka, Hideyoshi Kaga, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Seiki Konishi
Summary: Insulin resistance may lead to structural and functional abnormalities in the human brain, which may be mediated through resting-state functional connectivity between the hypothalamus and the cerebral cortex.
Article
Nutrition & Dietetics
Yoshifumi Tamura, Hideyoshi Kaga, Yasuko Abe, Hidenori Yoshii, Hiroaki Seino, Toru Hiyoshi, Nobuichi Kuribayashi, Ikuo Inoue, Hirotaka Watada
Summary: This study evaluated the efficacy and dose dependency of ALA combined with iron in sarcopenia. The results showed that ALA intake at different doses significantly improved or tended to improve hand grip strength in patients with sarcopenia, but had no significant effect on other measures such as skeletal muscle mass index, calf circumference, physical function, and quality of life. Further research is needed to investigate the role of ALA in the treatment of sarcopenia.