Article
Neurosciences
Azadeh Kushki, Robyn E. Cardy, Sina Panahandeh, Mahan Malihi, Christopher Hammill, Jessica Brian, Alana Iaboni, Margot J. Taylor, Russell Schachar, Jennifer Crosbie, Paul Arnold, Elizabeth Kelley, Muhammad Ayub, Robert Nicolson, Stelios Georgiades, Jason P. Lerch, Evdokia Anagnostou
Summary: The study discovered associations between social communication abilities and distributed cortical and subcortical networks implicated in social behaviors, language, attention, memory, and executive functions, as well as three data-driven, diagnosis-agnostic subgroups based on the patterns of association in these networks.
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Hsin-Yi Fan, Cheuk-Kwan Sun, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Chun-Ning Ho, Kuo-Chuan Hung
Summary: This study provides a systematic review and analysis of the effectiveness of electroencephalogram-based neurofeedback (EEG-NF) in treating the core symptoms of attention-deficit hyperactivity disorder (ADHD) in adolescents/adults. The results suggest that EEG-NF can effectively improve inattention symptoms, but its effectiveness in reducing hyperactivity/impulsivity remains inconclusive.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
E. M. Bruxel, C. R. Moreira-Maia, G. C. Akutagava-Martins, T. P. Quinn, M. Klein, B. Franke, M. Ribases, P. Rovira, C. Sanchez-Mora, D. B. Kappel, N. R. Mota, E. H. Grevet, C. H. D. Bau, M. Arcos-Burgos, L. A. Rohde, M. H. Hutz
Summary: This study conducted a meta-analysis to investigate the association between ADGRL3 gene variants and ADHD susceptibility in children and adults, finding significant correlation in children but not in adults. The results suggest that ADGRL3 gene is predominantly associated with childhood ADHD.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Erica D. Musser, Stephanie S. J. Morris, Kathleen Feeney, Rosario Pintos Lobo, Edward F. Ester
Summary: Inattention is a key symptom of ADHD, but the mechanisms underlying it are unclear. More specific approaches are needed to link disruptions in cognitive performance with ADHD behaviors. A pilot study found that even typically developing children did not maximally extract and combine information to maximize rewards in a cognitive task targeting attention selection mechanisms.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Health Care Sciences & Services
Peng Wang, Xuejing Zhao, Jitao Zhong, Ying Zhou
Summary: In this paper, a random-forest-based method was proposed for the classification and localization of Attention-Deficit/Hyperactivity Disorder (ADHD), which achieved more accurate identification results through analyzing MRI data. Experimental results showed that the method performed with higher accuracy in discriminating ADHD patients.
Article
Pediatrics
Li-Fan Pai, Der-Shiun Wang, Wan-Fu Hsu, Shao-Wei Huang, Chi-Hsiang Chung, Shyi-Jou Chen, Wu-Chien Chien, Der-Ming Chu
Summary: This study found that children with ADHD have a higher risk of central precocious puberty. Early referral to a pediatric endocrinologist for evaluation can lead to correct diagnosis. Early intervention treatment with gonadotropin-releasing hormone agonist may improve final height in children with central precocious puberty.
PEDIATRIC RESEARCH
(2022)
Review
Multidisciplinary Sciences
Jung Tae Kim, Kibong Kim, Lin Ang, Hye Won Lee, Jun-Yong Choi, Myeong Soo Lee
Summary: This article describes a systematic review that aims to evaluate the effectiveness of acupuncture as a treatment for ADHD. The study will conduct literature searches in multiple databases and analyze the selected studies using the Cochrane Risk of Bias Assessment Tool. The findings of this review will be used to support relevant health policies and practices.
Article
Medicine, General & Internal
Johannes Lieslehto, Jari Tiihonen, Markku Laehteenvuo, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Heidi Taipale
Summary: This study investigated the impact of pharmacotherapy on suicide risk in patients with borderline personality disorder (BPD). The results indicated that ADHD medication may reduce the risk of suicide, while mood stabilizers and antidepressants may increase the risk. The findings suggest that benzodiazepines should be used with caution due to their association with increased suicide risk in patients with BPD.
