Article
Rheumatology
Gabriel Figueroa-Parra, Jose A. Meade-Aguilar, Cassondra A. Hulshizer, Tina M. Gunderson, Alanna M. Chamberlain, Uma Thanarajasingam, Kurt J. Greenlund, Kamil E. Barbour, Cynthia S. Crowson, Ali Duarte-Garcia
Summary: The study aimed to assess the prevalence and incidence of multimorbidity and its association with the SLICC/ACR damage index (SDI) among patients with SLE. The results showed that patients with SLE were more likely to have multimorbidity, both before and after the onset of the disease. Multimorbidity was driven by both SDI-related and unrelated conditions.
Review
Medicine, General & Internal
Matteo Piga, Laurent Arnaud
Summary: Systemic lupus erythematosus is an immune-mediated multi-systemic disease with unpredictable clinical course. Despite advances in pathophysiology understanding, challenges remain in early diagnosis, biomarker identification, and development of new drugs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Article
Immunology
Fulvia Ceccarelli, Carlo Perricone, Francesco Natalucci, Licia Picciariello, Giulio Olivieri, Giacomo Cafaro, Elena Bartoloni, Gerli Roberto, Fabrizio Conti
Summary: The prevention of chronic damage, especially in early disease phases, remains an unmet need in the management of Systemic Lupus Erythematous (SLE) patients. Multiple factors, including disease activity, antiphospholipid antibodies, drugs used for treatment, genetic background, and demographic factors, contribute to the development of SLE-related damage. New outcomes are needed to assess comprehensive disease control.
AUTOIMMUNITY REVIEWS
(2023)
Article
Rheumatology
Beatriz Tejera Segura, Irene Altabas Gonzalez, Inigo Rua-Figueroa, Natalia Perez Veiga, Victor Del Campo Perez, Alejandro Olive-Marques, Maria Galindo, Jaime Calvo, Juan Gabriel Ovalles-Bonilla, Antonio Fernandez-Nebro, Raul Menor-Almagro, Eva Tomero, Natividad del Val del Amo, Esther Uriarte Isacelaya, Victor Manuel Martinez-Taboada, Jose L. Andreu, Alina Boteanu, Javier Narvaez, Atusa Movasat, Carlos Montilla, Jose Miguel Senabre Gallego, Blanca Hernandez-Cruz, Mariano Andres, Eva Salgado, Mercedes Freire, Sergio Machin Garcia, Clara Moriano, Lorena Exposito, Clara Perez Velasquez, M. L. Velloso-Feijoo, Ana Paula Cacheda, Nuria Lozano-Rivas, Gema Bonilla, Marta Arevalo, Inmaculada Jimenez, Victor Quevedo-Vila, Francisco J. Manero-Ruiz, Paloma Garcia de la Pena Lefebvre, Tomas Ramon Vazquez-Rodriguez, Jesus Ibanez-Rua, Tatiana Cobo-Ibanez, Jose Maria Pego-Reigosa
Summary: The study investigates gastrointestinal manifestations in SLE patients and finds that those with GI damage typically have more severe disease, longer disease duration, higher likelihood of organ involvement, and higher mortality rates.
Article
Immunology
Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. C. Quevedo-Abeledo, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Inigo de la Rua-figueroa, Raquel Lopez-Mejias, Federico Diaz-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study assessed the function of the three complement pathways in SLE patients and found that AL and LE pathways had lower functional values compared to the CL pathway. Clinical activity was not related to functional values of the C pathways, but increased DNA binding was negatively associated. Disease damage was positively correlated with C pathways and components. Anti-ribosomes and anti-nucleosomes antibodies showed a higher relationship with C activation, mainly through the LE and CL pathways. IgG anti-beta 2GP antibodies were most closely related to C activation, predominantly involving the AL pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Alexandra Legge, Alicia Malone, John G. Hanly
Summary: The SLICC frailty index (SLICC-FI) has been validated in a prevalent cohort of individuals with longstanding SLE, showing that higher baseline SLICC-FI values are associated with increased mortality risk and damage accrual.
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yolanda Fernandez-Cladera, Fuensanta Gomez-Bernal, Maria Garcia-Gonzalez, Juan C. Quevedo-Abeledo, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Ana L. Nunes-Andrade, Raquel Lopez-Mejias, Miguel a. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study examined the relationship between fibroblast growth factor 23 (FGF23) and systemic lupus erythematosus (SLE). The results showed that elevated serum FGF23 levels were associated with disease damage in SLE patients, particularly in relation to musculoskeletal complications and proteinuria.
