Article
Neuroimaging
Miriam Langerbeck, Teresa Baggio, Irene Messina, Salil Bhat, Alessandro Grecucci
Summary: This study used the machine learning method KRR to investigate the neural correlates of subclinical borderline personality traits (BPT). The results showed that certain brain regions, including the frontal and parietal regions, as well as other structures, could predict borderline traits. Additionally, the study confirmed the role of the default mode network in borderline personality disorder (BPD) and found that the BPT circuit was not able to predict histrionic traits.
NEUROIMAGE-CLINICAL
(2023)
Review
Medicine, General & Internal
Tina Wu, Jennifer Hu, Dimitry Davydow, Heather Huang, Margaret Spottswood, Hsiang Huang
Summary: Borderline personality disorder is a common mental health diagnosis observed in the primary care population and is associated with various challenges in diagnosis and treatment. This article aims to describe the impact of BPD in primary care, review current knowledge, and provide evidence-based treatment approaches for these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Veronica Guillen, Sara Bolo, Sara Fonseca-Baeza, Sandra Perez, Joaquin Garcia-Alandete, Cristina Botella, Jose Heliodoro Marco
Summary: This study aimed to explore the clinical symptomatology in parents of people diagnosed with Borderline Personality Disorder (BPD) and compare them with a sample of people without a relative with a personality disorder. The results showed that parents of people with BPD exhibited greater depressive and anxious symptomatology, higher levels of expressed emotion, and worse quality of life. Additionally, a high percentage of these parents (50%) met the diagnostic criteria for different personality disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
J. Lumikukka Socada, John J. Soderholm, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: This study investigated the prevalence, severity, co-occurrence, and overlap of manic symptoms and borderline personality features in unipolar and bipolar major depressive episodes. The results showed that the presence of mixed and borderline features in MDEs is common, with differences in diagnosis-specific features among different subcohorts. The study highlighted the impact of hypomania on perceived BPD features and the correlation between manic symptoms and borderline features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Julieta Ramos-Loyo, Cristina Juarez-Garcia, Luis A. Llamas-Alonso, Armando Q. Angulo-Chavira, Rebeca Romo-Vazquez, Hugo Velez-Perez
Summary: Borderline personality disorder patients show greater neural effort in response inhibition tasks in the presence of emotional contexts, which is correlated with more pronounced psychopathological symptoms. They also exhibit lower synchronization between cortical regions, possibly indicating disrupted temporal coupling during emotional stimuli processing.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Karen Kelley, Maggie Walgren, Hilary L. DeShong
Summary: This study found that anger rumination is the strongest predictor of both antisocial and borderline symptoms, while worry negatively predicts antisocial symptoms. Rumination and worry explain far more variance in borderline symptoms compared to antisocial symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Frank D. Buono, Kaitlyn Larkin, David Rowe, M. Mercedes Perez-Rodriguez, Matthew E. Sprong, Amir Garakani
Summary: This study compared the benefits of a 28-day transitional DBT treatment program for individuals with BPD with and without substance use disorders, showing significant differences between the two groups in improvement of coping skills and depressive symptoms. After the treatment program, there were significant decreases from severe to moderate depression scores in both groups, supporting the effectiveness of DBT treatment in patients with comorbid BPD and SUD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Joana Henriques-Calado, Bruno Goncalves, Catarina Marques, Marco Paulino, Joao Gama Marques, Jaime Gracio, Rute Pires
Summary: This study aims to identify the best set of predictors to differentiate between borderline personality disorder and bipolar spectrum disorders. The results indicate that the major common discriminants of borderline PD across the bipolar spectrum are unusual beliefs & experiences, paranoid ideation, obsession-compulsion and extraversion. Depressivity and impulsivity traits display the greatest predictive value in the differential diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Mark Zimmerman, Caroline Balling, Iwona Chelminski, Kristy Dalrymple
Summary: Patients with both bipolar disorder and BPD exhibit more severe psychosocial morbidity compared to those with only one of these disorders.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Gordon Parker, Adam Bayes, Michael J. Spoelma
Summary: The comorbidity of bipolar disorder (BD) and borderline personality disorder (BPD) is higher in community samples than expected and the reasons for this phenomenon are still unclear. This paper reviews previous explanations, considers new potential causes, and emphasizes the role of transdiagnostic features and genetic influences. Measurement errors in diagnostic assignment may have affected previous studies and led to misleading interpretations.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Florence Gressier, Nine M. C. Glangeaud-Freudenthal, Bruno Falissard, Anne-Laure Sutter-Dallay
