Review
Nutrition & Dietetics
Valeria Cernaro, Michela Calderone, Guido Gembillo, Vincenzo Calabrese, Chiara Casuscelli, Claudia Lo Re, Elisa Longhitano, Domenico Santoro
Summary: Hyperphosphatemia is a common complication in advanced chronic kidney disease and can lead to cardiovascular morbidity and mortality. This review focuses on the management of phosphatemia in uremic patients receiving peritoneal dialysis. The control of serum phosphate in peritoneal dialysis patients is influenced by various factors such as patient transporter characteristics, peritoneal dialysis modalities, prescriptions, and diet. There is a need for more clinical trials specifically designed for peritoneal dialysis patients to evaluate the effects of multiple therapeutic approaches on serum phosphate control and clinical outcomes.
Article
Urology & Nephrology
Yan Zhu, Jinlan Rao, Xueling Liao, Jihong Ou, Wei Li, Chao Xue
Summary: This study found that iron-based phosphate binders can effectively decrease serum phosphate levels and improve anemia in dialysis patients. However, different IBPBs have varying impacts on anemia, with more research needed for further understanding.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Christopher Rugg, Mirjam Bachler, Robert Kammerlander, Daniel Niederbrunner, Johannes Boesch, Stefan Schmid, Janett Kreutziger, Mathias Stroehle
Summary: Hyperphosphataemia in polytrauma patients at ICU admission is associated with injury severity, tissue damage, and mortality. Admission phosphate levels are a strong predictor for in-hospital mortality in polytrauma patients and perform as well as injury severity scores in predicting outcomes.
Article
Physiology
Andrew J. King, Jill Kohler, Cyra Fung, Zhengfeng Jiang, Allison Quach, Padmapriya Kumaraswamy, Glenn M. Chertow, David P. Rosenbaum
Summary: The study demonstrated that the combination treatment of tenapanor and sevelamer carbonate significantly reduced intestinal phosphate absorption and urinary phosphorus excretion in rats. This synergistic effect suggests a potential for using the combination therapy to address hyperphosphatemia in patients with chronic kidney disease undergoing dialysis.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Ziad A. Massy, Thomas Merkling, Sandra Wagner, Nicolas Girerd, Marie Essig, Christoph Wanner, Bengt C. Fellstrom, Patrick Rossignol, Faiez Zannad
Summary: The study revealed that statins have limited treatment efficacy in patients on dialysis with hyperphosphatemia. Higher serum phosphate levels, both at baseline and during treatment, were associated with reduced protective effects of statins on major adverse cardiovascular events and all-cause death. This suggests that the presence of hyperphosphatemia may contribute to the resistance of dialysis patients to statins.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Multidisciplinary Sciences
Shengfeng Wei, Yunhan Li, Chunhua Zhang, Xiangjian Guo, Xinmeng Liang, Yanmei Huang, Fan Zhang, Jihong Li, Qiangqiang Liu
Summary: This study investigated the association between different serum phosphate levels and the prognosis of sepsis patients. The results showed that high serum phosphate levels were associated with increased all-cause mortality risk and prolonged ICU length of stay. However, low serum phosphate levels before interventions were not significantly associated with the prognosis indicators.
Article
Cardiac & Cardiovascular Systems
Hiroto Hiyamuta, Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: This study demonstrates a significant association between high serum phosphate levels and the risk of sudden death in patients undergoing hemodialysis.
Article
Chemistry, Physical
Chen Tzror-Azankot, Adi Anaki, Tamar Sadan, Menachem Motiei, Rachela Popovtzer
Summary: Hyperphosphatemia, a common complication of end-stage renal disease, can be effectively controlled and reduced by using phosphate-trapping liposomes modified with polyethylene glycol and encapsulated with ferric citrate.
Article
Medicine, General & Internal
Beong Ki Kim, Chi Young Kim, Sua Kim, Yu Jin Kim, Seung Heon Lee, Je Hyeong Kim
Summary: This study investigated the association between phosphate concentrations and hospital mortality among patients in the intensive care unit. The results showed that Delta P and Pmean values were significantly associated with hospital mortality, highlighting the importance of maintaining stable phosphate concentrations during hospitalization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Physical
Magdalena Teresa Spicher, Sebastian Patrick Schwaminger, Daniela von der Haar-Leistl, Marco Reindl, Friedrich Ernst Wagner, Sonja Berensmeier
Summary: This study demonstrates different binding mechanisms of two similar phosphate-binding agents and reveals the significant influence of the composition of the organic shell on the interaction between iron(oxyhydr)oxide nanoparticles and phosphate. The experiments show that, at low concentrations, phosphate is bound through complexation reactions, while at high concentrations, iron phosphate species are formed. The ligands in the shell play a crucial role in the binding mechanism.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Health Care Sciences & Services
Lee-Fang Teong, Ban-Hock Khor, Kristo Radion Purba, Abdul Halim Abdul Gafor, Bak-Leong Goh, Boon-Cheak Bee, Rosnawati Yahya, Sunita Bavanandan, Hi-Ming Ng, Sharmela Sahathevan, Sreelakshmi Sankara Narayanan, Zulfitri Azuan Mat Daud, Pramod Khosla, Tilakavati Karupaiah
Summary: This study describes the development and validation of a mobile application for clinical phosphate management. The application was found to be acceptable and useful by adult Malaysian HD patients in low-resource settings.
Article
Urology & Nephrology
Akiko Hashimoto, Jiaqi Gao, Yuki Kanome, Yukihiro Ogawa, Masaharu Nakatsu, Masahiro Kohno, Koji Fukui
Summary: This study evaluated cerium oxide as a potential phosphate binder, showing that it can adsorb phosphate at both acidic and neutral pH levels. Cerium oxide reduced serum phosphate concentrations in 5/6 nephrectomy model rats without causing hepatotoxicity, and it maintained serum creatinine and blood urea nitrogen levels.
Article
Chemistry, Applied
Min Li, Xianlin Fan, Qian Mao, Qing Li, Xiujuan Zhang, Gaohong He, Shufen Zhang, Wenjun Zhang
Summary: Fe@CH microcapsules, with enhanced phosphate binding and limited iron leakage, are a proper candidate as the phosphate binder for hyperphosphatemia patients due to their improved bio-compatibility and binding efficacy.
CARBOHYDRATE POLYMERS
(2021)
Article
Physiology
Weichen Zhang, Qiuna Du, Jing Xiao, Zhaori Bi, Chen Yu, Zhibin Ye, Mengjing Wang, Jing Chen
Summary: A new model for quantifying phosphate removal in 4-h HD and HDF treatments with a dialyzer surface area of 1.3-1.8 m(2) was generated and validated, showing superior performance compared to the original model in terms of bias and accuracy in internal validation. External validation results were consistent with internal validation results.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Article
Agronomy
Perumal Palanivell, Osumanu Haruna Ahmed, Latifah Omar, Nik Muhamad Abdul Majid
Summary: Clinoptilolite zeolite can enhance soil nutrient availability, improve nutrient adsorption and desorption, and enhance soil pH buffering capacity. Additionally, it effectively increases potassium adsorption, reduces nutrient adsorption, and prevents nutrient loss.