Review
Medicine, General & Internal
Sigrid Reppe Moe, Hilde Haukeland, Oyvind Molberg, Karoline Lerang
Summary: Research on outcomes of Systemic Lupus Erythematosus (SLE) shows that the standardized mortality ratio ranges from 1.9 to 4.6, with cardiovascular disease being the most common cause of death and ESRD progressing in 5-11% of all SLE patients. There is currently no data supporting an increased incidence of cancer in SLE patients. Further population-based studies are needed, especially inception studies with control groups and follow-up times over 15 years.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Julia Mercader-Salvans, Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. Quevedo-Abeledo, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Raquel Lopez-Mejias, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the association between serum IL-6 levels and disease characteristics in patients with SLE. The results showed that IL-6 was positively associated with age, C-reactive protein, and male gender, while it was negatively associated with HDL cholesterol and apolipoprotein A1. In addition, IL-6 was positively associated with the alternative complement cascade, C1inh, and C3a. Stratification of the Systematic Coronary Risk Assessment 2 (SCORE2) results according to different categories of cardiovascular risk was also associated with higher IL-6 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Fulvia Ceccarelli, Giulio Olivieri, Alessio Sortino, Lorenzo Dominici, Filmon Arefayne, Alessandra Ida Celia, Enrica Cipriano, Cristina Garufi, Matteo Lapucci, Silvia Mancuso, Francesco Natalucci, Valeria Orefice, Carlo Perricone, Carmelo Pirone, Viviana Antonella Pacucci, Francesca Romana Spinelli, Simona Truglia, Cristiano Alessandri, Marco Sciandrone, Fabrizio Conti
Summary: This study evaluated a monocentric SLE cohort to assess the frequency of Lupus comprehensive disease control (LupusCDC), which includes achieving remission and preventing damage progression. Results showed that patients who achieved LupusCDC were less likely to have renal involvement, higher use of immunosuppressant drugs, and glucocorticoids. Machine learning models were able to provide significant information to build predictive models for SLE patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Biochemistry & Molecular Biology
Nayra Merino de Paz, Maria Garcia-Gonzalez, Fuensanta Gomez-Bernal, Juan C. Quevedo-Abeledo, Antonia de Vera-Gonzalez, Raquel Lopez-Mejias, Pedro Abreu-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: Malondialdehyde (MDA) is a marker of oxidative stress and antioxidant status. This study found that cumulative musculoskeletal and skin damage in SLE patients is associated with higher serum levels of MDA. In addition, activation of the complement system is also related to higher circulating MDA levels.
Article
Rheumatology
Ji-Hyoun Kang, Min-Ho Shin, Sung-Eun Choi, Haimuzi Xu, Dong-Jin Park, Shin-Seok Lee
Summary: This study investigated the performance of three definitions of low-level disease activity in SLE patients, finding that the lupus low disease activity state (LLDAS) was significantly associated with less organ damage, reduced flare, and improved quality of life during follow-up, while minimal disease activity (MDA) and low disease activity (LDA) showed no associations with these variables.
Article
Pediatrics
Ana Luisa Rodriguez-Lozano, Francisco Eduardo Rivas-Larrauri, Silvestre de la Puente, Daniel Alfredo Alcivar-Arteaga, Alejandro Gabriel Gonzalez-Garay
Summary: This study found that neurologic disease, vasculitis, and hemolytic anemia present at diagnosis in childhood-onset systemic lupus erythematosus patients are prognostic factors associated with the development of damage. Therefore, closer follow-up is recommended for patients with these factors to reduce the likelihood of damage development.
FRONTIERS IN PEDIATRICS
(2022)
Article
Allergy
Osman Ozan Yegit, Semra Demir, Derya Unal, Muge Olgac, Kadriye Terzioglu, Deniz Eyice Karabacak, Can Tuzer, Vehbi Ayhan, Bahattin Colakoglu, Suna Buyukozturk, Asli Gelincik
Summary: This study investigated adherence to SCIT during the COVID-19 pandemic, finding that delays in treatment administration can lead to worsening symptoms. It emphasizes the importance of strict adherence to SCIT and patient education during a pandemic to ensure optimal clinical outcomes.