Summary: This study found that women with MDPE-BPD were more likely to report a history of childhood maltreatment, being single, low social support, a history of depression, smoking during pregnancy, and suicide attempt during the perinatal period. These women had longer hospital stays and were more likely to experience neglect, abuse, and separation in infant care.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Catarina Rosada, Martin Bauer, Sabrina Golde, Sophie Metz, Stefan Roepke, Christian Otte, Claudia Buss, Katja Wingenfeld
Summary: This study compared cortical thickness in healthy women, women with posttraumatic stress disorder (PTSD), and women with borderline personality disorder (BPD). The findings showed that reduced cortical thickness in the occipital lobe and frontal and cingulate cortex may be related to childhood trauma and serve as neuroanatomical markers for BPD.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Livia Graumann, An Bin Cho, Eugenia Kulakova, Christian Eric Deuter, Oliver T. Wolf, Stefan Roepke, Julian Hellmann-Regen, Christian Otte, Katja Wingenfeld
Summary: The aim of this study was to investigate the effects of perceived social exclusion without accompanying cortisol increase on empathy in women with BPD and healthy women. The findings showed that women with BPD reported lower emotional empathy for positive emotions, but not for negative emotions. Additionally, emotional empathy in women with BPD seems to be more sensitive to the effects of stress or ambiguous social situations.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychology, Social
Gareth Richards, Sally Kelly, Darren Johnson, John Galvin
Summary: The co-occurrence of autism and borderline personality disorder (BPD) has been found to be more prevalent in women than men. However, the relationship between these conditions and the traits in the general population are still poorly understood. Two studies were conducted in UK and US adults, confirming the positive correlation between autistic and BPD traits in both samples. Furthermore, it was found that the association between autistic traits and BPD traits becomes non-significant once anxiety and depression symptoms are controlled for in the UK sample, while specific domains of autistic traits remained significantly associated with BPD traits in the US sample.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2023)
Article
Psychiatry
Peter Beiling, Susan Schurig, Andrea Keller, Kerstin Weidner, Rene Noack
Summary: This study investigated the relationship between therapeutic alliance and therapy outcome in patient groups with borderline personality disorder (BPD) and obsessive-compulsive personality disorder (OCPD). The results showed that the alliance was a significant predictor of symptom reduction, especially in the OCPD group. Building a strong alliance and measuring it early in therapy may be particularly beneficial for OCPD patients. Regular screening of the therapeutic alliance may be helpful for BPD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Developmental Biology
Karen Hillmann, Corinne Neukel, Johannes Zimmermann, Anna Fuchs, Anna-Lena Zietlow, Eva Moehler, Sabine C. Herpertz, Michael Kaess, Katja Bertsch
Summary: Early life maltreatment (ELM) and maternal mental disorders are associated with higher cortisol levels in children upon awakening (S1), with maternal cortisol predicting child cortisol levels. Maternal ELM and psychopathology may impact the child's endocrine stress system, highlighting the importance of early life experiences in intergenerational mental health outcomes.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Article
Psychology, Biological
Julian Koenig, Birgit Abler, Ingrid Agartz, Torbjorn akerstedt, Ole A. Andreassen, Mia Anthony, Karl-Juergen Baer, Katja Bertsch, Rebecca C. Brown, Romuald Brunner, Luca Carnevali, Hugo D. Critchley, Kathryn R. Cullen, Eco J. C. de Geus, Feliberto de la Cruz, Isabel Dziobek, Marc D. Ferger, Hakan Fischer, Herta Flor, Michael Gaebler, Peter J. Gianaros, Melita J. Giummarra, Steven G. Greening, Simon Guendelman, James A. J. Heathers, Sabine C. Herpertz, Mandy X. Hu, Sebastian Jentschke, Michael Kaess, Tobias Kaufmann, Bonnie Klimes-Dougan, Stefan Koelsch, Marlene Krauch, Deniz Kumral, Femke Lamers, Tae-Ho Lee, Mats Lekander, Feng Lin, Martin Lotze, Elena Makovac, Matteo Mancini, Falk Mancke, Kristoffer N. T. Mansson, Stephen B. Manuck, Mara Mather, Frances Meeten, Jungwon Min, Bryon Mueller, Vera Muench, Frauke Nees, Lin Nga, Gustav Nilsonne, Daniela Ordonez Acuna, Berge Osnes, Cristina Ottaviani, Brenda W. J. H. Penninx, Allison Ponzio, Govinda R. Poudel, Janis Reinelt, Ping Ren, Michiko Sakaki, Andy Schumann, Lin Sorensen, Karsten Specht, Joana Straub, Sandra Tamm, Michelle Thai, Julian F. Thayer, Benjamin Ubani, Denise J. van Der Mee, Laura S. van Velzen, Carlos Ventura-Bort, Arno Villringer, David R. Watson, Luqing Wei, Julia Wendt, Melinda Westlund Schreiner, Lars T. Westlye, Mathias Weymar, Tobias Winkelmann, Guo-Rong Wu, Hyun Joo Yoo, Daniel S. Quintana
Summary: The decline in heart rate variability (HRV) and cortical thickness (CT) with increasing age was observed, with CT, particularly in the orbitofrontal cortex, explaining additional variance in HRV beyond the effects of aging. These effects were independent of sex and specific to HRV, with no significant association between CT and heart rate. The findings suggest that greater CT across adulthood may be crucial for maintaining healthy cardiac regulation, and greater cardiac vagal activity as reflected in HRV may slow brain atrophy.
