Review
Rheumatology
Caroline Ospelt
Summary: New analytical methods and the increasing availability of synovial biopsies have shed light on the role of synovial fibroblasts (SFs) in rheumatoid arthritis (RA). Recent studies have revealed heterogeneity and propagation of SFs in RA, expanding our understanding of their active involvement in the invasion of synovium into cartilage. This review provides an overview of the processes occurring at sites of invasive synovial tissue growth in RA by integrating old and new evidence.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sascha L. Heckert, Sytske Anne Bergstra, Xanthe M. E. Matthijssen, Yvonne P. M. Goekoop-Ruiterman, Faouzia Fodili, Saskia Ten Wolde, Cornelia F. Allaart, Tom W. J. Huizinga
Summary: In patients with rheumatoid arthritis, baseline joint swelling was significantly associated with swelling in the same joint during follow-up, and it was found to better predict local joint swelling compared to baseline swelling in other joints. This suggests that local factors play a role in the recurrence of joint swelling over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Yi Qin, Ming-Long Cai, Hui-Zhi Jin, Wei Huang, Chen Zhu, Aline Bozec, Jingang Huang, Zhu Chen
Summary: This study found that ABCs contribute to the pathogenesis of RA by inducing the activation of FLS via TNF-alpha-mediated signaling pathways.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Cell Biology
Hanxiao Zhao, Li Li, Ning Zhao, Aiping Lu, Cheng Lu, Xiaojuan He
Summary: This paper reviews the role and expression changes of long non-coding RNAs (lncRNAs) in joint destruction of rheumatoid arthritis (RA), providing a comprehensive understanding for the treatment of RA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
York Kiat Tan, Cassandra Hong, HuiHua Li, John Carson Allen, Julian Thumboo
Summary: The study demonstrated the superiority of combined thermal and ultrasound imaging in assessing joint inflammation in rheumatoid arthritis, with MAX (PD) and AVG (PD) showing the highest correlation with the 28-joint disease activity score (DAS28).
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Rheumatology
Shinichiro Ishie, Hiromu Ito, Shuichiro Nakabo, Hideaki Tsuji, Toshiki Nakajima, Yuko Tsuji, Maiko Inagaki, Moritoshi Furu, Motomu Hashimoto, Koichi Murata, Kosaku Murakami, Kohei Nishitani, Masao Tanaka, Yasutomo Fujii, Shuichi Matsuda
Summary: The study found that ultrasound-detected foot synovitis is related to systemic inflammation, clinical symptoms, and future joint destruction with region specificity.
MODERN RHEUMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ling-ling Zhang, Hui Xiao, Feng Zhang, Yu-jing Wu, Jin-ling Shu, Ying Li, Yu Tai, Sheng-qian Xu, Jian-hua Xu, Wei Wei
Summary: The study found that the serum BAFF level is significantly higher in rheumatoid arthritis patients, and is positively correlated with clinical variables, laboratory parameters, and X-ray scores. BAFF is involved in the differentiation, proliferation, and activation of B cells in rheumatoid arthritis through the NF-kappa B signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Rheumatology
Silvia Hayer, Margriet J. Vervoordeldonk, Maria C. Denis, Marietta Armaka, Markus Hoffmann, Johan Backlund, Kutty Selva Nandakumar, Birgit Niederreiter, Christina Geka, Anita Fischer, Nina Woodworth, Stephan Blueml, George Kollias, Rikard Holmdahl, Florence Apparailly, Marije Koenders
Summary: Animal models for inflammatory arthritides like rheumatoid arthritis and psoriatic arthritis are widely used for research, but many publications lack detailed descriptions and evaluations of arthritis pathology. The European consortium BeTheCure developed SMASH recommendations for standardised histological evaluation to improve information and promote reproducibility in preclinical research on inflammatory arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Pharmacology & Pharmacy
Chuyu Shen, Meilin Xu, Siqi Xu, Shuoyang Zhang, Wei Lin, Hao Li, Shan Zeng, Qian Qiu, Liuqin Liang, Youjun Xiao, Hanshi Xu
