Article
Polymer Science
Alejandra Ortega, Silvia Valencia, Ernesto Rivera, Tania Segura, Guillermina Burillo
Summary: In this paper, the synthesis of acrylamide hydrogels reinforced with cellulose nanocrystals using gamma radiation was reported. The cellulose nanocrystals had a notable influence over the swelling and mechanical properties, resulting in a more rigid material. The reinforced hydrogels showed the ability to load large amounts of ciprofloxacin, but released the drug quickly.
Article
Chemistry, Physical
Lorna S. Relleve, Alvin Kier R. Gallardo, Mariel G. Tecson, John Andrew A. Luna
Summary: Radiation-crosslinked CMHA hydrogels with DS of 0.34-0.74 were prepared in this study, showing increased gel content and swelling properties with higher concentrations. CMHA hydrogels prepared at 60 and 120 kGy exhibited good biocompatibility.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Akihiro Hiroki, Mitsumasa Taguchi
Summary: This study focused on producing hydrogels composed of hydroxypropyl cellulose (HPC) by radiation for disposable soft contact lenses, aiming to improve their mechanical properties and sustainability.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Junyan Tan, Yuning Luo, Yuqiong Guo, Yue Zhou, Xinying Liao, Dingxilei Li, Xinyi Lai, Yang Liu
Summary: Natural polysaccharide-based hydrogels, especially alginate, have become a research hotspot due to their abundant source, biodegradability, biocompatibility, solubility, and modification flexibility. Various crosslinking strategies and the application progress of alginate-based hydrogels in drug delivery, wound healing, and tissue engineering are comprehensively discussed in this article. The future prospects, challenges, and development trends of alginate-based hydrogels are also explored.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Jin-Oh Jeong, Youn-Mook Lim, Jae Young Lee, Jong-Seok Park
Summary: A smart drug delivery system delivers drugs to specific sites and targets. Microneedle patches are effective in treating pain and preventing skin aging, but have mechanical weaknesses and low drug release efficiency. In this study, conductive stimuli microneedle patches were developed using the gamma-ray crosslinking technique for a smart drug delivery system.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Karol K. Klosinski, Radoslaw A. Wach, Malgorzata K. Girek-Bak, Bozena Rokita, Damian Kolat, Zaneta Kaluzinska-Kolat, Barbara Klosinska, Lukasz Duda, Zbigniew W. Pasieka
Summary: Hydrogels formed from CMCS and crosslinking agent via electron beam irradiation showed potential as wound dressings. The gel's elasticity was influenced by component concentrations and irradiation dose. The hydrogels exhibited biocompatibility and could stimulate cell growth. Ionizing radiation proved to be a suitable tool for synthesis and sterilization of CMCS hydrogels.
Article
Polymer Science
Jiahui Hua, Renyan Huang, Ying Huang, Shuqin Yan, Qiang Zhang
Summary: Silk fibroin hydrogels have garnered extensive attention in biomedical materials due to their superior properties. This study investigates different methods of preparing silk fibroin hydrogels and evaluates their performance. The results show that photopolymerization-derived hydrogels exhibit higher compressive properties, chemical crosslinked and enzyme-catalyzed hydrogels show superior toughness, while sonication-induced hydrogels exhibit brittle performance. Furthermore, all silk fibroin hydrogels support cell growth, with higher cell viability observed in hydrogels without chemical agents.
Article
Chemistry, Multidisciplinary
Radoslaw A. Wach, Giorgia Palmeri, Agnieszka Adamus-Wlodarczyk, Bozena Rokita, Alicja K. Olejnik, Clelia Dispenza, Piotr Ulanski
Summary: This paper presents the results of the radiation-induced crosslinking of polysaccharides modified with hydroxypropyl and carboxymethyl functional groups to obtain dual stimuli-responsive hydrogels. The swelling of the hydrogels is controlled by both temperature and pH, making them suitable for applications where a combination of two stimuli is essential. These biopolymers-based hydrogels have potential applications in various fields.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Nahum Andres Medellin-Castillo, Elizabeth Diane Isaacs-Paez, Itzia Rodriguez-Mendez, Raul Gonzalez-Garcia, Gladis Judith Labrada-Delgado, Antonio Aragon-Pina, Maria Elena Garcia-Arreola
Summary: Crosslinked chitosan hydrogels were synthesized through ionic and covalent interactions using tripolyphosphate (TPP) and formaldehyde (CH2O). An experimental design was used to predict physiochemical properties, revealing that chitosan concentration affects the point of zero charge, crosslinker concentration influences the swelling ratio, and contact time has the most significant effect on equilibrium water content.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Polymer Science
Kathrina Lois M. Taaca, Eloise Prieto, Magdaleno R. Vasquez
Summary: This review discusses the evolution and different approaches for hydrogel preparation. It also presents plasma treatment as an enabling technology for tailoring hydrogel properties and explores the current uses of plasma-treated hydrogels.
Review
Biochemistry & Molecular Biology
Yuning Luo, Junyan Tan, Yue Zhou, Yuqiong Guo, Xinying Liao, Li He, Dingxilei Li, Xinxin Li, Yang Liu
Summary: Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility and moisturizing effect, which can affect angiogenesis, inflammation, and cell behavior. HA-based hydrogels formed by physical or chemical crosslinking strategies have both the physiological function of HA and the skeleton function of hydrogel. However, natural HA-based hydrogels have limitations such as insufficient mechanical strength and susceptibility to degradation. Researchers have developed various HA-based multifunctional hydrogels with notable properties by modifying the structure, using novel crosslinking strategies, and introducing reactive molecules. These hydrogels have extended the application scope in anticancer drug delivery, cartilage repair, three-dimensional cell culture, skin dressing, and other fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Engineering, Biomedical
Maryam Farokhi, Mina Aleemardani, Atefeh Solouk, Hamid Mirzadeh, Andreas Herbert Teuschl, Heinz Redl
Summary: Silk fibroin hydrogels have strong biomimetic potential and are excellent candidates for tissue engineering due to their tunable properties. Different crosslinking strategies, either chemical or physical, can alter the structure of silk fibroin and improve its mechanical stability. However, each method has its own advantages and disadvantages, and the choice of method depends on the specific application requirements.
BIOMEDICAL MATERIALS
(2021)
Review
Polymer Science
Hao Ma, Yuan Peng, Shunuo Zhang, Yixin Zhang, Peiru Min
Summary: Wound healing is a complex physiological process, and the use of photo-crosslinking hydrogels can play an important role in improving its quality.
Review
Chemistry, Multidisciplinary
Yongsheng Gao, Kevin Peng, Samir Mitragotri
Summary: Hydrogels are biomaterials with high water content and chemically crosslinked hydrogels have made significant clinical impact. Selecting appropriate crosslinking chemistries and polymers for clinical application is challenging and requires integration of polymer chemistry knowledge. Design parameters of hydrogels and barriers in regulatory process need to be considered.
ADVANCED MATERIALS
(2021)
Article
Polymer Science
Ana P. C. Almeida, Joao N. Saraiva, Goncalo Cavaco, Raquel P. Portela, Catarina R. Leal, Rita G. Sobral, Pedro L. Almeida
Summary: Bacterial cellulose-based membranes have gained increasing attention as dressings for healing purposes. This study produced, modified, and characterized hydrated and dehydrated BC membranes for biomedical applications. The results showed that the cross-linked bacterial cellulose membranes exhibit suitable physical properties for use as wound dressings.
EUROPEAN POLYMER JOURNAL
(2022)
