Article
Behavioral Sciences
Liangliang Ping, Cong Zhou, Shan Sun, Wenqiang Wang, Qi Zheng, Zhiyi You
Summary: This study investigated the voxel-wise changes of functional connectivity patterns in bipolar disorder (BD) patients using publicly available data. The results showed lower functional connectivity homogeneity values in the left middle temporal gyrus (MTG) in BD patients compared to healthy controls, and decreased functional connectivities between left MTG and other brain regions. The findings also suggested correlations between the functional connectivities of left MTG and symptoms such as insomnia and grandiose delusions in BD patients.
BRAIN AND BEHAVIOR
(2022)
Article
Psychiatry
Charles Okanda Nyatega, Li Qiang, Mohammed Jajere Adamu, Halima Bello Kawuwa
Summary: This study investigated functional abnormalities in the striatum among individuals with bipolar disorder (BD) compared to healthy controls (HC) using MRI evaluations. The findings revealed increased striatal connectivity in BD patients, along with gray matter deficits in specific brain regions. These results suggest that BD may be associated with both structural and functional brain alterations.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Joseph J. Taylor, Hatice Guncu Kurt, Amit Anand
Summary: There are currently no validated treatment biomarkers in psychiatry, with cortico-limbic connectivity being implicated in different analyses, but without a single biomarker being validated or replicated across multiple independent datasets. Further research is needed to identify reliable treatment biomarkers in mood disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Clinical Neurology
Mahan Shafie, Elnaz Shahmohamadi, Giulia Cattarinussi, Hossein Sanjari Moghaddam, Shahin Akhondzadeh, Fabio Sambataro, Chiara Moltrasio, Giuseppe Delvecchio
Summary: This review summarizes the findings of resting-state functional magnetic resonance imaging (rsfMRI) studies in individuals with borderline personality disorder (BPD). The results indicate aberrant functional connectivity within and between several brain networks, including the default mode network (DMN), salience network (SN), and central executive network (CEN), as well as selective functional impairments in specific brain regions. However, the generalizability of these results is limited by the observational design, small sample size, and heterogeneity across imaging methodologies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Gwen van der Wijk, Jacqueline K. Harris, Stefanie Hassel, Andrew D. Davis, Mojdeh Zamyadi, Stephen R. Arnott, Roumen Milev, Raymond W. Lam, Benicio N. Frey, Geoffrey B. Hall, Daniel J. Muller, Susan Rotzinger, Sidney H. Kennedy, Stephen C. Strother, Glenda M. MacQueen, Andrea B. Protzner
Summary: By studying a large group of MDD patients and controls using fMRI data, differences in functional connectivity in patients were identified. Baseline connectivity of the anterior/posterior cingulate and insula seeds could differentiate patients with different treatment outcomes, highlighting features that might predict remission prior to pharmacotherapy.
Article
Psychiatry
Lydia Fortea, Alexander T. Ysbaek-Nielsen, Julian Macoveanu, Jeff Zarp Petersen, Patrick M. Fisher, Lars V. Kessing, Gitte M. Knudsen, Joaquim Radua, Eduard Vieta, Kamilla W. Miskowiak
Summary: This study investigated the relationship between brain connectivity and cognitive impairments in patients with bipolar disorder. The results showed that cognitively impaired patients had stronger connectivity within the default mode network and weaker connectivity within the executive central network. These findings suggest that aberrant connectivity within the default mode network and executive central network may serve as targets for pro-cognitive interventions.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Hua Yu, Ming-Li Li, Yajing Meng, Xiao-Jing Li, Wei Wei, Yin-Fei Li, Lei Li, Wanjun Guo, Qiang Wang, Wei Deng, Xiaohong Ma, Jeremy Coid, Tao Li
Summary: The study found increased functional connectivity between the right inferior frontal gyrus and other brain regions in bipolar patients, as well as decreased connectivity with sensorimotor areas. Impaired sustained attention was observed in bipolar manic and depressive subgroups compared to healthy controls, with manic and psychotic symptoms significantly impacting sustained attention task performance.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
John R. Younce, Meghan C. Campbell, Tamara Hershey, Aaron B. Tanenbaum, Mikhail Milchenko, Mwiza Ushe, Morvarid Karimi, Samer D. Tabbal, Albert E. Kim, Abraham Z. Snyder, Joel S. Perlmutter, Scott A. Norris
Summary: Resting-state functional connectivity MRI may predict motor response to subthalamic nucleus deep brain stimulation, with stronger connectivity between the left subthalamic nucleus and ipsilateral internal globus pallidus correlating with greater improvement in postsurgical motor outcomes. The integrity of pallidal-subthalamic nucleus circuits may be critical to motor benefits from deep brain stimulation.
