Article
Behavioral Sciences
Nicole M. Sekula, Anastasia K. Yocum, Steven Anderau, Melvin G. McInnis, David F. Marshall
Summary: This study reveals that comorbid migraine in patients with BD is associated with worse clinical outcomes, and the use of lithium may exacerbate manic symptoms in BD patients with a history of migraines.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Jorge M. Aguiar-Geraldo, Taise Possamai-Della, Samira Menegas, Jefte Peper-Nascimento, Joao Quevedo, Samira S. Valvassori
Summary: This study aimed to evaluate the effects of lithium and folic acid on behavioral changes and oxidative stress parameters in an animal model of mania induced by ouabain. The results showed that ouabain induced mania-like behavior and oxidative stress in rats' brains, but lithium could reverse these alterations. Folic acid did not affect behavior parameters but had an antioxidant effect on the evaluated brain structures.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Priya Sunder, Ming -Fang Chia, Kate Filia, Craig Macneil, Melissa Hasty, Christopher Davey, Patrick McGorry, Michael Berk, Sue Cotton, Aswin Ratheesh
Summary: This study examined the impact of guideline concordance on outcomes in youth with early-stage BD-I. Higher concordance was associated with worse outcomes, but this relationship was moderated by illness characteristics, severity, and insight. More interventions or modified guidelines may be needed for youth with poor insight, greater severity, and mixed/rapid cycling features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Anthony G. Pacholko, Lane K. Bekar
Summary: Lithium carbonate is commonly used for bipolar disorder treatment, but its narrow therapeutic index can cause complications. Lithium orotate, on the other hand, has unique uptake characteristics that allow for reduced dosing and lower toxicity. Mouse experiments showed that lithium orotate had superior efficacy, potency, and tolerability compared to lithium carbonate.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Manuel Gardea-Resendez, Javier Ortiz-Orendain, Alessandro Miola, Manuel Fuentes Salgado, Mete Ercis, Brandon J. Coombes, Peggy M. Gruhlke, J. Michael Bostwick, Ian Michel, Jennifer L. Vande Voort, Aysegul Ozerdem, Alastair McKean, Mark A. Frye, Monica Taylor-Desir
Summary: This study compares psychiatric diagnoses and psychotropic drug use before the first episode of mania or psychosis in racially diverse patients. The findings indicate that non-White patients had a shorter duration of psychiatric antecedents and sought mental health care at an older age compared to White patients. There were no significant differences in pathways to care or age of first seeking mental health between racial groups, but non-White patients had lower rates of psychotropic drug use.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Ariana J. Cahn, Kamyar Keramatian, Christian Frysch, Lakshmi N. Yatham, Trisha Chakrabarty
Summary: Studies on grey matter changes in patients with bipolar I disorder following the first episode of mania show inconsistent results, with some suggesting that ACC volume decrease may be a marker for neuroprogression. However, the findings are not conclusive and larger studies are needed to better understand neuroprogression in early BD-I.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Lingzhuo Kong, Yuting Shen, Shaohua Hu, Jianbo Lai
Summary: This study investigated the impact of quetiapine monotherapy or combination therapy with lithium on thyroid function in depressed patients with bipolar disorder. The results showed that both treatment methods significantly disturbed thyroid function, with quetiapine monotherapy being associated with immune dysregulation in the thyroid.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Luis R. Patino, Maxwell J. Tallman, Hongbo Wen, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: The objective of this study was to evaluate differences in sustained attention and associated neurofunctional profiles between bipolar disorder type I, attention-deficit/hyperactivity disorder, and healthy comparison youth. Adolescent participants underwent MRI while completing a modified Continuous Performance Task. BD participants displayed deficits in sustained attention and lower activation in brain regions associated with performance and neural integration. These differences were distinct to the BD group and not attributable to ADHD comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tong Guo, Yuan Yang, Qian Zhao, Lei Zhang, Chee H. Ng, Teris Cheung, Yang Li, Xue-Quan Zhu, Xiao-Hong Li, Yu-Tao Xiang
Summary: The study aimed to assess the clinical phenomenology and characteristics of prodromal symptoms in Chinese patients with bipolar disorder prior to their index mood episode. The findings indicated that identifying prodromal symptoms of BPD may be beneficial for early diagnosis and intervention before the development of full episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Behavioral Sciences
Thomas van Neerven, Dienke J. Bos, Neeltje E. M. van Haren
Summary: Deficiencies in Theory of Mind (ToM) are commonly found in individuals with schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD), with severity increasing along the affective-psychotic spectrum. ToM deficits appear to be part of a broader developmental phenotype associated with SZ and BD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
F. Pacchioni, F. Casoni, A. Sarzetto, F. Attanasio, B. Barbini, M. Locatelli, C. Colombo, M. C. Cavallini, L. Fregna
Summary: Sleep plays a crucial role in the development and manifestation of mood disorders, but few studies have examined sleep architecture during manic episodes of Bipolar Disorder (BD) and changes in sleep parameters. This study investigated 21 BD patients in the manic phase and found that their sleep quantity and quality improved during hospitalization, accompanied by clinical improvement. The study also revealed an increase in REM sleep. These findings suggest that changes in sleep architecture can serve as sensitive markers for clinical variations during manic phases of Bipolar Disorder.
