Article
Psychiatry
Alexandra E. Dingemans, S. Alida Volkmer, Sandra Mulkens, Richard Vuijk, Yanda R. van Rood
Summary: Several studies have found that OCD, ED, ASD, and BDD share common symptoms and often co-occur, suggesting a common etiological basis. The study found that executive functioning skills such as attention switching and social communication skills were central in individuals with these disorders. Difficulty with cognitive flexibility and social factors are key factors in OC-spectrum disorders.
PSYCHIATRY RESEARCH
(2022)
Article
Behavioral Sciences
Jon E. Grant, Samuel R. Chamberlain
Summary: This study examined the presence of autistic traits in adults with trichotillomania and found a higher rate of probable ASD. The results highlight the importance of screening for autistic traits in individuals with trichotillomania.
BRAIN AND BEHAVIOR
(2022)
Article
Medicine, General & Internal
Lilach Rachamim, Hila Mualem-Taylor, Osnat Rachamim, Michael Rotstein, Sharon Zimmerman-Brenner
Summary: This study found that in children and adolescents with tic disorders, both the presence of ADHD and the absence of comorbid ADHD were associated with similar reductions in tic symptoms after internet-delivered, self-help comprehensive behavioral intervention for tics (ICBIT). However, the presence of OCD comorbidity was associated with a lesser response to intervention. Furthermore, the intervention also led to significant reductions in parental reports of inattention, hyperactivity, and impulsivity. Larger studies are needed to further optimize the application of ICBIT in children and teens with both tic disorders and comorbid ADHD and OCD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Tingting Xu, Qiumeng Gu, Qing Zhao, Pei Wang, Qiang Liu, Qing Fan, Jue Chen, Zhen Wang
Summary: The study identified alterations in striatal functional connectivity in patients with OCD compared to healthy controls, suggesting a breakdown in cognitive circuits involved in inhibitory control. The relationship between trait impulsivity and frontal-striatal connectivity may have negative implications in OCD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Liliana Dell'Osso, Benedetta Nardi, Chiara Bonelli, Davide Gravina, Francesca Benedetti, Luca Del Prete, Gabriele Massimetti, Giulia Amatori, Barbara Carpita, Ivan Mirko Cremone
Summary: Recent research emphasizes the importance of a dimensional perspective on mental disorders, particularly the conceptualization of an obsessive-compulsive spectrum. The current study aims to evaluate the psychometric characteristics of the Obsessive-Compulsive Spectrum-Short Version (OBS-SV) questionnaire. The results demonstrate strong reliability and validity of the OBS-SV, showing significant correlations with other measures of obsessive-compulsive symptoms.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: This study revealed a bidirectional longitudinal relationship between eating disorders and obsessive-compulsive disorder, particularly in terms of cognitive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Shruti S. Kinkel-Ram, William Grunewald, Shelby N. Ortiz, Joshua M. Magee, April R. Smith
Summary: The study found a bidirectional, longitudinal relationship between symptoms of eating disorders (ED) and obsessive-compulsive disorder (OCD), particularly in terms of cognitive symptoms. However, this longitudinal association was only present at certain time points.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Psychiatry
Beatriz Moreno-Amador, Jose A. Piqueras, Tiscar Rodriguez-Jimenez, Agustin E. Martinez-Gonzalez, Matti Cervin
Summary: This study expanded the OCD and related disorders dimensional scales to include the four major symptom dimensions of OCD, and found that the expanded scale showed excellent psychometric properties and correlations with well-being and mental health. The results indicate that the expanded OCRD-D may serve as a unified way to assess symptoms across the major symptom dimensions of OCD and related disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Hugues Lamothe, Ophelia Godin, Chloe Stengel, Safiyah Benmansour, Soline Burckard, Julie Brouillet, Jean Petrucci, Delphine Weil, Florian Lejuste, Marion Leboyer
Summary: This study aimed to investigate if adults with ASD and comorbid OCD exhibit specific clinical profiles. The results showed that adults with ASD and comorbid OCD had lower verbal IQ and more severe impairments in social cognition. This suggests that ASD with comorbid OCD could be a possible subtype of ASD.
PSYCHIATRY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Dennis Vollweiter, Jasmeet Kaur Shergill, Alexandra Hilse, Gaga Kochlamazashvili, Stefan Paul Koch, Susanne Mueller, Philipp Boehm- Sturm, Volker Haucke, Tanja Maritzen
Summary: The cortico-striatal-thalamocortical loop is crucial for the expression of motor routines and habits. Mutations in the intersectin proteins have been linked to neuropsychiatric diseases such as ASD and OCD. Deletion of the intersectin proteins leads to severe ASD/OCD-like behavioral alterations and defective cortico-striatal neurotransmission. The findings provide insights into the physiological role of intersectin in countering ASD/OCD and the molecular pathomechanism behind these neuropsychiatric symptoms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Leonardo F. Fontenelle, Louise Destree, Mary-Ellen Brierley, Emma M. Thompson, Murat Yucel, Rico Lee, Lucy Albertella, Sam R. Chamberlain
Summary: This study identified one healthy cluster and three clinical clusters (compulsive, impulsive, and mixed-compulsive and impulsive), and found that different OCRDs symptoms were associated with different clusters.
