4.3 Article

Increased miRNA-22 expression sensitizes esophageal squamous cell carcinoma to irradiation

期刊

JOURNAL OF RADIATION RESEARCH
卷 54, 期 3, 页码 401-408

出版社

OXFORD UNIV PRESS
DOI: 10.1093/jrr/rrs113

关键词

miRNA-22; ESCC; gamma-ray; radiosensitivity; Rad51

资金

  1. National Natural Science Foundation of China [30901723, 81272511]
  2. Natural Science Foundation of Tianjin [11JCYBJC13700]
  3. Institute Fund of Radiation Medicine [SF1103, SF1106]

向作者/读者索取更多资源

miRNA-22 was previously reported to be a tumor suppressor. The aim of this study was to explore the expression and function of miRNA-22 in esophageal squamous cell carcinoma (ESCC). Expression of miRNA-22 in 100 ESCC tissues was examined by q-PCR. The correlation between miRNA-22 level and clinicopathological features was analyzed using SPSS16.0 statistical software. Moreover, the effect of miRNA-22 expression on radiosensitivity of ESCC cells was examined. miRNA-22 expression decreased in ESCC tissues, and statistical analyses showed that the expression of miRNA-22 was associated with the stage of clinical classification. No correlation was found between miRNA-22 expression and the overall survival of ESCC patients. However, significant positive correlation was found between miRNA-22 expression and the survival of patients who received radiotherapy (P < 0.05). Increased expression of miRNA-22 sensitized ESCC cells to gamma-ray radiation and promoted the apoptosis of ESCC cells induced by gamma-ray radiation. Increased expression level of miRNA-22 had effects on Rad51 expression after irradiation. These results demonstrate for the first time that decreased miRNA-22 expression correlates with increased radiotherapy resistance of ESCC, and that this effect is mediated, at least in part, by the Rad51 pathway.

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