Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Review
Medicine, General & Internal
Myung Chul Yoo, Jeong Hee Kim, Yong Jun Kim, Junyang Jung, Sung Soo Kim, Sang Hoon Kim, Seung Geun Yeo
Summary: Electrical stimulation therapy is frequently used to treat facial paralysis but its effectiveness varies and no clear standards have been developed. This review presents evidence from preclinical and clinical studies supporting the efficacy of electrical stimulation in promoting nerve regeneration after peripheral nerve injuries. However, the outcomes depend on various factors and potential negative outcomes need to be considered.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Annabella Kurz, Gerd Fabian Volk, Dirk Arnold, Berit Schneider-Stickler, Winfried Mayr, Orlando Guntinas-Lichius
Summary: This article discusses the potential clinical value of surface electrical stimulation in the acute phase of denervation after facial nerve or recurrent laryngeal nerve paralysis, highlighting similarities between the two nerve lesions and the importance of directly stimulating denervated muscles. Early electromuscular stimulation may improve functional outcomes, but further research is needed to confirm its efficacy in larger controlled trials.
FRONTIERS IN NEUROLOGY
(2022)
Article
Surgery
Peter J. Nicksic, D'Andrea T. Donnelly, Weifeng Zeng, Allison J. Seitz, Samuel O. Poore, Aaron J. Suminski, Aaron M. Dingle
Summary: The study demonstrates that trigeminal nerve stimulation (TNS) or peripheral nerve stimulation (PNS) can improve functional outcomes of peripheral nerve injury in rats. This finding is important in translating the therapy as a non-invasive treatment for high, mixed nerve injuries in humans.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Engineering, Biomedical
Shang Song, Kelly W. McConnell, Danielle Amores, Alexa Levinson, Hannes Vogel, Marco Quarta, Thomas A. Rando, Paul M. George
Summary: Electric stimulation through conductive nerve guides enhances the efficacy of human neural progenitor cells in treating nerve injuries, promoting nerve regeneration and functional recovery.
Review
Engineering, Biomedical
Woo-Youl Maeng, Wan-Ling Tseng, Song Li, Jahyun Koo, Yuan-Yu Hsueh
Summary: This review examines the potential and challenges of using bioelectronic implantable devices for peripheral nerve regeneration. It summarizes modern fabrication methods and integration techniques to deliver effective and controllable electroceuticals.
Article
Neurosciences
Sofia Meyer Zu Reckendorf, Diana Moser, Anna Blechschmidt, Venkata Neeha Joga, Daniela Sinske, Jutta Hegler, Stefanie Deininger, Alberto Catanese, Sabine Vettorazzi, Gregor Antoniadis, Tobias Boeckers, Bernd Knoell
Summary: In postmitotic neurons, PTEN inhibition is crucial for successful axon regeneration in the central nervous system, but its influence in peripheral neurons is less understood. This study demonstrates that conditional PTEN deletion in mouse facial motoneurons not only induces morphological and physiological changes, but also promotes facial nerve regeneration and recovery after injury, highlighting the dual function of PTEN in neuronal function impairment and axon regeneration.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Runyi Mao, Bin Yu, Jinjie Cui, Zeying Wang, Xintai Huang, Hongbo Yu, Kaili Lin, Steve G. F. Shen
Summary: This study developed a piezoelectric nerve conduit using a composite of PCL/ZnO nanofiber, which demonstrated faster and superior sciatic nerve repair compared to conventional materials. The piezoelectric stimulation from PZNF increased the expression of nerve growth factor/vascular endothelial growth factor and activated downstream pathways, leading to accelerated nerve repair and function recovery. This novel strategy offers potential for rapid peripheral nerve regeneration.