Article
Psychiatry
Katja I. Seitz, Johanna Leitenstorfer, Marlene Krauch, Karen Hillmann, Sabrina Boll, Kai Ueltzhoeffer, Corinne Neukel, Nikolaus Kleindienst, Sabine C. Herpertz, Katja Bertsch
Summary: The study found that patients with BPD exhibit hypersensitivity to interpersonal threat cues and tend to misclassify emotional faces as angry, which is correlated with self-reported adverse childhood experiences. Further research is needed to clarify the specificity of altered visual attention allocation and the role of childhood trauma in anger recognition in patients with BPD.
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2021)
Article
Multidisciplinary Sciences
Johanna Hepp, Pascal J. Kieslich, Andrea M. Wycoff, Katja Bertsch, Christian Schmahl, Inga Niedtfeld
Summary: Individuals with Borderline Personality Disorder (BPD) or Social Anxiety Disorder (SAD) tend to have difficulties in establishing social bonds and forming negative first impressions of others. This study compared the impression formation of women with BPD or SAD to healthy women (HCs) using the Thin Slices paradigm, finding that BPD and SAD raters were more likely to agree with negative adjectives and reject positive adjectives. Despite expectations, there were similar levels of cognitive conflict among BPD and SAD raters, with all three groups experiencing substantial conflict when agreeing with negative adjectives.
Article
Psychiatry
Marius Schmitz, Katja Bertsch, Annette Loeffler, Sylvia Steinmann, Sabine C. Herpertz, Robin Bekrater-Bodmann
Summary: The study reveals that certain dimensions of body connection are disturbed in patients with BPD, with body dissociation being an important feature linking a history of traumatic childhood experiences to current deficits in emotion regulation.
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2021)
Article
Psychology, Biological
Andre Schulz, Sarah N. Back, Violetta K. Schaan, Katja Bertsch, Claus Voegele
Summary: Interoceptive accuracy (IAcc) assessed with the heartbeat counting task (IAcc(HBCT)) can be influenced by factors such as the ability to detect cardiac signals effectively (measured by IAcc in a heartbeat discrimination task, IAcc(HBDT)), cardiac signal properties impacted by sympathetic and parasympathetic tone, and non-interoceptive processes like time estimation accuracy (TEAcc). This study found that IAcc(HBDT) scores were the strongest and most consistent predictor of absolute and Delta IAcc(HBCT) scores across different orthostatic conditions. Cardiac signal properties and TEAcc did not predict IAcc(HBCT) scores. These results support the validity of absolute and Delta IAcc(HBCT) scores.
BIOLOGICAL PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Katja Seitz, Nicola Ehler, Marius Schmitz, Sara E. Schmitz, Isabel Dziobek, Sabine C. Herpertz, Katja Bertsch
Summary: Childhood trauma is associated with impairments in theory of mind, particularly in individuals with PTSD. Different mental disorders show varying levels of theory of mind performance, and childhood trauma is negatively correlated with theory of mind abilities.
BRITISH JOURNAL OF CLINICAL PSYCHOLOGY
(2022)
Article
Psychiatry
Karen Hillmann, Corinne Neukel, Marlene Krauch, Angelika Spohn, Knut Schnell, Sabine C. Herpertz, Katja Bertsch
Summary: Empirical studies have shown deficits in cognitive and affective theory of mind in patients with borderline personality disorder, possibly related to a more negative affective state raised by false-belief stories.
