期刊
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
卷 33, 期 5, 页码 261-266出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10799893.2013.822889
关键词
GPCR; HAT; HDAC; reversible protein acetylation; signal transduction
Emerging data suggest that interaction with reversible protein acetylation is an important mediator of GPCR-initiated changes in transcription and other processes. Alteration of acetylation downstream of GPCR activation occurs through a variety of mechanisms, including kinase-dependent and -independent regulation of histone deacetylases (HDACs) and histone acetyltransferases (HATs). The prominence of both GPCR and acetylation in pathology and drug development efforts highlights the importance of understanding cross-talk between these two signaling mechanisms.
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