Article
Neurosciences
Scott Ferguson, Robyn McCartan, Mackenzie Browning, Coral Hahn-Townsend, Arissa Gratkowski, Alexander Morin, Laila Abdullah, Ghania Ait-Ghezala, Joseph Ojo, Kimberly Sullivan, Michael Mullan, Fiona Crawford, Benoit Mouzon
Summary: The relationship between chemical and pharmaceutical exposures and traumatic brain injury (TBI) has not been extensively studied. This study found that Gulf War toxicant exposure may worsen TBI-related deficits, affecting spatial memory and behavior in mice.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Neurosciences
Nicole Schwab, Daria Taskina, Emily Leung, Brendan T. Innes, Gary D. Bader, Lili-Naz Hazrati
Summary: Mild traumatic brain injury (mTBI) is a significant public health issue, with unclear pathophysiological mechanisms and no effective therapies. This study on mice found that repeated mild brain injury led to neurological impairment and DNA damage, with sex differences influencing the recovery of brain function after injury.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Genetics & Heredity
Yawen Ma, Yunhui Liu, Xuelei Ruan, Xiaobai Liu, Jian Zheng, Hao Teng, Lianqi Shao, Chunqing Yang, Di Wang, Yixue Xue
Summary: By analyzing gene expression and coexpression networks, we identified important modules and hub genes associated with neurodevelopment and immune inflammation in TBI. These findings may offer new insights for the early diagnosis and treatment of TBI.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Alex S. Aguirre, Kenny Rojas, Alcy R. Torres
Summary: Our study reveals that head injuries are the most common casualties in war zones, affecting both male and female children with an average age of 8-10 years. Most children are from Afghanistan, and blasts are the most common mechanism of injury, with a mortality rate ranging from 3% to 47%.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Henry W. Mahncke, Joseph DeGutis, Harvey Levin, Mary R. Newsome, Morris D. Bell, Chad Grills, Louis M. French, Katherine W. Sullivan, Sarah-Jane Kim, Annika Rose, Catherine Stasio, Michael M. Merzenich
Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.
Review
Radiology, Nuclear Medicine & Medical Imaging
Cyrus Ayubcha, Mona-Elisabeth Revheim, Andrew Newberg, Mateen Moghbel, Chaitanya Rojulpote, Thomas J. Werner, Abass Alavi
Summary: PET has been widely used in the study of traumatic brain injury (TBI) for decades, with recent focus on imaging biomarkers related to TBI and chronic traumatic encephalopathy (CTE). This review critically assesses the use of glycolysis, beta-amyloid, and tau protein radiotracers in the context of TBI, weighing their strengths and weaknesses. Despite the ongoing debate, PET remains a powerful modality in diagnosing TBI-related conditions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Multidisciplinary Sciences
Yana Naumenko, Irada Yuryshinetz, Yelyzaveta Zabenko, Tetyana Pivneva
Summary: Traumatic brain injury (TBI) refers to brain dysfunction or evidence of brain pathology caused by external physical force. Over 69 million new cases of TBI are registered worldwide each year, with 80% of them being mild TBI. Mechanically induced brain injury initiates various changes in the CNS, leading to acute, subacute, and chronic neurological consequences. The heterogeneity, lack of a unified classification system, and variability of long-term consequences pose challenges for research and therapeutic strategies.
Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Cell Biology
Ruslan Prus, Olena Appelhans, Maksim Logash, Petro Pokotylo, Grzegorz Jozef Nowicki, Barbara Slusarska
Summary: Traumatic brain injury is a serious issue in modern medicine, with our study showing that mild TBI causes different histological changes in the livers of adult and juvenile rats. The most significant changes were observed on days 5-7, with compensatory phenomena prevailing on days 14-21 in both groups.
Review
Neurosciences
Yishu Liu, Chudong Wang, Zhiyun Pi, Tingting Wang, Changquan Zhang, Jifeng Cai
Summary: Reliable diagnostic methods for mild traumatic brain injury (mTBI) are lacking, and researchers are searching for objective biomarkers to define and detect mTBI. This study analyzes the scientific development in mTBI diagnosis over the past two decades, including publication trends, authors, countries/regions, and molecular markers. The analysis of 1,023 publications from 2000 to 2022 reveals a continuous increase in the number of publications, with the majority of authors from the USA. Molecular markers are the most studied markers, accounting for 28.4% of all publications, and their research focus has sharply increased in the past 5 years, suggesting their potential as a future research trend.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yang Wan, Wenqiang Fang, Rika Wright Carlsen, Haneesh Kesari
Summary: Rotational head motions play a crucial role in traumatic brain injury, and there is a need for methods to quickly predict brain tissue strains and strain rates to estimate injury risk and guide protective equipment design. Idealized continuum mechanics based head models provide a simpler and faster approach to estimate brain strains and strain rates. In this study, a new head model accounting for finite rotations is proposed, which shows comparable strain predictions to a more detailed finite element head model. This model can serve as a basis for introducing finite rotations into more sophisticated head models in the future.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Review
Neurosciences
Nozar Aghakhani
Summary: There is growing evidence for the important role of gut microbiota in the development and progression of neurological disorders, with studies suggesting that modifying the microbiome profile can benefit patients. Animal models have shown disturbances in the GMB following TBI, with probiotic supplementation improving neurological function. However, clinical studies are needed to determine the impact of restoring gut microbiome profile on long-term outcomes for mTBI patients.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Clinical Neurology
Jean-Nicolas Tourigny, Valerie Boucher, Veronique Paquet, Emile Fortier, Christian Malo, Eric Mercier, Jean-Marc Chauny, Gregory Clark, Pierre-Gilles Blanchard, Pierre-Hugues Carmichael, Jean-Luc Gariepy, Myreille D'Astous, Marcel Emond
Summary: The study validated the sensitivity and specificity of the updated BIG in predicting the need for interhospital transfer in patients with complicated mild traumatic brain injury. The results showed that patients in the uBIG-1 group could be safely managed at their initial center without the need for transfer.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Harvey S. Levin, Nancy R. Temkin, Jason Barber, Lindsay D. Nelson, Claudia Robertson, Jeffrey Brennan, Murray B. Stein, John K. Yue, Joseph T. Giacino, Michael A. McCrea, Ramon Diaz-Arrastia, Pratik Mukherjee, David O. Okonkwo, Kim Boase, Amy J. Markowitz, Yelena Bodien, Sabrina Taylor, Mary J. Vassar, Geoffrey T. Manley
Summary: This study identified that women are more susceptible than men to persistent mTBI-related cognitive and somatic symptoms, with no sex differences observed after orthopedic injury. Post-concussion symptoms were also more severe in women aged 35 to 49 than in younger and older women.