Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ping-Ping Sun, Dan Li, Meng Su, Qing Ren, Wen-Ping Guo, Jiang-Li Wang, Luan-Ying Du, Guang-Cheng Xie
Summary: This study investigated the effects of TLR1/2/4/6 monomers and TLR2 heterodimer on EV71 replication and innate immune activation. It was found that TLR monomers and TLR2 heterodimer inhibited EV71 replication and induced the production of IL-8. Additionally, the EV71 capsid proteins served as pathogen-associated molecular patterns for TLR monomers and TLR2 heterodimer, activating innate immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yu Chen, Xiao Xiao Wang, Corrie H. C. Ng, Sai Wah Tsao, Wai Keung Leung
Summary: Transcripts and proteins of TLR1/2/4/5/6, NOD1/2 and NLRP1/2 were expressed in human periodontal tissue in health and disease, with NOD2 possibly considered as a key damage-associated molecular pattern sensor on periodontal resident cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Cell Biology
Juan Felipe Valdes-Lopez, Geysson J. Fernandez, Silvio Urcuqui-Inchima
Summary: The study reveals that CHIKV infection induces high levels of IL27 in MDMs, promoting pro-inflammatory and antiviral response through activation of TLR1/2-MyD88 and TLR3-TRIF signaling pathways, independent of IFN signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Anil K. Singh, Mahamudul Haque, Bhanupriya Madarampalli, Yuanyuan Shi, Benjamin J. Wildman, Abdul Basit, Sadik A. Khuder, Bhagwat Prasad, Quamarul Hassan, Salahuddin Ahmed, Madhu M. Ouseph
Summary: IL-6 trans-signaling induces molecular reprogramming of RASFs to osteoclast-like cells through the activation of transcription factor Ets2, leading to increased expression of osteoclast-specific proteins and markers of invasive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Maarit Eskuri, Niko Kemi, Olli Helminen, Heikki Huhta, Joonas H. Kauppila
Summary: TLR2 and TLR6 expression in the cytoplasm appear to have independent prognostic impact in gastric cancer patients, while TLR1, TLR4, and TLR5 do not show any significant association with 5-year survival.
Article
Chemistry, Medicinal
Maham Israr, Nadia Naseem, Tasleem Akhtar, Usman Aftab, Muhammad Shoaib Zafar, Muhammad Asif Faheem, Muhammad Shahzad
Summary: This study found that nimbolide can attenuate rheumatoid arthritis by downregulating toll-like receptors and related expressions, reducing symptoms and inflammation. Nimbolide showed comparable effects to the standard drug piroxicam, suggesting its potential as a therapeutic candidate for rheumatoid arthritis.
PHYTOTHERAPY RESEARCH
(2023)
Review
Immunology
Domenico Supino, Luna Minute, Andrea Mariancini, Federica Riva, Elena Magrini, Cecilia Garlanda
Summary: This article explores the roles of interleukin-1 (IL-1) family members and their receptors in regulating immune and inflammatory processes at the molecular level. It discusses their significance in the development of diseases and their potential therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Kurianowicz, Maria Klatka, Agnieszka Polak, Anna Hymos, Dominika Bebnowska, Martyna Podgajna, Rafal Hrynkiewicz, Olga Sierawska, Paulina Niedzwiedzka-Rystwej
Summary: This study found significant differences in the expression levels of TLR2, TLR4, and TLR9 in early stage and chronically treated DM1 patients compared to healthy controls. Additionally, differences were observed in the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells among newly diagnosed DM1 individuals, chronic patients, and healthy controls. Higher levels of IL-10 were also found in newly diagnosed DM1 patients, consistent with existing literature reports.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Tongzhou Liang, Taiqiu Chen, Jincheng Qiu, Wenjie Gao, Xianjian Qiu, Yuanxin Zhu, Xudong Wang, Yanbo Chen, Hang Zhou, Zhihuai Deng, Pengfei Li, Caixia Xu, Yan Peng, Anjing Liang, Peiqiang Su, Bo Gao, Dongsheng Huang
Summary: Evidence suggests that ROR alpha plays a crucial role in cartilage development and OA pathogenesis by regulating the expression of cartilage matrix components. Blocking ROR alpha can reverse cartilage damage and elevate the expression of cartilage matrix components. Additionally, ROR alpha affects the IL-6/STAT3 signaling pathway, highlighting its potential as a treatment target in OA therapy.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Article
Chemistry, Applied
C. Fernandez-Lainez, R. Akkerman, M. M. P. Oerlemans, M. J. Logtenberg, H. A. Schols, L. A. Silva-Lagos, G. Lopez-Velazquez, P. de Vos
Summary: The study reveals that GTFs have immunomodulatory effects through their interaction with Toll-like receptors (TLRs), and can attenuate the production of pro-inflammatory cytokines in dendritic cells (DCs).
