Article
Psychiatry
Maja Kesic, Gordana Mokrovic, Ante Tvrdeic, Branko Mise, Jasminka Stefulj, Lipa Cicin-Sain
Summary: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications for treating mood disorders, but individual response to SSRIs varies. Individual serotonin levels may play a role in influencing the biological actions of SSRIs.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Paloma Molina Hernandes, Matheus Fitipaldi Batistela, Heloisa Helena Vilela-Costa, Ana Beatriz Sant 'Ana, Vinicius Dias Kumpel, Mariane Cariati Tirapelle, Ariela de Oliveira Pedro Bom, Telma Goncalves Carneiro Spera de Andrade, Helio Zangrossi Jr
Summary: Changes in 5-HT1A receptor-mediated neurotransmission in the hippocampus are associated with anxiety, depression, and the action of antidepressant drugs. Studies have shown that 5-HT1ARs in the ventral pole play a tonic inhibitory role in anxiety processing, while not being involved in regulating panic-related escape behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Heloisa H. Vilela-Costa, Jhonatan Christian Maraschin, Plinio C. Casarotto, Ana Beatriz Sant'Ana, Valquiria C. de Bortoli, Maria Adrielle Vicente, Alline Cristina Campos, Francisco S. Guimaraes, Helio Zangrossi Jr
Summary: Antidepressant drugs are effective in treating panic disorder, with facilitation of 5-HT1A receptors in the dPAG implicated in panic relief. The panicolytic effect caused by chronic administration of ADs may be related to 5-HT1A receptor-mediated neurotransmission, while the anxiogenic effect of short-term treatment with these drugs may not depend on 5-HT2C receptors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Cell Biology
Priscila Vazquez-Leon, Abraham Miranda-Paez, Kenji Valencia-Flores, Hugo Sanchez-Castillo
Summary: Serotonin is a crucial neurotransmitter that regulates various physiological processes and psychiatric disorders. The periaqueductal gray matter is an important center for defensive behaviors, and electrical stimulation in this region can induce panic, fight-flight, and freezing responses. Serotonergic activity in the periaqueductal gray matter is influenced by other brain areas and the activation of specific receptors, promoting serotonin release. This review emphasizes the role of 5-HT1A and 5-HT2A/C receptors in anxiety, panic, fear, analgesia, and aggression, suggesting their potential for the treatment of mental disorders.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Shama N. Huq, Allison K. Warner, Kerry Buckhaults, Benjamin D. Sachs
Summary: Clinical studies have shown that women are more likely than men to suffer from depression, anxiety, and obesity among individuals who are obese. However, the effects of obesity-promoting diets on depression- and anxiety-like behavior remain controversial.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Rida Nisar, Zehra Batool, Saida Haider
Summary: This study aims to improve the practice of using electric foot-shock to generate anxiety-like symptoms by identifying an optimum current intensity and combining it with behavioral paradigms. The results showed that 1.0 mA electric foot-shock induced abnormal behavioral effects similar to anxiety-like effects. Furthermore, aberrations in various physiological parameters were observed in the rat model of anxiety, which were successfully alleviated by diazepam.
Article
Behavioral Sciences
Daiane Santos Rosa, Alana Tercino Frias, Heloisa Helena Vilela-Costa, Ailton Spiacci, Ana Beatriz Sant'Ana, Eduardo Junji Fusse, Deborah Suchecki, Alline Cristina Campos, Thelma Anderson Lovick, Helio Zangrossi Jr
Summary: There is a wealth of evidence linking disruptions in the parent-infant relationship with panic disorder. In rodents, neonatal maternal separation and deprivation lead to increased anxiety-related responses in adulthood. However, the long-term consequences of these stressors in animal models of panic are not well understood.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Neurosciences
Xuyan Guan, Peng Cao
Summary: This article provides an overview of panic disorder in humans, including its definition, subtypes, models used to trigger panic attacks, related hypotheses, neurotransmitter systems involved, and current clinical treatments. It also discusses animal models of panic-like behavior and brain regions that may be involved, offering insights for further understanding of the neural circuit mechanisms behind panic attacks.
