Article
Clinical Neurology
Palmiero Monteleone, Giammarco Cascino, Alessio Maria Monteleone, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Eugenio Aguglia, Mario Amore, Enrico Collantoni, Giulio Corrivetti, Alessandro Cuomo, Antonello Bellomo, Enrico D'Ambrosio, Liliana Dell'Osso, Marianna Frascarelli, Giulia Maria Giordano, Luigi Giuliani, Carlo Marchesi, Cristiana Montemagni, Lucio Oldani, Federica Pinna, Maurizio Pompili, Rita Roncone, Rodolfo Rossi, Alberto Siracusano, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj
Summary: The study assessed the prevalence of EPS in schizophrenia patients treated with FGAs and SGAs, and found associations between EPS and the severity of the illness, neurocognitive impairments, and social cognition deficits. EPS were shown to impact patients' neurocognitive functions, but did not directly affect their social cognition abilities.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Haixia Liu, Hua Liu, Shuling Jiang, Lei Su, Yi Lu, Zhenli Chen, Xiaojing Li, Xirong Li, Xuemei Wang, Meihong Xiu, Xiangyang Zhang
Summary: There are differences in the response to risperidone treatment between male and female patients with ANFE schizophrenia. Changes in GPx activity are associated with treatment response specifically in female patients.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Psychiatry
Chadia Haddad, Pascale Salameh, Hala Sacre, Jean-Pierre Clement, Benjamin Calvet
Summary: This study aimed to evaluate the impact of medications used for schizophrenia on cognitive function and found that patients with higher anticholinergic burden and higher antipsychotic doses had poorer cognitive function. The study confirmed the influence of medications on cognitive function in chronic schizophrenia patients and highlighted the role of cholinergic neurotransmission and general neurochemical mechanisms in cognitive impairment.
Article
Behavioral Sciences
Mary Seeman
Summary: The review examines the potential role of intestinal organisms in response/non-response to antipsychotics, highlighting that current research in this area is mostly theoretical but showing increasing evidence from animal experiments and clinical trials on the impact of gut bacteria on drug response.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Keqiang Wang, Meihong Xiu, Xiuru Su, Fengchun Wu, Xiangyang Zhang
Summary: This study examined the effect of risperidone monotherapy on total antioxidant status (TAS) in antipsychotic-naive first-episode schizophrenia (ANFE) patients, and found that antioxidant protection may be associated with clinical improvement.
Review
Neurosciences
Alexandre Gonzalez-Rodriguez, Jose A. Monreal, Mary Seeman
Summary: This narrative review investigates the relationship between menopause and increased psychosis symptoms in women. The evidence suggests that besides hormonal factors, the loss of estrogen and the subsequent decrease in efficacy of antipsychotic drugs may contribute to the worsening of symptoms. Effective clinical intervention remains challenging but there are some promising approaches.
Article
Psychology, Clinical
Anne Emilie Sturup, Merete Nordentoft, Espen Jimenez-Solem, Merete Osler, Josefine Winther Davy, Thomas Nordahl Christensen, Helene Speyer, Nikolai Albert, Carsten Hjorthoj
Summary: This study found that most individuals with first-episode schizophrenia discontinued or did not use antipsychotic medication in the years following diagnosis, and they had better functional outcomes. Compared to continuous users, individuals with non-sustained discontinuation had more psychiatric hospital admissions and longer admissions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Qian Zhang, Yajie Wan, Xinzhe Du, Yao Gao, Xiao Wang, Kewen Wu, Xiaohu Zheng, Yu Wang, Cheng Zhao, Li Li, Xianju Guo, Xinrong Li, Sha Liu, Yong Xu
Summary: This study explored the relationship between polymorphisms in the NPY gene and antipsychotic drug response in the Chinese population. The results did not find a significant association between the gene polymorphisms and treatment response. This suggests that there may not be a clear relationship between the gene polymorphisms and the efficacy of antipsychotic drugs in patients with schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Dong-Mei Wang, Lu-Yao Xia, Hui-Xia Zhou, Yang Tian, Qi-Long Dai, Mei-Hong Xiu, Da-Chun Chen, Li Wang, Xiang-Yang Zhang
Summary: This study compared sensory gating and cognitive performance between smoking and non-smoking Chinese Han population with schizophrenia. The findings suggest that smoking may have a positive effect on sensory gating and cognition in schizophrenia patients.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Lena Feber, Natalie Peter, Johannes Schneider-Thoma, Spyridon Siafis, Irene Bighelli, Wulf-Peter Hansen, Daniel Prates Baldez, Georgia Salanti, Richard S. E. Keefe, Rolf R. Engel, Stefan Leucht
Summary: This study aims to provide support for evidence-based antipsychotic treatment choices for cognitive deficits in schizophrenia patients by analyzing existing RCTs on this subject. Through conducting a network meta-analysis, this study will evaluate the effects of different antipsychotic drugs on cognitive functioning and provide the latest available evidence for treatment decisions.
