Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Niklas Hauptstein, Michael Dirauf, Kevin Wittwer, Gizem Cinar, Oliver Siering, Martina Raschig, Tessa Luehmann, Oliver Scherf-Clavel, Bevan Sawatsky, Ivo Nischang, Ulrich S. Schubert, Christian K. Pfaller, Lorenz Meinel
Summary: This study re-engineered Interferon-alpha 2a (IFN-alpha 2a) bioconjugates into influenza therapeutics by conjugating it with PEtOx. The results showed that this new drug can alter the disease course and potentially combat antiviral drug resistance in influenza.
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Critical Care Medicine
Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Penuelas, Jesus Ruiz-Cabello, Jose L. Izquierdo-Garcia
Summary: This study compared the metabolic alterations induced by COVID-19 and Influenza A pneumonia (IAP) in ARDS patients, finding that these two conditions lead to different regulation of metabolic pathways. COVID-19 patients experience a significant energy supply deficit, while IAP patients exhibit more marked inflammatory and oxidative stress responses. The findings suggest a potential biomarker for diagnosing, prognosticating, and managing ARDS patients with different etiologies.
Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Jung Won Kwon, Hailian Quan, Juha Song, Hyewon Chung, Daun Jung, Jung Joo Hong, Yi Rang Na, Seung Hyeok Seok
Summary: This study demonstrates the therapeutic efficacy of liposomal dexamethasone in controlling the symptoms and reducing the death rate of influenza virus infection. The treatment can reduce the level of pro-inflammatory cytokines and the number of infiltrated immune cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Irfan A. Rather, Majid Rasool Kamli, Jamal S. M. Sabir, Bilal Ahmad Paray
Summary: The development of antiviral resistance has led to an increasing demand for unconventional antivirals. This study isolated lactiplantibacillus plantarum from raw camel milk and found it exhibited high antiviral activity against the H1N1 influenza virus. The findings highlight the potential of camel milk as a source of beneficial lactiplantibacillus with antagonistic properties against H1N1.
Review
Immunology
Sofia M. Buonocore, Robbert G. van der Most
Summary: This article reviews the association between the 2009-2010 H1N1 influenza pandemic and the increased risk of narcolepsy in children and adolescents after vaccination. Studies have suggested that immune responses and molecular mimicry may play a role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Article
Microbiology
Pavithra Daulagala, Brian R. Mann, Kathy Leung, Eric H. Y. Lau, Louise Yung, Ruipeng Lei, Sarea I. N. Nizami, Joseph T. Wu, Susan S. Chiu, Rodney S. Daniels, Nicholas C. Wu, David Wentworth, Malik Peiris, Hui-Ling Yen
Summary: Immune imprinting shapes the anti-HA antibody landscape, but the evaluation of anti-HA and anti-NA antibody responses in individuals born within the same birth cohort has been limited. This study characterized NA antigenic variants and found age-dependent imprinting of both anti-HA and anti-NA antibodies. Including NA proteins in influenza vaccine preparations may enhance vaccine efficacy.
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Medicine, General & Internal
Hyun-Jong Lee, Gwanghui Ryu, Ki-Il Lee
Summary: This study compared the symptomatic characteristics of influenza A/H3N2 and A/H1N1 subtypes in primary healthcare settings in Korea. The results showed that the H3N2-dominant season had higher average body temperature and more patients with high fever compared to the H1N1-dominant season. On the other hand, symptoms such as myalgia, cough, and sore throat were more common in the H1N1-dominant season. Antiviral drugs were prescribed to the majority of febrile patients in both seasons.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Magdalena L. Plancarte, Ganna Kovalenko, Julie Baldassano, Ana Ramirez, Selina Carrillo, Padraig J. Duignan, Ian Goodfellow, Eric L. Bortz, Jayeeta Dutta, Harm van Bakel, Lark Coffey
Summary: From 2011-2018, surveillance of marine mammals along the California coast detected anti-influenza antibodies and intermittent influenza A virus (IAV), with a change observed in spring 2019. Despite no increase in surveillance intensity, IAV RNA was detected in samples from northern elephant seals, showing close genetic identity to the pandemic H1N1 IAV subclade 6B.1A.1 circulating in humans during the 2018/19 influenza season. This suggests ongoing spillover of IAV from humans to pinnipeds.
Article
Medicine, Research & Experimental
Yuchong Wang, Xujun Zhang, Kefan Bi, Hongyan Diao
Summary: MicroRNAs play important roles in regulating virus replication and host antiviral response during H1N1 infection, with some defending against the virus and others promoting viral replication. They are involved in host-viral interactions and have versatile functions in this process.