Article
Clinical Neurology
Irina A. Vanzhula, Shruti S. Kinkel-Ram, Cheri A. Levinson
Summary: The study found that difficulty controlling thoughts acts as a bridge between ED and OCD symptoms, with perfectionism playing a significant role in the ED-OCD-Perfectionism comorbidity network. Additionally, specific and distinct pathways were identified between OCD and two types of ED pathology.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Developmental Biology
Donn A. Van Deren, Shrutokirti De, Ben Xu, Kayla M. Eschenbacher, Shuhua Zhang, Mario R. Capecchi
Summary: This study demonstrates that Hoxb8 microglia are derived from the Hoxb8 lineage and have a distinct ontogeny. Dysfunctional Hoxb8 microglia can contribute to anxiety and obsessive-compulsive behaviors. Additionally, Hoxb8 progenitors can mark erythromyeloid progenitors, hematopoietic stem cells, and their progeny, particularly monocytes. In adulthood, all immune lineages and resident macrophages in hematopoietic-lymphoid tissues are derived from Hoxb8 precursors.
Article
Psychiatry
Kirupamani Viswasam, David Berle, Denise Milicevic, Vladan Starcevic
Summary: This study investigated the prevalence of anxiety and related disorders during pregnancy, with OCD showing a steady increase in prevalence from the first to the third trimester. A significant proportion of women developed these disorders during pregnancy, indicating a potential risk factor. The findings have important implications for the recognition, prevention, and treatment of anxiety disorders during pregnancy.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Donatella Marazziti, Filippo M. Barberi, Leonardo Fontenelle, Beatrice Buccianelli, Manuel G. Carbone, Elisabetta Parra, Stefania Palermo, Lucia Massa, Claudia Tagliarini, Alessandra Della Vecchia, Federico Mucci, Alessandro Arone, Liliana Dell'Osso
Summary: This study compared vitamin D levels in adult patients with obsessive-compulsive disorder (OCD) and explored possible correlations with patients' characteristics. The results showed a negative correlation between vitamin D levels and the severity of OCD and specific symptoms, with some differences based on gender. Further research is needed to confirm these findings and evaluate the effectiveness of vitamin D supplementation in OCD patients.
Article
Clinical Neurology
Mary-Ellen E. Brierley, Lucy Albertella, Kristian Rotaru, Louise Destree, Emma M. Thompson, Chang Liu, Erynn Christensen, Amelia Lowe, Rebecca A. Segrave, Karyn E. Richardson, Edouard Kayayan, Samuel R. Chamberlain, Jon E. Grant, Rico S. C. Lee, Sam Hughes, Murat Yucel, Leonardo F. Fontenelle
Summary: This study investigates the relationships between compulsivity and diet quality, sleep quality, and physical activity, and finds that psychological distress mediates these relationships. Lifestyle interventions for compulsivity should focus on reducing psychological distress, followed by improving sleep and diet quality.
Article
Psychiatry
Zoe Bettess, Lucy Albertella, Louise Destree, Maria C. Rosario, Ygor Arzeno Ferrao, Euripedes C. Miguel, Leonardo F. Fontenelle
Summary: This study found that transformation obsessions (TO) may be better conceptualized as forbidden/taboo thoughts rather than contamination. Patients with TO displayed increased suicidality, overall younger age, and a significantly larger disparity between seeking treatment and OCD diagnosis.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Mary-Ellen E. Brierley, Lucy Albertella, Erynn Christensen, Kristian Rotaru, Felice N. Jacka, Rebecca A. Segrave, Karyn E. Richardson, Rico S. C. Lee, Edouard Kayayan, Sam Hughes, Murat Yucel, Leonardo F. Fontenelle
Summary: This study examined the impact of lifestyle factors on obsessive-compulsive symptoms and problematic repetitive behaviors. The results showed that lower intake of vegetables and oily fish, as well as lower moderate intensity physical activity, predicted higher obsessive-compulsive symptoms. Higher intake of high-fat foods predicted higher compulsive problematic repetitive behaviors. The study suggests the potential importance of lifestyle interventions for individuals experiencing compulsivity-related behaviors and/or symptoms.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Clinical Neurology
Barbara P. Stumpf, Leonardo C. de Souza, Marina S. F. Mourao, Fabio L. Rocha, Leonardo F. Fontenelle, Izabela G. Barbosa
Summary: This study aimed to review the cognitive performance of patients with hoarding disorder (HD) compared to controls. The results showed that HD patients only showed impairment in categorization skills, while their cognitive performance in other domains did not differ significantly from controls. There is a lack of research on social cognition and the impact of emotions on cognitive performance in HD patients, calling for further investigation.