MOVEMENT DISORDERS
(2021)
Article
Computer Science, Artificial Intelligence
Mingliang Wang, Jiashuang Huang, Mingxia Liu, Daoqiang Zhang
Summary: This study proposes a temporal dynamics learning (TDL) method for network-based brain disease identification using rs-fMRI time-series data. By integrating network feature extraction and classifier training into a unified framework, it addresses the issues of previous studies paying less attention to the evolution of global network structures over time and treating feature extraction and training as separate tasks.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Clinical Neurology
Liqian Cui, Hao Li, Jin Biao Li, Huixing Zeng, Yizhi Zhang, Wenhao Deng, Wenjin Zhou, Liping Cao
Summary: This study found that patients with bipolar I disorder (BP-I) have decreased gray matter volume (GMV) in the cerebellum and disrupted cerebellar-cortex resting-state functional connectivity (FC). This suggests that cerebellar abnormalities may play an important role in the pathogenesis of BP-I.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Aleksandra Miljevic, Neil W. Bailey, Oscar W. Murphy, M. Prabhavi N. Perera, Paul B. Fitzgerald
Summary: The brain works as an organised, network-like structure of functionally interconnected regions, and disruptions to interconnectivity in certain networks have been linked to symptoms of depression and impairments in cognition. This systematic review aimed to synthesize evidence on EEG functional connectivity (FC) in depression. Fifty-two studies were identified, and while consistent findings were found in resting-state studies, no clear conclusions could be drawn about the direction of differences in FC due to inconsistencies in study design and methodology. More robust research is needed to understand the true differences in EEG FC in depression, as characterizing how FC differs in depression is essential for understanding its etiology.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yun-si Liang, Shu-zhe Zhou, Yi-jing Zhang, Xin-lu Cai, Yi Wang, Eric F. C. Cheung, Simon S. Y. Lui, Xin Yu, Kristoffer H. Madsen, Yan-tao Ma, Raymond C. K. Chan
Summary: This study examined the neural mechanisms of empathy impairments in patients with bipolar disorder (BD) and found that cognitive empathy was related to the strength of brain connectivity, with some connections weaker in BD patients compared to healthy controls.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Weijie Bao, Yingxue Gao, Lingxiao Cao, Hailong Li, Jing Liu, Kaili Liang, Xinyue Hu, Lianqing Zhang, Xinyu Hu, Qiyong Gong, Xiaoqi Huang
Summary: Studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit decreased functional connectivity within the default mode network (DMN) and between the affective network (AN) and DMN, while hyperconnectivity between the affective network and somatomotor network (SMN), and between the DMN and SMN is specifically related to PTSD. These results emphasize the impact of trauma on alterations in intrinsic brain networks and highlight disease-associated network changes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Behavioral Sciences
Sabrina K. Syan, Carly McIntyre-Wood, Luciano Minuzzi, Geoffrey Hall, Randi E. McCabe, James MacKillop
Summary: The study reviewed 29 studies that consistently supported the association between obesity and differences in Rs-FC. Specifically, obesity/overweight was associated with DMN hypoconnectivity and salience network hyperconnectivity; increased Rs-FC between the hypothalamus and reward, limbic, and salience networks, as well as decreased Rs-FC between the hypothalamus and cognitive regions; increased power within regions related to inhibition/emotional reasoning; decreased nodal efficiency, degree centrality, and global efficiency.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Xiaofang Hou, Bohui Mei, Fukun Wang, Hua Guo, Shilong Li, Gang Wu, Chen Zang, Bing Cao
Summary: Resting-state functional magnetic resonance imaging studies have revealed significant neural activity pattern alterations in Chinese adults with major depressive disorder (MDD), which may be related to cognitive deficits in self-referential processing and emotional processing. These findings provide important neural markers for the clinical diagnosis and treatment of MDD.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Sonya Grewal, Stuart McKinlay, Flavio Kapczinski, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar
Summary: This systematic review examines the biological markers associated with illness progression in bipolar disorder. It finds that increased ventricular size and reduction of grey matter volume are common brain changes associated with the progression of the disorder. In addition, peripheral inflammatory markers also play a role in this process.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Arela Agako, Lisa Burckell, Randi E. McCabe, Benicio N. Frey, Emily Barrett, Katherine Silang, Sheryl M. Green
Summary: This study developed and evaluated a targeted dialectical behavioral therapy skills group for perinatal women experiencing emotion dysregulation. The findings suggest that this group is effective in reducing emotion dysregulation symptoms and has the potential to improve overall perinatal care.