Article
Psychology, Developmental
Luise Kazda, Kevin McGeechan, Katy Bell, Rae Thomas, Alexandra Barratt
Summary: The study compared ADHD diagnoses with behaviors in Australian children, finding that while ADHD diagnoses increased, the behaviors remained steady. A quarter of diagnosed children had behaviors within the normal range, indicating potential overdiagnosis of ADHD. Children born in a later cohort were more likely to be diagnosed with ADHD, regardless of their behaviors.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Mia Moses, Jeggan Tiego, Ditte Demontis, G. Bragi Walters, Hreinn Stefansson, Kari Stefansson, Anders D. Borglum, Aurina Arnatkeviciute, Mark A. Bellgrove
Summary: This study examined three potential endophenotypes for attention-deficit hyperactivity disorder (ADHD): working memory function, response inhibition, and reaction time variability. The results showed that higher genetic risk for ADHD was associated with higher ADHD traits, as well as poorer working memory performance and increased reaction time variability. Lower working memory performance, poorer response inhibition, and increased reaction time variability were associated with more pronounced ADHD traits. Working memory and reaction time variability partially mediated the relationship between genetic risk for ADHD and ADHD traits, explaining 14% and 16% of the association, respectively.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychology, Clinical
Michael A. Mooney, Christopher Neighbor, Sarah Karalunas, Nathan F. Dieckmann, Molly Nikolas, Elizabeth Nousen, Jessica Tipsord, Xubo Song, Joel T. Nigg
Summary: This study reports on the performance of multiple classification methods in predicting ADHD diagnosis and finds that the multistage Bayesian classifier can predict expert-consensus ADHD diagnosis with high accuracy. In most cases, parent and teacher surveys are sufficient for high-confidence classifications, but some important cases require further evaluation.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Anyi Yang, Edmund T. Rolls, Guiying Dong, Jingnan Du, Yuzhu Li, Jianfeng Feng, Wei Cheng, Xing-Ming Zhao
Summary: This study investigates the neural links between ADHD symptoms and prolonged screen time utilization (STU) using a large-scale dataset. The findings suggest that higher polygenic risk scores for ADHD are associated with longer STU and more severe symptoms. White matter microstructure, particularly in visual-related functions, plays a crucial role in mediating the association between ADHD risk and STU.
Article
Neurosciences
Markus Koelle, Sarah Mackert, Katharina Heckel, Alexandra Philipsen, Martin Ulrich, Georg Groen
Summary: This study found an association between RTV and white matter structural properties of the corticothalamic tract in adults with ADHD, which was not observed in healthy controls.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Psychology, Developmental
Stephanie G. Craig, Margaret D. Weiss, Kristen L. Hudec, Christopher Gibbins
JOURNAL OF ATTENTION DISORDERS
(2020)
Article
Psychology, Developmental
Margaret D. Weiss, Ann C. Childress, Graeme A. E. Donnelly
Summary: PRC-063 demonstrated good tolerability and significant improvement in ADHD symptoms in adults, with a notable impact on symptom reduction. There was no significant impact on sleep quality.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Neurosciences
Merideth A. Addicott, John M. Pearson, Julia C. Schechter, Jeffrey J. Sapyta, Margaret D. Weiss, Scott H. Kollins
Summary: This study found that individuals with ADHD tend to make more exploratory decisions and methylphenidate does not alter this behavior. Exploratory choices are positively associated with ADHD symptoms, suggesting that unexplained variance in ADHD decisions may be due to insufficient value tracking.
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ann C. Childress, Nathalie Beltran, Carl Supnet, Margaret D. Weiss
Summary: The review discusses the development of new stimulant and nonstimulant formulations, particularly those in phase II and III trials. It describes the efficacy, mechanism of action, and adverse effect data of these medications, as well as the abuse liability studies for abuse-deterrent formulations in development. The review highlights a strong pipeline of stimulant and nonstimulant drugs designed to offer improvements in onset and duration of effect, administration timing, and deterrence of abuse.