NEUROSCIENCE BULLETIN
(2023)
Article
Clinical Neurology
Man Wu, Yunqing Zhu, Jun Lv, Yu Guo, Ling Yang, Yiping Chen, Wei Tang, Shengping Xiang, Xiaohui Sun, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li
Summary: Anxiety symptoms or generalized anxiety disorder may be important risk factors for cardiovascular diseases among Chinese adults.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Nikita Deo, Gregory Redpath
Summary: This article examines the important role of endocytosis in the cellular basis of depression and anxiety. It provides a detailed explanation of the endocytic regulation of 5-HT receptors and SERT, and explores how SSRIs and hallucinogenic compounds modulate serotonin signaling through endocytosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Sebastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P. Guiard
Summary: The study found that 5d-RFSS mice exhibited strong depressive characteristics in the FST, but the model has limitations in replicating the broad spectrum of depressive symptoms observed in other chronic models. However, it showed a significant impact on the hypothalamic-pituitary-adrenal axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Eun Jung Cha, Sumin Hong, Doo-Heum Park, Seung-Ho Ryu, Jee Hyun Ha, Hong Jun Jeon
Summary: This study aimed to improve our understanding of panic disorder by estimating a network structure of its symptoms using network analysis. The results showed that fear of cognitive dyscontrol, impairment in social functioning, phobic avoidance of situations, and panic-focused anticipatory anxiety were central symptoms in panic disorder. These findings have implications for the etiology of panic disorder and support the efficacy of Cognitive Behavioral Therapy.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemical Research Methods
Kamyar Khoshnevisan, Hadi Baharifar, Farzad Torabi, Mahsa Sadeghi Afjeh, Hassan Maleki, Elham Honarvarfard, Hassan Mohammadi, Sayed Mahmoud Sajjadi-Jazi, Sadegh Mahmoudi-Kohan, Farnoush Faridbod, Bagher Larijani, Farshid Saadat, Reza Faridi Majidi, Mohammad Reza Khorramizadeh
Summary: A new approach for using 5-HT levels as a novel biomarker for diabetes mellitus was considered in this study, utilizing a simple nanocomposite and HPLC method. The sensor showed high selectivity, excellent reproducibility, notable anti-interference ability, and long-term stability. The significant reduction in 5-HT levels in diabetic zebrafish compared to the control group suggests that 5-HT can be applied for early diagnosis of diabetes mellitus.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Psychology, Multidisciplinary
Ashish Vazirani, Titas Bhattacharjee
Summary: This study examines the anxiety response of Indian citizens to the COVID-19 lockdown by measuring responses at both individual and government levels. The researchers found that specific types of anxiety are associated with specific responses, and not all responses are driven by anxiety. The response mechanisms for health and food anxieties differ significantly, and the role of information is not significant in all anxieties.
CURRENT PSYCHOLOGY
(2022)
Article
Environmental Sciences
Asma Al Shuraiqi, Aziz Al-Habsi, Michael J. Barry
Summary: Despite the publication of numerous papers, the effects of fluoxetine on fish behavior remain controversial and contradictory. This study exposed adult zebrafish to various concentrations of fluoxetine and found that the effects varied over time and in a non-monotonic manner, suggesting a complex interaction between the serotonergic system and environmental stimuli.
ENVIRONMENTAL POLLUTION
(2021)
Article
Psychology, Clinical
Ilaria Tarricone, Giuseppe D'Andrea, Hannah E. Jongsma, Sarah Tosato, Charlotte Gayer-Anderson, Simona A. Stilo, Federico Suprani, Conrad Iyegbe, Els van der Ven, Diego Quattrone, Marta di Forti, Eva Velthorst, Paulo Rossi Menezes, Celso Arango, Mara Parellada, Antonio Lasalvia, Caterina La Cascia, Laura Ferraro, Julio Bobes, Miguel Bernardo, Iulio Sanjuan, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Giada Tripoli, Pierre-Michel Llorca, Lieuwe de Haan, Jean-Paul Selten, Andrea Tortelli, Andrei Szoke, Roberto Muratori, Bart P. Rutten, Jim van Os, Peter B. Jones, James B. Kirkbride, Domenico Berardi, Robin M. Murray, Craig Morgan
Summary: The study found that social disadvantages before and after migration, as well as discrepancies between achievements and expectations, were significantly associated with psychosis in migrants, while migration adversities were not. Additionally, there was a dose-response effect between the number of adversities across different phases and the odds of psychosis.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Supriya Misra, Bizu Gelaye, David R. Williams, Karestan C. Koenen, Christina P. C. Borba, Diego Quattrone, Marta Di Forti, Giada Tripoli, Caterina La Cascia, Daniele La Barbera, Laura Ferraro, Ilaria Tarricone, Domenico Berardi, Antonio Lasalvia, Sarah Tosato, Andrei Szoke, Pierre-Michel Llorca, Celso Arango, Andrea Tortelli, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel Bernardo, Julio Sanjuan, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B. Jones, Hannah E. Jongsma, James B. Kirkbride, Bart P. F. Rutten, Jim van Os, Robin M. Murray, Charlotte Gayer-Anderson, Craig Morgan
