Article
Rheumatology
Xia Chen, Qiong-Yi Hu, Mengyan Wang, Jinchao Jia, Jialin Teng, Yue Sun, Xiaobing Cheng, Junna Ye, Yutong Su, Hui Shi, Huihui Chi, Zhuochao Zhou, Tingting Liu, Zhihong Wang, Liyan Wan, Xin Qiao, Fan Wang, Xinyao Wu, Chengde Yang, Hong-Lei Liu
Summary: This study found a close association between serum VEGF-C levels and AOSD including disease activity and clinical hematological manifestations, suggesting the potential utility of VEGF-C as a candidate biomarker to assess disease activity in AOSD.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Beatrice Maranini, Giovanni Ciancio, Marcello Govoni
Summary: Adult-onset Still's disease is a systemic inflammatory disease with unknown etiology, characterized by a cytokine storm. A portion of patients with severe symptoms, known as refractory AOSD patients, are resistant to standard treatments and may require higher dosages of glucocorticoids and immunosuppressive drugs. Analysis of literature data aims to identify biomarkers that could guide clinical decisions and lead to new therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Luana Andreea Macovei, Alexandra Burlui, Ioana Bratoiu, Ciprian Rezus, Anca Cardoneanu, Patricia Richter, Andreea Szalontay, Elena Rezus
Summary: Adult-onset Still's disease is a systemic inflammatory disorder with unknown etiology, characterized by symptoms such as high fever, lymphadenopathy, hepatosplenomegaly, hyperferritinemia, and leukocytosis. Treatment options include NSAIDs, corticosteroids, csDMARDs, and biological therapy targeting various inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Rheumatology
Yuning Ma, Jianfen Meng, Jinchao Jia, Mengyan Wang, Jialin Teng, Dehao Zhu, Chengde Yang, Qiongyi Hu
Summary: Adult-onset Still's disease is a rare auto-inflammatory disorder characterized by high fever, skin rash, polyarthritis, and other symptoms. Treatment options have expanded beyond traditional medications to include anti-cytokine biologic agents.
Review
Medicine, General & Internal
Stylianos Tomaras, Carl Christoph Goetzke, Tilmann Kallinich, Eugen Feist
Summary: Adult-onset Still's disease is a rare systemic autoinflammatory disease characterized by arthritis, spiking fever, skin rash, and elevated ferritin levels. Immune dysregulation plays a central role in the disease, involving pathogenic involvement of both arms of the immune system. Extensive research has led to a better understanding of AoSD and revolutionary advances in treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Jianfen Meng, Yuning Ma, Jinchao Jia, Mengyan Wang, Jialin Teng, Hui Shi, Honglei Liu, Yutong Su, Junna Ye, Yue Sun, Xiaobing Cheng, Huihui Chi, Tingting Liu, Dehao Zhu, Zhuochao Zhou, Liyan Wan, Zhihong Wang, Fan Wang, Xin Qiao, Xia Chen, Hao Zhang, Zihan Tang, Chengde Yang, Qiongyi Hu
Summary: This study compared the cytokine and ferritin levels between severe COVID-19 and active AOSD patients, revealing significant differences in IL-6, IL-10, and ferritin levels, laying the groundwork for developing therapeutic strategies targeting the hyperinflammatory process in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Nicolas Poursac, Itsaso Odriozola, Marie-Elise Truchetet
Summary: Adult-onset Still's disease is a complex autoinflammatory disease with a multifactorial etiology. This review provides a detailed overview of the different complementary tests used in diagnosing and managing the disease, including their value in positive diagnosis, differential diagnosis, and screening for complications. A structured algorithm is proposed for clinical practice, and potential new complementary examinations are discussed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Seoung Wan Nam, SuMan Kang, Jun Hyeok Lee, Dae Hyun Yoo
Summary: This study evaluated the usefulness of serum interleukin (IL)-37 and IL-18 as disease activity markers of adult-onset Still's disease (AOSD) and found that they can complement each other in reflecting different aspects of AOSD. IL-37 correlated better with CRP while IL-18 correlated with ferritin, AST, and LDH, as well as certain disease manifestations like pleuritis and pneumonitis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Mengzhu Zhao, Di Wu, Min Shen
Summary: A total of 187 patients with adult-onset Still's disease (AOSD) were studied, revealing a 7.5% prevalence of neurological involvement. Common symptoms included fever, rash, liver dysfunction, arthralgia/arthritis, and lymphadenopathy. Treatment strategies mainly consisted of high-dose corticosteroids and immunosuppressive agents, with a 100% clinical remission rate.
