Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemical Research Methods
Prabina Kumar Meher, Ansuman Mohapatra, Subhrajit Satpathy, Anuj Sharma, Isha Saini, Sukanta Kumar Pradhan, Anil Rai
Summary: A computational method based on Support Vector Machine (SVM) was developed to identify circadian genes, achieving an accuracy of 62.48%. The method was also applied for proteome-wide identification of circadian proteins in two cereal crops and functional annotation with Gene Ontology terms.
Article
Psychiatry
Simona Iodice, Martina Di Paolo, Jennifer Lynn Barkin, Letizia Tarantini, Silvia Grassi, Marta Redaelli, Marta Serati, Virginia Favalli, Luisa Cirella, Valentina Bollati, Massimiliano Buoli
Summary: The study suggests a role for oxytocin in the development of perinatal depression by promoting a favorable methylation pattern characterized by reduced expression of CRY1 and CRY2. Oxytocin also strengthens the association between maternal prenatal attachment with a favorable pattern of methylation of clock genes and HERV-W, crucial for pregnancy outcomes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Immunology
Feng Ling, Caijie Zhang, Xin Zhao, Xiangyang Xin, Shaozhen Zhao
Summary: This study identified key genes associated with circadian rhythms and explored potential drugs related to these genes in diabetic retinopathy (DR). The findings contribute to a better understanding of the pathogenesis of DR and provide insights for future therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cesar Rodriguez-Santana, Javier Florido, Laura Martinez-Ruiz, Alba Lopez-Rodriguez, Dario Acuna-Castroviejo, Germaine Escames
Summary: The circadian clock system plays a crucial role in regulating various physiological processes, and disruptions in this system have been linked to diseases such as cancer. Tumor cells exhibit abnormal circadian machinery, which affects cell cycle, repair mechanisms, and energy metabolism. Melatonin, produced by the pineal gland, has been shown to regulate clock gene expression in cancer cells, suggesting its potential anti-neoplastic effects. This review aims to explore the role of clock genes in cancer and the mechanisms through which melatonin regulates the tumor's circadian machinery, with the goal of proposing future clinical treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Bala S. C. Koritala, Yin Yeng Lee, Shweta S. Bhadri, Laetitia S. Gaspar, Corinne Stanforth, Gang Wu, Marc D. Ruben, Lauren J. Francey, David F. Smith
Summary: The study used an IH mouse model to investigate the impact of IH on the circadian gene expression in central and peripheral tissues, revealing that the circadian clock in the liver is less sensitive to IH compared to the brain.
Review
Biochemistry & Molecular Biology
Amnon Brzezinski, Seema Rai, Adyasha Purohit, Seithikurippu R. Pandi-Perumal
Summary: Circadian rhythms play a crucial role in controlling reproductive function, with melatonin regulating the reproductive responses of animals to environmental light conditions. Clock genes and circadian rhythms are associated with optimal reproductive performance through the synchronization of endogenous molecular clocks in various tissues throughout the body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Min Yang, Ping He, Xiaoming Xu, Dan Li, Jing Wang, Yanjun Wang, Bin Wang, Wo Wang, Mei Zhao, Hui Lin, Mingming Deng, Tianwei Deng, Li Kuang, Dongfeng Chen
Summary: This study evaluated the disruptions of life, work, and entertainment rhythms during the initial phase of the COVID-19 pandemic in China and found that social rhythm disruption was independently associated with depression and anxiety, especially for those vulnerable to rhythm disruptions.
Review
Physiology
Tamara J. Varcoe, Kathryn L. Gatford, David J. Kennaway
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2018)
Meeting Abstract
Clinical Neurology
C. C. Gupta, J. Dorrian, S. Centofanti, A. Coates, D. Kennaway, G. Wittert, L. Heilbronn, P. Catcheside, M. Noakes, J. Stepien, D. Chandrakumar, D. Coro, S. Banks
Article
Medicine, General & Internal
Tracey L. Sletten, Michelle Magee, Jade M. Murray, Christopher J. Gordon, Nicole Lovato, David J. Kennaway, Stella M. Gwini, Delwyn J. Bartlett, Steven W. Lockley, Leon C. Lace, Ronald R. Grunstein, Shantha M. W. Rajaratnam
Meeting Abstract
Clinical Neurology
C. C. Gupta, J. Dorrian, S. Centofanti, A. Coates, D. Kennaway, G. Wittert, L. Heilbronn, P. Catcheside, M. Noakes, J. Stepien, D. Chandrakumar, D. Coro, S. Banks
Article
Neurosciences
Kathryn L. Gatford, David J. Kennaway, Hong Liu, David O. Kleemann, Timothy R. Kuchel, Tamara J. Varcoe
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Review
Endocrinology & Metabolism
David J. Kennaway
JOURNAL OF PINEAL RESEARCH
(2019)
Article
Clinical Neurology
Jade M. Murray, Andrew J. K. Phillips, Michelle Magee, Tracey L. Sletten, Christopher Gordon, Nicole Lovato, Bei Bei, Delwyn J. Bartlett, David J. Kennaway, Leon C. Lack, Ronald R. Grunstein, Steven W. Lockley, Shantha M. W. Rajaratnam, E. Armstrong, K. Chohan, Y. Djavadkhani, K. Dodds, S. Gunaratnam, M. Hardy, S. Joosten, J. Lee, G. Micic, B. Raman, E. Roese, M. Salkeld, E. Verberne, K. Wong, B. Yee, A. Yeo, K. Yu
Review
Biology
David J. Kennaway
CHRONOBIOLOGY INTERNATIONAL
(2019)
Article
Nutrition & Dietetics
Charlotte C. Gupta, Stephanie Centofanti, Jillian Dorrian, Alison M. Coates, Jacqueline M. Stepien, David Kennaway, Gary Wittert, Leonie Heilbronn, Peter Catcheside, Manny Noakes, Daniel Coro, Dilushi Chandrakumar, Siobhan Banks
Article
Biology
Charlotte C. Gupta, Stephanie Centofanti, Jillian Dorrian, Alison Coates, Jacqueline M. Stepien, David Kennaway, Gary Wittert, Leonie Heilbronn, Peter Catcheside, Manny Noakesh, Daniel Coro, Dilushi Chandrakumar, Siobhan Banks
CHRONOBIOLOGY INTERNATIONAL
(2019)
Review
Endocrinology & Metabolism
David J. Kennaway
JOURNAL OF PINEAL RESEARCH
(2020)
Letter
Oncology
David J. Kennaway
Meeting Abstract
Clinical Neurology
J. Stepien, J. Dorrian, D. Kennaway, A. Coates, C. Yates, S. Centofanti, C. Gupta, G. Wittert, L. Heilbronn, P. G. Catcheside, M. Noakes, R. Matthews, D. Chandrakumar, D. Coro, S. Banks
JOURNAL OF SLEEP RESEARCH
(2019)
Meeting Abstract
Clinical Neurology
R. Matthews, P. Roma, S. Hursh, S. Centofanti, C. Yates, J. Stepien, D. Sidebottom, E. Greer, C. Gupta, J. Dorrian, A. Coates, D. Kennaway, G. Wittert, L. Heilbronn, P. G. Catcheside, M. Noakes, S. Banks
JOURNAL OF SLEEP RESEARCH
(2019)
Article
Ergonomics
Jillian Dorrian, Steven Hursh, Lauren Waggoner, Crystal Grant, Maja Pajcin, Charlotte Gupta, Alison Coates, David Kennaway, Gary Wittert, Leonie Heilbronn, Chris Della Vedova, Siobhan Banks
ACCIDENT ANALYSIS AND PREVENTION
(2019)