Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Falko Ensle, Jan A. Schaab, Florentia Dimitriou, Martin W. Huellner, Alexander Maurer
Summary: We report the F-18-FDG PET/CT findings of an internal thoracic vein tumor thrombus in a 76-year-old woman with melanoma. The restaging F-18-FDG PET/CT revealed disease progression with an internal thoracic vein tumor thrombus associated with sternal bone metastasis. Although cutaneous malignant melanoma can metastasize to any organ, direct tumor invasion of veins leading to tumor thrombus formation is an extremely rare complication.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Ding, Jiangdong Qiu, Zhixin Hao, Hua Huang, Qiaofei Liu, Wenjing Liu, Chao Ren, Marcus Hacker, Taiping Zhang, Wenming Wu, Xiang Li, Li Huo
Summary: This study evaluated the performance of [(68) Ga]Ga-FAPI-04 and [F-18]F-FDG PET/CT on the disease staging and prognostic value of patients with localized PDAC. The results showed that [(68) Ga]Ga-FAPI-04 was more sensitive and accurate than [F-18]F-FDG, and could be used for staging and prognostic evaluation of PDAC, providing a non-invasive guide for clinical management.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Yunze Wang, Qingyu Lin, Hongcheng Shi, Dengfeng Cheng
Summary: Positron emission tomography (PET) molecular imaging technology is a critical tool for evaluating biological and biochemical processes. Fluorine-18 has favorable characteristics for labeling and molecular imaging, making it significant in radiochemistry and radiopharmaceutics. The development of new reagents and catalysts has led to rapid growth in F-18 labeling methods over the past decades.
FRONTIERS IN CHEMISTRY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Weicheng Zhou, Jinju Sun, Fangyang Wang, Yi Wang, Xiao Chen
Summary: We presented cardiac F-18-FAPI PET/CT findings in 3 cases with myocarditis of varying duration. Different F-18-FAPI uptake was observed in myocarditis with different symptom durations, indicating the potential of F-18-FAPI PET/CT in evaluating fibrosis extent caused by myocarditis. This information may guide treatment decisions for patients with myocarditis.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela-Elena Oprea-Lager, Eric Gontier, Lina Garcia-Canamaque, Mathieu Gauthe, Pierre Olivier, Mercedes Mitjavila, Pilar Tamayo, Philippe Robin, Ana Maria Garcia Vicente, Anne-Charlotte Bouyeure, Alban Bailliez, Antonio Rodriguez-Fernandez, Sinan Ben Mahmoud, Juan Antonio Vallejo-Casas, Philippe Maksud, Charles Merlin, Paul Blanc-Durand, Clement Drouet, Hubert Tissot, Irina Vierasu, Thierry Vander Borght, Evelyne Boos, Florence Chossat, Marina Hodolic, Caroline Rousseau
Summary: The purpose of this study was to compare the per-patient detection rates of [F-18]DCFPyL and [F-18]fluoromethylcholine PET/CT in patients with first prostate cancer biochemical recurrence. The results showed that [F-18]DCFPyL had a significantly higher detection rate compared to [F-18]fluoromethylcholine.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Yachao Liu, Hongkai Yu, Jiajin Liu, Xiaojun Zhang, Mu Lin, Holger Schmidt, Jiangping Gao, Baixuan Xu
Summary: This study demonstrated that F-18-DCFPyL PET/CT-US or PET/MRI-US fusion targeted prostate biopsies may be valuable for prostate cancer diagnosis, with a high detection rate of clinically significant prostate cancer for PET-positive lesions. PET/MR can help rule out false PET-positive lesions, potentially reducing unnecessary prostate biopsies.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Ki Seong Park, Hyun Ju Seon, Ju-Sik Yun, Su Woong Yoo, Changho Lee, Sae-Ryung Kang, Jahae Kim, Sang-Geon Cho, Ho-Chun Song, Hee-Seung Bom, Jung-Joon Min, Seong Young Kwon
Summary: This study aimed to characterize solitary pulmonary nodule (SPN) using imaging parameters for F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) or enhanced CT corrected by tumor shadow disappearance rate (TDR) to reflect the tissue density. The results showed that high values of SUVmax and HUpeak-pre were significant factors in the characterization of SPN, and the combined approach using TDR-corrected parameters had better predictive performance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Chemistry, Multidisciplinary
