期刊
PHYTOCHEMISTRY
卷 117, 期 -, 页码 194-199出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2015.04.007
关键词
Cananbis; Cannabis sativa; Cannabaceae; High potency; Oxygenated cannabinoids; Anti-bacterial; Anti-leishmanial; Anti-malarial
资金
- National Center for Research Resources [5P20RR021929]
- National Institute on Drug Abuse [N01DA-10-7773]
Nine oxygenated cannabinoids were isolated from a high potency Cannabis sativa L. variety. Structure elucidation was achieved using spectroscopic techniques, including 1D and 2D NMR, HRMS and GC-MS. These minor compounds include four hexahydrocannabinols, four tetrahydrocannabinols, and one hydroxylated cannabinol, namely 9 alpha-hydroxyhexahydrocannabinol, 7-oxo-9 alpha-hydroxyhexa-hydrocannabinol, 10 alpha-hydroxyhexahydrocannabinol, 10aR-hydroxyhexahydrocannabinol, Delta(9)-THC aldehyde A, 8-oxo-Delta(9)-THC, 10a alpha-hydroxy-10-oxo-Delta(9)-THC, 9 alpha-hydroxy-10-oxo-Delta(6a,10a)-THC, and 1'S-hydroxycannabinol, respectively. The latter compound showed moderate anti-MRSa (IC50 10.0 mu g/mL), moderate antileishmanial (IC50 14.0 mu g/mL) and mild antimalarial activity against Plasmodium falciparum (D6 clone) and P. falciparum (W2 clone) with IC50 values of 3.4 and 2.3 mu g/mL, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据