Article
Rheumatology
Helen L. Leavis, Paul L. A. van Daele, Catharina Mulders-Manders, Renee Michels, Abraham Rutgers, Elizabeth Legger, Marc Bijl, Elisabeth A. Hak, Wai-Kwan Lam-Tse, Femke Bonte-Mineur, Peter Fretter, Anna Simon, Pieter van Paassen, Marlies C. van der Goes, Marcel Flendrie, Ward Vercoutere, Antoine W. T. van Lieshout, Arjen Leek, Sebastiaan J. Vastert, Sander W. Tas
Summary: This study used a Delphi panel to reach consensus on diagnostic and treatment strategies for adult-onset Still's disease. The panel agreed on recommendations for diagnosis and therapy, including the use of biologics and reduction of glucocorticoid use. The results can serve as a basis for a treatment guideline.
Article
Immunology
Zhiye Xu, Linyu Geng, LiLi Guo, Hongyan Song, Jie Pan, Han Shen, Sen Wang
Summary: This study suggests that ADA activity may have potential clinical significance in the diagnosis and disease activity assessment of AOSD.
Article
Immunology
Pascale Palassin, Virginie Bres, Samaher Hassan, Ange Alfonsi, Nathalie Massy, Valerie Gras-Champel, Alexandre Thibault Jacques Maria, Jean-Luc Faillie
Summary: This study provides a comprehensive description and analysis of cases of adult-onset Still's disease (AOSD) reported after COVID-19 vaccination. The results show that AOSD cases were more frequently reported in women, with a median age of 43.4 years. The majority of cases occurred within the first three weeks after vaccination, predominantly associated with the BNT162b2 mRNA vaccine. Disproportionality analyses suggested an association between AOSD and COVID-19 vaccines, as well as other vaccines. Clinicians should be aware of the potential risk of AOSD following COVID vaccines and the importance of early detection and management.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Jinchao Jia, Luyu Yang, Zhujun Cao, Mengyan Wang, Yuning Ma, Xiong Ma, Qiaoyan Liu, Jialin Teng, Hui Shi, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Huihui Chi, Tingting Liu, Zhihong Wang, Liyan Wan, Chengde Yang, Qiongyi Hu
Summary: The study identified Lipocalin-2 (LCN2) as a potential biomarker for liver damage in adult-onset Still's disease (AOSD). LCN2 levels were found to be significantly elevated in AOSD patients compared to healthy controls, and were closely correlated with inflammatory markers and liver dysfunction. This suggests that LCN2 could be a useful tool for identifying AOSD patients with systemic inflammation, particularly those with liver involvement.
Review
Medicine, General & Internal
Jasper F. F. Nies, Udo Schneider, Martin Krusche
Summary: Pulmonary involvement in AOSD, a rare but serious complication, can manifest in various forms and IL-1 and IL-6 inhibitors have shown success in the management of AOSD.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Arthur Guerber, Etienne Garneret, Thomas El Jammal, Sabine Zaepfel, Mathieu Gerfaud-Valentin, Pascal Seve, Yvan Jamilloux
Summary: Glycosylated ferritin (GF) has been found to be a good diagnostic biomarker for adult-onset Still's disease (AOSD), with high diagnostic accuracy and specificity. Setting the GF threshold at 16% can increase the specificity and positive predictive value for AOSD diagnosis. GF is important for ruling out differential diagnoses and classifying AOSD in clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2022)