Article
Psychology, Developmental
Xiaoping Yi, Yan Fu, Jun Ding, Furong Jiang, Zaide Han, Yinping Zhang, Zhejia Zhang, Qian Xiao, Bihong T. Chen
Summary: The study examined brain structure and function in adolescents with borderline personality disorder (BPD) and found reductions in gray matter volume in certain brain regions. This decreased volume was associated with non-suicidal self-injury (NSSI) behavior in BPD adolescents. Additionally, there were alterations in functional connectivity in these regions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Clinical Neurology
Yuan Cao, Hongsheng Xie, Huan Sun, Hongqi Xiao, Xipeng Long, Changjian Qiu, Zhiyun Jia
Summary: A meta-analysis was conducted to explore the common and distinct gray matter volume (GMV) alterations in young adults with borderline personality disorder (BPD) and major depressive disorder (MDD). Results showed that BPD was associated with GMV reduction in the prefrontal cortex, medial temporal network, and insula, while MDD was associated with GMV alteration in the visual and sensorimotor networks. Differences in GMV between the two disorders were observed in the orbitofrontal cortex, cingulate cortex, insula, and cerebellum.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Jing Lou, Yueji Sun, Zhixi Cui, Lei Gong
Summary: The study found that both BPD and PTSD patients showed GM volume reductions in the orbitofrontal gyrus and anterior cingulate cortex. However, GM volume increases in the posterior cingulate gyrus and precuneus were observed in BPD patients, while GM volume decreases in the amygdala-hippocampal fear circuit and fusiform gyrus were seen in PTSD patients.
NEUROSCIENCE LETTERS
(2021)
Article
Neuroimaging
Frederic Sampedro, Cristina Carmona i Farres, Joaquim Soler, Matilde Elices, Carlos Schmidt, Iluminada Corripio, Elisabet Dominguez-Clave, Edith Pomarol-Clotet, Raymond Salvador, Juan C. Pascual
Summary: In this study using imaging techniques, structural brain abnormalities were found in patients with BPD, manifested as reduced GMV/Cth in prefrontal areas and increased GMV in limbic structures. These structural abnormalities were associated with clinical severity and could potentially serve as biomarkers for predicting psychotherapy response.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Psychiatry
Yiran Zhang, Yun Yang, Licheng Zhu, Qing Zhu, Yuxi Jia, Lan Zhang, Qinmu Peng, Jiazheng Wang, Jia Liu, Wenliang Fan, Jing Wang
Summary: This study confirmed structural abnormalities in gray matter volume in patients with depression, identifying specific brain regions involved in the pathophysiology of the disorder. The severity of illness in drug-naive depression patients was found to be correlated with GMV in specific brain areas, providing insights into potential biomarkers of the disease.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Mark Zimmerman, Lena Becker
Summary: Despite the association between self-harm behavior and borderline personality disorder (BPD), engaging in self-harm behavior does not necessarily indicate the presence of BPD. The absence of self-harm behavior and suicide threats/gestures or attempts does not rule out the diagnosis of BPD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Aleksandra Kaurin, Alexandre Y. Dombrovski, Michael N. Hallquist, Aidan G. C. Wright
Summary: There is evidence that individuals with a history of suicide attempts, especially those diagnosed with borderline personality disorder, have a long-term suicidal inclination. However, the progression of suicidal crises in people prone to suicidal behavior is still poorly understood.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychology, Multidisciplinary
Maurizio Sicorello, Christian Schmahl
Summary: Borderline personality disorder is characterized by a dysfunction in the experience and regulation of emotions, potentially due to an imbalance between prefrontal regulatory and limbic emotion generating structures. However, challenges exist in the notion that amygdala hyperreactivity leads to emotional hyperreactivity and deficits in prefrontal activity or fronto-limbic connectivity contribute to emotion regulation deficits. Suggestions for improving consolidation and interpretation of research in this area are provided.
CURRENT OPINION IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Aleksandra Kaurin, Alexandre Y. Dombrovski, Michael N. Hallquist, Aidan G. C. Wright
Summary: This study demonstrates that individuals with BPD are more likely to experience suicidal ideation when facing interpersonal problems, which is indirectly mediated by negative affect and lower positive affect. Interpersonal triggers lead to affective dysregulation, which in turn gives rise to suicidal ideation.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Nahathai Wongpakaran, Awirut Oon-Arom, Nuntaporn Karawekpanyawong, Trustsavin Lohanan, Thanakorn Leesawat, Tinakon Wongpakaran
Summary: This study examined the predictive effects of perceived stress, depressive symptoms, borderline personality symptoms, and perceived social support on suicidal ideation among university students. Results indicated that these factors were significantly associated with suicidal thoughts, highlighting the importance of considering depressive symptoms in intervention plans.