Summary: This study investigated the relationship between perceived discrimination and the risk of psychotic disorders, particularly in minority ethnic groups. It found that pervasive experiences of discrimination were associated with slightly increased odds of psychotic disorders, with a stronger association seen in minority ethnic groups compared to the ethnic majority. Exploratory mediation analysis suggested that pervasive discrimination minimally explained the excess risk observed in minority ethnic groups.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Monica Aas, Luis Alameda, Marta Di Forti, Diego Quattrone, Paola Dazzan, Antonella Trotta, Laura Ferraro, Victoria Rodriguez, Evangelos Vassos, Pak Sham, Giada Tripoli, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Roberto Muratori, Domenico Berardi, Antonio Lasalvia, Sarah Tosato, Andrei Szoke, Pierre-Michel Llorca, Celso Arango, Andrea Tortelli, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel Bernardo, Julio Sanjuan, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B. Jones, Hannah E. Jongsma, James B. Kirkbride, Bart P. F. Rutten, Jim van Os, Charlotte Gayer-Anderson, Robin M. Murray, Craig Morgan
Summary: This study found possible synergistic effects of childhood adversity experiences and high polygenic risk scores for schizophrenia in the onset of first-episode psychosis. However, larger samples are needed for more precise estimation.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Giada Tripoli, Diego Quattrone, Laura Ferraro, Charlotte Gayer-Anderson, Caterina La Cascia, Daniele La Barbera, Crocettarachele Sartorio, Fabio Seminerio, Victoria Rodriguez, Ilaria Tarricone, Domenico Berardi, Stephane Jamain, Celso Arango, Andrea Tortelli, Pierre-Michel Llorca, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miquel Bernardo, Julio Sanjuan, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Els van der Ven, Peter B. Jones, Hannah E. Jongsma, James B. Kirkbride, Sarah Tosato, Antonio Lasalvia, Alex Richards, Michael O'Donovan, Bart P. F. Rutten, Jim van Os, Craig Morgan, Pak C. Sham, Marta Di Forti, Robin M. Murray, Graham K. Murray
Summary: This study investigates global and specific facial emotion recognition deficits in first-episode psychosis and explores the association between polygenic liability to psychotic disorders and facial emotion recognition.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychiatry
Laura Ferraro, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Craig Morgan, James B. Kirkbride, Alastair G. Cardno, Pak Sham, Giada Tripoli, Lucia Sideli, Fabio Seminerio, Crocettarachele Sartorio, Andrei Szoke, Ilaria Tarricone, Miquel Bernardo, Victoria Rodriguez, Simona A. Stilo, Charlotte Gayer-Anderson, Lieuwe de Haan, Eva Velthorst, Hannah Jongsma, Rutten B. P. Bart, Alexander Richards, Celso Arango, Paulo Rossi Menezez, Antonio Lasalvia, Sarah Tosato, Andrea Tortelli, Cristina Marta Del Ben, Jean-Paul Selten, Peter B. Jones, Jim van Os, Marta Di Forti, Evangelos Vassos, Robin M. Murray
Summary: This study identified four distinct transdiagnostic clusters among first-episode psychosis patients based on their premorbid and cognitive abilities. The study also found differences in polygenic risk scores, patterns of cannabis use, and genetic predisposition to schizophrenia among these clusters.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Daiane Leite da Roza, Marcos Goncalves de Rezende, Regis Eric Maia Barros, Joao Mazzoncini de Azevedo-Marques, Jair Licio Ferreira Santos, Lilian Cristina Correia Morais, Carlos Eugenio de Carvalho Ferreira, Bernadette Cunha Waldvogel, Paulo Rossi Menezes, Cristina Marta Del-Ben
Summary: This study estimated the mortality rates of Brazilian patients after their first psychiatric admission and identified possible risk factors associated with higher mortality rates. The results showed that the mortality rates were three times higher than expected, with the highest rates found in patients with alcohol-related disorders. Male sex, older age, and unemployment significantly increased the risk of mortality from all causes.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Giuseppe D'Andrea, Jatin Lal, Sarah Tosato, Charlotte Gayer-Anderson, Hannah E. Jongsma, Simona A. Stilo, Els van der Ven, Diego Quattrone, Eva Velthorst, Domenico Berardi, Paulo Rossi Menezes, Celso Arango, Mara Parellada, Antonio Lasalvia, Caterina La Cascia, Laura Ferraro, Daniele La Barbera, Lucia Sideli, Julio Bobes, Miguel Bernardo, Julio Sanjuan, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Giada Tripoli, Pierre-Michel Llorca, Lieuwe de Haan, Jean-Paul Selten, Andrea Tortelli, Andrei Szoke, Roberto Muratori, Bart P. Rutten, Jim van Os, Peter B. Jones, James B. Kirkbride, Robin M. Murray, Marta di Forti, Ilaria Tarricone, Craig Morgan
Summary: This study examined the prevalence of child maltreatment (CM) among migrants and found that migrants had a higher prevalence of CM. Migrant status attenuated the association between CM and first-episode psychosis (FEP). The higher exposure to CM among migrants accounted for a greater proportion of FEP cases.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Family Studies
Adriana M. Saur, Jorge Sinval, Cristina M. Del-Ben, Rosangela F. L. Batista, Antonio A. M. Da Silva, Marco A. Barbieri, Heloisa Bettiol
Summary: The aim of this study was to investigate the validity of the Brazilian version of the Postpartum Bonding Questionnaire. The results showed that a one-factor model fit the data well, indicating that the questionnaire is suitable for assessing the mother-infant relationship in the Brazilian general population. The study also highlights the importance of cross-cultural research.