Xiao Wang, Chen Li, Dong Niu, Ruojie Sha, Nadrian C. Seeman, James W. Canary
Article
Chemistry, Medicinal
Jingli Xu, Hang Liu, Guixia Li, Yong He, Rui Ding, Xiao Wang, Man Feng, Shuting Zhang, Yurong Chen, Shilei Li, Mingxia Zhao, Chuanmin Qi, Yonghong Dang
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Chemistry, Medicinal
Yurong Chen, Man Feng, Shilei Li, Jingli Xu, Hongyu Ning, Yong He, Xiao Wang, Rui Ding, Chuanmin Qi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2012)
Article
Chemistry, Medicinal
Shilei Li, Xiao Wang, Yong He, Mingxia Zhao, Yurong Chen, Jingli Xu, Man Feng, Jin Chang, Hongyu Ning, Chuanmin Qi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Chemistry, Medicinal
Yong He, Jingli Xu, Hang Liu, Man Feng, Xiao Wang, Rui Ding, Chuanmin Qi, Yurong Chen, Fang Li, Zhao-Hui Zhu, Yong-Hong Dang, Ming Wang, Ying Xie
MEDICINAL CHEMISTRY RESEARCH
(2012)
Article
Chemistry, Medicinal
Rui Ding, Yong He, Jingli Xu, Hang Liu, Xiao Wang, Man Feng, Chuanmin Qi, Junbo Zhang, Cheng Peng
MEDICINAL CHEMISTRY RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Rui Ding, Yong He, Xiao Wang, Jingli Xu, Yurong Chen, Man Feng, Chuanmin Qi
Article
Biochemistry & Molecular Biology
Jingli Xu, Hang Liu, Guixia Li, Yong He, Rui Ding, Xiao Wang, Man Feng, Shuting Zhang, Yurong Chen, Shilei Li, Mingxia Zhao, Yingruo Li, Chuanmin Qi, Yonghong Dang
Article
Chemistry, Inorganic & Nuclear
Jingli Xu, Hang Liu, Guixia Li, Yong He, Rui Ding, Xiao Wang, Man Feng, Shuting Zhang, Yurong Chen, Shilei Li, Mingxia Zhao, Yingruo Li, Chuanmin Qi
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
(2012)
Article
Multidisciplinary Sciences
Hyungmin Jun, Xiao Wang, William P. Bricker, Mark Bathe
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Hyungmin Jun, Xiao Wang, Molly F. Parsons, William P. Bricker, Torsten John, Shanshan Li, Steve Jackson, Wah Chiu, Mark Bathe
Summary: ATHENA is an open-source software that automatically renders single-stranded DNA scaffold routing and staple strand sequences for any target wireframe DNA origami, expanding the possibilities of designing 3D DNA-based assemblies. The software also allows external editing of sequences and provides atomic-level models for molecular dynamics, coarse-grained dynamics with oxDNA, and other computational chemistry simulation approaches.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xiao Wang, Ruojie Sha, William B. Knowlton, Nadrian C. Seeman, James W. Canary, Bernard Yurke
Summary: A chiral dimer of an organic semiconductor was created by assembling an octamer of polyaniline with DNA. The dimer showed easy reconfiguration between its monomeric and dimeric forms. Experimental and theoretical studies were conducted to examine the dimer's geometry and the exciton coupling between its molecules. Protonic doping allowed for easy switching between different electronic states, and the dimer exhibited a Davydov splitting similar to DNA-dye systems with strong transition dipoles. This research provides a possible platform for studying the fundamental properties of organic semiconductors with DNAtemplated assemblies, which have potential applications in artificial light-harvesting systems and excitonic devices.
Article
Chemistry, Multidisciplinary
Xiao Wang, Rahul Deshmukh, Ruojie Sha, Jens J. Birktoft, Vinod Menon, Nadrian C. Seeman, James W. Canary
Summary: A quasi-one-dimensional organic semiconductor, hepta(p-phenylene vinylene) (HPV), was incorporated into a DNA tensegrity triangle motif using a covalent strategy, leading to self-assembly of 3D arrays characterized by X-ray diffraction and anisotropic fluorescence emission from well-aligned HPV molecules in macroscopic DNA lattices. This strategy offers potential for developing sophisticated nanodevices and functional materials with molecular accuracy using DNA as a template.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Xiao Wang, Shanshan Li, Hyungmin Jun, Torsten John, Kaiming Zhang, Hannah Fowler, Jonathan P. K. Doye, Wah Chiu, Mark Bathe
Summary: The study investigates the three-dimensional structure of wireframe DNA origami assemblies with six-helix bundle edges using cryo-electron microscopy, revealing a high degree of planarity and homogeneity suitable for applications and geometries that require high structural fidelity and local control over duplex orientations.