Summary: This study investigated the role and mechanism of Myricitrin (Myr) in regulating synovitis and joint destruction mediated by fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). The results showed that Myr treatment inhibited the migration and invasion of RA FLS, reduced the expression of inflammatory cytokines and MMPs, and suppressed the phosphorylation of AKT. Furthermore, Myr administration relieved arthritis symptoms in a mouse model of collagen-induced arthritis (CIA).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Clement Triaille, Gaelle Tilman, Tatiana Sokolova, Axelle Loriot, Joelle Marchandise, Stephanie De Montjoye, Adrien Nzeusseu-Toukap, Laurent Meric de Bellefon, Caroline Bouzin, Christine Galant, Patrick Durez, Bernard R. Lauwerys, Nisha Limaye
Summary: This study used transcriptomic profiling to explore clinically relevant subgroups in early, untreated rheumatoid arthritis (RA) patients. The synovial transcriptome closely mirrored clinical disease activity, and the ratio of M2:M1 macrophages was inversely correlated with inflammation and disease activity, suggesting a protective role for tissue resident macrophages in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Yi Lin, Ying-Jie Zhao, Hai-Lin Zhang, Wen-Juan Hao, Ren-Di Zhu, Yan Wang, Wei Hu, Ren-Peng Zhou
Summary: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by inflammation, and immune dysfunction plays an essential role in its pathogenesis. Abnormal activation of KCa3.1 channel has been observed in RA patients, and it is involved in synovial inflammation and cartilage damage. KCa3.1 is considered a potential therapeutic target for RA based on its role in immune cell function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Katerina Chatzidionysiou, Alexandra Circiumaru, Bence Rethi, Vijay Joshua, Marianne Engstrom, Aase Hensvold, Erik af Klint, Anca Catrina
Summary: Tocilizumab reduced synovial T-cell counts but not macrophages in rheumatoid arthritis patients. A significant increase in serum IL-6 was observed in responders to tocilizumab.
Review
Rheumatology
Nadia M. T. Roodenrijs, Melinda Kedves, Attila Hamar, Gyorgy Nagy, Jacob M. van Laar, Desiree van der Heijde, Paco M. J. Welsing
Summary: This study summarized the evidence on diagnostic issues in difficult-to-treat rheumatoid arthritis (D2T RA) and found a scarcity of high-quality studies, no diagnostic tests with sufficient validity and accuracy identified, with ultrasonography (US) showing promise for assessing inflammatory activity.
Review
Rheumatology
Aurelie Najm, Felicie Costantino, Catherine Weill, Andrew Filer, Maria Antonieta D'Agostino
Summary: This study aims to summarize the impact of biopsy procedures, tissue handling, tissue quality, and disease-specific factors on synovial tissue outcome. The study found that study design, population, sample handling, randomization, and analysis can affect the final results of synovial tissue research.
Article
Rheumatology
Raphael Micheroli, Muriel Elhai, Sam Edalat, Mojca Frank-Bertoncelj, Kristina Buerki, Adrian Ciurea, Lucy MacDonald, Mariola Kurowska-Stolarska, Myles J. Lewis, Katriona Goldmann, Cankut Cubuk, Tadeja Kuret, Oliver Distler, Costantino Pitzalis, Caroline Ospelt
Summary: This study integrated single-cell RNA sequencing data to assess the contribution of synovial fibroblast subsets to synovial pathotypes and clinical characteristics in treatment-naive early arthritis. The findings revealed a previously unexplored association between specific synovial pathologies and subtypes of synovial fibroblasts.
Article
Ecology
Yibo Liu, Baiyu Zhang, Yixin Zhang, Yanping Shen, Cheng Cheng, Weilin Yuan, Ping Guo
Summary: This study investigates the microbial interactions in organic matter decomposition (OMD) and the influence of environmental factors on microbial interactions in river ecosystems. The researchers use cotton strip as a substitute for organic matter in the Luanhe River Basin in China. The results show that bacteria and fungi cooperatively form an interaction network to achieve the decomposition of cotton strip. The key modules in the network, mainly composed of Proteobacteria and Ascomycota, are identified as the effective decomposers. Water temperature and total nitrogen are dominant environmental factors positively influencing the decomposition process.