PSYCHOLOGICAL SERVICES
(2023)
Article
Public, Environmental & Occupational Health
Mario Simjanoski, Taiane de Azevedo Cardoso, Bianca Wollenhaupt-Aguiar, Bianca Pfaffenseller, Vicent Balanza-Martinez, Luciano Minuzzi, Flavio Kapczinski
Summary: This study investigated the association between lifestyle behaviors and symptoms of depression and anxiety during the COVID-19 pandemic in Canada. The results showed that unhealthy lifestyle behaviors were associated with depression and anxiety symptoms, emphasizing the importance of lifestyle medicine education and targeted interventions.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Nancy Ciccone, Maya B. Kovacheff, Benicio N. Frey
Summary: This article provides an update on the epidemiology, pathophysiology, clinical presentation, and diagnosis of premenstrual dysphoric disorder (PMDD), with a focus on the pharmacological management of this condition. Prospective daily symptom monitoring is crucial for accurately diagnosing PMDD. Serotonin-based antidepressants are the recommended first-line treatment, while Chasteberry extract and compounds blocking the synthesis of allopregnanolone may be effective in mild to moderate cases.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Maiko A. Schneider, Devon Malhotra, Poli M. Spritzer, Taylor Hatchard, Luciano Minuzzi, Benicio N. Frey, Sasha A. Haefner, Andrew Nicholson, Margaret McKinnon, Sabrina K. Syan, Taiane de Azevedo Cardoso, Karine Schwarz, Mauricio Anes, Alejandro Santos-Diaz, Maria I. R. Lobato
Summary: This study investigated the effect of estradiol treatment on glutamate concentration in the brain in trans women. The results showed that estradiol increased and semantic memory improved after 60 days of treatment. Additionally, there was a positive correlation between glutamate in the DLPFC and working memory recall during the treatment phase. These findings suggest that estradiol replacement may have therapeutic effects on cognitive decline and impairment in post-gonadectomy trans women.
NEUROENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Karen Jansen, Mateus Grellert, Adile Nexha, Jean Pierre Oses, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Flavio Kapczinski, Benicio N. Frey, Taiane de Azevedo Cardoso
Summary: This study examines whether the link between mothers diagnosed with bipolar disorder and emotional and behavioral problems in their offspring is mediated by disruptions in the offspring's biological rhythms. The findings show that offspring of mothers with bipolar disorder have more difficulty in maintaining biological rhythms and a higher prevalence of emotional and behavioral problems compared to offspring of mothers without bipolar disorder. Therefore, disruptions in the biological rhythms of the offspring fully mediate the impact of the mother's bipolar disorder on their emotional and behavioral problems.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Leonardo Carvalho Oliveira, Natalia Wirowski, Pedro Borges de Souza, Andressa Schneider Lobato, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Jean Pierre Oses, Flavio Kapczinski, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: This study aims to compare the serum cytokine levels between controls, individuals with a current depressive episode (CDE) with childhood trauma and individuals with CDE without childhood trauma. The study found that individuals with CDE had elevated levels of certain cytokines compared to the control group, while other cytokines showed decreased levels. However, there was no significant difference in cytokine levels between individuals with CDE, with and without trauma. The findings suggest that monitoring cytokine levels may be beneficial in preventing the development of a CDE.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Coral Rakovski, Pedro L. Ballester, Bruno Braga Montezano, Luciano Dias de Mattos Souza, Karen Jansen, Ricardo Azevedo da Silva, Thaise Campos Mondin, Fernanda Pedrotti Moreira, Raquel Brandini De Boni, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This study employed machine learning techniques to identify predictors of illicit substance abuse/dependence among a large community sample of young adults in Brazil. The strongest predictors included alcohol abuse/dependence, tobacco abuse/dependence, current major depressive episode, history of a lifetime manic episode, current suicide risk, and male sex. The findings indicate that machine learning techniques can accurately predict illicit substance abuse/dependence among young adults using sociodemographic/clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Jee Su Suh, Christopher D. Rowley, Manpreet Sehmbi, Christine L. Tardif, Luciano Minuzzi, Nicholas A. Bock, Benicio N. Frey
Summary: Age-related changes in intracortical myelin differ between bipolar disorder (BD) and healthy controls (HC), particularly at varying cortical depths. This study compared BD and HC participants and found that only HC exhibited age-related changes at certain cortical depths. These findings may suggest abnormal brain structure in BD and lifetime disease burden.
