Review
Biochemistry & Molecular Biology
Jin Li, Xianyanling Yi, Jianzhong Ai
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease with a negative impact on quality of life. Diagnoses and treatments are still unsatisfactory, calling for new approaches. This study aims to provide a comprehensive overview of IC/BPS research, promoting progress in diagnosis, treatment, and prognosis. The complexity of IC/BPS and emerging evidence call for further studies to optimize management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Lori A. A. Birder, Hann-Chorng Kuo
Summary: The aim of this study was to investigate the expression levels of sensory receptors, inflammatory proteins, and pro-apoptotic proteins in the urothelium of non-Hunner's interstitial cystitis (NHIC) bladders of patients with different clinical and cystoscopic phenotypes. The study concluded that IC/BPS patients with frequency and bladder pain complaints have higher levels of urothelial sensory receptors, and inflammatory and pro-apoptotic proteins. The expression levels of these sensory receptors, inflammatory proteins, and pro-apoptotic proteins are not significantly different among IC/BPS bladders with different conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Timothy J. Ness, Cary DeWitte, Alan Randich
Summary: This study investigates the role of corticotropin-releasing factor receptor type II (CRFR2) mechanisms in bladder hyperalgesia. The findings demonstrate the association between CRFR2-related mechanisms and bladder hypersensitivity, supporting the therapeutic value of these agents in the treatment of painful bladder disorders.
Article
Psychiatry
Chloe Woodling, Dustin B. Wygant, Robert L. Umlauf, Ryan J. Marek
Summary: Through analyzing a sample of patients with chronic low-back pain, this study found that in the HiTOP model, the Somatoform spectrum fits better as a separate spectrum rather than a subfactor of Internalizing. Discriminant and convergent validity with an external criteria confirmed the distinctiveness of the Somatoform spectrum from the Internalizing spectrum within the HiTOP model.
PSYCHIATRY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zhenming Zheng, Jintao Hu, Wenshuang Li, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Yousheng Yao
Summary: This study used 16S rRNA sequencing and untargeted metabolomics techniques to analyze the urinary microbial and metabolite profiles of IC/BPS patients and healthy controls. The results showed differential genera and metabolites associated with the inflammatory response of IC/BPS, including Lactobacillus as a protective bacterium and Sphingomonas as a pathogenic factor. The metabolite theophylline may also play a role in downregulating the inflammatory response of IC/BPS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi
Summary: Activation of TRPV4 can negatively regulate bladder inflammation induced by LPS and alleviate bladder hypersensitivity. This finding may provide new therapeutic targets for refractory bladder pain syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Jung Hyun Shin, Bosik Kang, Myung-Soo Choo
Summary: The study found that the features of HLs in IC patients were not associated with subjective symptoms, but inflammatory changes in HLs were a predictive factor for IC recurrence and associated with frequent urgency episodes and smaller bladder capacity.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Hung-Yu Lin, Jian-He Lu, Shu-Mien Chuang, Kuang-Shun Chueh, Tai-Jui Juan, Yi-Chang Liu, Yung-Shun Juan
Summary: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic bladder disorder characterized by suprapubic pain and discomfort during bladder filling, accompanied by lower urinary tract symptoms. The diagnosis of IC/BPS is still not standardized, but cystoscopy and bladder biopsy can determine the presence of ulcers. The pathophysiology of IC/BPS may involve chronic inflammation, autoimmune disorders, and other factors. Biomarkers in urine and serum specimens could be useful for the diagnosis of IC/BPS.
Article
Pharmacology & Pharmacy
Yuan-Hong Jiang, Jia-Fong Jhang, Teng-Yi Lin, Han-Chen Ho, Yung-Hsiang Hsu, Hann-Chorng Kuo
Summary: The study found that intravesical PRP injection is effective in relieving symptoms of IC/BPS patients, with slightly lower efficacy after a single high-dose PRP injection compared to four low-dose PRP injections. The addition of components and injection site did not significantly affect therapeutic outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Dan-Yun Chiou, Hann-Chorng Kuo
Summary: Urine oxidative stress biomarkers and inflammatory cytokines play important roles in diagnosing and differentiating clinical subtypes of interstitial cystitis/bladder pain syndrome (IC/BPS).
Article
Medicine, General & Internal
Pedro Abreu-Mendes, Beatriz Araujo-Silva, Ana Charrua, Francisco Cruz, Rui Pinto
Summary: This study suggests that daily silodosin can be an effective and well-tolerated treatment for refractory BPS/IC female patients. Additionally, stress coping levels may be associated with symptom improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Amy M. Ivare, Aneta Obloza, Jonathan C. Goddard
Summary: Bladder pain syndrome (BPS) is often overlooked in pregnancy, despite being a common symptom. This article reviews the current evidence on the impact of BPS on pregnancy and the available options for diagnosis and management, aiming to improve patient experience and outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zhinoos Taidi, Tommy Zhou, Kate H. Moore, Kylie J. Mansfield, Lu Liu
Summary: Inflammatory conditions of the urinary bladder are associated with urothelial damage and loss of function. The purinergic P2X7 receptor plays a role in such inflammatory conditions and may be a new therapeutic target for bladder inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Wenshuang Li, Zhenming Zheng, Kaiqun Ma, Caixia Zhang, Kuiqing Li, Paierhati Tayier, Yousheng Yao
Summary: This study found that in patients with interstitial cystitis/bladder pain syndrome (IC/BPS), repeated intravesical instillations of Sapylin after botulinum toxin A (BoNT/A) injection can produce significantly better clinical outcomes than BoNT/A alone, with good safety.
Article
Clinical Neurology
Christine M. Biddle, Rachel L. Fazio, Fiona Dyshniku, Robert L. Denney
APPLIED NEUROPSYCHOLOGY-ADULT
(2018)
Article
Clinical Neurology
Rachel L. Fazio, Allison N. Faris, Karim Z. Yamout
APPLIED NEUROPSYCHOLOGY-ADULT
(2019)
Article
Clinical Neurology
Leah Hanson Misialek, Rachel L. Fazio, Robert L. Denney, William G. Myers
APPLIED NEUROPSYCHOLOGY-ADULT
(2013)
Article
Clinical Neurology
Rachel Fazio, Kathryn J. Dunham, Shannon Griswold, Robert L. Denney
APPLIED NEUROPSYCHOLOGY-ADULT
(2013)
Article
Clinical Neurology
Kari Eng, Summer Rolin, Rachel Fazio, Christine Biddle, Megan O'Grady, Robert Denney
APPLIED NEUROPSYCHOLOGY-ADULT
(2013)
Article
Psychology, Multidisciplinary
Rachel Fazio, Craig Coenen, Robert L. Denney
Article
Psychiatry
Xiuxiu Zhao, Junlin Li, Xianhai Xie, Zhaojing Fang, Yue Feng, Yi Zhong, Chen Chen, Kaizong Huang, Chun Ge, Hongwei Shi, Yanna Si, Jianjun Zou
Summary: This study developed dynamic prediction models for postoperative delirium (POD) after cardiac surgery using machine learning algorithms. The models showed satisfactory predictive performance and were used to create online risk calculators for identifying high-risk patients and facilitating early intervention or care.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2024)
Article
Psychiatry
Miaolan Guo, Jing Su, Shaoyan Zheng, Baixin Chen
Summary: Psoriasis is associated with poor sleep quality and higher risk for sleep disturbance, especially among patients with psoriatic arthritis, severe psoriasis, shorter duration of psoriasis, and younger age. Patients with psoriasis are also more likely to experience insomnia, restless legs syndrome (RLS), and depression.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2024)
