Article
Immunology
Ai Kuzumi, Yuta Norimatsu, Kazuki M. Matsuda, Chihiro Ono, Taishi Okumura, Emi Kogo, Naoki Goshima, Takemichi Fukasawa, Natsumi Fushida, Motoki Horii, Takashi Yamashita, Asako Yoshizaki-Ogawa, Kei Yamaguchi, Takashi Matsushita, Shinichi Sato, Ayumi Yoshizaki
Summary: A novel multiplex protein assay (A-Cube) was developed using a proteome-wide human cDNA library to evaluate 65 antigens of 43 autoantibodies associated with SSc and PM/DM. A-Cube showed high sensitivity and agreement with traditional detection methods. Analysis of serum samples from SSc and PM/DM patients revealed a diverse autoantibody landscape and enabled correlation analysis between multiple autoantibodies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Maheswari Muruganandam, Angie Ariza-Hutchinson, Rosemina A. Patel, Wilmer L. Sibbitt
Summary: Systemic sclerosis is a complex autoimmune disease characterized by vascular damage, inflammation, and fibrosis. Biomarkers play an important role in understanding the disease process and potential therapeutic targets. Anti-nuclear antibodies are classical biomarkers, while other proteins and pathways are also implicated. The use of biomarker panels combined with advanced analysis techniques can help determine disease activity and treatment response.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Allergy
David F. Fiorentino, Livia Casciola-Rosen
Summary: Rheumatic diseases have a complex association with cancer, and studying this connection can provide insights into the mechanisms of autoimmunity and cancer immunity. Systemic sclerosis and dermatomyositis are closely related to internal malignancy, and studying autoantibodies can reveal the relationship between these diseases and cancer. The discovery of disease-specific autoantigens plays an important role in understanding disease emergence and developing effective anti-tumor responses.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Yanting Jiang, Xi Li, Wei Zhou, Min Jin, Sihui Li, Yuehong Lao, Haiqing Zhu, Jian Wang
Summary: The study showed that serum ferritin levels were significantly higher in SSc patients compared to healthy controls, and elevated ferritin levels were associated with skin diffuse cutaneous SSc, fingertip arthralgia, and cardiac involvement. Additionally, abnormal liver function, myocardial involvement, inflammatory status, and autoantibody production were correlated with elevated serum ferritin levels in SSc patients, with cardiac involvement, ALT, and ESR being identified as independent factors affecting ferritin levels in SSc.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Rheumatology
Kae Takagi, Manabu Kawamoto, Tomoaki Higuchi, Akiko Tochimoto, Hikaru Hirose, Masayoshi Harigai, Yasushi Kawaguchi
Summary: Calcinosis in SSc is associated with features like Raynaud's phenomenon, nail fold bleeding, peripheral bone resorption, myositis, and pulmonary hypertension. This suggests that peripheral circulatory insufficiency may be a cause of calcinosis. Additionally, factors related to skin fibrosis, such as modified Rodnan total skin-thickness score and diffuse cutaneous type, are also considered to play a role in calcinosis development.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Xiaoying Zhang, Huijuan Zhang, Jing Zhao, Yun Li, Hongyan Wang, Chun Li
Summary: This study determined the diagnostic accuracy and predictive value of autoantibody profiles in SSc patients. The results showed that specific autoantibodies were associated with certain clinical manifestations of SSc.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Ashley Tieu, Benjamin Chaigne, Bertrand Dunogue, Jeremie Dion, Alexis Regent, Marion Casadevall, Pascal Cohen, Paul Legendre, Benjamin Terrier, Nathalie Costedoat-Chalumeau, Claire Le Jeunne, Luc Mouthon
Summary: This study describes the prevalences, characteristics, and survivals of patients with anti-topoisomerase 1 antibodies (ATA) and limited cutaneous systemic sclerosis (lSSc) and anti-centromere antibodies (ACA) and diffuse cutaneous systemic sclerosis (dSSc). It found that ATA lSSc patients have more interstitial lung disease (ILD) and ACA dSSc patients have less ILD. ATA dSSc patients have the worst prognosis.