CARBOHYDRATE POLYMERS
(2022)
Article
Biology
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Maria Vanesa Hernandez-Hernandez, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to analyze the linear correlation between IL-1ra and IL-6 in patients with rheumatoid arthritis (RA) and their relationship with disease's inflammatory activity. IL-6 and IL-1ra levels were measured in 407 RA patients. No correlation was found between serum levels of IL-6 and IL-1ra. However, both cytokines were positively associated with disease activity and acute phase reactants. After controlling for covariates, disease activity scores were more strongly associated with IL-1ra compared to IL-6.
Article
Nutrition & Dietetics
Shinwon Lee, Jeong Eun Lee, Soon Ok Lee, Yong Ki Sim, Sun Hee Lee
Summary: Vitamin D deficiency is associated with the development of opportunistic infections in people living with HIV/AIDS, particularly tuberculosis and CMV infections.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2021)
Article
Infectious Diseases
Sook In Jung, Ye Eun Kim, Na Ra Yun, Choon-Mee Kim, Dong-Min Kim, Mi Ah Han, Uh Jin Kim, Seong Eun Kim, Jieun Kim, Seong Yeol Ryu, Hyun Ah Kim, Jian Hur, Young Keun Kim, Hye Won Jeong, Jung Yeon Heo, Dong Sik Jung, Hyungdon Lee, Kyungmin Huh, Yee Gyung Kwak, Sujin Lee, Seungjin Lim, Sun Hee Lee, Sun Hee Park, Joon-Sup Yeom, Shin-Woo Kim, In-Gyu Bae, Juhyung Lee, Eu Suk Kim, Jun-Won Seo
Summary: Severe fever with thrombocytopenia syndrome (SFTS) is a potentially fatal tick-borne disease caused by the SFTS Phlebovirus. This study evaluated the effects of steroid therapy in Korean patients with SFTS, suggesting caution in using steroids within 5 days of symptom onset or in patients with mild disease (APACHE II score <14).
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Multidisciplinary Sciences
Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang
Summary: Background information on illicit drug use among Korean individuals with HIV is lacking. This study found that about 5.13% of patients infected with HIV in Korea reported using illicit drugs, with a higher percentage among injection drug users. The most common drugs used were cannabis/marijuana and methamphetamine.
Article
Multidisciplinary Sciences
Jeong Eun Lee, Soon Ok Lee, Shinwon Lee, Sohee Park, Hyung-Hoi Kim, Kyung-Hwa Shin, Jin Suk Kang, Sun Hee Lee
Summary: The prevalence of non-B subtypes of HIV-1 in Korea has fluctuated over the years, with CRF01_AE being the most common subtype. The proportion of overseas sailors among non-B subtype patients has decreased, while the proportion of men who have sex with men (MSM) has increased. Transmission clusters involving non-B subtypes, including those with MSM, have been identified in the study.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Sehrish Jalal, Seong Yeon Hwang, Choon-Mee Kim, Dong-Min Kim, Na Ra Yun, Jun-Won Seo, Da Young Kim, Sook In Jung, Uh Jin Kim, Seong Eun Kim, Hyun ah Kim, Eu Suk Kim, Jian Hur, Young Keun Kim, Hye Won Jeong, Jung Yeon Heo, Dong Sik Jung, Jieun Kim, Sun Hee Park, Yee Gyung Kwak, Sujin Lee, Seungjin Lim, Sun Hee Lee
Summary: The NPCR-M designed in this study had a higher detection rate and exhibited good sensitivity and high specificity up to 40 days after symptom onset.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Shinwon Lee, Soon Ok Lee, Jeong Eun Lee, Kye-Hyung Kim, Sun Hee Lee, Soyoon Hwang, Shin-Woo Kim, Hyun-Ha Chang, Yoonjung Kim, Sohyun Bae, A-Sol Kim, Ki Tae Kwon
Summary: The study showed that the use of Regdanvimab in adult patients with COVID-19 significantly reduced the risk of patients progressing to severe/critical disease or death without unexpected safety issues. Additionally, treatment with Regdanvimab also resulted in overall cost reduction in medical utilization compared to control treatments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Infectious Diseases
Jeong Eun Lee, Soon Ok Lee, Yong Ki Sim, Shinwon Lee, Gwang Ha Kim, Jin Suk Kang, Sun Hee Lee
Summary: The seroprevalence of H. pylori infection is significantly associated with alcohol consumption, high CD4 cell count, and the age group of 40-59 years among Korean HIV-infected patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Hyunjin Son, Hyungi Lee, Jinmi Kim
