Article
Allergy
Yu-Wen Hsu, Hsing-Fang Lu, Wan-Hsuan Chou, Ho-Chang Kuo, Wei-Chiao Chang
Summary: This study found a close correlation between genetic polymorphisms of IP10 and Kawasaki disease, particularly the influence of rs3921 and rs4386624 genotypes on the susceptibility to Kawasaki disease.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
DruAnne L. Maxwell, Timothy D. Bryson, David Taube, Jiang Xu, Edward Peterson, Pamela Harding
Summary: Overexpression of the PGE2 EP3 receptor decreases cardiac function, especially after myocardial infarction. In addition, overexpression of EP3 leads to cardiac hypertrophy, increased collagen fraction, and inflammatory cell infiltration. These findings highlight the importance of EP3 in cardiac diseases.
Article
Biochemistry & Molecular Biology
Jairo Salazar, Joana Poejo, Ana M. Mata, Alejandro K. Samhan-Arias, Carlos Gutierrez-Merino
Summary: This study designed a hydrophobic peptide mimicking the interaction between calmodulin (CaM) and amyloid beta (1-42), and found that the synthetic peptide is a potent inhibitor of the formation of A beta(1-42):CaM and A beta(1-42):calbindin-D28k complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Evic Zeynep Basar, Hafize Emine Sonmez, Huseyin Uzuner, Aynur Karadenizli, Huseyin Salih Gungor, Goekmen Akgun, Ayse Filiz Yetimakman, Selim Oncel, Kadir Babaoglu
Summary: This study investigated the diagnostic accuracy of CXCL10/IP10 for left ventricular dysfunction in MIS-C patients. The results suggest that CXCL10/IP10 may be a potential biomarker for predicting LV dysfunction in MIS-C patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Jing Wu, Shi Fang, Ko-Ting Lu, Kelsey Wackman, Michal L. Schwartzman, Sergey Dikalov, Justin L. Grobe, Curt D. Sigmund
Summary: Interference with PPAR gamma in vascular smooth muscle leads to impaired vasodilation in systemic and renal vessels, resulting in salt-sensitive hypertension. Activation of the PGE2/EP3 signaling pathway may play a critical role in this process.
Article
Pharmacology & Pharmacy
Amaia Nazabal, Aitziber Mendiguren, Joseba Pineda
Summary: EP3 receptors modulate the activity of locus coeruleus neurons through a G(i/o) protein and GIRK-mediated mechanism.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa, Shuji Terai
Summary: ONO-1301 demonstrated therapeutic effects in ameliorating liver damage and fibrosis progression in a mouse model of NASH. It also suppressed liver tumor occurrence and showed anti-inflammatory properties in in vitro studies. Additionally, ONO-1301 can potentially be a new drug candidate against NASH due to its multidirectional effects on various pathways.
INFLAMMATION AND REGENERATION
(2022)
Article
Cardiac & Cardiovascular Systems
Yejiao Shen, Xia Wang, Ruosen Yuan, Xin Pan, Xiaoxiao Yang, Jiali Cai, Yi Li, Anwen Yin, Qingqing Xiao, Qingqi Ji, Yanjie Li, Ben He, Linghong Shen
Summary: PGE1 ameliorates AngII-induced cardiac hypertrophy through activation of the EP3 receptor, upregulating Ntn1 which inhibits the downstream MAPK signaling pathway. Targeting EP3 and the Ntn1-MAPK axis may represent a novel approach for treating pathological cardiac hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Respiratory System
Tian Jiang, Rudi Samapati, Sergej Klassen, Disi Lei, Lasti Erfinanda, Vera Jankowski, Szandor Simmons, Jun Yin, Christoph Arenz, Alexander Dietrich, Thomas Gudermann, Dieter Adam, Michael Schaefer, Joachim Jankowski, Veit Flockerzi, Rolf Nuesing, Stefan Uhlig, Wolfgang M. Kuebler
Summary: The study found that EP3 receptor activation triggers pulmonary edema through Gi-dependent activation of PLC and subsequent SrcFK-dependent tyrosine phosphorylation of TRPC6. In PAF-induced lung edema, this TRPC6 activation coincides with ASMase-dependent caveolar recruitment of TRPC6, resulting in rapid endothelial Ca2+ influx and barrier failure.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Fisheries
Nittiya Nontunha, Ruchanok Tinikul, Arada Chaiyamoon, Warinthip Vetkama, Tipsuda Thongbuakaew, Supakant Chaichotranunt, Tanes Poomtong, Prasert Sobhon, Yotsawan Tinikul
Summary: This study demonstrates the presence of PGE2 and its biosynthetic-associated enzymes in the gonadal tissues of sea cucumbers, and the effects of PGE2 on gonadal development and germ cell proliferation.
Article
Cell Biology
Kosuke Obayashi, Kazuki Yoshida, Masa-aki Ito, Tetsuya Mori, Kimiko Yamamoto, Toshiyashu Imai, Isao Matsuoka
Summary: ATP, an intercellular messenger, enhances degranulation and acute allergic reactions in mast cells by stimulating the ionotropic P2X4 receptor (P2X4R). This study found that co-stimulation of mast cells with ATP and prostaglandin E-2 (PGE-2) leads to increased secretion of various cytokines. This effect is mediated by P2X4R and can be blocked by P2X4R antagonists.
