Article
Nutrition & Dietetics
Jia-Quan Liang, Xi Chen, Yong Cheng
Summary: The study demonstrates that paeoniflorin can alleviate schizophrenia-like behaviors through inhibiting the oxidative stress pathway. The potential mechanisms of restoring neuronal expression and preventing neurotoxicity were also revealed.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Francini Franscescon, Thiele P. Souza, Talise E. Muller, Paula Michelotti, Julia Canzian, Flavia Stefanello, Denis B. Rosemberg
Summary: Schizophrenia is a chronic neuropsychiatric disorder characterized by a shortened lifespan and impaired social and vocational functioning, often involving dysfunctions in the hypothalamic-pituitary-adrenal axis and cortisol regulation. Taurine, with its neuroprotective properties, shows promise in targeting various brain disorders, including schizophrenia, by modulating behaviors and neuroendocrine responses. The study on zebrafish models suggests that taurine can have a protective effect on behaviors and neuroendocrine responses associated with MK-801-induced schizophrenia-like phenotypes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zhu
Summary: Treatment with MK-801 enhances proliferation of hippocampal astrocytes and upregulates BDNF mRNA expression. The NMDA, PI3K, and ERK1/2 signaling pathways may be involved in regulating MK-801-induced BDNF upregulation. These findings suggest that astrocytes may play a role in the acute neurological and behavioral response to MK-801 treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Masahito Sawahata, Hiroki Asano, Taku Nagai, Norimichi Ito, Takao Kohno, Toshitaka Nabeshima, Mitsuharu Hattori, Kiyofumi Yamada
Summary: The study showed that microinjection of recombinant Reelin into the medial prefrontal cortex prevented recognition memory impairment induced by MK-801, highlighting the potential therapeutic effects of Reelin on cognitive deficits associated with schizophrenia. Despite this positive effect, Reelin treatment did not ameliorate deficits in sensory-motor gating and short-term memory in the animal model of schizophrenia. The results suggest that Reelin acts on its receptors to suppress neural activity in the mPFC, thereby preventing cognitive deficits induced by MK-801.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Plant Sciences
Yongwoo Jeong, Ho Jung Bae, Keontae Park, Hyo Jeoung Bae, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Dae Sik Jang, Jong Hoon Ryu
Summary: Scrophularia buergeriana may be a potential treatment for mental illness, especially schizophrenia, by supplying kidney Yin and reducing blood heat to alleviate symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Patrick Latuske, Moritz von Heimendahl, Serena Deiana, Carsten T. Wotjak, Johann du Hoffmann
Summary: Cognitive flexibility is crucial for healthy functioning and is often impaired in neuropsychiatric diseases. Probabilistic reversal learning (PRL), a commonly used method to measure cognitive flexibility, is often limited in rodents. A novel rat PRL task that occurs at longer intervals demonstrates increased sensitivity to drugs, offering potential for testing and developing novel treatments for cognitive impairment in human patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Hyo Jeoung Bae, Ho Jung Bae, Jae Youn Kim, Keontae Park, Xingquan Yang, Seo Yun Jung, Se Jin Park, Dong Hyun Kim, Chan Young Shin, Jong Hoon Ryu
Summary: Schizophrenia is associated with neuroinflammation and elevated cytokine levels. Lansoprazole, a proton pump inhibitor, has been found to reduce neurotoxicity and inflammatory cytokines. This study investigated whether lansoprazole could ameliorate schizophrenia-like symptoms in mice. Results showed that lansoprazole improved sensorimotor gating deficits, spatial learning, and social deficits, without causing motor coordination deficits. Lansoprazole also decreased inflammatory cytokines in the cortex but not in the hippocampus. These findings suggest that lansoprazole could be a potential treatment for schizophrenia patients with specific symptoms, without motor-related adverse effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Environmental Sciences
