期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 47, 期 2, 页码 272-279出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2012.10.019
关键词
Suicide; Mental health; Brain lipids; Cholesterol; Phospholipids; Synaptosomes; Membrane lipids
类别
资金
- Fonds de la Recherche Quebec Sante (FRQS) through the Reseau Quebecois de Recherche sur le Suicide
- Canadian Institute of Health Research (CIHR) [MOP 53321]
- FRQS
Cholesterol (CHL) and phospholipid (PL) levels in synaptosomal membranes in particular can have an impact on cell signalling. Alterations in peripheral CHL measures have been consistently reported in suicidal behaviour. As CHL and PL turnover in the brain are important in synapse maintenance and function, the objective of this study was to determine if differences exist in synaptosomal cholesterol and phospholipid levels between suicide completers and controls. Expression measures of genes involved in lipid trafficking suggest an association between Lysosomal acid lipase A, cholesteryl ester hydrolase (LIPA) and brain PL levels, with LIPA being significantly increased in violent suicides and associated with alterations in brain PL The results of this study suggest an altered PL content mediated by LIPA expression in violent suicides in the prefrontal cortex, which would have important consequences for inhibitory neurotransmission. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
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