PSYCHIATRY RESEARCH
(2023)
Article
Pediatrics
Luis R. Patino, Christina C. Klein, Jeffrey R. Strawn, Thomas J. Blom, Maxwell J. Tallman, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: This study compared the efficacy and tolerability of lithium and quetiapine for treating manic or mixed episodes in youths with early course bipolar I disorder. Quetiapine showed greater reduction in YMRS score and higher response rate compared to lithium, while no significant differences were observed in remission rates between the two groups. Participants receiving quetiapine experienced more side effects such as somnolence, dizziness, and weight gain.
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2021)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Christopher R. K. Ching, Derrek P. Hibar, Tiril P. Gurholt, Abraham Nunes, Sophia I. Thomopoulos, Christoph Abe, Ingrid Agartz, Rachel M. Brouwer, Dara M. Cannon, Sonja M. C. de Zwarte, Lisa T. Eyler, Pauline Favre, Tomas Hajek, Unn K. Haukvik, Josselin Houenou, Mikael Landen, Tristram A. Lett, Colm McDonald, Leila Nabulsi, Yash Patel, Melissa E. Pauling, Tomas Paus, Joaquim Radua, Marcio G. Soeiro-de-Souza, Giulia Tronchin, Neeltje E. M. van Haren, Eduard Vieta, Henrik Walter, Ling-Li Zeng, Martin Alda, Jorge Almeida, Dag Alnaes, Silvia Alonso-Lana, Cara Altimus, Michael Bauer, Bernhard T. Baune, Carrie E. Bearden, Marcella Bellani, Francesco Benedetti, Michael Berk, Amy C. Bilderbeck, Hilary P. Blumberg, Erlend Boen, Irene Bollettini, Caterina del Mar Bonnin, Paolo Brambilla, Erick J. Canales-Rodriguez, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M. Diaz-Zuluaga, Danai Dima, Edouard Duchesnay, Torbjorn Elvsashagen, Scott C. Fears, Sophia Frangou, Janice M. Fullerton, David C. Glahn, Jose M. Goikolea, Melissa J. Green, Dominik Grotegerd, Oliver Gruber, Bartholomeus C. M. Haarman, Chantal Henry, Fleur M. Howells, Victoria Ives-Deliperi, Andreas Jansen, Tilo T. J. Kircher, Christian Knoechel, Bernd Kramer, Beny Lafer, Carlos Lopez-Jaramillo, Rodrigo Machado-Vieira, Bradley J. MacIntosh, Elisa M. T. Melloni, Philip B. Mitchell, Igor Nenadic, Fabiano Nery, Allison C. Nugent, Viola Oertel, Roel A. Ophoff, Miho Ota, Bronwyn J. Overs, Daniel L. Pham, Mary L. Phillips, Julian A. Pineda-Zapata, Sara Poletti, Mircea Polosan, Edith Pomarol-Clotet, Arnaud Pouchon, Yann Quide, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Aart H. Schene, Kang Sim, Jair C. Soares, Michael Staeblein, Dan J. Stein, Christian K. Tamnes, Georgios V. Thomaidis, Cristian Vargas Upegui, Dick J. Veltman, Michele Wessa, Lars T. Westlye, Heather C. Whalley, Daniel H. Wolf, Mon-Ju Wu, Lakshmi N. Yatham, Carlos A. Zarate, Paul M. Thompson, Ole A. Andreassen
Summary: MRI-derived brain measures have been widely studied in bipolar disorder (BD) and provide insights into the connections between genes, the environment, and behavior. The ENIGMA Bipolar Disorder Working Group is a collaborative effort that aims to generate consensus findings and improve the replicability of studies on BD. Through large-scale neuroimaging studies, the working group has discovered patterns of brain alterations associated with BD, as well as the effects of medications and clinical risk profiles.