Review
Urology & Nephrology
Giovanna Leoncini, Cecilia Barnini, Luca Manco, Giulia Nobili, Daniele Dotta, Martina Penso, Elisa Russo, Francesca Cappadona, Francesca Viazzi, Roberto Pontremoli
Summary: Hyperuricemia is associated with cardiovascular risk factors and is a predictor of kidney disease. Urate-lowering treatment has been proposed to improve kidney outcomes, but recent randomized controlled trials have failed to show its beneficial effect on renal disease.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Lin Zhang, Kang An, Xingyu Mou, Mei Zhang, Qiaoli Su, Shuangqing Li
Summary: Urate-lowering therapy did not significantly impact the progression of kidney function in asymptomatic hyperuricemia patients, but it did lower serum uric acid levels and the incidence of gout episodes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Katsunori Yanai, Keiji Hirai, Shohei Kaneko, Yuko Mutsuyoshi, Taisuke Kitano, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Susumu Ookawara, Yoshiyuki Morishita
Summary: We retrospectively analyzed the efficacy and safety of dotinurad, a selective urate reabsorption inhibitor, in hyperuricemic patients with advanced CKD. The results showed that dotinurad was able to decrease uric acid levels and might attenuate renal function decline.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Xiang Yu, Mingjia Gu, Yiye Zhu, Lixiang Zhang, Wei Kong, Yanqin Zou
Summary: This study systematically evaluated the efficacy and safety of urate-lowering therapy in patients with chronic kidney disease (CKD). The results showed that urate-lowering therapy could reduce urate levels and potentially delay the decline of estimated glomerular filtration rate (eGFR). Febuxostat was found to be the most effective treatment in lowering urate levels. There were no significant differences in the incidence of adverse effects between groups.
CLINICAL THERAPEUTICS
(2022)
Article
Food Science & Technology
Biqian Wei, Pengfei Ren, Changhu Xue, Yuming Wang, Qingjuan Tang
Summary: This study aimed to evaluate the amelioration of hyperuricemia and renal inflammation by guluronate oligosaccharides (GOS) derived from brown algae. Results showed that GOS treatment significantly reduced serum uric acid and blood urea nitrogen levels, while restoring the levels of xanthine oxidase and adenosine deaminase to normal. GOS treatment also improved renal pathologization associated with hyperuricemia and modulated intestinal microbiota. These findings support further development of GOS as a functional food ingredient for hyperuricemia.
Article
Medicine, General & Internal
Meng-Ko Tsai, Kuang-Chen Hung, Chun-Cheng Liao, Lung-Fa Pan, Chia-Lien Hung, Deng-Ho Yang
Summary: This study found that low testosterone levels in men may be associated with an increased risk of hyperuricemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Seokwoo Park, Jung Pyo Lee, Dong Ki Kim, Yon Su Kim, Chun Soo Lim
Summary: This study compared the renoprotective effects of allopurinol and febuxostat on chronic kidney disease and found that allopurinol could slow down the progression of the disease and prevent hypouricemia.
Review
Urology & Nephrology
Hans-Joachim Anders, Qiubo Li, Stefanie Steiger
Summary: Asymptomatic hyperuricaemia (HU) is linked to multiple diseases, but only gouty arthritis and urate nephropathy have proven causative relationships with uric acid crystals. Epidemiological studies show a strong association between HU and hypertension, cardiovascular disease (CVD), and CKD progression, but impaired UA clearance and the use of diuretics likely contribute to these associations. This review provides new insights into the effects of soluble and crystalline UA, discusses the role of asymptomatic HU in CKD, CVD, and sterile inflammation, and identifies areas of research that require further investigation.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Pediatrics
Jie Xu, Lingxiao Tong, Jianhua Mao
Summary: This study investigated the clinical characteristics and associated factors of hyperuricemia in Chinese children with chronic kidney disease (CKD). The results showed a significant association between hyperuricemia and kidney risk factors. Monitoring and controlling hyperuricemia, anemia, blood urea nitrogen, and serum creatinine levels in CKD children may help prevent disease progression.
Article
Medicine, General & Internal
Fu-Shun Yen, James Cheng-Chung Wei, Chia-Ling Chang, Chen-Chang Yang, Chih-Cheng Hsu, Chii-Min Hwu
Summary: Studies have shown that urate-lowering therapy (ULT) is not significantly associated with a lower risk of chronic kidney disease (CKD) development among gout patients. However, in specific patient subgroups such as those with diabetes mellitus and without hypertension, ULT may be significantly associated with a reduced risk of incident CKD.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wei-Zheng Zhang
Summary: Gout is a multifactorial metabolic disease where the role of hyperuricemia in its development is not solely definitive. Understanding the intricate role of serum uric acid (SUA) in gout pathogenesis is crucial for advancing clinical and pharmaceutical approaches towards a cure for the disease.
Article
Agriculture, Multidisciplinary
Bendong Yang, Meiling Xin, Shufei Liang, Yuhong Huang, Jingda Li, Chao Wang, Chao Liu, Xinhua Song, Jinyue Sun, Wenlong Sun
Summary: Naringenin reduces hyperuricemia and renal inflammation by promoting uric acid excretion and attenuating the release of inflammatory cytokines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Ling Cao, Tianyi Zhao, Yu Xue, Luan Xue, Yueying Chen, Feng Quan, Yu Xiao, Weiguo Wan, Man Han, Quan Jiang, Liwei Lu, Hejian Zou, Xiaoxia Zhu
Summary: This study found that Si-Miao-San (SMS) has anti-inflammatory effects and can improve gouty arthritis while inhibiting hyperuricemia. The anti-inflammatory mechanism of SMS may be via promoting M2 polarization through the PI3K/Akt signaling pathway. Ecdysone and estrone might be the potentially effective ingredients of SMS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Deng-Ho Yang, Hsiang-Cheng Chen, James Cheng-Chung Wei
Summary: This study evaluated the effect of early urate-lowering therapy on acute flares of gouty arthritis. The results showed that early aggressive control of hyperuricemia using probenecid plus colchicine led to a rapid decrease in serum uric acid levels, but did not significantly alleviate arthritis pain.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Immunology
Wenxue Hou, Xiaomin Xia, Ying Li, Hanlin Lv, Jie Liu, Xue Li
Summary: Periodontitis is a common oral disease that may not only affect tooth structures but also have implications for overall health. Studies have suggested a potential connection between periodontitis and hyperuricemia.
FRONTIERS IN IMMUNOLOGY
(2022)