Article
Materials Science, Biomaterials
Goeun Choe, Ul Gyu Han, Seongryeol Ye, Sujee Kang, Jin Yoo, Young Sang Cho, Youngmee Jung
Summary: This study examined the effects of electrical stimulation (ES) on nerve guidance conduits (NGCs) made of poly(D,L-lactide-co-epsilon-caprolactone) in promoting the recovery of facial function and nerve regeneration after facial nerve (FN) injury in rats. The experimental group received both NGC and transcutaneous ES, while the control group only received NGCs. The ES groups showed significant improvement in whisker movement, with a higher number of myelinated neurons, thicker and more uniform myelin sheaths, and increased expression of neurostructural proteins compared to the NGC-only group.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Health Care Sciences & Services
Sophie Hasiba-Pappas, Lars-P. Kamolz, Hanna Luze, Sebastian P. Nischwitz, Judith C. J. Holzer-Geissler, Alexandru Cristian Tuca, Theresa Rienmueller, Mathias Polz, Daniel Ziesel, Raimund Winter
Summary: The combined application of nerve guidance conduits and electrical stimulation can improve peripheral nerve regeneration in rat models, but there is high variation in treatment protocols and further evaluation under standardized conditions is needed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rehabilitation
Kelly J. Negley, Alysha Rasool, Patrick J. Byrne
Summary: Facial paralysis is a clinical condition with significant functional and psychosocial impact. Management of the condition is evolving, with surgical techniques like hypoglossal-facial nerve anastomosis being used to restore facial muscle reinnervation through tongue movement.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Review
Clinical Neurology
Lingmei Ni, Zhao Yao, Yifan Zhao, Tianfang Zhang, Jie Wang, Siyue Li, Zuobing Chen
Summary: Peripheral nerve injury is common in extremity trauma patients and surgical therapeutic approaches may not ensure functional recovery. Rehabilitation plays a vital role in promoting nerve repair and sensorimotor recovery through individualized electrical stimulation therapy. However, the parameters and long-term effectiveness of electrical stimulation need further exploration.
FRONTIERS IN NEUROLOGY
(2023)
Article
Chemistry, Physical
Shunyi Lu, Wen Chen, Jiayi Wang, Zilong Guo, Lan Xiao, Lingyu Wei, Jieqin Yu, Ya Yuan, Weisin Chen, Mengxuan Bian, Lei Huang, Yuanyuan Liu, Jian Zhang, Yu-Lin Li, Li-Bo Jiang
Summary: A biodegradable, conductive poly(l-lactide-co-caprolactone)/graphene (PLCL/GN) composite conduit with a micropatterned surface and electrical stimulation capability is developed. It effectively stimulates cell migration, adhesion, and elongation, enhances neuronal expression of SCs, and promotes myelin sheath growth and nerve regeneration in vivo.
Review
Biotechnology & Applied Microbiology
Zhipeng Zeng, Yajing Yang, Junyong Deng, Muhammad Saif Ur Rahman, Chengmei Sun, Shanshan Xu
Summary: This paper reviews the combined application of physical stimulation and biomaterials in peripheral nerve injury (PNI) repair. The combination of physical stimulation therapy with nerve biomaterials can enhance the repair effect and provide broader application prospects for PNI repair.
