Review
Endocrinology & Metabolism
Suhad Ali, Dana Hamam, Xueqing Liu, Jean-Jacques Lebrun
Summary: Breast cancer is a major disease affecting women worldwide, and current treatment strategies are ineffective once metastasis has occurred. Loss of differentiation and increased cellular plasticity and stemness are key drivers of breast cancer heterogeneity and metastasis. However, the hormone prolactin has been found to play a role in inhibiting tumor development and metastasis in breast cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Yuan Li, Xiangyi Kong, Lixue Xuan, Zhongzhao Wang, Yen-Hua Huang
Summary: Breast cancer, divided into different types, can be treated with endocrine therapy, but endocrine resistance may lead to treatment failure. Prolactin, a protein hormone, is related to the development of breast cancer and endocrine therapy resistance. Studying PRL and its receptor helps in reversing endocrine therapy resistance in breast cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Eugenia Landolfo, Debora Cutuli, Laura Petrosini, Carlo Caltagirone
Summary: Palmitoylethanolamide (PEA) is an endogenous lipid mediator that has neuroprotective, anti-inflammatory, and analgesic functions. It is currently used for the treatment of neuropathic pain and shows potential in the treatment of neurodegenerative diseases.
Review
Endocrinology & Metabolism
Raghuveer Kavarthapu, Maria L. L. Dufau
Summary: PRLR plays a crucial role in breast epithelium growth, differentiation, lactation, and breast cancer development. Its expression in humans is controlled by multiple promoters, leading to alternative splice products such as short forms that can inhibit the long form activity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Vedang Murthy, Ketaki Adsul, Priyamvada Maitre, Aarushi Singla, Pallavi Singh, Gitanjali Panigrahi, Vysakh Raveendran, Reena Phurailatpam
Summary: This study compared the urinary and gastrointestinal adverse effects in patients with prostate cancer treated with extreme hypofractionated stereotactic radiation therapy with or without inclusion of pelvic nodal regions. The results showed that overall, WP-SBRT was associated with significantly higher rates of acute gastrointestinal toxic effects and late urinary adverse effects compared with PO-SBRT.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Biotechnology & Applied Microbiology
Yindan Lin, Ze Yang, Jingjia Li, Yandi Sun, Xueyun Zhang, Zihao Qu, Yan Luo, Lihong Zhang
Summary: This study used Mendelian randomization to explore the impact of genetically predicted levels of glutamate and aspartate on the development of prostate and breast cancers. The results showed that serum aspartate level was positively associated with both types of cancer, while glutamate level had no association.
Article
Pharmacology & Pharmacy
Patricia Marques Soares Valente, Paula Nogueira da Silva, Licinio Esmeraldo da Silva, Wolney de Andrade Martins, Selma Rodrigues de Castilho
Summary: This study aimed to identify and classify adverse cardiovascular reactions in breast cancer patients using Trastuzumab. The results showed that Trastuzumab may cause late onset moderate cardiovascular reactions, such as dyspnea, increased blood pressure, fatigue, and reduced left ventricular ejection. Identifying these reactions and understanding the toxicity profile of Trastuzumab is crucial for safe treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
Christopher Jackson, Alexandra L. J. Freeman, Zsofia Szlamka, David J. Spiegelhalter
Summary: This meta-analysis identified and quantified a range of potential adverse effects associated with bisphosphonate drugs in breast cancer patients, most of which are clinically recognized. The study showed that bisphosphonate drugs may lead to various adverse effects, but there was little variation in side effects between patients of different ages, menopausal status, cancer types, and concurrent breast cancer therapies.
Article
Multidisciplinary Sciences
Corinde E. Wiers, Leandro F. Vendruscolo, Jan-Willem Van der Veen, Peter Manza, Ehsan Shokri-Kojori, Danielle S. Kroll, Dana E. Feldman, Katherine L. McPherson, Catherine L. Biesecker, Rui Zhang, Kimberly Herman, Sophie K. Elvig, Janaina C. M. Vendruscolo, Sara A. Turner, Shanna Yang, Melanie Schwandt, Dardo Tomasi, Mackenzie C. Cervenka, Anders Fink-Jensen, Helene Benveniste, Nancy Diazgranados, Gene-Jack Wang, George F. Koob, Nora D. Volkow
Summary: This study suggests that a ketogenic diet may help in managing alcohol withdrawal and reducing alcohol consumption by decreasing the need for benzodiazepines during withdrawal, lowering cravings for alcohol, and improving brain bioenergetics.
Article
Medicine, General & Internal
Olena Kolomiiets, Oleksandr Yazykov, Artem Piddubnyi, Mykola Lyndin, Ivan Lukavenko, Volodymyr Andryushchenko, Anatolii Romaniuk, Roman Moskalenko
Summary: The study revealed that the expression of PRL-R in BBT tissue is not dependent on serum PRL levels, but has a significant correlation with healthy breast tissue. Elevated serum PRL levels do not show a significant correlation with PRL receptor expression and the proliferative marker Ki-67 in BBT tissue. No presence of PRL and its receptors was detected in the BBT cystic fluid of women with elevated serum PRL levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Nan Xu, Theodore J. LaGrow, Nmachi Anumba, Azalea Lee, Xiaodi Zhang, Behnaz Yousefi, Yasmine Bassil, Gloria P. Clavijo, Vahid Khalilzad Sharghi, Eric Maltbie, Lisa Meyer-Baese, Maysam Nezafati, Wen-Ju Pan, Shella Keilholz
Summary: This review examines the similarities and differences between rodents and humans in terms of functional connectivity, focusing on the use of rs-fMRI as a translational tool for cross-species analysis. It compares anatomical features, acquisition parameters, preprocessing techniques, and various aspects of the BOLD fluctuations. The review also discusses the applications of rs-fMRI in neurological and psychiatric disorders and presents open questions for future research.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Rosalin Mishra, Hima Patel, Samar Alanazi, Mary Kate Kilroy, Joan T. Garrett
Summary: The PI3K pathway is crucial in cancer development and is a promising therapeutic target. Clinical trials are ongoing to evaluate the efficacy and potential risks associated with PI3K inhibitors in overcoming resistance to current therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar
Summary: Breast cancer survivors may experience various adverse health effects up to 14 years after diagnosis, including coughing, respiratory and urinary infections, fatigue, sleep problems, osteoporosis, and lymphedema. Understanding individual risks is crucial for healthcare professionals to manage patient expectations and improve monitoring, detection, and treatment of adverse health effects.
Article
Environmental Sciences
Hector Lamphar, Miroslav Kocifaj, Jorge Limon-Romero, Jorge Paredes-Tavares, Safei Diba Chakameh, Michal Mego, Natalia Jorgelina Prado, Yolanda Angelica Baez-Lopez, Emiliano Raul Diez
Summary: Light pollution is a global environmental issue that may be associated with an increase in breast cancer incidence.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: Evidence suggests that women with schizophrenia are more likely to develop breast cancer, especially with prolonged exposure to prolactin-raising antipsychotic drugs. However, there is no statistically significant association with prolactin-sparing antipsychotics. Research on this topic is inconclusive and further studies are needed to evaluate the potential risks involved.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)