Article
Rheumatology
Zhibo Song, Xuerong Deng, Wenhui Xie, Borui Li, Zhuoli Zhang
Summary: Among Chinese patients with psoriatic arthritis, polyarticular involvement was the most common, while ultrasound significantly increased the identification of peripheral enthesitis. Active PsA patients were more likely to have comorbidities.
RHEUMATOLOGY AND THERAPY
(2021)
Article
Medicine, General & Internal
Alberto Lo Gullo, Andrea Becciolini, Simone Parisi, Patrizia Del Medico, Antonella Farina, Elisa Visalli, Ylenia Dal Bosco, Aldo Biagio Molica Colella, Federica Lumetti, Rosalba Caccavale, Palma Scolieri, Romina Andracco, Francesco Girelli, Elena Bravi, Matteo Colina, Alessandro Volpe, Aurora Ianniello, Maria Chiara Ditto, Valeria Nucera, Veronica Franchina, Ilaria Plate, Eleonora Di Donato, Giorgio Amato, Carlo Salvarani, Simone Bernardi, Gianluca Lucchini, Francesco De Lucia, Francesco Molica Colella, Daniele Santilli, Natalia Mansueto, Giulio Ferrero, Antonio Marchetta, Eugenio Arrigoni, Rosario Foti, Gilda Sandri, Vincenzo Bruzzese, Marino Paroli, Enrico Fusaro, Alarico Ariani
Summary: The aim of this study is to evaluate the improvement in enthesitis and dactylitis activity in Psoriatic Arthritis (PsA) patients treated with apremilast. Results showed that PsA patients treated with apremilast experienced significant improvement in enthesitis and dactylitis activity, with over one-third of patients achieving remission after 1 year.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Mads Bruner, Anders Dige, Anne Gitte Loft, Trine Bay Laurberg, Jorgen Steen Agnholt, Kare Clemmensen, Iain McInnes, Rik Lories, Lars Iversen, Kasper Fjellhaugen Hjuler, Tue Wenzel Kragstrup
Summary: This article discusses the distinct group of axial spondyloarthritis, psoriatic arthritis, psoriasis, inflammatory bowel disease, and noninfectious uveitis, and reviews new targeted pharmacological treatment options for these diseases. It highlights the efficacy of different drugs, such as TNF inhibitors and specific inhibitors for certain inflamed tissues, and aims to assist clinicians in making stratified treatment decisions for patients with this disease spectrum.
AUTOIMMUNITY REVIEWS
(2021)
Review
Rheumatology
Iain B. McInnes, Laura M. Sawyer, Kristen Markus, Corinne LeReun, Celia Sabry-Grant, Philip S. Helliwell
Summary: This study compared the efficacy and safety of different types of drugs in treating PsA, and found that IL-17A and IL-17RA inhibitors and guselkumab were more effective than TNF inhibitors in treating skin manifestations, and had similar efficacy for other symptoms such as enthesitis and dactylitis.
Review
Medicine, General & Internal
Nicolo Girolimetto, Ivan Giovannini, Gloria Crepaldi, Gabriele De Marco, Ilaria Tinazzi, Niccolo Possemato, Pierluigi Macchioni, Rebecca McConnell, Dennis McGonagle, Annamaria Iagnocco, Alen Zabotti
Summary: Dactylitis, a common feature of PsA, is characterized by swelling of the digits and involvement of various anatomical structures. Imaging plays an important role in managing dactylitis in PsA patients and uncovering underlying mechanisms of its onset and chronicity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Serife Gul Karadag, Taner Coskuner, Fatma Gul Demirkan, Hafize Emine Sonmez, Semanur Ozdel, Mustafa Cakan, Gulcin Otar Yener, Kubra Ozturk, Ferhat Demir, Betul Sozeri, Nuray Aktay Ayaz
Summary: This study describes the clinical features and treatment outcomes of children with juvenile psoriatic arthritis (JPsA) and compares the different patterns of the disease between early-onset and late-onset age groups. The study found that about one-third of JPsA patients do not have psoriasis at the time of diagnosis, and children with PsA seem to display two different phenotypes.