BIOENGINEERING-BASEL
(2022)
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Geriatrics & Gerontology
Keith N. Fargo, Cyndy B. Cordell, Maria C. Carrillo
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2015)
Article
Geriatrics & Gerontology
John E. Morley, John C. Morris, Marla Berg-Weger, Soo Borson, Brian D. Carpenter, Natalia del Campo, Bruno Dubois, Keith Fargo, L. Jaime Fitten, Joseph H. Flaherty, Mary Ganguli, George T. Grossberg, Theodore K. Malmstrom, Ronald D. Petersen, Carroll Rodriguez, Andrew J. Saykin, Philip Scheltens, Eric G. Tangalos, Joe Verghese, Gordon Wilcock, Bengt Winblad, Jean Woo, Bruno Vellas
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2015)
Article
Neurosciences
Gina N. Monaco, Todd J. Brown, Ryan C. Burgette, Keith N. Fargo, Lee M. Akst, Kathryn J. Jones, Eileen M. Foecking
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2015)
Editorial Material
Clinical Neurology
Keith N. Fargo, Maria C. Carrillo, Michael W. Weiner, William Z. Potter, Zaven Khachaturian, George Vradenburg, Michael W. Weiner
ALZHEIMERS & DEMENTIA
(2016)
Article
Neurosciences
Susanna C. Byram, Scott W. Byram, Nicholas M. Miller, Keith N. Fargo
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2017)
Article
Clinical Neurology
Rafid Mustafa, Jared R. Brosch, Gil D. Rabinovici, Bradford C. Dickerson, Maria C. Carrillo, Bradley S. Glazier, Sujuan Gao, Martha Tierney, Keith N. Fargo, Mary G. Austrom, Susan De Santi, David G. Clark, Liana G. Apostolova
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2018)
Editorial Material
Clinical Neurology
Keith N. Fargo, Paul Aisen, Marilyn Albert, Rhoda Au, Maria M. Corrada, Steven DeKosky, David Drachman, Howard Fillit, Laura Gitlin, Magali Haas, Karl Herrup, Claudia Kawas, Ara S. Khachaturian, Zaven S. Khachaturian, William Klunk, David Knopman, Walter A. Kukull, Bruce Lamb, Rebecca G. Logsdon, Paul Maruff, Marsel Mesulam, William Mobley, Richard Mohs, David Morgan, Ralph A. Nixon, Steven Paul, Ronald Petersen, Brenda Plassman, William Potter, Eric Reiman, Barry Reisberg, Mary Sano, Rachel Schindler, Lon S. Schneider, Peter J. Snyder, Reisa A. Sperling, Kristine Yaffe, Lisa J. Bain, William H. Thies, Maria C. Carrillo
ALZHEIMERS & DEMENTIA
(2014)
Article
Otorhinolaryngology
Muhamad Amine, Lauren Lininger, Keith N. Fargo, Kevin C. Welch
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2013)
Article
Clinical Neurology
Ganesh M. Babulal, Yakeel T. Quiroz, Benedict C. Albensi, Eider Arenaza-Urquijo, Arlene J. Astell, Claudio Babiloni, Alex Bahar-Fuchs, Joanne Bell, Gene L. Bowman, Adam M. Brickman, Gael Chetelat, Carrie Ciro, Ann D. Cohen, Peggye Dilworth-Anderson, Hiroko H. Dodge, Simone Dreux, Steven Edland, Anna Esbensen, Lisbeth Evered, Michael Ewers, Keith N. Fargo, Juan Fortea, Hector Gonzalez, Deborah R. Gustafson, Elizabeth Head, James A. Hendrix, Scott M. Hofer, Leigh A. Johnson, Roos Jutten, Kerry Kilborn, Krista L. Lanctot, Jennifer J. Manly, Ralph N. Martins, Michelle M. Mielke, Martha Clare Morris, Melissa E. Murray, Esther S. Oh, Mario A. Parra, Robert A. Rissman, Catherine M. Roe, Octavio A. Santos, Nikolaos Scarmeas, Lon S. Schneider, Nicole Schupf, Sietske Sikkes, Heather M. Snyder, Hamid R. Sohrabi, Yaakov Stern, Andre Strydom, Yi Tang, Graciela Muniz Terrera, Charlotte Teunissen, Debora Melo van Lent, Michael Weinborn, Linda Wesselman, Donna M. Wilcock, Henrik Zetterberg, Sid E. O'Bryant
ALZHEIMERS & DEMENTIA
(2019)
Article
Clinical Neurology
