Article
Biochemistry & Molecular Biology
Sevil Senkardes, Didem Kart, Bilge Bebek, Miyase Gozde Gunduz, S. Guniz Kucukguzel
Summary: In this study, hydrazide-hydrazone and 4-thiazolidinone derivatives were synthesized and evaluated for their antimicrobial activity. Some compounds showed significant antimicrobial properties against E. coli and could potentially be developed as antimicrobial drug candidates. Molecular docking investigations revealed the potential antibacterial mechanism of one compound against E. coli.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Ayushi Singh, Manoj Trivedi, Gabriele Kociok-Kohn, Ashish Kumar Singh, Mohd Muddassir, Abhinav Kumar
Summary: Two new Cu(I) coordination polymers and one Ag(I) coordination polymer have been synthesized using a ferrocene-functionalized ligand, and characterized using various analytical techniques. Structural differences between the polymers are mainly due to different ligands bound to the metal centers, and the solid-state structures have been stabilized by various interactions. Weak interaction energies in the polymers have been assessed using density functional theory, and additional band gap calculations suggest differences in electronic properties among the three polymers.
Article
Biochemistry & Molecular Biology
Yosra O. Mekhlef, Asmaa M. AboulMagd, Ahmed M. Gouda
Summary: A series of 2,3-diaryl-1,3thiazolidin-4-one derivatives were synthesized and evaluated for their cytotoxicity and COXs inhibitory activities. Compounds 4k and 4j exhibited the highest inhibitory activities against COX-2, while compounds 4b, 4j, 4k, and 6b showed promising anti-proliferative activity against cancer cells. These compounds also demonstrated good antioxidant activity. The molecular docking study confirmed the binding affinity of compounds 4k and 4j to the active site of COX-2.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Yaqi Deng, Rou Pi, Li Niu, Yun Zhao, Dan Ni, Longlong Song, Zi Li, Wangyujing Han, Qinghua Wei, Yuqiao Han, Tong Zhu, Zhengli Luo, Donghui Sun, Suzhen Dong, Shunying Liu
Summary: This study identified a potential drug candidate for the treatment of osteosarcoma, which demonstrated significant cellular potency and in vivo efficacy by modulating the solubility of compounds. The candidate compound also showed inhibition of OS cell migration.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Qiaoyang Liu, Wantong Mei, Hongyong Zhou, Jiaxi Wang
Summary: A study on the photopolymerization mechanism of novel oxazolidine-2-one based acrylate monomers and their application in 3D printing.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Chemistry, Organic
Anjaneyulu Varluvothu, Krishnaiah Vaarla, Kurt Vermeire, Panaganti Leelavathi
Summary: A novel series of hydrazonothiazolidinyl acetic acid derivatives were synthesized via a straightforward microwave irradiated one-pot multicomponent reaction approach. The synthesized compounds exhibited good characterization and antiviral activity, particularly against Herpes simplex virus-1.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Tomislav Balic, Franc Perdih, Marta Pockaj, Maja Molnar, Mario Komar, Ivana Balic
Summary: Two novel polymorphs of coumarin thione-triazole compound were synthesized by recrystallization, with different crystal structures and intermolecular interactions. Form II exhibited a higher melting point, indicating a monotropic relationship between the two forms. This compound is the first structurally characterized compound containing coumarin thione-triazole moieties, as revealed by theoretical calculation and database search.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Ramandeep Kaur, Rajnish Kumar, Nilambra Dogra, Ashok Kumar Yadav
Summary: A novel series of hydrazolyl linked sulfonate ester analogues of 4-thiazolidinone nucleus were designed, synthesized and characterized using various spectroscopic techniques. In vitro studies showed appreciable alpha-glucosidase inhibitory activities of the synthesized derivatives compared to acarbose, and structure-activity relationship was established. Further in vivo experiments demonstrated the higher efficacy of the most potent derivative over acarbose in reducing postprandial hyperglycemia.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Amer A. Amer, Antar A. Abdelhamid, Amany Sh. Elnakeeb, Hanan A. Salah
Summary: An unprecedented series of 2-imino-1,3-thiazolidin-4-ones were designed using a straightforward and efficient method. The differences in the resulting products under different reaction conditions were also discovered.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Arash Tabei, Ramona Ejtemaei, Arash Mahboubi, Parastoo Saniee, Alireza Foroumadi, Alireza Dehdari, Ali Almasirad
Summary: In this study, a series of new compounds with strong antimicrobial activity were synthesized and their antibacterial efficacy was evaluated. Most of the compounds showed potent activity against Gram-positive bacteria and demonstrated strong antimicrobial activity against Helicobacter pylori strains.