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Unn K. Haukvik, Tiril P. Gurholt, Stener Nerland, Torbjorn Elvsashagen, Theophilus N. Akudjedu, Martin Alda, Dag Alnaes, Silvia Alonso-Lana, Jochen Bauer, Bernhard T. Baune, Francesco Benedetti, Michael Berk, Francesco Bettella, Erlend Boen, Caterina M. Bonnin, Paolo Brambilla, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M. Diaz-Zuluaga, Theo G. M. Erp, Mar Fatjo-Vilas, Sonya F. Foley, Katharina Foerster, Janice M. Fullerton, Jose M. Goikolea, Dominik Grotegerd, Oliver Gruber, Bartholomeus C. M. Haarman, Beathe Haatveit, Tomas Hajek, Brian Hallahan, Mathew Harris, Emma L. Hawkins, Fleur M. Howells, Carina Huelsmann, Neda Jahanshad, Kjetil N. Jorgensen, Tilo Kircher, Bernd Kraemer, Axel Krug, Rayus Kuplicki, Trine Lagerberg, Thomas M. Lancaster, Rhoshel K. Lenroot, Vera Lonning, Carlos Lopez-Jaramillo, Ulrik F. Malt, Colm McDonald, Andrew M. McIntosh, Genevieve McPhilemy, Dennis Meer, Ingrid Melle, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Viola Oertel, Lucio Oldani, Nils Opel, Maria C. G. Otaduy, Bronwyn J. Overs, Julian A. Pineda-Zapata, Edith Pomarol-Clotet, Joaquim Radua, Lisa Rauer, Ronny Redlich, Jonathan Repple, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Lauren E. Salminen, Raymond Salvador, Salvador Sarro, Jonathan Savitz, Aart H. Schene, Kang Sim, Marcio G. Soeiro-de-Souza, Michael Staeblein, Dan J. Stein, Frederike Stein, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Dick J. Veltman, Eduard Vieta, Lena Waltemate, Lars T. Westlye, Heather C. Whalley, Philipp G. Saemann, Paul M. Thompson, Christopher R. K. Ching, Ole A. Andreassen, Ingrid Agartz
Summary: By studying the volume of hippocampal subfields in individuals with bipolar disorder, this research found that there are widespread reductions in several subfields in bipolar disorder, compared to healthy controls. The use of medication, particularly lithium, may have a protective effect in bipolar disorder.
HUMAN BRAIN MAPPING
(2022)
Article
Psychiatry
Cicero A. C. Pereira, Alana C. Costa, Helena P. G. Joaquim, Leda L. Talib, Martinus T. van de Bilt, Alexandre A. Loch, Wagner F. Gattaz
Summary: This study investigated whether studying the inflammatory COX-2 pathway through quantifying eicosanoid levels can be useful for characterizing Ultra-High Risk (UHR) individuals. The results showed that levels of PGE(2) and TxB(2) were increased in the UHR group, with PGE(2) and PGF(2 alpha) correlated to negative symptoms and TxB(2) correlated to positive symptoms. The findings suggest that overactivation of the COX-2 pathway may be related to an increased risk for psychosis, but more research is needed to determine causation.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Beatriz Monteiro Fernandes, Estevao Scotti-Muzzi, Marcio Gerhardt Soeiro-de-Souza
Summary: This study conducted a systematic review and meta-analysis on the effects of antidepressant drug therapy on peripheral inflammatory markers in MDD patients, finding evidence of a potential reduction in inflammatory markers but with heterogeneous results. Further research is needed to explore how inflammatory biomarkers modulate physiological responses related to antidepressant therapy.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Estevao Scotti-Muzzi, Thais Chile, Homero Vallada, Maria Concepcion Garcia Otaduy, Marcio Gerhardt Soeiro-de-Souza
Summary: This study revealed an association between the CACNA1C genotype and increased glutamatergic metabolites in BD, especially in AAC carriers, suggesting a possible synergic role in intracellular Ca2+ overload and excitotoxicity.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Beatriz Monteiro Fernandes, Cristiana Carvalho Siqueira, Rodrigo Machado Vieira, Ricardo Alberto Moreno, Marcio Gerhardt Soeiro-de-Souza
Summary: This study found that although physical activity as an adjuvant to antidepressant treatment did not promote changes in cortisol or interleukins in individuals with major depressive disorder, cortisol appeared to be the most sensitive biomarker to antidepressant treatment.