Ara S. Khachaturian, Kathleen M. Hayden, John W. Devlin, Lee A. Fleisher, Sarah Lenz Lock, Colm Cunningham, Esther S. Oh, Tamara G. Fong, Donna Marie Fick, Edward R. Marcantonio, Vijeth Iyengar, Kenneth Rockwood, George A. Kuchel, Roderic G. Eckenhoff, Alasdair M. J. MacLullich, Richard N. Jones, Daniel Davis, Patricia M. D'Antonio, Keith N. Fargo, Marilyn S. Albert, Jeff D. Williamson, Shari M. Ling, Joan Weiss, Jason Karlawish, Ronald C. Petersen, Dan G. Blazer, Zaven S. Khachaturian, Sharon K. Inouye
ALZHEIMERS & DEMENTIA
(2020)
Article
Clinical Neurology
Rachel L. Nosheny, Monica R. Camacho, Chengshi Jin, John Neuhaus, Diana Truran, Derek Flenniken, Miriam Ashford, Maria C. Carrillo, Keith N. Fargo, James Hendrix, Lucy Hanna, Gil Rabinovici, Paul Maruff, R. Scott Mackin, Michael W. Weiner
ALZHEIMERS & DEMENTIA
(2020)
Review
Clinical Neurology
Claudio Babiloni, Xianghong Arakaki, Hamed Azami, Karim Bennys, Katarzyna Blinowska, Laura Bonanni, Ana Bujan, Maria C. Carrillo, Andrzej Cichocki, Jaisalmer de Frutos-Lucas, Claudio Del Percio, Bruno Dubois, Rebecca Edelmayer, Gary Egan, Stephane Epelbaum, Javier Escudero, Alan Evans, Francesca Farina, Keith Fargo, Alberto Fernandez, Raffaele Ferri, Giovanni Frisoni, Harald Hampel, Michael G. Harrington, Vesna Jelic, Jaeseung Jeong, Yang Jiang, Maciej Kaminski, Voyko Kavcic, Kerry Kilborn, Sanjeev Kumar, Alice Lam, Lew Lim, Roberta Lizio, David Lopez, Susanna Lopez, Brendan Lucey, Fernando Maestu, William J. McGeown, Ian McKeith, Davide Vito Moretti, Flavio Nobili, Giuseppe Noce, John Olichney, Marco Onofrj, Ricardo Osorio, Mario Parra-Rodriguez, Tarek Rajji, Petra Ritter, Andrea Soricelli, Fabrizio Stocchi, Ioannis Tarnanas, John Paul Taylor, Stefan Teipel, Federico Tucci, Mitchell Valdes-Sosa, Pedro Valdes-Sosa, Marco Weiergraeber, Gorsev Yener, Bahar Guntekin
Summary: The Electrophysiology Professional Interest Area and Global Brain Consortium endorsed recommendations on EEG measures for Alzheimer's disease clinical trials, emphasizing the need for standardized measurement methods and international collaboration.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Liana G. Apostolova, Paul Aisen, Ani Eloyan, Anne Fagan, Keith N. Fargo, Tatiana Foroud, Constantine Gatsonis, Lea T. Grinberg, Clifford R. Jack, Joel Kramer, Robert Koeppe, Walter A. Kukull, Melissa E. Murray, Kelly Nudelman, Malia Rumbaugh, Arthur Toga, Prashanthi Vemuri, Amy Trullinger, Leonardo Iaccarino, Gregory S. Day, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph Masdeu, Mario Mendez, Erik Musiek, Chiadi U. Onyike, Emily Rogalski, Steve Salloway, David A. Wolk, Thomas S. Wingo, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici
Summary: The Longitudinal EOAD Study (LEADS) aims to track EOAD patients, define their clinical, imaging, and fluid biomarker characteristics, develop sensitive cognitive and biomarker measures for future use, and establish a trial-ready network to advance Alzheimer's disease research.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Greg A. Jicha, Erin L. Abner, Steven E. Arnold, Maria C. Carrillo, Hiroko H. Dodge, Steven D. Edland, Keith N. Fargo, Howard H. Feldman, Larry B. Goldstein, James Hendrix, Ruth Peters, Julie M. Robillard, Lon S. Schneider, Jodi R. Titiner, Christopher J. Weber
Summary: Consensus guidance has been developed for the development and conduct of high-quality Alzheimer's disease clinical trials, covering aspects such as scientific justification, trial registration, conflict of interest disclosure, and defined trial population. This guidance aims to assist in protocol development and may also support the education of potential trial participants and the public on appropriate clinical trial participation decisions.
ALZHEIMERS & DEMENTIA
(2022)