Article
Clinical Neurology
Min Eun Jeon, Marielle M. Gomez, Rochelle A. Stewart, Thomas E. Joiner
Summary: This study aims to examine the symptom structure of Acute Suicidal Affective Disturbance (ASAD) and compare it with Borderline Personality Disorder (BPD). The results suggest that while there are some symptom correlations between ASAD and BPD, most symptoms are distinct.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Qian Xiao, Xueying Wang, Xiaoping Yi, Yan Fu, Jun Ding, Furong Jiang, Jing Wang, Zaide Han, Bihong T. Chen
Summary: This study aimed to assess alterations in brain surface morphology in adolescents with borderline personality disorder (BPD) and evaluate their relationship with core features of the disorder. The results showed significant differences in surface morphology in specific brain regions between adolescents with BPD and healthy controls, and these differences were correlated with core features of BPD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Medicine, General & Internal
Tina Wu, Jennifer Hu, Dimitry Davydow, Heather Huang, Margaret Spottswood, Hsiang Huang
Summary: Borderline personality disorder is a common mental health diagnosis observed in the primary care population and is associated with various challenges in diagnosis and treatment. This article aims to describe the impact of BPD in primary care, review current knowledge, and provide evidence-based treatment approaches for these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychiatry
Alessandro Grecucci, Gaia Lapomarda, Irene Messina, Bianca Monachesi, Sara Sorella, Roma Siugzdaite
Summary: This study used Multiple Kernel Learning (MKL) to analyze structural images of patients with Borderline Personality Disorder (BPD) and matched healthy controls (HC). The results showed that a circuit including the basal ganglia, amygdala, and portions of the temporal lobes and orbitofrontal cortex could effectively distinguish BPD patients from HC, and was correlated with affective disturbances.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Sophie R. DelDonno, Anne L. Weldon, Natania A. Crane, Alessandra M. Passarotti, Patrick J. Pruitt, Laura B. Gabriel, Wendy Yau, Kortni K. Meyers, David T. Hsu, Stephen F. Taylor, Mary M. Heitzeg, Ellen Herbener, Stewart A. Shankman, Brian J. Mickey, Jon-Kar Zubieta, Scott A. Langenecker
PSYCHIATRY RESEARCH
(2015)
Article
Endocrinology & Metabolism
Amy T. Peters, Anna Van Meter, Patrick J. Pruitt, Emily M. Briceno, Kelly A. Ryan, Melissa Hagan, Anne L. Weldon, Michelle T. Kasse, Aaron Vederman, Jon-Kar Zubieta, Melvin McInnis, Sara L. Weisenbach, Scott A. Langenecker
PSYCHONEUROENDOCRINOLOGY
(2016)
Article
Psychiatry
Vaibhav A. Diwadkar, Sunali Wadehra, Patrick Pruitt, Matcheri S. Keshavan, Usha Rajan, Caroline Zajac-Benitez, Simon B. Eickhoff
ARCHIVES OF GENERAL PSYCHIATRY
(2012)
Article
Clinical Neurology
Tracy Barbour, Patrick Pruitt, Vaibhav A. Diwadkar
JOURNAL OF AFFECTIVE DISORDERS
(2012)
Article
Psychiatry
Neil Bakshi, Patrick Pruitt, Jacqueline Radwan, Matcheri S. Keshavan, Usha Rajan, Caroline Zajac-Benitez, Vaibhav A. Diwadkar
JOURNAL OF PSYCHIATRIC RESEARCH
(2011)
Article
Psychiatry
Vaibhav A. Diwadkar, Patrick Pruitt, Allison Zhang, Jacqueline Radwan, Matcheri S. Keshavan, Eric Murphy, Usha Rajan, Caroline Zajac-Benitez
JOURNAL OF PSYCHIATRIC RESEARCH
(2012)
Article
Psychology, Developmental
Cecile D. Ladouceur, Tiffany Farchione, Vaibhav Diwadkar, Potrick Pruitt, Jacqueline Radwan, David A. Axelson, Boris Birmaher, Mary L. Phillips
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2011)
Article
Neurosciences
Vaibhav A. Diwadkar, Patrick Pruitt, Dhruman Goradia, Eric Murphy, Neil Bakshi, Matcheri S. Keshavan, Usha Rajan, Andrew Reid, Caroline Zajac-Benitez
Article
Clinical Neurology
Vaibhav A. Diwadkar, Jamie Segel, Patrick Pruitt, Eric R. Murphy, Matcheri S. Keshavan, Jacqueline Radwan, Usha Rajan, Caroline Zajac-Benitez
PSYCHIATRY RESEARCH-NEUROIMAGING
(2011)
Article
Psychiatry
Tracy Barbour, Eric Murphy, Patrick Pruitt, Simon B. Eickhoff, Matcheri S. Keshavan, Usha Rajan, Caroline Zajac-Benitez, Vaibhav A. Diwadkar
SCHIZOPHRENIA RESEARCH
(2010)
Article
Psychiatry
Sunali Wadehra, Patrick Pruitt, Eric R. Murphy, Vaibhav A. Diwadkar
SCHIZOPHRENIA RESEARCH
(2013)
Article
Psychiatry
Vaibhav A. Diwadkar, Neil Bakshi, Gita Gupta, Patrick Pruitt, Richard White, Simon B. Eickhoff
FRONTIERS IN PSYCHIATRY
(2014)
Article
Neurosciences
Raymond P. Viviano, Jessica M. Hayes, Patrick J. Pruitt, Zachary J. Fernandez, Sanneke van Rooden, Jeroen van der Grond, Serge A. R. B. Rombouts, Jessica S. Damoiseaux
Article
Psychology, Biological
Sophie R. DelDonno, Brian J. Mickey, Patrick J. Pruitt, Jonathan P. Stange, David T. Hsu, Anne L. Weldon, Jon-Kar Zubieta, Scott A. Langenecker
BIOLOGICAL PSYCHOLOGY
(2019)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)