Article
Chemistry, Organic
Andrey N. Komogortsev, Valeriya G. Melekhina, Boris Lichitsky, Mikhail E. Minyaev
Summary: A convenient method for the synthesis of novel imidazole-2-thione derivatives containing allomaltol fragment was elaborated, showing that the key intermediates are substituted alpha-aminoketones and corresponding imidazolidine-2-thione. The synthesis offers advantages such as mild reaction conditions, atom economy, easy workup procedure, and avoidance of chromatographic purifications. The structures of important intermediates and final products were determined using X-ray diffraction.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Fan Yang, Shijie Xu, Hui Fan, Xuechun Zhao, Xiaoxiang Zhang
Summary: The novel synthetic method described in this study utilizes various 2-alkynyl arylazides to efficiently produce products in moderate to good yields under mild reaction conditions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Saul F. Teloxa, Miguel Mellado-Hidalgo, Stuart C. D. Kennington, Pedro Romea, Felix Urpi, Gabriel Aullon, Merce Font-Bardia
Summary: A direct and asymmetric aldol reaction between N-azidoacetyl-1,3-thiazolidine-2-thione and aromatic aldehydes catalyzed by a chiral nickel(II)-Tol-BINAP complex has been developed. The reaction gives anti alpha-azido-beta-silyloxy adducts with excellent stereocontrol and high yields. The removal of thiazolidinethione allows for the synthesis of a wide array of enantiomerically pure derivatives, providing a new route to di- and tripeptide blocks containing a beta-aryl-beta-hydroxy-alpha-amino acid.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Polymer Science
Tieshuai Zhao, Ben Drain, Gokhan Yilmaz, C. Remzi Becer
Summary: In this study, pentafluoro benzyl bromide was used as a clickable initiator for the cationic ring opening polymerization of poly(2-oxazolines) to synthesize various multiblock copolymers. By combining the para-fluoro-thiol click reaction with terminating agents in a one-pot approach, multiblock copolymers such as PEtOx-mb-PMeOx were successfully prepared. Characterization of the polymers was done using SEC, H-1 NMR, and MALDI-ToF mass spectrometry, and the self-assembly properties were studied using DLS and TEM, which showed nanoparticles with diameters ranging from 184 nm to 250 nm for the PEtOx-mb-PMeOx copolymers.
Article
Chemistry, Organic
Imane Lazouni, Joelle Perard-Viret, Karim Hammad, Wassila Drici
Summary: In this paper, the synthesis of peptidomimetics containing oxazolidin-2-one and oxazolidine rings is reported. Two novel series of these heterocyclic peptidomimetics were obtained through an efficient intramolecular cyclization using serine as the starting material. In the case of oxazolidine, the formation of only one diastereoisomer was observed.
Article
Agriculture, Multidisciplinary
Eleonora Pagnotta, Niels Agerbirk, Carl E. Olsen, Luisa Ugolini, Susanna Cinti, Luca Lazzeri
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Pernille Osterbye Erthmann, Niels Agerbirk, Soren Bak
PLANT MOLECULAR BIOLOGY
(2018)
Article
Ecology
Stina Christensen, Swantje Enge, Karen Rysbjerg Jensen, Caroline Mueller, Lars Podenphant Kiaer, Niels Agerbirk, Christine Heimes, Thure P. Hauser
ARTHROPOD-PLANT INTERACTIONS
(2019)
Article
Biochemistry & Molecular Biology
Caroline Mueller, Monique Schulz, Eleonora Pagnotta, Luisa Ugolini, Ting Yang, Annemarie Matthes, Luca Lazzeri, Niels Agerbirk
JOURNAL OF CHEMICAL ECOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Niels Agerbirk, Annemarie Matthes, Pernille O. Erthmann, Luisa Ugolini, Susanna Cinti, Eleni Lazaridi, Jean-Marc Nuzillard, Caroline Mueller, Soren Bak, Patrick Rollin, Luca Lazzeri
Article
Biotechnology & Applied Microbiology
Tong-jin Liu, You-jun Zhang, Niels Agerbirk, Hai-ping Wang, Xiao-chun Wei, Jiang-ping Song, Hong-ju He, Xue-zhi Zhao, Xiao-hui Zhang, Xi-xiang Li
Review
Biochemistry & Molecular Biology
Ivica Blazevic, Sabine Montaut, Franko Burcul, Carl Erik Olsen, Meike Burow, Patrick Rollin, Niels Agerbirk
Article
Plant Sciences
Cuiwei Wang, Mads Moller Dissing, Niels Agerbirk, Christoph Crocoll, Barbara Ann Halkier
FRONTIERS IN PLANT SCIENCE
(2020)
Editorial Material
Biochemistry & Molecular Biology
Niels Agerbirk
NATURE CHEMICAL BIOLOGY
(2020)
Article
Plant Sciences
Cuiwei Wang, Christoph Crocoll, Niels Agerbirk, Barbara Ann Halkier
Summary: This study investigated the engineering of 2PE production in Nicotiana benthamiana, demonstrating the efficiency and impact of different plant gene combinations on the biosynthesis of homophenylalanine and 2PE. The strategy to produce important compounds in a heterologous host has potential applications in biotechnology and plant breeding, offering insights into catalytic properties of individual enzymes and biochemical evolution.