EXPERT OPINION ON EMERGING DRUGS
(2021)
Article
Psychology, Developmental
Eugene Merzon, Margaret D. Weiss, Samuele Cortese, Ann Rotem, Tzipporah Schneider, Stephanie G. Craig, Shlomo Vinker, Avivit Golan Cohen, Ilan Green, Shai Ashkenazi, Abraham Weizman, Iris Manor
Summary: Age, male sex, and BMI were significant risk factors for increased COVID-19 severity, while ADHD was associated with more severe symptoms and referral to hospitalization in COVID-19 infection.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Clinical Neurology
Margaret Danielle Weiss, Craig Surman, Atul Khullar, Ellie He, Marc Cataldo, Graeme Donnelly
Summary: On average, PRC-063 had no significant impact on overall sleep quality in adults with ADHD. However, when measuring sleep as an outcome in its own right, more patients showed improvement in sleep than deterioration under dose-optimized open-label treatment.
Article
Pediatrics
Margaret Danielle Weiss, Craig Surman, Atul Khullar, Judith Owens, Ellie He, Marc Cataldo, Graeme Donnelly
Summary: The study analyzed the impact of extended-release methylphenidate on sleep parameters in adolescents with attention-deficit/hyperactivity disorder. Results showed a trend of improvement in sleep quality with PRC-063 that was maintained over 6 months, with no significant differences reported in self-reported sleep outcomes between PRC-063 and placebo on the PSQI scale.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2021)
Article
Pediatrics
Margaret D. Weiss, Andrew J. Cutler, Scott H. Kollins, Graeme A. E. Donnelly
Summary: PRC-063 significantly improved ADHD symptomatology in adolescents, especially in the 45 mg and 70 mg dose groups. Some participants were identified as responders based on CGI-I assessment. Further improvements in ADHD symptoms were observed during open-label treatment from 1 month through 6 months.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Eugene Merzon, Margaret Weiss, Beth Krone, Shira Cohen, Gili Ilani, Shlomo Vinker, Avivit Cohen-Golan, Ilan Green, Ariel Israel, Tzipporah Schneider, Shai Ashkenazi, Abraham Weizman, Iris Manor
Summary: This study examines the factors associated with diagnosis of long COVID syndrome in children. The findings show that children with long COVID syndrome are more likely to have severe symptoms, require hospitalization, and have recurrent acute infections. They are also more likely to have ADHD, chronic urticaria, and allergic rhinitis. The study suggests that clinicians should be vigilant for the possibility of long COVID syndrome in children with pre-existing ADHD. Further research on morbidity related to long COVID syndrome in children is needed.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Neurosciences
Margaret Danielle Weiss
Summary: The time frame and definition of functional impairment in DSM 5 is ambiguous. Functional impairment can be classified as a stable trait or a state sensitive to emotional or behavior problems. Treatment outcome measures of functional impairment include change from baseline and status at treatment endpoint.
Editorial Material
Psychology, Developmental
Mark A. Stein, Margaret D. Weiss
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Behnaz Kiani, Habib Hadianfard, Margaret D. Weiss, Sara Dehbozorgi
Summary: The aim of this study was to examine the ability of the WFIRS-P to assess functional impairment in children with ADHD and determine optimal cutoff scores. The results showed that the WFIRS-P had good discriminatory ability, but low sensitivity in the self-concept and life skills subscales.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Lee A. Robinson, Laura Gaugh, Scott Yapo, Rami Al-Sumairi, Aileen Lorenzo, Margaret Weiss
Summary: Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder that poses challenges for many youth, especially those from disadvantaged backgrounds. This study presents a quality improvement initiative aimed at addressing the barriers faced by underserved families seeking a timely diagnosis of ASD.
HEALTHCARE-THE JOURNAL OF DELIVERY SCIENCE AND INNOVATION
(2022)
Article
Psychiatry
Habib Hadianfard, Behnaz Kiani, Margaret D. Weiss
Summary: The study found that 11.9% of children and 29.5% of adolescents showed impairment in at least two functional domains, with life skills being the most frequent impaired domain. While no significant sex and age effects were found during childhood, male adolescents showed more impairment in externalizing domains, and female adolescents showed more internalizing difficulties. In addition, older adolescents showed more functional impairment relative to younger adolescents.
JOURNAL OF THE CANADIAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Mahmut Cem Tarakcioglu, Yasin Caliskan, Muhammed Tayyib Kadak, Nilufer Okumus Aliyev, Umut Mert Aksoy, Ali Evren Tufan, Ozlem Yildiz Gundogdu, Nursu Cakin Memik, Margaret D. Weiss
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
(2020)