期刊
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
卷 30, 期 6, 页码 376-384出版社
INFORMA HEALTHCARE
DOI: 10.3109/10799891003641074
关键词
Exercise; PGC-1 alpha; signal transduction; skeletal muscle; transcriptional regulation
资金
- Swiss National Science Foundation (SNF) [PP00A-110746]
- Muscular Dystrophy Association USA [MDA68442]
- SwissLife Jubilaumsstiftung fur Volksgesundheit und medizinische Forschung
- Swiss Society for Research on Muscle Diseases (SSEM)
- United Mitochondrial Disease Foundation (UMDF)
- Association Francaise contre les myopathies (AFM)
- Roche Research Foundation
- SystemsX.ch (the Swiss initiative in systems biology)
- University of Basel
Exercise triggers a pleiotropic response in skeletal muscle, which results in a profound remodeling of this tissue. Physical activity-dependent muscle fiber plasticity is regulated by a number of distinct signaling pathways. Even though most of these pathways are activated by different stimuli and in a temporally and spatially separated manner during exercise, many of the major signal transduction events converge on the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) by post-translationally modifying the PGC-1 alpha protein, modulating PGC-1 alpha gene expression or both. In turn, depending on the cellular context, PGC-1 alpha regulates specific gene programs. Ultimately, PGC-1 alpha modulates most of the transcriptional adaptations of skeletal muscle to exercise. In this review, the regulation and function of this pivotal transcriptional coactivator in muscle are discussed.
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