Article
Medicine, Legal
Elisabeth Pendl, Udo Pauritsch, Manfred Kollroser, Martin G. Schmid
Summary: The study compared the concentration of cathinone and cathine in fresh Khat leaves and two seizures of dried material, finding a significant decrease in cathinone content after drying and storage. These findings are intended to help Justice authorities estimate the content of controlled ingredients in Khat leaves in the future.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Environmental Sciences
Ghassan Shaikhain, Mohammed Gaballah, Ahmad Alhazmi, Ibrahim Khardali, Ahmad Hakami, Magbool Oraiby, Sultan Alharbi, Mohammad Tobaigi, Mohammed Ghalibi, Mohsen Fageeh, Mohammed Albeishy, Ibraheem Attafi
Summary: This study investigated the autopsy findings and toxicological results of fatalities involving khat in Saudi Arabia's Jazan region from 2018 to 2021. The study found that 57% of the postmortem samples tested positive for khat only, while 43% tested positive for khat with other drugs.
Article
Biology
Abdulsamad Alsalahi, Zamri Chik, Zahurin Mohamed, Nelli Giribabu, Mohammed Abdullah Alshawsh
Summary: The study found that cathinone had a weaker in vitro inhibition on alpha-amylase and alpha-glucosidase compared to alpha-acarbose, and it significantly affected the blood sugar levels of diabetic rats, exacerbating their hyperglycemia.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Shuang Ye, Jin Hu, Zilong Liu, Man Liang
Summary: Catha edulis, known as Khat, has become a public health concern worldwide due to its abuse. Research shows that Ethiopia and the USA have made significant contributions in this field, and recent studies have shifted focus towards investigating the mechanism of Catha edulis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amal O. Arab, Fawaz Alasmari, Awatif B. Albaker, Hassan A. Alhazmi, Alaa Alnoor Alameen, Naser M. Alagail, Saleh A. Alwaeli, Syed Rizwan Ahamad, Abdullah F. Alasmari, Shakir D. Alsharari
Summary: The study finds that clavulanic acid can modulate neurobehavioral changes, including memory impairment and anxiety-like behaviors, in mice exposed to khat. The improvement is achieved through upregulation of GLT-1 in the nucleus accumbens (NAc).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Multidisciplinary Sciences
Gamilah Al-Qadhi, Marwan Mansoor Ali Mohammed, Mohammed Al-Ak'hali, Essam Ahmed Al-Moraissi
Summary: This scoping review systematically mapped the toxicological potential effects of khat on cultured human or animal cells, revealing that khat treatment induced cellular changes such as decreased survival, apoptosis induction, increased ROS production, alteration of cell phenotype, and cell cycle arrest.
Review
Biochemistry & Molecular Biology
Eleni Aklillu, Ephrem Engidawork
Summary: Despite the increasing trend of khat chewing with medications and the potential risk for the occurrence of clinically significant interactions, there is a lack of data in the literature demonstrating the magnitude of the risk. Available data clearly demonstrate that the consequence of drug-khat interaction is dependent on genotype, and genotyping could be used to improve clinical outcome and minimize adverse reactions.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Review
Food Science & Technology
Barbara Silva, Jorge Soares, Carolina Rocha-Pereira, Premysl Mladenka, Fernando Remiao
Summary: This review paper summarizes current knowledge on the khat plant from a toxicokinetic and toxicodynamic perspective. The psychoactive effects of khat are primarily caused by its main constituents, cathinone, cathine, and norephedrine. Long-term use of khat is associated with severe physical and psychological complications.
Review
Biotechnology & Applied Microbiology
Mohammed A. Al-Duais, Yahya S. Al-Awthan
Summary: Khat, a plant grown in East Africa and southern Arabia, has been widely studied for its ingredients, global prevalence, legal status, and effects on lipid profiles. The chewing habit of khat has been identified as a serious economic and health issue, requiring specialized programs to assist in quitting or reducing this habit.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
Meshari A. Alzahrani, Majed A. Alsahli, Fasial F. Alarifi, Basel O. Hakami, Fawaz W. Alkeraithe, Mohammed Alhuqbani, Zyad Aldosari, Omar Aldosari, Abdalah Emad Almhmd, Saleh Binsaleh, Raed Almannie
Summary: Khat, a stimulating narcotic, is grown in East and Southern Africa and is known for its negative effects on the central nervous system, blood pressure, genitourinary system, and psychological health. This article reviews the reproductive toxicity and sexual dysfunction caused by regular khat usage in humans and animals.
MEDICAL SCIENCE MONITOR
(2023)
Article
Multidisciplinary Sciences
Tesfaye Gabriel, Kebede Wondu, Jemal Dilebo
Summary: Cellulose fibers (C-40 and C-80) were successfully extracted from khat waste using a chlorine-free process, followed by isolation of cellulose nanocrystals (CNCs40 and CNCs80) through sulfuric acid hydrolysis. The study showed the potential of khat waste as an alternative source for producing cellulose fibers and nanocrystals with improved crystallinity.
Article
Public, Environmental & Occupational Health
Ahmed Abdulahi Hussen, Foziya Mohammed Hussien, Nejib Yusuf, Aragaw Yimer Ahmed, Hamid Yimam Hassen
Summary: The case reports describe two young adult male patients who developed acute myocardial infarction (AMI) after frequent khat chewing, suggesting that khat could be an important cardiovascular disease (CVD) risk factor among young adults. Further epidemiological and association studies are needed to establish the causal relationship between khat use and AMI.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Multidisciplinary Sciences
Ayan Ahmed, Manuel J. Ruiz, Kathrin Cohen Kadosh, Robert Patton, Davinia M. Resurreccion
Summary: Khat, a plant known for its amphetamine-like properties, is popular in certain regions but research on its potential neurobehavioral impairments is lacking. Studies suggest long-term khat use is associated with deficits in cognitive functions, both in human and rodent studies. Further research is needed to fully understand the health consequences of khat use.
Article
Biology
Gamilah Al-Qadhi, Rabab Mubarak
Summary: The study examined the effect of khat extract on the ultrastructure of submandibular salivary gland cells in rats, revealing that oral administration of khat extract produced degenerative changes in the secretory and ductal cells. These changes included irregular boundaries of nuclei, dilated rough endoplasmic reticulum, cytoplasmic vacuoles, as well as swollen and degenerated mitochondria.
BMC RESEARCH NOTES
(2021)
Article
Psychology, Clinical
Md Dilshad Manzar, Mohammed Salahuddin, Tufail Ahmad Khan, Showkat Ahmad Shah, Nymathullah Sharief Mohammad, Dejen Nureye, Habtamu Acho Addo, Wakuma Wakene Jifar, Abdulrhman Albougami
Summary: The study validated the psychometric properties of the BMMS in substance users, showing good internal consistency and validity of the two-factor model. Significant differences were found in BMMS total score, factor scores, and most item scores between khat dependents and non-dependents.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2021)