SYSTEMATIC REVIEWS
(2023)
Article
Neurosciences
Yi Yin, Shuangshuang Li, Jinghui Tong, Junchao Huang, Baopeng Tian, Song Chen, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Yongsheng Tong, L. Elliot Hong, Yunlong Tan
Summary: This study aimed to compare pre-treatment neurocognitive profiles among individuals with early-onset schizophrenia (EOS), typical-onset schizophrenia (TOS), and late-onset schizophrenia (LOS). The results showed that TOS patients had lower scores in verbal learning compared to LOS patients, while there were no differences in other cognitive domains. The association between age of onset and verbal memory showed a U-shaped curve.
COGNITIVE NEURODYNAMICS
(2023)
Article
Psychiatry
Yuta Kawakita, Masahiro Takeshima, Tomonari Komatsu, Aya Imanishi, Dai Fujiwara, Yu Itoh, Kazuo Mishima
Summary: This study retrospectively compared the incidence of appendicitis in patients with schizophrenia with and without a history of clozapine exposure, finding a relationship between clozapine exposure and appendicitis onset.
Article
Biochemistry & Molecular Biology
Arnim Johannes Gaebler, Michelle Finner-Prevel, Federico Pacheco Sudar, Felizia Hannah Langer, Fatih Keskin, Annika Gebel, Jana Zweerings, Klaus Mathiak
Summary: Vitamin D deficiency may contribute to neurocognitive dysfunction in schizophrenia, particularly affecting processing speed and executive functioning. However, increased exposure to anticholinergic antipsychotics mediated by cytochrome P450 is not the main cause of these cognitive impairments.
Article
Medicine, General & Internal
Giammarco Cascino, Rossella Ceres, Alessio Maria Monteleone, Paola Bucci, Giulia Maria Giordano, Silvana Galderisi, Palmiero Monteleone
Summary: This study aimed to investigate the switching of antipsychotic medications in people with schizophrenia and analyze potential predictors. Over a four-year period, 34.9% of the participants switched their medication. The use of first-generation antipsychotics and the presence of extrapyramidal symptoms at baseline were associated with switching antipsychotic classes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Jingsong Ma, Mingzhe Zhao, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Ting Wang, Hao Wu, Na Zhang, Zhiruo Zhang, Lin He, Shengying Qin
Summary: The study used meta-analysis to demonstrate a significant association between COMT Val158Met polymorphism and antipsychotic response, which was consistent in both Caucasian and Asian patient populations. Genotyping of patients for predicting antipsychotic response may be relevant for future randomized clinical trials.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Clinical Neurology
Luca Kleineidam, Michael Wagner, Jannis Guski, Steffen Wolfsgruber, Lisa Miebach, Horst Bickel, Hans-Helmut Koenig, Siegfried Weyerer, Dagmar Luehmann, Hanna Kaduszkiewicz, Melanie Luppa, Susanne Rohr, Michael Pentzek, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Johannes Kornhuber, Oliver Peters, Lutz Frolich, Jens Wiltfang, Piotr Lewczuk, Michael Huell, Alfredo Ramirez, Frank Jessen, Steffi G. Riedel-Heller, Kathrin Heser
Summary: This study found that subjective cognitive decline (SCD) typically precedes depressive symptoms (DS), and individuals with SCD and high DS are at an increased risk for cognitive decline and dementia progression. Additionally, levels of CSF Ass42 can predict increasing DS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Cindy Sumaly Lor, Amelie Haugg, Mengfan Zhang, Letitia Schneider, Marcus Herdener, Boris B. Quednow, Narly Golestani, Frank Scharnowski
Summary: Tobacco smoking is associated with negative health outcomes and high relapse rates. A recent study investigated the role of the thalamus in substance use disorders in human smokers and found that both structural and functional measures of the thalamus were associated with smoking characteristics. The study highlights the importance of the thalamus in understanding addiction mechanisms and suggests it as a potential target for interventions to support smoking cessation.