Article
Medical Laboratory Technology
Tsai-Hung Yen, Jun-Peng Chen, Tsu-Yi Hsieh, Wei-Ting Hung, Kuo-Lung Lai, Chia-Wei Hsieh, Hsin-Hua Chen, Wen-Nan Huang, Yi-Hsing Chen, Yi-Ming Chen
Summary: This study aimed to assess the diagnostic performance and prognostic value of disease-specific antibodies and anti-Ro52 in Taiwanese SSc patients using a commercial line immunoblot assay (LIA). The study found that LIA exhibited a sensitivity and specificity of 65.4%. It was also observed that the presence of anti-Ro52 or the absence of SSc-specific autoantibodies was associated with more advanced diseases in SSc patients. The combination of IIF and LIA testing may improve the diagnostic specificity of SSc.
CLINICA CHIMICA ACTA
(2023)
Article
Immunology
Wynand Alkema, Hans Koenen, Brigit E. Kersten, Charlotte Kaffa, Jacqueline W. B. Dinnissen, Jan G. M. C. Damoiseaux, Irma Joosten, Sophie Driessen-Diks, Renate G. van der Molen, Madelon C. Vonk, Ruben L. Smeets
Summary: The study found that 79% of systemic sclerosis (SSc) patients tested positive for one or more SSc-associated autoantibodies. There was high agreement between different diagnostic methods for detecting SSc-specific autoantibodies, but lower agreement for SSc-associated autoantibodies and less prevalent SSc-specific autoantibodies. Further standardization is needed for low prevalent SSc-specific and SSc-associated autoantibodies.
Article
Rheumatology
Eduardo Luis Callejas-Moraga, Alfredo Guillen-Del-Castillo, Janire Perurena-Prieto, Maria Teresa Sanz-Martinez, Vicente Fonollosa-Pla, Karen Lorite-Gomez, Adriana Severino, Chiara Bellocchi, Lorenzo Beretta, Michael Mahler, Carmen P. Simeon-Aznar
Summary: This study found that the presence of anti-U11/U12 RNP (RNPC-3) antibodies is associated with an increased prevalence of interstitial lung disease (ILD) in systemic sclerosis (SSc) patients and is independently associated with more severe lung disease and shorter survival.
Article
Rheumatology
Jun Inamo
Summary: This study investigated the relationship between different types of autoantibodies and gene expression profiles in skin lesions of patients with Systemic Sclerosis (SSc), identifying specific dysregulated pathways associated with each autoantibody type. By analyzing gene expression data, the study revealed potential new therapeutic targets for SSc based on specific autoantibody profiles.
Article
Rheumatology
Rachel S. Wallwork, Ami A. Shah, Livia Casciola-Rosen
Summary: This study aims to define the clinical phenotype of SSc patients with antibodies against Sjogren's syndrome (SS)/scleroderma autoantigen 1 (SSSCA1), and examine the association between these antibodies and cancer in SSc patients. The study found that SSc patients with anti-SSSCA1 antibodies were more likely to have severe Raynaud's phenomenon and cardiac involvement. Among patients with cancer, there was a trend towards a longer cancer-SSc interval in anti-SSSCA1-positive patients. Patients with anti-SSSCA1 antibodies had an increased adjusted risk of cancer compared with anti-SSSCA1-negative patients.
Article
Immunology
Hantao Lou, Guang Sheng Ling, Xuetao Cao
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by organ damage and a wide range of autoantibodies. The mechanisms of tissue damage and inflammation caused by autoantibodies are not fully understood, but studying autoreactive B cells and pathogenic autoantibodies can enhance our understanding of the origins and targets of SLE. Developing specific therapies targeting pathogenic B cell subsets and autoantibodies remains a challenge. Comprehensive autoantibody profiling and functional characterization can provide new insights into the etiology and pathogenesis of SLE.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Rheumatology
Hideaki Tsuji, Nobuo Kuramoto, Tsuneo Sasai, Mirei Shirakashi, Hideo Onizawa, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Ryu Watanabe, Akira Onishi, Kosaku Murakami, Hajime Yoshifuji, Masao Tanaka, Motomu Hashimoto, Koichiro Ohmura, Akio Morinobu
Summary: Specific SSc-related autoantibodies are associated with the morbidity and mortality of SRC. Anti-topoisomerase I, anti-RNAPIII, and anti-U1-RNP are associated with the development of SRC, while anti-topoisomerase I is associated with 1-year mortality of SRC.