Article
Environmental Sciences
Cuirin Cantwell, Xing Song, Xixi Li, Baiyu Zhang
Summary: In this study, quantitative structure-property relationship (QSAR) modeling was used to predict the adsorption behavior of 209 PBDE congeners, and the biodegradability of common PBDE congeners was evaluated through molecular docking analysis. The results highlight the significant role of bromination degree in the absorption and biodegradation of PBDEs in soil.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Xiuqi Hou, Xi Yang, Yanwen Xu, Jiayin Lin, Fang Zhang, Xiaohui Duan, Sitong Liu, Jie Liu, Jun Shen, Xintao Shuai, Zhong Cao
Summary: This study developed a theranostic nanodrug that combines MRI and cancer therapy, which released specific drugs and metal ions in the tumor microenvironment and achieved high sensitivity MRI monitoring and gas therapy, while synergistically targeting tumor-promoting macrophages.
Article
Radiology, Nuclear Medicine & Medical Imaging
Taihui Yu, Zhaoxi Cai, Zehong Yang, Wenhao Lin, Yun Su, Jixin Li, Shuanglun Xie, Jun Shen
Summary: This study aimed to determine the added value of myocardial fibrosis parameters derived from cardiac magnetic resonance imaging (MRI) in the risk stratification of hypertrophic cardiomyopathy (HCM) patients. The results showed that the global extracellular volume fraction (ECV) was an effective predictor of sudden cardiac death (SCD) risk and outperformed other cardiac MRI features and the HCM Risk-SCD score. The integration of global ECV and HCM Risk-SCD score yielded a more accurate prediction model for SCD risk stratification in HCM patients.
ACADEMIC RADIOLOGY
(2023)
Article
Neurosciences
Zhuozhi Dai, Zhiqi Yang, Xiaofeng Chen, Wenbin Zheng, Zerui Zhuang, Yuting Liao, Mu Li, Shaoxian Chen, Daiying Lin, Xianheng Wu, Jun Shen
Summary: This study aimed to investigate the aging of the glymphatic system in healthy adults and its correlation with brain charts and neuropsychological functioning. Two independent brain MRI datasets were analyzed, and the function of the glymphatic system was quantified. The results showed that the aging of the glymphatic system exists in healthy adults but is not correlated with changes in brain charts and neuropsychological functioning.
Review
Computer Science, Artificial Intelligence
Chenji Zhao, Shun Xiang, Yuanquan Wang, Zhaoxi Cai, Jun Shen, Shoujun Zhou, Di Zhao, Weihua Su, Shijie Guo, Shuo Li
Summary: This paper proposes a context-aware network (CA-Net) for semi-supervised left atrium (LA) segmentation from 3D MRI. Experimental results show that contextual information is helpful in extracting accurate atrial structures, and CA-Net achieves better performance than some state-of-the-art semi-supervised networks.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Ya-Ping Wang, Xiao-Hui Duan, Yin-Hui Huang, Ya-Jun Hou, Kai Wu, Fang Zhang, Mei Pan, Jun Shen, Cheng-Yong Su
Summary: In this study, a discrete Os-based metal-organic nanocage was designed as a versatile theranostic nanoplatform for multipurpose diagnosis and treatment. The nanocage exhibits various functions, including synergistic treatments for breast cancer, NIR imaging and anticancer drug transport. The micellization of the nanocage enables efficient subcellular endocytosis and uptake. Promising antitumor performance was demonstrated both in vitro and in vivo, offering a conceptual protocol for collaborative cancer theranostics on a single-nanomaterial platform.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Environmental Sciences
Fukai Xu, Jiunian Guan, Yumei Zhou, Ziwei Song, Yanping Shen, Yibo Liu, Xiaohui Jia, Baiyu Zhang, Ping Guo
Summary: This study is the first to investigate the effects of freeze-thaw (FT) and microplastics (MPs) on the distribution of antibiotic resistance genes (ARGs) in soil aggregates. The results showed that FT increased the relative abundance of ARGs in different aggregates by promoting the growth of intI1 and ARG host bacteria. However, polyethylene MPs hindered this increase caused by FT. The study also revealed that FT, MPs, and their integration promoted the proliferation of human pathogenic bacteria in soil aggregates.