Article
Psychiatry
Ming-Chyi Huang, Chun-Hsin Chen, Tung-Hsia Liu, An-Nie Chung, Yu-Li Liu, Boris B. Quednow, Francesco Bavato
Summary: We found that patients with ketamine dependence (KD) who also had major depressive disorder (MDD) had significantly higher levels of neurofilament light chain (NfL), indicating active neuroaxonal pathology. However, it was uncertain whether the NfL elevation was caused by the interaction of KD with MDD or by MDD itself. To clarify this, we compared serum NfL levels in different groups and found that the KD with MDD group had the highest NfL levels, suggesting that the interaction of KD with MDD, rather than MDD alone, leads to increased vulnerability to neuroaxonal pathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Developmental
Annekatrin Steinhoff, Lilly Shanahan, Laura Bechtiger, Josua Zimmermann, Denis Ribeaud, Manuel P. Eisner, Markus R. Baumgartner, Boris B. Quednow
Summary: This study examined the consistency between self-reports and hair toxicology analyses in determining the prevalence of illicit substance use, and found that self-reports underestimated the frequency of substance use compared to hair tests. Underestimation was associated with low levels of substances in hair. Combining self-reports with hair tests may be most beneficial in study samples with occasional substance use.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Oliver G. Bosch, Dario A. Dornbierer, Francesco Bavato, Boris B. Quednow, Hans-Peter Landolt, Erich Seifritz
Summary: This article discusses the potential of drug repurposing in the field of psychiatric disorders and highlights dexmedetomidine as a promising candidate. Dexmedetomidine has fast-acting effects on sedation, anxiety reduction, pain relief, sleep modulation, and inflammation inhibition, which may be beneficial for the treatment of neuropsychiatric symptoms. Although evidence from animal and human studies supports these properties, larger controlled trials and systematic studies in psychiatric populations are currently lacking.
PHARMACOPSYCHIATRY
(2023)
Article
Clinical Neurology
Josua Zimmermann, Niklaus Zolch, Rebecca Coray, Francesco Bavato, Nicole Friedli, Markus R. Baumgartner, Andrea E. Steuer, Antje Opitz, Annett Werner, Georg Oeltzschner, Erich Seifritz, Ann-Kathrin Stock, Christian Beste, David M. Cole, Boris B. Quednow
Summary: This study used proton magnetic resonance spectroscopy (MRS) to measure the glutamate-glutamine complex (GLX) and gamma-aminobutyric acid (GABA) concentrations in the brains of chronic MDMA users and MDMA-naive healthy controls. The results showed that chronic MDMA users had elevated GLX levels in the striatum, which may offer new mechanistic explanations for cognitive deficits observed in MDMA users. Overall, this study suggests that MDMA use affects not only serotonin but also striatal GLX and GABA concentrations.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Dario A. A. Dornbierer, Niklaus Zolch, Diego M. M. Baur, Andreas Hock, Benjamin Stucky, Boris B. B. Quednow, Thomas Kraemer, Erich Seifritz, Oliver G. G. Bosch, Hans-Peter Landolt
Summary: In a randomized controlled trial, researchers found that the level of glutamate in the anterior cingulate cortex significantly increased after enhanced sleep, which could be one of the mechanisms of action of sodium oxybate (SXB) in the treatment of insomnia and excessive daytime sleepiness.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Neurosciences
Francesco Bavato, Ann-Kathrin Kexel, Bruno Kluwe-Schiavon, Aleksandra Maceski, Markus R. R. Baumgartner, Erich Seifritz, Jens Kuhle, Boris B. B. Quednow
Summary: This study found that plasma levels of the neurofilament light chain (NfL), a marker of neuroaxonal pathology, were elevated in chronic cocaine users and correlated with changes in cocaine use. This suggests that NfL may be a sensitive marker for assessing cocaine-related neuroaxonal pathology and has important implications for addiction research.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Behavioral Sciences