Article
Medicine, General & Internal
Fan Yang, Chaofan Lu, Huilan Liu, Lei Dou, Yanhong Wang, Hongbin Li, Xinwang Duan, Lijun Wu, Yongfu Wang, Xiuying Zhang, Jian Xu, Jinmei Su, Dong Xu, Jiuliang Zhao, Qingjun Wu, Mengtao Li, Xiaomei Leng, Xiaofeng Zeng
Summary: Enthesitis is common in Chinese patients with PsA, and it is important to evaluate both peripheral and axial sites. Compared with other cohorts, Chinese patients with enthesitis tend to be younger, have a lower body mass index, a higher rate of positive HLA-B27, more frequent dactylitis, and a higher proportion of csDMARDs use.
CHINESE MEDICAL JOURNAL
(2023)
Review
Rheumatology
Patricia Harkins, Eoghan Burke, Catherine Swales, Alan Silman, Richard Conway
Summary: This study evaluated the safety and efficacy of Janus kinase inhibitors (JAKi) in the management of key clinical domains of Psoriatic arthritis (PsA). The results demonstrated that JAKi were more effective than placebo in improving outcomes such as peripheral arthritis, psoriasis, enthesitis, and dactylitis. However, JAKi treatment was associated with an increased risk of adverse events, including infections.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Emilio Filippucci, Gianluca Smerilli, Andrea Di Matteo, Walter Grassi
Summary: Enthesitis plays a crucial role in the diagnosis and management of patients with spondyloarthritis and psoriatic arthritis, but clinical assessment is often inaccurate due to poor specificity. Ultrasound has the potential to improve the evaluation of enthesitis and enhance patient management in this context. Reviewing the OMERACT definitions for ultrasound enthesitis can help identify current limitations and their potential implications for rheumatology research and clinical practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Antonio Carriero, Ennio Lubrano, Valentina Picerno, Angela Anna Padula, Salvatore D'Angelo
Summary: Dactylitis is a common clinical feature in 30-50% of psoriatic arthritis (PsA) patients, serving as a marker for disease severity, independent predictor of cardiovascular morbidity, and impairing motor functions. Current treatment strategies primarily involve corticosteroid injections, with a lack of evidence from randomized controlled trials specifically targeting dactylitis as a primary endpoint.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)
Article
Rheumatology
Nicolo Girolimetto, Alen Zabotti, Ilaria Tinazzi, Niccolo Possemato, Luisa Costa, Alberto Batticciotto, Marco Canzoni, Giorgia Citriniti, Orazio De Lucia, Fabiana Figus, Luca Idolazzi, Rebecca McConnel, Rosario Peluso, Garifallia Sakellariou, Annarita Tullio, Carlo Salvarani, Raffaele Scarpa, Annamaria Iagnocco, Francesco Caso, Pierluigi Macchioni
Summary: The study assessed the performance of the DACTOS score in a PsA dactylitis clinical setting, finding that the score performs well in identifying affected fingers, sensitivity to change after treatment, and correlations with clinical parameters.
Article
Rheumatology
Sayam Dubash, Oras A. Alabas, Xabier Michelena, Leticia Garcia-Montoya, Richard J. Wakefield, Philip S. Helliwell, Paul Emery, Dennis G. McGonagle, Ai Lyn Tan, Helena Marzo-Ortega
Summary: Dactylitis in DMARD-naive early psoriatic arthritis signifies a more severe disease phenotype independently associated with increased disease burden, presenting with greater tender and swollen joint counts, C reactive protein levels, and more prevalent ultrasound-detected synovitis and bone erosions.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Clementina Lopez-Medina, Sylvie Chevret, Anna Molto, Joachim Sieper, Tuncay Duruoz, Uta Kiltz, Bassel Elzorkany, Najia Hajjaj-Hassouni, Ruben Burgos-Vargas, Jose Maldonado-Cocco, Nelly Ziade, Meghna Gavali, Victoria Navarro-Compan, Shue-Fen Luo, Alessandro Biglia, Kim Tae-Jong, Mitsumasa Kishimoto, Fernando M. Pimentel-Santos, Jieruo Gu, Laura Muntean, Floris A. van Gaalen, Pal Geher, Marina Magrey, Sebastian E. Ibanez-Vodnizza, Wilson Bautista-Molano, Walter Maksymowych, Pedro M. Machado, Robert Landewe, Desiree van der Heijde, Maxime Dougados
Summary: The study identified two main phenotypes (predominantly axial and predominantly peripheral) in patients with SpA, based on the presence and location of peripheral manifestations. In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis, and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement.