Article
Rheumatology
Omer Uludag, Erhan Cene, Erdem Gurel, Cigdem Cetin, Murat Bektas, Yasemin Yalcinkaya, Reyhan Diz-Kucukkaya, Ahmet Gul, Murat Inanc, Bahar Artim-Esen
Summary: This study aimed to identify different clinical phenotypes of antiphospholipid syndrome (APS) using cluster analysis and describe the cumulative damage of these disease clusters. The results showed that SLE+APS patients with extra-criteria manifestations and older APS patients with arterial thrombosis and increased cardiovascular risk had higher cumulative damage. Effective treatment of SLE disease activity and control of cardiovascular risk may help reduce cumulative damage in these patients.
Article
Rheumatology
Selma Sari, Suzan Cinar, Yasemin Yalcinkaya, Bahar Artim-Esen, Yasemin Ozluk, Ahmet Gul, Lale Ocal, Gunnur Deniz, Murat Inanc
Summary: This study aimed to investigate the association between serum B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) levels with disease activity and clinical findings in SLE patients. The results showed that both BAFF and APRIL levels were higher in patients with SLE compared to the control group, but there was no correlation between BAFF/APRIL levels and disease activity scores. Serum BAFF levels were higher in patients with renal disease activity, while APRIL levels were significantly correlated with proteinuria. The study suggests that BAFF can be a valuable biomarker in SLE, especially in patients with renal activity.
Article
Rheumatology
Ege Sinan Torun, Nevzat Koca, Yasemin Yalcinkaya, Bahar Artim Esen, Ahmet Gul, Murat Inanc
Summary: This case presents a patient with Takayasu arteritis-induced malignant hypertension, resulting in bilateral renal artery stenosis, acute kidney injury, and advanced stage hypertensive retinopathy. Thrombotic microangiopathy is also detected, which is uncommon in Takayasu arteritis cases with malignant hypertension.
OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS
(2022)
Meeting Abstract
Rheumatology
M. Oztas, M. Bektas, I. Karacan, N. Aliyeva, A. Dag, S. Aghamuradov, S. B. Cevirgen, S. Sari, M. Bolayirli, G. Can, G. Hatemi, E. Seyahi, H. Ozdogan, A. Gul, S. Ugurlu
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Nilgun Sallakci, Ilhan Tahrali, Umut Can Kucuksezer, Esin Aktas Cetin, Ahmet Gul, Gunnur Deniz
Summary: This study investigated the activation status and function of NK cells in Behcet's disease patients. The results showed that patients in active and inactive phases displayed different activation levels of NK cells, indicating their potential association with immune attacks and remissions during the course of the disease.
IMMUNOLOGIC RESEARCH
(2022)
Article
Rheumatology
Ege Sinan Torun, Erdem Bektas, Fatih Kemik, Murat Bektas, Cigdem Cetin, Yasemin Yalcinkaya, Bahar Artim Esen, Ahmet Gul, Murat Inanc
Summary: This study compared the performances of three SLE classification criteria sets in a large cohort of patients and relevant diseased controls. The results showed that EULAR/ACR criteria were more sensitive than the 1997 criteria and had a comparable performance with SLICC criteria. The presence of false positive results in ANA positive patients decreased the specificity of both SLICC and EULAR/ACR criteria.
Article
Rheumatology
Rabia Deniz, Zeliha Emrence, Yasemin Yalcinkaya, Bahar Artim Esen, Murat Inanc, Mahdume Lale Ocal, Ahmet Gul
Summary: The skin pathergy test (SPT) conducted using a 20G needle prick and PS-23 antigens has been shown to have improved sensitivity in the diagnosis of Behcet disease (BD). This method can increase the diagnostic rate of BD, especially in patients with active disease.