Review
Biochemistry & Molecular Biology
Niels Agerbirk, Cecilie Cetti Hansen, Christiane Kiefer, Thure P. Hauser, Marian Orgaard, Conny Bruun Asmussen Lange, Don Cipollini, Marcus A. Koch
Summary: This study reviewed the diversity of glucosinolates (GSLs) and analyzed phylogeny in the crucifer tribe Cardamineae as well as selected species from Brassicaceae and Resedaceae. The research found that the tribe Cardamineae contains a significant portion of the total known GSLs, with unique GSLs contributing to 19% of the conclusively identified GSLs. Intraspecific GSL polymorphism was observed in at least four species in the tribe, providing valuable insights into GSL biosynthesis and evolution.
Article
Biochemistry & Molecular Biology
Niels Agerbirk, Cecilie Cetti Hansen, Carl Erik Olsen, Christiane Kiefer, Thure P. Hauser, Stina Christensen, Karen R. Jensen, Marian Orgaard, David Pattison, Conny Bruun Asmussen Lange, Don Cipollini, Marcus A. Koch
Summary: By utilizing a library of ion trap MS2 spectra and HPLC retention times, researchers were able to distinguish at least 70 known glucosinolates (GSLs) and some additional proposed GSLs in plants. They identified GSL profiles in selected plants of the tribe Cardamineae and Reseda, focusing on minor peaks and undetected GSLs. Phylogenetic analysis based on nuclear rDNA sequences revealed that aliphatic GSLs were absent or below detection limits in two major evolutionary lines of B. vulgaris.
Article
Agriculture, Multidisciplinary
Niels Agerbirk, David Pattison, Terezie Mandakova, Martin A. Lysak, Sabine Montaut, Dan Staerk
Summary: The GSL profiles of four Limnanthaceae species, including the oil crop Limnanthes alba, were investigated using ultrahigh-performance liquid chromatographyquadrupole time-of-flight tandem mass spectrometry (UHPLC-QToF-MS/MS) analysis. The study provided an overview of biosynthetic capabilities in the genera Floerkea and Limnanthes and proposed potential biosynthetic schemes and gene families relevant for tailoring GSL profiles in Limnanthes crops.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemical Research Methods
Davide Mancinotti, Maria Cecilia Rodriguez, Karen Michiko Frick, Bjorn Dueholm, Ditte Goldschmidt Jepsen, Niels Agerbirk, Fernando Geu-Flores
Summary: By utilizing the apple latent spherical virus (ALSV) for virus-induced gene silencing (VIGS), an efficient method has been established to validate gene function in narrow-leafed lupins (NLL). This approach can be used to silence target genes alone or simultaneously, resulting in decreased levels of toxic alkaloid biosynthesis, providing direct evidence for research and improvement of this underutilized crop.
Article
Biochemistry & Molecular Biology
Pablo D. Cardenas, Jonas P. Landtved, Signe H. Larsen, Nicolai Lindegaard, Sebastian Wohlk, Karen R. Jensen, David I. Pattison, Meike Burow, Soren Bak, Christoph Crocoll, Niels Agerbirk
Summary: This study investigated the production of phytoalexins in the crucifer plant Barbarea vulgaris after exposure to abiotic stress. The results showed that two genotypes of B. vulgaris accumulated three major phytoalexins in the treated leaves. The levels of phytoalexins varied among plant types and individual phytoalexins. Summary: Two genotypes of B. vulgaris accumulated three major phytoalexins in response to abiotic stress.
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.