Murat Sirri Akosman, Ruhi Turkmen, Hasan Huseyin Demirel
Summary: The study demonstrated that resveratrol has a protective effect against glial cell infiltration and shrinkage of nerve cell nuclei induced by MK-801 in the brain. However, it did not correct behavioral disorders and demyelination of schizophrenia. Resveratrol partially prevented oxidative damage but not significantly.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Neurosciences
Jinwei Xu, Yaohao Li, Biqing Tian, Haiying Liu, Shengxi Wu, Wenting Wang
Summary: This article investigates the effect of environmental enrichment on cognitive symptoms in schizophrenia and explores the significance of NMDA receptor hypofunction in cognitive impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Jae Youn Kim, Chang Hyeon Kong, Do Yeon Kim, Ji Won Min, Keontae Park, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jong Hoon Ryu
Summary: In this study, we investigated the potential of D-pinitol to ameliorate schizophrenia-like behaviors induced by MK-801. The results showed that single administration of D-pinitol improved sensorimotor gating deficits, social behavior deficits, and cognitive impairments induced by MK-801 without causing motor coordination deficits.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hao Zhu, Yu Yang, Min Zhu, Xiao Shi, Le Ye, Song Zhang, Hongwei Fang, Wenjuan Yu
Summary: The study revealed that MK-801 treatment enhanced astrocytic viability, elevating the expression and secretion levels of IL1β, IL6, and TNFα, while decreasing IL10 expression, possibly through the regulation of the ERK1/2 and PI3K signaling pathways.
Article
Biochemistry & Molecular Biology
Paulina Cieslik, Anna Siekierzycka, Adrianna Radulska, Agata Ploska, Grzegorz Burnat, Piotr Branski, Leszek Kalinowski, Joanna M. Wieronska
Summary: The study reveals that chronic administration of MK-801 or scopolamine decreases the availability of L-arginine and alters its derivatives in the brain. Both compounds impair eNOS-derived NO production, with no significant impact on nNOS. They also affect the expression of various enzymes and proteins related to NO pathways. MK-801 induces a decrease in cGMP levels and NMDA expression in the hippocampus, while scopolamine administration results in increased cGMP production and decreased NMDA receptor expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Gang Li, Shijie Xu, Ung Gu Kang
Summary: Repeated administration of drugs of abuse leads to behavioral sensitization, which is also observed with MK-801, a NMDA receptor antagonist. This study investigated the characteristics of MK-801-induced behavioral sensitization and found that it occurred rapidly with only five consecutive treatments. The optimal dose for sensitization was identified, which corresponded to typical doses of abused NMDA antagonists. Changes were observed in the expression and phosphorylation of NMDA receptor subunits after MK-801-induced behavioral sensitization.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Qian Wang, Meng-wei Wang, Yan-yun Sun, Xiao-yan Hu, Pan-pan Geng, Hui Shu, Xiao-na Wang, Hao Wang, Jun-fang Zhang, Hong-qiang Cheng, Wei Wang, Xin-chun Jin
Summary: Increasing evidence suggests that chronic nicotine treatment can alleviate MK-801-induced schizophrenia-like symptoms and cognitive impairment in mice. This study found that nicotine treatment reversed the increased expression levels of PDZ and LIM domain 5 (Pdlim5) and prevented the decrease in CREB-regulated transcription coactivator 1 (CRTC1) in the prefrontal cortex (PFC), resulting in improved cognition in mice.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Su Hui Seong, Seo Hyun Kim, Jong Hoon Ryu, Jin-Woo Jeong, Hyun Ah Jung, Jae Sue Choi
Summary: Icariin and its metabolites have regulatory effects on neurodegenerative disorders. Icariside II acts as an agonist for dopamine D3 receptor, while icaritin acts as an antagonist for muscarinic acetylcholine M2 receptor. These compounds can alleviate schizophrenia-like symptoms.