Review
Behavioral Sciences
Mario Simjanoski, Swara Patel, Raquel De Boni, Vicent Balanza-Martinez, Benicio N. Frey, Luciano Minuzzi, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This review and meta-analysis examine interventions targeting the 6 pillars of Lifestyle Psychiatry for bipolar disorder. The study found that sleep, physical activity, and diet were the most targeted domains, while substance use, stress management, and social relationships were least targeted. Combined diet and physical activity interventions showed significant improvement in depressive symptoms and functioning. Sleep interventions also led to significant improvements in depressive symptoms. Future research should focus on developing multidimensional lifestyle interventions for better outcomes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Molly L. Scarfe, Kyla Belisario, Jessica Gillard, Jane De Jesus, Benicio N. Frey, Michael Van Ameringen, Margaret C. McKinnon, Mahmood R. Gohari, Jason W. Busse, James MacKillop
Summary: This study examined the mental health changes during the COVID-19 pandemic through 10 waves of data collection. Depression and anxiety showed significant changes, initially increasing and then decreasing over time. The severity of depression and anxiety before the pandemic moderated these changes, with lower severity participants experiencing increases and higher severity participants showing no significant change or decreases. Approximately 10% to 11% exhibited minimal important differences (MID) increases in depression and anxiety, while approximately 4% to 6% exhibited MID decreases.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Ana Teresa Caliman-Fontes, Gustavo C. Leal, Fernanda S. Correia-Melo, Camilla S. Paixao, Michelle S. Carvalho, Ana Paula Jesus-Nunes, Flavia Vieira, Guilherme Magnavita, Igor D. Bandeira, Rodrigo P. Mello, Graziele Beanes, Samantha S. Silva, Mariana Echegaray, Lucas P. Carvalho, Paulo Machado, Aline S. Sampaio, Taiane de A. Cardoso, Flavio Kapczinski, Acioly L. T. Lacerda, Lucas C. Quarantini
Summary: Evidence suggests that the influence of ketamine on BDNF may play a role in its rapid antidepressant action. However, this study found no significant impact of ketamine or esketamine on serum BDNF levels in treatment-resistant depression (TRD) patients. Both drugs showed similar therapeutic effects, and there was no association between BDNF levels and treatment response or severity of depressive symptoms.
TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY
(2023)
Review
Psychiatry
Dante Duarte, Mirret M. El-Hagrassy, Tiago Couto, Wagner Gurgel, Luciano Minuzzi, Karen Saperson, Humberto Correa
Summary: Suicide among physicians, particularly female physicians, deserves attention as it has been found that post-1980 suicide mortality rates are higher for female physicians compared to women in the general population, while male physicians have lower rates than men in general. This article discusses the limitations of epidemiological data, the presence of psychiatric comorbidities, and the impact of professional workload on physician suicides. Additionally, it addresses the role of healthcare judicialization and organizational failures in increasing physician burnout.
TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY
(2023)
Article
Cell Biology
Carine Moigneu, Soumia Abdellaoui, Mariana Ramos-Brossier, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar, Taiane de Azevedo Cardoso, Aurelie Chiche, Nicolas Kuperwasser, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira, Han Li, Franck Oury, Flavio Kapczinski, Pierre-Marie Lledo, Lida Katsimpardi
Summary: Moigneu, Abdellaoui and colleagues discovered that GDF11 can alleviate depression symptoms and improve memory in aged mice by promoting neuronal autophagy and inhibiting mTOR activity. Low levels of GDF11 are associated with depression in human patients. This study provides insights into the mechanisms of GDF11 in the brain and suggests its potential as an antidepressant candidate and biomarker.