JOURNAL OF CHILD AND FAMILY STUDIES
(2023)
Article
Psychiatry
Fabiana Corsi-Zuelli, Ayda Henriques Schneider, Thamyris Santos-Silva, Camila Marcelino Loureiro, Rosana Shuhama, Paulo Rossi Menezes, Francisco Silveira Guimaraes, Felipe Villela Gomes, Fernando Queiroz Cunha, Paulo Louzada, Cristina Marta Del-Ben
Summary: This study found elevated NETs in the plasma of patients with early schizophrenia, which were related to childhood maltreatment scores, and identified two main clusters through unsupervised clustering analysis.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Cell Biology
N. B. Amaral, T. S. Rodrigues, M. C. Giannini, M. I. Lopes, L. P. Bonjorno, P. I. S. O. Menezes, S. M. Dib, S. L. G. Gigante, M. N. Benatti, U. C. Rezek, L. L. Emrich-Filho, B. A. Sousa, S. C. L. Almeida, R. Luppino-Assad, F. P. Veras, A. H. Schneider, L. O. S. Leiria, L. D. Cunha, J. C. Alves-Filho, T. M. Cunha, E. Arruda, C. H. Miranda, A. Pazin-Filho, M. Auxiliadora-Martins, M. C. Borges, B. A. L. Fonseca, V. R. Bollela, C. M. Del-Ben, F. Q. Cunha, R. C. Santana, F. C. Vilar, D. S. Zamboni, P. Louzada-Junior, R. D. R. Oliveira
Summary: This study evaluated whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients with COVID-19. The results showed that colchicine reduced the need for supplemental oxygen and the length of hospitalization, and lowered the serum levels of Casp1p20 and IL-18 in the first two days of treatment.
INFLAMMATION RESEARCH
(2023)
Meeting Abstract
Psychiatry
G. Correa-Oliveira, L. Scarabelot, J. Morais Araujo, A. Boin, R. Mendes Paula Pessoa, L. Rodrigues Leal, C. Del-Ben
EUROPEAN PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
F. Corsi-Zuelli, C. Loureiro, R. Shuhama, D. Quattrone, B. Deakin, P. Menezes, R. Lacchini, F. Coeli-Lacchini, P. Louzada-Junior, C. Del-Ben
EUROPEAN PSYCHIATRY
(2022)
Article
Psychiatry
B. Pignon, H. Peyre, A. Ayrolles, J. B. Kirkbride, S. Jamain, A. Ferchiou, J. R. Richard, G. Baudin, S. Tosato, H. Jongsma, L. de Haan, I Tarricone, M. Bernardo, E. Velthorst, M. Braca, C. Arango, M. Arrojo, J. Bobes, C. M. Del-Ben, M. Di Forti, C. Gayer-Anderson, P. B. Jones, C. La Cascia, A. Lasalvia, P. R. Menezes, D. Quattrone, J. Sanjuan, J. P. Selten, A. Tortelli, P. M. Llorca, J. van Os, B. P. F. Rutten, R. M. Murray, C. Morgan, M. Leboyer, A. Szoke, F. Schurhoff
Summary: This study on subjects without psychotic disorders suggests that the positive dimension of subclinical psychosis may be particularly influenced by both genetic and environmental factors independently, and interactions between genetic and individual environmental factors were not identified in this sample.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2022)
Article
Psychiatry
Juliana Arantes Figueiredo de Paula Eduardo, Felipe Pinheiro Figueiredo, Marcos Goncalves de Rezende, Daiane Leite da Roza, Stella Felippe de Freitas, Rosangela Fernandes Lucena Batista, Antonio Augusto Moura da Silva, Marco Antonio Barbieri, Ricardo Carvalho Cavalli, Heloisa Bettiol, Alexandre Archanjo Ferraro, Cristina Marta Del-Ben
Summary: Preterm birth and postpartum depression were not found to be significantly associated in two Brazilian cities with different socioeconomic profiles. However, maternal health during pregnancy plays a crucial role in predicting postpartum depression.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Meeting Abstract
Neurosciences
Fabiana Corsi-Zuelli, Diego Quattrone, Taciana Cristina Carvalho Ragazzi, Camila Marcelino Loureiro, Rosana Shuhama, Jim van Os, Paulo Rossi Menezes, Paulo Louzada-Junior, Cristina Marta Del-Ben
BIOLOGICAL PSYCHIATRY
(2022)