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2022)
Article
Clinical Neurology
Gregory Jones, Carola Rong, Courtney M. Vecera, Christopher Gurguis, Roshan Chudal, Rushaniya Khairova, Edison Leung, Ana C. Ruiz, Lokesh Shahani, Marcus Zanetti, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: Lithium may play an important role in treating comorbid anxiety in bipolar disorder, both as adjunct and monotherapy. Lower doses of lithium may provide equivalent efficacy and enhance tolerability and compliance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Gustavo C. Medeiros, Todd D. Gould, William L. Prueitt, Julie Nanavati, Michael F. Grunebaum, Nuri B. Farber, Balwinder Singh, Sudhakar Selvaraj, Rodrigo Machado-Vieira, Eric D. Achtyes, Sagar V. Parikh, Mark A. Frye, Carlos A. Zarate, Fernando S. Goes
Summary: (R,S)-ketamine and (S)-ketamine have rapid and substantial antidepressant effects, but there is no well-accepted method to differentiate responders from non-responders. The association between blood-based biomarkers and response to ketamine was examined in a systematic review/meta-analysis, revealing limited evidence of a consistent relationship.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Marco Aurelio Cigognini, Alia Garrudo Guirado, Denise van de Meene, Monica Andreia Schneider, Monica Sarah Salomon, Vinicius Santana de Alexandria, Juliana Pisseta Adriano, Ana Maria Thaler, Fernando dos Santos Fernandes, Adriana Carneiro, Ricardo Alberto Moreno
Summary: This study aims to evaluate the long-term use of ketamine in the treatment of treatment-resistant depression (TRD) and compare it with active treatment. By assessing efficacy, safety, and tolerability, the study may provide evidence for a new, low-cost, rapid, and feasible approach to depression treatment.
FRONTIERS IN PSYCHIATRY
(2022)
Letter
Biochemistry & Molecular Biology
Gregory Jones, Rodrigo Machado-Vieira
MOLECULAR PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Krista Wartchow, Giselli Scaini, Tina Li, Giovana Zunta-Soares, Rodrigo Machado-Vieira, Jair Soares, Joao Quevedo
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Diego Freitas Tavares, Paulo Suen, Doris Hupfeld Moreno, Eduard Vieta, Ricardo Alberto Moreno, Andre R. Brunoni
Summary: This study explores the association between distractibility, anxiety, irritability, and agitation (DAIA) symptoms and the severity of depressive and manic symptoms. The results show that in patients with mixed depression, DAIA symptoms are significantly associated with the severity of both depressive and manic symptoms, with anxiety playing a major role in the association.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Ana Caroline Lopes-Rocha, Cheryl Mary Corcoran, Julio Cesar Andrade, Leonardo Peroni, Natalia Mansur Haddad, Lucas Hortencio, Mauricio Henriques Serpa, Martinus Theodorus van de Bilt, Wagner Farid Gattaz, Alexandre Andrade Loch
Summary: This study found that movement abnormalities are commonly observed in schizophrenia and at-risk mental states. Automated analysis using motion energy analysis software enhanced the assessment of movement. The study examined the movement during free-speech videos in ARMS and control individuals and investigated the associations between movement metrics and symptoms. The results showed that ARMS individuals had lower mean amplitude of head movement and higher coefficients of movement variability. Higher coefficient of variability was related to higher risk of conversion. The study highlights the importance of movement analysis in ARMS and suggests that it could be a potentially important tool for early diagnosis, intervention, and outcome prediction.
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