Review
Medicine, General & Internal
Amit Garg, Haley B. Naik, Joslyn S. Kirby
Summary: Hidradenitis suppurativa is a chronic, progressive inflammatory disease of the skin, often underdiagnosed or misdiagnosed. This review provides a comprehensive overview of the disease's clinical presentation, associated comorbidities, and life impact. It aims to facilitate earlier identification, differentiation from mimickers, and timely referrals for multidisciplinary management.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Rheumatology
Dhruvkumar Laheru, Anna Antony, Sueli Carneiro, Vito Di Lernia, Amit Garg, Thorvardur Jon Love, Karla del Rocio Macias Garcia, Jose Alexandre Mendonca, Sandeep Mukherjee, Rodica Olteanu, Lourdes Perez-Chada, Cheryl F. Rosen, Rachel Tannenbaum, Michel Alexandre Yazbek
Summary: This article updates the treatment recommendations for nail psoriasis, and suggests that biologic agents are the preferred treatment option.
JOURNAL OF RHEUMATOLOGY
(2023)
Letter
Dermatology
Bernice Y. Yan, Marcus L. Elias, Priya Duvvuri, Andrew Strunk, Amit Garg, Victoria R. Sharon
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Amit Garg, Haley B. Naik, Afsaneh Alavi, Paul Hazen, Jennifer L. Hsiao, Vivian Y. Shi, Jamie Weisman, Tanja Tran, Jan Rudnik, Adam Jedrzejczyk, Ingrid Pansar, Alexa B. Kimball
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with high prevalence and negative impact on quality of life. This study evaluated the care and treatment trends of HS patients in the USA using real-world data. Results showed increased prevalence of HS, improved care, but gaps in access to dermatologic care and low utilization of biologic therapies.
DERMATOLOGY AND THERAPY
(2023)
Letter
Dermatology
Amit Garg, Sahil Rawal, Oleg Akilov, Afsaneh Alavi, Christine Ardon, Falk G. Bechara, Arnon D. Cohen, Steven R. Cohen, Steven Daveluy, Veronique del Marmol, Maia Delage, Solveig Esmann, Shani Fisher, Evangelos J. Giamarellos-Bourboulis, Amelia Glowaczewska, Noah Goldfarb, Elena Gonzalez Brant, Oystein Grimstad, Sandra Guilbault, Iltefat Hamzavi, Rosalind Hughes, John R. Ingram, Gregor B. E. Jemec, Qiang Ju, Naomi Kappe, Brian Kirby, Joslyn S. Kirby, Michelle A. Lowes, Lukasz Matusiak, Stella Micha, Robert G. Micheletti, Angela P. Miller, Dagfinn Moseng, Haley B. Naik, Aude Nassif, Georgios Nikolakis, So Yeon Paek, Jose Carlos Pascual, Errol Prens, Barry Resnik, Hassan Riad, Christopher Sayed, Saxon D. Smith, Yssra Soliman, Jacek C. Szepietowski, Jerry Tan, Linnea Thorlacius, Thrasyvoulos Tzellos, Hessel H. van der Zee, Bente Villumsen, Lanqi Wang, Christos C. Zouboulis, Andrew Strunk
Summary: Patients with hidradenitis suppurativa are greatly affected in their lives. Factors such as younger age, Black race, high BMI, active smoking, flares, depression, anxiety, high comorbidity burden, disability, and difficult access to a dermatologist have a negative impact on their quality of life. Attention should be given to these factors, especially those that can be modified, to reduce the overall impact of the disease.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Marcus L. Elias, Jonathan Koptyev, Bernice Y. Yan, Andrew Strunk, Victoria R. Sharon, Amit Garg
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Nicole Mastacouris, Abigail Feda, Andrew Strunk, Amit Garg
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Letter
Dermatology
Nicole Mastacouris, Andrew Strunk, Amit Garg
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Nene Sy, Nicole Mastacouris, Andrew Strunk, Amit Garg
Summary: This cross-sectional study found that there is a significant burden of alopecia areata (AA), particularly among people of color, especially Asian Americans, in the US. Cases of alopecia totalis (AT) and alopecia universalis (AU) comprised approximately 9% of patients diagnosed with AA.