JOURNAL OF PERSONALITY DISORDERS
(2021)
Article
Clinical Neurology
Sarah N. Back, Marius Schmitz, Julian Koenig, Max Zettl, Nikolaus Kleindienst, Sabine C. Herpertz, Katja Bertsch
Summary: This study found that reduced heart-rate variability (HRV) in individuals with borderline personality disorder (BPD) is associated with childhood trauma and attachment insecurity. However, intranasal oxytocin administration did not have a significant effect on HRV, and there was no interaction effect between childhood trauma and attachment insecurity.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Review
Psychiatry
Peter Falkai, Nikolaos Koutsouleris, Katja Bertsch, Mirko Bialas, Elisabeth Binder, Markus Buehner, Alena Buyx, Na Cai, Silvia Cappello, Thomas Ehring, Jochen Gensichen, Johannes Hamann, Alkomiet Hasan, Peter Henningsen, Stefan Leucht, Karl Heinz Moehrmann, Elisabeth Nagelstutz, Frank Padberg, Annette Peters, Lea Pfaeffel, Daniela Reich-Erkelenz, Valentin Riedl, Daniel Rueckert, Andrea Schmitt, Gerd Schulte-Koerne, Elfriede Scheuring, Thomas G. Schulze, Rudolf Starzengruber, Susanne Stier, Fabian J. Theis, Juliane Winkelmann, Wolfgang Wurst, Josef Priller
Summary: The Federal Ministry of Education and Research has issued a call for a nationwide research network on mental disorders, the German Center of Mental Health. This center aims to reduce chronicity and mortality of mental illnesses by deepening understanding, predicting accurately, and providing personalized prevention and therapeutic management.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Pediatrics
Lea Teresa Jendreizik, Christopher Hautmann, Elena von Wirth, Christina Dose, Ann-Kathrin Thoene, Anne-Katrin Treier, Tobias Banaschewski, Katja Becker, Daniel Brandeis, Julia Geissler, Johannes Hebebrand, Sarah Hohmann, Martin Holtmann, Michael Huss, Thomas Jans, Anna Kaiser, Sabina Millenet, Luise Poustka, Priska Schneider, Manfred Doepfner
Summary: This study examines the effects of family adversity, parental psychopathology, and parenting practices on symptoms of ADHD and ODD in children. It reveals that family adversity and parental psychopathology are directly associated with both ADHD and ODD symptoms, while negative parenting practices only relate to ODD symptoms. The detrimental effect of negative parenting practices is stronger in girls. Positive parenting practices show no significant associations with ADHD or ODD symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2022)
Article
Psychology, Clinical
Ann-Kathrin Thoene, Christina Dose, Michaela Junghaenel, Christopher Hautmann, Lea Teresa Jendreizik, Anne-Katrin Treier, Paula Vetter, Elena von Wirth, Tobias Banaschewski, Katja Becker, Daniel Brandeis, Ute Duerrwaechter, Julia Geissler, Johannes Hebebrand, Sarah Hohmann, Martin Holtmann, Michael Huss, Thomas Jans, Anna Kaiser, Johanna Ketter, Tanja Legenbauer, Sabina Millenet, Luise Poustka, Tobias Renner, Marcel Romanos, Henrik Uebel-von Sandersleben, Priska S. Schneider, Jasmin Wenning, Mirjam Ziegler, Anja Goertz-Dorten, Manfred Doepfner
Summary: This study examines how symptoms of ADHD and disruptive behavior disorders (ODD, CD, CU) relate to functional impairment (FI). The findings reveal the impact of individual symptoms on global FI and identify the strongest associations with FI domains. The study highlights the importance of analyzing individual symptoms and emphasizes the clinical usefulness of symptom-based approaches.
JOURNAL OF PSYCHOPATHOLOGY AND BEHAVIORAL ASSESSMENT
(2023)
Article
Psychiatry
Matthias A. Reinhard, Stephanie Rek, Tabea Nenov-Matt, Barbara B. Barton, Julia Dewald-Kaufmann, Katharina Merz, Richard Musil, Andrea Jobst, Eva-Lotta Brakemeier, Katja Bertsch, Frank Padberg
Summary: Loneliness is strongly associated with childhood maltreatment, especially emotional neglect and abuse, and mediates the relationship between childhood maltreatment and depressive symptoms, while social network size does not have the same impact.
EUROPEAN PSYCHIATRY
(2022)
Article
Psychiatry
Max Zettl, Zeynep Akin, Sarah Back, Svenja Taubner, Kirstin Goth, Catharina Zehetmair, Christoph Nikendei, Katja Bertsch
Summary: Refugees are at risk for the development of mental disorders due to exposure to stressors and traumatic events. This study found that young refugees had higher levels of identity diffusion and maladaptive personality traits compared to migrants.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Marius Schmitz, Laura E. Muller, Katja Seitz, Andre Schulz, Sylvia Steinmann, Sabine C. Herpertz, Katja Bertsch
Summary: This study aimed to investigate the cortical representation of cardiac interoceptive signals in patients with PTSD and its associations with early life maltreatment, trait dissociation, and emotion dysregulation. The results showed no deficits in interoceptive signal representation at rest in individuals with PTSD. Further studies are needed to explore whether patients with PTSD show altered HEP modulations during emotion regulation tasks and might benefit from therapeutic approaches targeting bodily signals perception.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2021)