Article
Psychiatry
Erin Crowe, Maria C. Rosario, Ygor A. Ferrao, Lucy Albertella, Euripedes C. Miguel, Leonardo F. Fontenelle
Summary: The study aimed to investigate the demographics, comorbid disorders, and obsessive-compulsive symptoms associated with Obsessional Slowness (OS). The cross-sectional data from 667 OCD outpatients were analyzed, revealing that being single, having tics, and displaying higher severity of specific OCD symptoms predicted the presence of OS.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychiatry
Wilson Baldin Depress Med Students Res Grp, Wilson Baldin Zatt, Kenneth Lo, Wilson Tam
Summary: This study aimed to improve the precision of previous research on the prevalence of depressive symptoms among medical students by gathering individual participant data (IPD). The findings showed that the pooled prevalence obtained from IPD meta-analysis was lower compared to previous meta-analyses using aggregated data. Age, sex, and year of study were significantly associated with the depression z-score.
Article
Clinical Neurology
Louise Destree, Lucy Albertella, Laura Jobson, Patrick McGorry, Andrew Chanen, Aswin Ratheesh, Christopher Davey, Andrea Polari, Paul Amminger, Hok Pan Yuen, Jessica Hartmann, Rachael Spooner, Leonardo F. Fontenelle, Barnaby Nelson
Summary: This study investigated the association between stressful experiences and obsessive-compulsive symptoms. The results showed that stressful experiences were associated with the symmetry dimension of obsessive-compulsive symptoms. Borderline personality disorder symptoms were positively associated with the symmetry and fear of harm dimensions, while psychosis symptoms were negatively associated with the fear of harm dimension.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Matheus Ghossain Barbosa, Viviane Machado, Carolina Ziebold, Tais Moriyama, Rodrigo A. Bressan, Pedro Pan, Luis Augusto Rohde, Euripedes Constantino Miguel, Lais Fonseca, Jim Van Os, Ary Gadelha
Summary: The Brazilian High-Risk Cohort study examined the measurement invariance of the CAPE-positive scale in children and adolescents over a three-year period. The results show that the scale is not invariant over time, indicating the need for further investigation into the factors influencing its results.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shinsuke Suzuki, Xiaoliu Zhang, Amir Dezfouli, Leah Braganza, Ben D. Fulcher, Linden Parkes, Leonardo F. Fontenelle, Ben J. Harrison, Carsten Murawski, Murat Yucel, Chao Suo
Summary: Obsessive-compulsive disorder (OCD) and pathological gambling (PG) are associated with deficits in behavioural flexibility. Model-based functional magnetic resonance imaging (fMRI) reveals altered reward-learning in OCD and PG, with OCD patients showing lower learning rates for worse-than-expected outcomes and attenuated encoding of negative reward prediction errors, and PG patients showing higher and lower learning rates for better- and worse-than-expected outcomes, respectively, accompanied with higher encoding of positive reward prediction errors. Perseveration did not significantly differ between the patient groups and healthy controls.
Article
Multidisciplinary Sciences
Campbell Ince, Leonardo F. Fontenelle, Adrian Carter, Lucy Albertella, Jeggan Tiego, Samuel R. Chamberlain, Kristian Rotaru
Summary: Problematic pornography use is a complex and growing research area, but limited knowledge exists regarding the lived experience of individuals with this issue. An online qualitative study revealed dimensions that have not been fully explored, including various mental and physical complaints, sexual functioning deficits with real partners, and subjective changes in sexual arousal while using pornography. The study also expanded on understanding the inner conflict associated with problematic pornography use and clarified ways in which users can progress to more intensified patterns of use.
SCIENTIFIC REPORTS
(2023)
Review
Psychiatry
Ygor Arzeno Ferrao, Rodrigo Bolsson Radins, Joao Vitor Bueno Ferrao
Summary: This scoping review explores the psychopathological similarities and differences between post-traumatic stress disorder and obsessive-compulsive disorder. The study found that while both disorders share some psychopathological aspects, their core symptoms and purposes differ.
TRENDS IN PSYCHIATRY AND PSYCHOTHERAPY
(2023)
Article
Psychiatry
Marcelo Piquet-Pessoa, Joane de Oliveira, Ana Paula Ribeiro, Lucy Albertella, Gabriela M. Ferreira, Gabriela B. de Menezes, Leonardo F. Fontenelle
Summary: This study investigated whether the habitual use of alcohol in patients with alcohol use disorder (AUD) at baseline would lead to worse outcomes after one year of follow-up. The results showed that greater fear and reward motivations for alcohol use predicted a greater improvement in AUD symptoms at the end of one year. These findings may contribute to the development of new approaches for AUD treatment and inform addiction research models.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)