Article
Dermatology
Muge Olgac, Osman Ozan Yegit, Sengul Beyaz, Nida Oztop, Can Tuzer, Deniz Eyice, Pelin Karadag, Raif Coskun, Semra Demir, Bahaauddin Colakoglu, Suna Buyukozturk, Asli Gelincik
Summary: The impact of the COVID-19 pandemic on the course of refractory chronic spontaneous urticaria (CSU) was investigated in this study. It was found that disease activity and levels of anxiety and depression were higher during the quarantine period. Some patients discontinued or prolonged the interval of omalizumab treatment. Therefore, it is recommended for patients to continue their omalizumab treatment and consider prolonging the interval based on disease control.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2023)
Article
Rheumatology
Shirkhan Amikishiyev, M. Guven Gunver, Murat Bektas, Sarvan Aghamuradov, Burak Ince, Nevzat Koca, Ege Sinan Torun, Numune Aliyeva, Selma Sari, Cigdem Cetin, Banu C. Yalcin-Dulundu, Rabia Deniz, Fatih Kemik, Besim Fazil Agargun, Ubeyde Ayse Gulseren, Beliz Besisik, Onur Alkan, Ceren Bagriacik, Yavuz B. Tor, Naci Senkal, Yunus Catma, Gorkem Durak, Sevim Mese, Ali Agacfidan, Murat Kose, Mustafa Erelel, A. Atahan Cagatay, Serap Simsek-Yavuz, Sevgi Kalayoglu-Besisik, Figen Esen, Ahmet Guel
Summary: This study aimed to identify criteria for early detection of hyperinflammation (HI) in patients with COVID-19, and found a 12-item criteria that showed high sensitivity and specificity. The use of these criteria can help identify patients in need of treatment earlier and initiate timely interventions.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Allergy
D. unal, D. Eyice-Karabacak, A. Kutlu, S. Demir, C. Tuzer, A. F. Arslan, S. R. Isik, A. Gelincik
Summary: The long-term safety and efficacy of a novel red meat oral immunotherapy (OIT) for α-gal allergy in adults were established. All patients who underwent OIT became tolerant to red meat. In addition, alpha-gal specific Immunoglobulin-E (sIgE) may serve as a potential biomarker for monitoring OIT.
Article
Chemistry, Medicinal
Ozge Soylu-Eter, Zekiye Seyma Sevincli, Betul Ersoy, Bahar Hasanusta, Ugur Gatfar, Nathan A. Lack, Burak Erman, Ahmet Gul, Hakan S. Orer, Nilgun Karali
Summary: This study aimed to develop drugs with anti-interleukin-1 activity. Through evaluation and screening of compounds, as well as in vitro studies and molecular modeling, it was found that compounds 78 and 81 had the strongest IL-1 receptor inhibitory effects and the most favorable drug-like properties.
ARCHIV DER PHARMAZIE
(2023)
Article
Rheumatology
Murat Bektas, Nevzat Koca, Emin Oguz, Selma Sari, Gizem Dagci, Burak Ince, Pelin Karaca Ozer, Besim Fazil Agargun, Yasemin Yalcinkaya, Bahar Artim-Esen, Lale Ocal, Murat Inanc, Ahmet Gul
Summary: This study evaluated the clinical, laboratory, and genetic characteristics of patients with AA amyloidosis in Turkey. It found that FMF is the most common cause of AA amyloidosis and patients with homozygous or compound heterozygous MEFV exon 10 variants tend to develop the disease earlier. Patients with a low estimated glomerular filtration rate at admission had a higher risk of progressing to end-stage renal disease. The study also found that the mortality rate increased with the amyloid burden.
Article
Ophthalmology
Ceylan Uslu Dogan, Can Tuzer, Ibrahim Cagri Turker, Abdurrahman Alpaslan Alkan, Damla Culha, Semra Demir
Summary: This study aimed to assess the clinical efficacy of topical cyclosporine A and subcutaneous allergen immunotherapy (SCIT) in treating perennial allergic conjunctivitis. The results showed that both treatments significantly improved symptoms in patients. The study suggests that allergen immunotherapy and cyclosporin A treatment may be considered as effective options for perennial allergic conjunctivitis, especially in cases refractory to other treatments and with positive skin prick tests to specific allergens.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Ege Sinan Torun, Mert Erciyestepe, Yasemin Yalcinkaya, Ahmet Gul, Murat Inanc, Lale Ocal, Sabahattin Kaymakoglu, Bora Peynircioglu, Bahar Artim-Esen
Summary: Budd-Chiari syndrome is a disease characterized by obstruction of hepatic venous outflow, with etiologies such as hypercoagulable states. Interventional radiology procedures like TIPS can be used to reduce portal hypertension and improve complications in BCS patients.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2022)
