Article
Neurosciences
Wilber Romero-Fernandez, Jaume J. Taura, Rene A. J. Crans, Marc Lopez-Cano, Ramon Fores-Pons, Manuel Narvaez, Jens Carlsson, Francisco Ciruela, Kjell Fuxe, Dasiel O. Borroto-Escuela
Summary: The study demonstrates the role of A(2A)R in modulating the D2R-mGluR(5) heteromeric component, showing that A(2A)R and mGluR(5) can interact to influence D2R signaling, indicating integrative activity within higher-order heteroreceptor complexes.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zuzana Trosanova, Petr Lousa, Aneta Kozelekova, Tomas Brom, Norbert Gasparik, Jan Tungli, Veronika Weisova, Erik Zupa, Gabriel Zoldak, Joze Hritz
Summary: This study describes the equilibrium between monomers, homo- and heterodimers of 14-3-3ζ isoform in the unmodified and phosphorylated form. The researchers found that phosphorylation of 14-3-3ζ at Ser58 significantly increases its homodimeric K-d value. Various experimental methods were used to efficiently monitor the dimerization of 14-3-3ζ protein and observe the effects of external factors and client protein binding.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Biology
Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Mark Voorhies, Carlos Rivera, Anita Sil, R. Dyche Mullins, Matthew P. Jacobson, Jirka Peschek, Peter Walter
Summary: The study demonstrates the functional specialization of Ire1's RNase activity, which is determined by the protomer alignment at the dimer interface, and this alteration affects the substrate specificity.
Article
Biochemistry & Molecular Biology
Ikuo Kurisaki, Shigenori Tanaka
Summary: Amyloid proteins, particularly amyloid-beta (Aβ42), play a role in neurodegenerative diseases by forming fibrils, but the mechanisms are still unclear. Molecular dynamics simulations reveal that stable formation of dimeric forms of Aβ42 is crucial in triggering rapid growth of amyloid fibrils.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2022)
Article
Engineering, Environmental
Onur Dogu, Andreas Eschenbacher, Robin John Varghese, Maarten Dobbelaere, Dagmar R. D'hooge, Paul H. M. Van Steenberge, Kevin M. Van Geem
Summary: This paper presents a new kinetic Monte Carlo model for studying the product yield variations of polystyrene pyrolysis. The model accurately predicts the yields of major products and reveals the contributions of different reaction pathways to product formation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Cell Biology
Joanne C. Clark, Foteini-Nafsika Damaskinaki, Yam Fung Hilaire Cheung, Alexandre Slater, Steve P. Watson
Summary: GPVI is a critical signaling receptor responsible for collagen-induced platelet activation and a promising anti-thrombotic target. Understanding of the structure-function relationships is inadequate and contradictory, with dimerization not essential for collagen binding. GPVI exists as a mixture of monomers and dimers on resting platelets, with multivalent ligands inducing higher order clustering.
Review
Biochemistry & Molecular Biology
Irene Lee-Rivera, Edith Lopez, Ana Maria Lopez-Colome
Summary: This review discusses the interactions of protease activated receptors (PARs) with their own family members as well as with other types of receptors. The authors point out that the cross-talk between receptors and signaling pathways is a novel mechanism providing diversity to receptor function and playing important roles in physiology and disease.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Chemistry, Analytical
Helen Sepman, Sofja Tshepelevitsh, Henrik Hupatz, Anneli Kruve
Summary: The structural annotation of isomeric metabolites is a significant challenge in untargeted metabolomic analysis. This study explores the use of protomer formation for structural elucidation in metabolomics, using caffeine and its metabolites as examples. The results show that the formation of protomers is structure-dependent and can facilitate the identification of structural isomers.
ANALYTICAL CHEMISTRY
(2022)
Article
Microbiology
Alfa Herrera, Youngchang Kim, Jiexi Chen, Robert Jedrzejczak, Shantanu Shukla, Natalia Maltseva, Grazyna Joachimiak, Lukas Welk, Grant Wiersum, Lukasz Jaroszewski, Adam Godzik, Andrzej Joachimiak, Karla J. F. Satchell
Summary: Alpha-pore-forming toxins (alpha-PFTs) are secreted by various bacteria and can form bi- or tripartite toxins, specifically targeting phagocytic cells.
JOURNAL OF BACTERIOLOGY
(2022)
Review
Cell Biology
Steven Timmermans, Jolien Vandewalle, Claude Libert
Summary: This review paper provides an overview of the current knowledge and insights about the important aspect of glucocorticoid receptor (GR) biology, including the versatility of GR, its interactions with other proteins, the structural aspects of dimerization, and its impact on biological functions.
Article
Pharmacology & Pharmacy
Jyrki P. Kukkonen
Summary: Recent data indicates cooperative effects between identical orthosteric binding sites in a G-protein-coupled receptor dimer. A mathematical model was created to test this concept, showing that even a neutral receptor ligand can allosterically affect agonist binding through the orthosteric binding site.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Physical
Thien Khuu, Santino J. Stropoli, Kim Greis, Nan Yang, Mark A. Johnson
Summary: 4-aminobenzoic acid (4ABA) serves as a model scaffold for studying solvent-mediated proton transfer. The formation of hydrated deuterium isotopologues of the N-protomers in a liquid nitrogen cooled ion trap is reported, which confirms the intact structure of the metastable N-protomer. Spectroscopic analysis reveals H/D exchange on the acidic OH group of the acid scaffold.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Medicinal
Tingting Fan, Boqiang Liang, Lingling Nie, Juan Wang, Huijun Zhang, Aaron Ciechanover, Yan Xu, Jing An, Ziwei Huang
Summary: The interaction between EphB4 and EFNB2 plays a crucial role in cancer by controlling bidirectional signaling that affects tumor growth and angiogenesis. In this study, researchers designed a bivalent ligand that showed higher binding affinity to EphB4 and successfully inhibited cancer cell motility and tube formation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemical Research Methods
Xia Zhang, Jiaqi Yin, Wei Pan, Yanhua Li, Na Li, Bo Tang
Summary: This review introduces the importance of receptor tyrosine kinases (RTKs) and their dimers in cell signal transduction pathways and highlights the strategies and advances in imaging RTK dimers. The visualization of RTK dimers is significant for monitoring physiological processes and expanding applications in biomedical areas.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Nina Romantini, Shahidul Alam, Stefanie Dobitz, Martin Spillmann, Martina De Foresta, Roger Schibli, Gebhard F. X. Schertler, Helma Wennemers, Xavier Deupi, Martin Behe, Philipp Berger
Summary: This study demonstrates that using rigid oligoproline backbones can develop ligands with biased GPCR signaling, and stabilizing GPCR dimers by fixing the distance between their recognition motifs can expand the space for medicinal chemistry.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)