Article
Peripheral Vascular Disease
Dae-Seop Shin, Kwang Ik Yang, Doh-Eui Kim, Young Hwangbo, Brian B. Koo, Yong Won Cho
AMERICAN JOURNAL OF HYPERTENSION
(2018)
Article
Plant Sciences
Dong Gu Lee, Jaemin Lee, Kyung-Tack Kim, Sang-Won Lee, Young-Ock Kim, Ik-Hyun Cho, Hak-Jae Kim, Chun-Gun Park, Sanghyun Lee
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Plant Sciences
Jong Hee Choi, Min Jung Lee, Minhee Jang, Hak-Jae Kim, Sanghyun Lee, Sang Won Lee, Young Ock Kim, Ik-Hyun Cho
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Biology
Hak-Jae Kim, Kyeong-Hun Park, Dong-Hwi Kim, Han-Jung Chae, Gi-Ho Sung, Young-Ock Kim
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2018)
Article
Neurosciences
Hwayoung Lee, Hyung-Ki Kim, Jun-Tack Kwon, Young Ock Kim, Jonghoon Seo, Sanghyun Lee, Ik-Hyun Cho, Hak-Jae Kim
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2018)
Article
Public, Environmental & Occupational Health
Hyun Park, Young Hwangbo, Younghyeon Nam
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2018)
Article
Gastroenterology & Hepatology
Ka Young Lee, Hyun Deuk Cho, Young Hwangbo, Jae Kook Yang, Su Jung Han, Hyun Jong Choi, Yun Nah Lee, Sang-Woo Cha, Jong Ho Moon, Young Deok Cho, Sang-Heum Park, Tae Hoon Lee
GASTROINTESTINAL ENDOSCOPY
(2019)
Article
Gastroenterology & Hepatology
Yunho Jung, Young-Eun Joo, Hyun Gun Kim, Seong Ran Jeon, Jae Myung Cha, Hyo-Joon Yang, Jong Wook Kim, Jun Lee, Kyeong Ok Kim, Hye Kyung Song, Young Hwangbo, Jeong Eun Shin
GASTROINTESTINAL ENDOSCOPY
(2019)
Article
Gastroenterology & Hepatology
Tae Hoon Lee, Jong Ho Moon, Jun-Ho Choi, Sang Hyub Lee, Yun Nah Lee, Woo Hyun Paik, Dong Kee Jang, Byeong Wook Cho, Jae Kook Yang, Young Hwangbo, Sang-Heum Park
GASTROINTESTINAL ENDOSCOPY
(2019)
Article
Clinical Neurology
Jun-Sang Sunwoo, Dae-Seop Shin, Young Hwangbo, Won-Joo Kim, Min Kyung Chu, Chang-Ho Yun, Taekyoung Jang, Kwang Ik Yang
SLEEP AND BREATHING
(2019)
Article
Neurosciences
Se-Hoon Shim, Yong-Ku Kim, Young Hwangbo, Hee-Jung Yoon, Ji Sun Kim, Youn Jung Lee, Young Sup Woo, Won-Myong Bahk
Summary: This study found a correlation between plasma EPO levels and ADHD symptoms, with higher EPO levels associated with more severe inattention and hyperactivity-impulsivity symptoms.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Biology
R. Usha Kalyani, K. Perinbam, P. Jeyanthi, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Galal Ali Esmail, Young Ock Kim, Hyungsuk Kim, Hak-Jae Kim
Article
Medicine, General & Internal
Sun Mi Lim, Sung-Hyo Seo, Ki Soo Park, Young Hwangbo, Yeonok Suh, Sungin Ji, Jeongmook Kang, Hyeonji Hwang, Jose Rene Bagani Cruz, Yoon Hyung Park
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)
Article
Clinical Neurology
Hyeyun Kim, Mija Lee, Young Hwangbo, Kwang Ik Yang
JOURNAL OF CLINICAL NEUROLOGY
(2020)
Article
Medicine, General & Internal
Sun Mi Lim, Yoon Hyung Park, Won Gi Jhang, Young Taek Kim, Eun Mi Ahn, Ga Hyun Kim, Young Hwangbo
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2018)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)