Article
Allergy
Constanze A. Jakwerth, Adam M. Chaker, Ferdinand Guerth, Madlen Oelsner, Lisa Pechtold, Lynn S. Zur Bonsen, Julia T. Ullmann, Susanne Krauss-Etschmann, Anna Erb, Josephine Kau, Mirjam Plaschke, Marlene Winkler, Alexandra Kurz, Antonia Kloss, Julia Esser-von Bieren, Carsten B. Schmidt-Weber, Ulrich M. Zissler
Summary: This study analyzed miR expression patterns in the sputum of allergic patients and uncovered an association between miR-3935 and the PGE(2)-PTGER3 axis, which might mediate AIT effects on allergic asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Medicine, Research & Experimental
Xin Meng, Ying Li, Qingxue Li, Jian Yang, Mingli An, Xinping Fu, Shuancheng Zhang, Jingwei Chen
Summary: The study found that in patients with EM, there was an increase in the expression of BKB1 receptor protein and mRNA, as well as a significant release of PGE(2), PGF2α, and BK, all of which were positively correlated with pain intensity. These data suggest that BK and BKB1 receptor may be involved in the pathological mechanism of EM-associated pain, serving as important factors in EM-related pain.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Allergy
Hanan M. Osman, Noussa Ragab El Basha, Ahmed F. Mansour, Mariam Onsy F. Hanna
Summary: Serum levels of CXCL10 were significantly higher in patients experiencing asthma exacerbations compared to stable patients. CXCL10 values were also elevated in severe asthma compared to moderate and mild disease. In patients with asthma exacerbations, higher CXCL10 levels were observed in atopic patients compared to non-atopic patients and in uncontrolled and partly controlled patients compared to controlled patients.
Review
Biochemistry & Molecular Biology
Dimitrios Kotsos, Konstantinos Tziomalos
Summary: Nonalcoholic fatty liver disease (NAFLD) is common in the general population and even more prevalent in obese and diabetic patients. NAFLD, especially nonalcoholic steatohepatitis (NASH), increases the risk for liver-related and cardiovascular morbidity. The development and progression of NAFLD involve complex and multifactorial pathogenesis, with potential involvement of microsomal prostaglandin E synthase-1 and -2. Targeting these enzymes may offer a novel therapeutic approach for NAFLD. This review discusses the association between microsomal prostaglandin E synthase-1 and -2 and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Tomohiro Kondo, Yoko Kitano-Amahori, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Ken Takeshi Kusakabe, Toshiya Okada
CONGENITAL ANOMALIES
(2015)
Article
Pediatrics
Tomohiro Kondo, Yoko Kitano-Amahori, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Ken Takeshi Kusakabe, Toshiya Okada
CONGENITAL ANOMALIES
(2015)
Article
Pediatrics
Ko Yuasa, Tomohiro Kondo, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Toshiya Okada
CONGENITAL ANOMALIES
(2016)
Article
Biochemistry & Molecular Biology
Tomohiro Kondo, Taketo Nakamori, Hiroaki Nagai, Ai Takeshita, Ken-Takeshi Kusakabe, Toshiya Okada
Article
Pediatrics
Ko Yuasa, Tomohiro Kondo, Hiroaki Nagai, Masaki Mino, Ai Takeshita, Toshiya Okada
CONGENITAL ANOMALIES
(2016)
Article
Biochemistry & Molecular Biology
Hideshi Ihara, Hideyuki Yamamoto, Tomoaki Ida, Hiroyasu Tsutsuki, Tatsuji Sakamoto, Tomoyuki Fujita, Toshiya Okada, Shunji Kzaki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2012)
Article
Pediatrics
Tomohiro Kondo, Naoko Ishiga-Hashimoto, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Ken Takeshi Kusakabe, Toshiya Okada
CONGENITAL ANOMALIES
(2014)
Article
Immunology
Ai Takeshita, Ken Takeshi Kusakabe, Masato Hiyama, Nobue Kuniyoshi, Tomohiro Kondo, Kiyoshi Kano, Yasuo Kiso, Toshiya Okada
Article
Veterinary Sciences
Tomohiro Kondo, Suguru Yoshida, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Takayuki Nakajima, Ken Takeshi Kusakabe, Toshiya Okada
JOURNAL OF VETERINARY SCIENCE
(2018)
Article
Biology
Tomohiro Kondo, Naoko Ishiga-Hashimoto, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Ken Takeshi Kusakabe, Toshiya Okada
MEDICAL MOLECULAR MORPHOLOGY
(2011)
Article
Zoology
Toshiya Okada, Yusuke Kataoka, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Ken Takeshi Kusakabe, Tomohiro Kondo
ZOOLOGICAL SCIENCE
(2013)
Article
Neurosciences
Paitoon Srimontri, Haruna Hirota, Hiroki Kanno, Toshiya Okada, Yoshio Hirabayashi, Keiko Kato
EXPERIMENTAL BRAIN RESEARCH
(2014)
Article
Cell Biology
Kazuhiro Nishiyama, Kimiya Aono, Yasuyuki Fujimoto, Mitsuru Kuwamura, Toshiya Okada, Hayato Tokumoto, Takeshi Izawa, Ryoichi Okano, Hidemitsu Nakajima, Tadayoshi Takeuchi, Yasu-Taka Azuma
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Veterinary Sciences
Shoji Ogawa, Tamaki Yana, Tomohiro Kondo, Toshiya Okada
Summary: Maternal 5/6 nephrectomy results in low-birth-weight neonates, but catch-up growth leads to increased systolic blood pressure and renin-positive cells in the kidney.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Tomohiro Kondo, Hiroaki Nagai, Takamune Kawashima, Yusuke Taniguchi, Nozomu Koyabu, Ai Takeshita, Ken-Takeshi Kusakabe, Toshiya Okada
COMPARATIVE MEDICINE
(2014)