Article
Dermatology
Amit Garg, Yvonne Geissbuhler, Emma Houchen, Nilesh Choudhary, Disha Arora, Varun Vellanki, Abhishek Srivastava, Priyanka, John Darcy, Craig Richardson, Alexa B. Kimball
Summary: This study evaluated the sociodemographic characteristics, comorbidities, treatment patterns, healthcare resource utilization, and associated costs of patients with Hidradenitis suppurativa (HS) following the approval of a biologic (adalimumab). The study found that the burden of comorbidities in HS patients continues to increase after diagnosis, and healthcare resource utilization and costs are high. These findings highlight the need for a multidisciplinary comprehensive care strategy for HS patients.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Immunology
Michael Melgar, Joseph Y. Abrams, Shana Godfred-Cato, Ami B. Shah, Amit Garg, Andrew Strunk, Mangala Narasimhan, Jonathan Koptyev, Alexandra Norden, David Musheyev, Fahmida Rashid, Rachel Tannenbaum, Rosa M. Estrada-Y-Martin, Bela Patel, Siddharth Karanth, Chad J. Achenbach, Gavin T. Hall, Sara M. Hockney, Matthew Caputo, Lilian M. Abbo, Laura Beauchamps, Stephen Morris, Renzo O. Cifuentes, Annabelle de St Maurice, Douglas S. Bell, Kavitha K. Prabaker, Fernando J. Sanz Vidorreta, Evan Bryant, David K. Cohen, Rohith Mohan, Christopher P. Libby, Spencer SooHoo, Tristel J. Domingo, Angela P. Campbell, Ermias D. Belay
Summary: This retrospective cohort study compared the clinical manifestations and treatments of MIS-A patients with COVID-19 patients. The findings showed that MIS-A patients were more likely to have gastrointestinal symptoms and chest pain, had a higher mortality rate, and required longer hospitalization, more intensive care, and mechanical ventilation compared to COVID-19 patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Dermatology
Natalia Pelet del Toro, Andrew Strunk, Amit Garg, George Han
Summary: The study aimed to validate the use of diagnostic codes to establish LP and LPP cohorts. The results showed that LP and LPP diagnosis codes applied by any physician can generate reliable and specific cohorts, while the use of LP codes applied by a dermatologist is necessary to accurately identify non-oral LP cases.
Review
Dermatology
Nanja van Geel, Jolien Duponselle, Liesbeth Delbaere, Sandrine Herbelet, Viktoria Eleftheriadou, Khaled Ezzedine, Maxine Forman, Amit Garg, Iltefat H. Hamzavi, Julien Seneschal, Phyllis Spuls, Caroline B. Terwee, Albert Wolkerstorfer, Reinhart Speeckaert, Amit G. Pandya
Summary: This article reviews the importance of clinician-reported outcome measures (ClinROMs) in assessing vitiligo and describes 14 different ClinROMs that can be used to measure vitiligo extent, repigmentation, and activity. The choice of an appropriate ClinROM depends on practical strengths and limitations as well as the research question and setting.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Nicole Mastacouris, Andrew Strunk, Amit Garg
Summary: This study analyzed the incidence and prevalence of diagnosed vitiligo in the US and found that vitiligo diagnosis was more common in older patients, Hispanic/Latino patients, and Asian American patients.
Article
Dermatology
Amaris Nicole Geisler, Jonathan Koptyev, Andrew Strunk, Pooja R. Shah, Amit Garg
Summary: This study describes the demographics, clinical characteristics and skin-related quality of life in patients with vulvar lichen sclerosus (VLS), and assesses the relationship between quality of life and treatment adherence. Treatment adherence was positively correlated with quality of life, and the most common factor preventing adherence was application/treatment time. These findings can help healthcare providers facilitate better treatment adherence and improve the quality of life for patients with VLS.