Article
Cell Biology
Carine Moezinia, Valerie Wong, James Watson, Lydia Nagib, Sandra Lopez Garces, Siyu Zhang, Bahja Ahmed Abdi, Florence Newton, David Abraham, Richard Stratton
Summary: This study investigates the role of Immunoglobulin G (IgG) autoantibodies in activating keratinocytes and inducing IL-1α release in patients with systemic sclerosis. The enhanced binding of IgG to keratinocytes suggests a potential initiating pathway in the fibrotic cascade of systemic sclerosis.
Editorial Material
Dermatology
Takuya Takeichi, Kazumitsu Sugiura, Chao-Kai Hsu, Toshifumi Nomura, Hiroyuki Takama, Michael A. Simpson, Hiroshi Shimizu, John A. McGrath, Masashi Akiyama
ACTA DERMATO-VENEREOLOGICA
(2016)
Letter
Dermatology
Yohei Iwata, Tsukane Kobayashi, Masaru Arima, Shigeki Numata, Akiko Yagami, Ken Okamura, Yuta Araki, Kazumitsu Sugiura, Tamio Suzuki, Kayoko Matsunaga
JOURNAL OF DERMATOLOGY
(2017)
Article
Dermatology
Yuki Marubashi, Takeshi Yanagishita, Jun Muto, Nobuhiko Taguchi, Kazumitsu Sugiura, Yoshiyuki Kawamoto, Masashi Akiyama, Daisuke Watanabe
JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Haruka Koizumi, Atsushi Tokuriki, Noritaka Oyama, Hideki Ido, Kazumitsu Sugiura, Masashi Akiyama, Minoru Hasegawa
JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
M. Kono, K. Fukai, R. Omura, K. Sugawara, D. Tsuruta, K. Sugiura, M. Akiyama
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2017)
Letter
Dermatology
M. Kono, K. Fukai, N. Shimizu, J. Nagao, T. Takeichi, D. Tsuruta, K. Sugiura, M. Akiyama
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2017)
Letter
Dermatology
M. Kono, K. Nishida, T. Takeichi, K. Sugiura, M. Akiyama
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2017)
Article
Immunology
Akitaka Shibata, Kazumitsu Sugiura, Yasuhide Furuta, Yoshiko Mukumoto, Osamu Kaminuma, Masashi Akiyama
JOURNAL OF AUTOIMMUNITY
(2017)
Letter
Dermatology
Takuya Takeichi, Yaei Togawa, Yusuke Okuno, Rieko Taniguchi, Michihiro Kono, Hiroyuki Matsue, Kazumitsu Sugiura, Masashi Akiyama
JOURNAL OF DERMATOLOGICAL SCIENCE
(2017)
Letter
Dermatology
Shigeki Numata, Yohei Iwata, Rie Okumura, Masaru Arima, Tsukane Kobayashi, Soichiro Watanabe, Keita Suzuki, Masayuki Horiguchi, Kazumitsu Sugiura
JOURNAL OF DERMATOLOGY
(2018)
Article
Dermatology
Takuya Takeichi, Kazumitsu Sugiura, Toshifumi Nomura, Taiko Sakamoto, Yasushi Ogawa, Naoki Oiso, Yuko Futei, Aki Fujisaki, Akiko Koizumi, Yumi Aoyama, Kimiko Nakajima, Yutaka Hatano, Kei Hayashi, Akemi Ishida-Yamamoto, Sakuhei Fujiwara, Shigetoshi Sano, Keiji Iwatsuki, Akira Kawada, Yasushi Suga, Hiroshi Shimizu, John A. McGrath, Masashi Akiyama
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Dermatology
Y. Iwata, T. Kobayashi, M. Kuroda, Y. Mizoguchi, M. Arima, S. Numata, S. Watanabe, A. Yagami, K. Matsunaga, K. Sugiura
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
T. Takeichi, A. Kobayashi, E. Ogawa, Y. Okuno, S. Kataoka, M. Kono, K. Sugiura, R. Okuyama, M. Akiyama
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
T. Takeichi, T. Nomura, H. Takama, M. Kono, K. Sugiura, D. Watanabe, H. Shimizu, M. A. Simpson, J. A. McGrath, M. Akiyama
BRITISH JOURNAL OF DERMATOLOGY
(2017)
Article
Dermatology
Yohei Iwata, Yuichi Hasebe, Seiji Hasegawa, Satoru Nakata, Akiko Yagami, Kayoko Matsunaga, Kazumitsu Sugiura, Hirohiko Akamatsu
ACTA DERMATO-VENEREOLOGICA
(2017)