Article
Materials Science, Multidisciplinary
Yuxun Ding, Xiaohui Xiao, Lu Bai, Bowen Yang, Guanghui Lin, Lingli Zeng, Lisi Xie, Lei Li, Xiaohui Duan, Jun Shen, Jianhua Zhou, Yue Pan
Summary: This paper describes a novel multifunctional superparamagnetic iron oxide nanoparticle (SPION)@polymer hybrid nanosensitizer (SPHN) with enhanced radiosensitization and dual-targeting capability. These unique structures endow SPHN with outstanding radiosensitization and tumor targeting abilities. Through a combination of radiation and chemotherapy, this nanotechnology can achieve remarkable inhibition of tumor growth in vivo.
NPG ASIA MATERIALS
(2023)
Article
Environmental Sciences
Zheng Wang, Chunjiang An, Kenneth Lee, Qi Feng, Baiyu Zhang
Summary: This study investigates the effects of nanobubbles (NBs) on the fate and transport of pollutants in coastal areas. The properties and influencing factors of NBs were determined. NBs significantly increased dissolved oxygen concentration and altered water pH, zeta potential, and surface tension. Low salinity favored NB generation, while high salinity inhibited it. This study demonstrates the significant role of NBs in the environmental behaviors of pollutants in coastal areas.
Article
Green & Sustainable Science & Technology
Bo Liu, Baiyu Zhang, Guihua Dong, Fei Wu, Bing Chen
Summary: Chlorination is a commonly used technique for drinking water disinfection, but it can produce disinfection by-products (DBPs) that threaten water safety. This study introduces environmental microfluidics to a UVA-LED photocatalytic oxidation system for the rapid oxidation of organic matter. The results show that low pH conditions favor the adsorption and degradation of organic matter. The microreactor effectively reduces DBP formation potential and increases water purification efficiency.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunping Mao, Lanxin Hu, Wei Jiang, Ya Qiu, Zehong Yang, Yeqing Liu, Mengzhu Wang, Dongye Wang, Yun Su, Jinru Lin, Xu Yan, Zhaoxi Cai, Xiang Zhang, Jun Shen
Summary: The objective of this study was to evaluate the value of conventional DWI, CTRW, FROC, and SEM in discriminating HER2 status in breast cancer. The study found that α(CTRW) was the best discriminative metric, which could help differentiate HER2-low-expressing and HER2-overexpressing breast cancers.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Fatemeh Salami, Jian-bin Lin, Bing Chen, Baiyu Zhang, Yuming Zhao
Summary: In this work, the elusive macrocyclic organic compound cyclo-di-BADGE, a by-product of co-polymerization reactions of bisphenol A and bisphenol A diglycidyl ether, was comprehensively characterized using NMR, single crystal X-ray diffraction, UV-Vis, dynamic light scattering, molecular dynamics simulations, fluorescence, and molecular docking analyses. The results provide valuable knowledge about the physico-chemical properties and relevant effects of cyclo-di-BADGE on the environment and biological systems.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Environmental Sciences
Yanping Shen, Yibo Liu, Yutong Du, Xu Wang, Jiunian Guan, Xiaohui Jia, Fukai Xu, Ziwei Song, Hongjie Gao, Baiyu Zhang, Ping Guo
Summary: This study investigated the transfer of antibiotic resistance genes (ARGs) from soils to plants, focusing on the role of host bacteria and its impact on seed-derived bacteria. Results showed that host bacteria in the rhizosphere soil were the main source of ARGs in wheat, and some seed-derived bacteria and pathogenic Acinetobacter obtained ARGs through horizontal gene transfer. Factors such as total organic carbon and available nitrogen in the rhizosphere soil were identified as key factors affecting the transfer of potential host bacteria to wheat.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Physical
Xiuqi Hou, Xi Yang, Yanwen Xu, Jiayin Lin, Fang Zhang, Xiaohui Duan, Sitong Liu, Jie Liu, Jun Shen, Xintao Shuai, Zhong Cao
Summary: A multifunctional nanodrug combining MRI imaging and cancer therapy has been developed, which can release drugs and achieve sensitive MRI imaging in tumor microenvironment, as well as achieve synergistic antitumor effects through immune activation and gas therapy.