Antje Opitz, Miriam-Sophie Petasch, Regine Klappauf, Josephine Kirschgens, Julian Hinz, Lena Dittmann, Anthea S. Dathe, Boris B. Quednow, Christian Beste, Ann- Kathrin Stock
Summary: In substance use and addiction, inhibitory control is crucial for ignoring triggers, resisting cravings, and maintaining abstinence. This study investigated the relationship between interference control and chronic ATS use in adults. The findings revealed small effect sizes for ATS-related deficits in interference control, with differences observed between methamphetamine and MDMA users.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Andrea E. Steuer, Francesco Bavato, Laura K. Schnider, Dario A. Dornbierer, Oliver G. Bosch, Boris B. Quednow, Erich Seifritz, Christian Steuer, Thomas Kraemer
Summary: We investigated new GHB conjugates as markers for GHB ingestion/application in urine. Significant differences were found in the concentrations of GHB and its metabolites between placebo and GHB administration. The detection of GHB-glycine showed prolonged detection over GHB, especially when compared to a second urine sample.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Clinical
Joaquin Rodriguez-Ruiz, Izabela Zych, Denis Ribeaud, Annekatrin Steinhoff, Manuel Eisner, Boris B. Quednow, Lilly Shanahan
Summary: This study examined the longitudinal links between parent-child relationship and adolescent substance use, and found that low positive parenting, low parental supervision, and aversive parenting correlated with substance use. The study also found that low self-control at age 13 mediated these associations. The findings suggest that involving parents and increasing their knowledge about effective parental practices and ways to help their children develop adequate self-control may be effective in preventing substance use.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Neurosciences
Rebecca C. Coray, Jatta Berberat, Josua Zimmermann, Erich Seifritz, Ann-Kathrin Stock, Christian Beste, David M. Cole, Paul G. Unschuld, Boris B. Quednow
Summary: The study found significantly increased iron deposition in the striatum of regular MDMA users, suggesting potential neurotoxic effects. While no linear relationship was observed between intake levels and iron deposition values, there may be physiological risk factors among MDMA users that could lead to neurodegenerative diseases.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Letter
Clinical Neurology
Francesco Bavato, Erich Seifritz, Boris B. Quednow
Article
Biochemistry & Molecular Biology
Rafael Campos-Martin, Katharina Bey, Bjoern Elsner, Benedikt Reuter, Julia Klawohn, Alexandra Philipsen, Norbert Kathmann, Michael Wagner, Alfredo Ramirez
Summary: Obsessive-compulsive disorder (OCD) is a common mental disorder affecting around 2-3% of the population. This study investigated the epigenetic factors associated with OCD by analyzing DNA methylation patterns in 185 OCD patients and 199 controls. The researchers identified differentially methylated CpG positions and validated their findings using a subset of 12 CpGs. These CpGs were found to be related to genes associated with the sweet-compulsive brain hypothesis, suggesting a potential role of aberrant dopaminergic transmission in OCD pathogenesis.
MOLECULAR PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Debora Melo van Lent, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Birgit Stoffel-Wagner, Horst Bickel, Birgitt Wiese, Siegfried Weyerer, Michael Pentzek, Frank Jessen, Matthias Schmid, Wolfgang Maier, Martin Scherer, Steffi G. G. Riedel-Heller, Alfredo Ramirez, Michael Wagner
Summary: Deficiency of vitamin D increases the risk of developing Alzheimer's dementia. It is recommended to monitor vitamin D levels in the elderly and provide supplementation in cases of deficiency.
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)