Summary: This study aimed to determine the trends in the incidence rates of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) among Korean people living with HIV/AIDS (PLWHA). The study found that the incidence rate of ADCs decreased, while that of NADCs remained unchanged. PLWHA were at an increased risk of ADCs and some NADCs.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Chan Mi Lee, Chung -Jong Kim, Seong Eun Kim, Kyung-Hwa Park, Ji Yun Bae, Hee Jung Choi, Younghee Jung, Seung Soon Lee, Pyoeng Gyun Choe, Wan Beom Park, Eu Suk Kim, Je Eun Song, Yee Gyung Kwak, Sun Hee Lee, Shinwon Lee, Shinhye Cheon, Yeon Sook Kim, Yu Min Kang, Ji Hwan Bang, Sook-In Jung, Kyoung-Ho Song, Hong Bin Kim
Summary: This study aimed to identify the risk factors for early mortality (EM) in carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia and compare them with the risk factors for late mortality (LM). The results showed that the severity of illness was an independent risk factor for EM.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Sanghee Han, Hail Kim, Min Young Lee, Junhee Lee, Kwang Seok Ahn, In Jin Ha, Seok-Geun Lee
Summary: A new herbal formula, PSY, composed of Patriniae Radix, Coix Seed, and Mori Cortex Radicis, shows potential therapeutic effects in human CRC cells by suppressing proliferation through the inhibition of the STAT3 signaling pathway. PSY ethanol extract contains 21 bioactive compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sunhee Lee, Hye-Min Ju, Donald Ho, Byong-Sop Song, Sung-Hee Jeong, Yong-Woo Ahn, Soo-Min Ok, Kyounga Cheon
Summary: This study aimed to define quantitative indicators for predicting the outcome of masticatory muscle pain (MMP) treatment. The results showed that treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) was effective in patients with high masseter muscle palpation score (MPS) and interleukin-6 (IL-6) levels, but not in patients with high temporalis muscle palpation score (TPS), pain duration, and graded chronic pain scale (GCPS) grade.
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dong-Min Kim, Byung Jun Yu, Da Young Kim, Jun-Won Seo, Na-Ra Yun, Choon Mee Kim, Young Keun Kim, Sook In Jung, Uh Jin Kim, Seong Eun Kim, Hyun ah Kim, Eu Suk Kim, Jian Hur, Sun Hee Lee, Hye Won Jeong, Jung Yeon Heo, Dong Sik Jung, Jieun Kim, Sun Hee Park, Yee Gyung Kwak, Sujin Lee, Seungjin Lim, Shilpa Chatterjee
Summary: This study analyzed the key differences between HGA and SFTS in patients with suspected tick-borne infection and developed a scoring system based on clinically discriminable parameters. The analysis revealed that sex, neutropenia, prolonged activated partial thromboplastin time, and normal C-reactive protein concentration were significantly associated with SFTS. The scoring system showed high sensitivity and specificity, facilitating the differential diagnosis of HGA and SFTS in the emergency room.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Min Hee Yang, In Jin Ha, Seok-Geun Lee, Junhee Lee, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of BSN on chronic myelogenous leukemia cells and found that it induces apoptosis, autophagy, and paraptosis. It was also discovered that BSN activates the MAPK signaling pathway.
Article
Infectious Diseases
Shinwon Lee, Jeong Eun Lee, Soon Ok Lee, Yong Ki Sim, Sun Hee Lee
Summary: This retrospective study investigated the epidemiological information on hepatitis A among people living with HIV in Korea. The findings indicate an increasing proportion of individuals susceptible to HAV infection among adult PLHIV, with female sex and HBs antigen positivity as independent risk factors for HAV seropositivity. Therefore, HAV vaccination is highly recommended for young PLHIV, especially for women or HBsAg-positive individuals.
INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Jin Suk Kang, Chisook Moon, Seok Jun Mun, Jeong Eun Lee, Soon Ok Lee, Shinwon Lee, Sun Hee Lee
Summary: The study retrospectively reviewed the medical records of patients with Pseudomonas aeruginosa bacteremia admitted to a tertiary hospital in Korea from 2009 to 2020, analyzing changes in antimicrobial susceptibility and risk factors for antimicrobial resistance. The results showed increasing rates of carbapenem-resistant P. aeruginosa, multidrug-resistant P. aeruginosa, and extensively drug-resistant P. aeruginosa, which were associated with discordant empirical antimicrobial therapy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)