Article
Psychiatry
Adam Wysokinski, Elzbieta Kozlowska, Ewa Szczepocka, Anna Lucka, Justyna Agier, Ewa Brzezinska-Blaszczyk, Katarzyna Sobierajska
Summary: Schizophrenia patients exhibit a distinctive mRNA expression profile of dopamine and serotonin receptors in peripheral blood mononuclear cells. This expression is minimally affected by antipsychotic treatment, suggesting it may serve as a useful diagnostic biomarker for schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Gordana Nedic Erjavec, Mirko Grubor, Maja Zivkovic, Nada Bozina, Marina Sagud, Matea Nikolac Perkovic, Alma Mihaljevic-Peles, Nela Pivac, Dubravka Svob Strac
Summary: Antipsychotic-induced parkinsonism is the most common extrapyramidal side effect caused by the blockage of dopamine receptors. This study found significant associations between HTR6 gene polymorphism and tremor and rigidity induced by haloperidol. Additionally, a combined effect of HTR6 T and SLC6A3 9R alleles on AIP was observed.
Review
Chemistry, Medicinal
Itaru Miura, Sho Horikoshi, Mizue Ichinose, Yuhei Suzuki, Kenya Watanabe
Summary: This review provides a comprehensive overview of the drug design, development, and therapy of lurasidone for schizophrenia treatment. Lurasidone has specific effects on different receptors and has been found to be effective in improving symptoms and preventing relapse in patients with schizophrenia. It also has minimal metabolic side effects and improves cognitive and functional performance.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Immunology
Erica Leandro Marciano Vieira, Maria Carolina Machado da Silva, Ana Paula Goncalves, Gabriela Lopes Martins, Antonio Lucio Teixeira, Antonio Carlos Pinheiro de Oliveira, Helton Jose Reis
Summary: Inflammation and immune cells play a crucial role in neurological diseases such as epilepsy. The expression of dopamine and serotonin receptors on immune blood cells of patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) may contribute to the pathophysiology of the disease.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Biographical-Item
Psychology, Clinical
Mary V. Seeman
Summary: Philip Seeman's discovery of the dopamine D2 receptor's isolation is an example of how a small step can lead to a major shift in our understanding of the etiology of schizophrenia.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka A. Kaczor, Katarzyna M. Targowska-Duda, Piotr Stepnicki, Andrea G. Silva, Oliwia Koszla, Ewa Kedzierska, Angelika Grudzinska, Marta Kruk-Slomka, Grazyna Biala, Marian Castro
Summary: The study investigates a potential antipsychotic drug D2AAK3, which shows affinity to multiple receptors and demonstrates effects of reducing hyperactivity and improving memory consolidation in animal experiments.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Dmitrii S. Traktirov, Ilya R. Nazarov, Valeria S. Artemova, Raul R. Gainetdinov, Nina S. Pestereva, Marina N. Karpenko
Summary: This article explores the roles of dopamine and serotonin in the central nervous system and the impact of knockout of the DAT gene on neurotransmission. The study reveals that excessive dopamine leads to dysregulation of neurotransmission in multiple brain regions and significant effects on the serotonin system. These findings highlight the importance of considering these factors in drug therapies.
Article
Biochemistry & Molecular Biology
Ester Anton-Galindo, Elisa Dalla Vecchia, Javier G. Orlandi, Gustavo Castro, Emilio J. Gualda, Andrew M. J. Young, Marc Guasch-Piqueras, Concepcio Arenas, Carlos Herrera-Ubeda, Jordi Garcia-Fernandez, Fernando Aguado, Pablo Loza-Alvarez, Bru Cormand, William H. J. Norton, Noelia Fernandez-Castillo
Summary: Genetic variants in YWHAZ contribute to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Using zebrafish as a model, researchers found that YWHAZ is expressed widely in neurons during development and limited to Purkinje cells in the adult cerebellum. Knocking out YWHAZ resulted in altered neuronal activity and connectivity in the hindbrain, decreased monoamine levels, and freeze behavior in adult fish, which could be reversed with drugs targeting monoamine neurotransmission.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Laoise Casserly, Daniel R. Garton, Ana Montano-Rodriguez, Jaan-Olle Andressoo
Summary: The increase in presynaptic striatal dopamine is the main abnormality observed in schizophrenia. The treatment of schizophrenia mainly focuses on modulating the activity of dopamine and serotonin receptors. Glial cell line-derived neurotrophic factor (GDNF) is a strong dopaminergic factor that has been found to be correlated with schizophrenia. The researchers analyzed the effects of methamphetamine on Gdnf and its receptors in the mouse brain, and found that acute methamphetamine increases Gdnf expression while chronic methamphetamine decreases the expression of GDNF receptors. Methamphetamine treatment also upregulates the expression of genes related to dopamine and serotonin metabolism. These findings provide insights into the mechanism by which methamphetamine increases the risk of psychosis, and may guide future development of precision medicine for methamphetamine-induced psychosis using GDNF/GFRa1/RET antagonists.
Review
Chemistry, Medicinal
Akash Rathore, Vivek Asati, Sushil Kumar Kashaw, Shivangi Agarwal, Deepa Parwani, Sushanta Bhattacharya, Chaitali Mallick
Summary: Schizophrenia is a chronic neuropsychiatric disorder affecting nearly 1% of the global population, and there is a need to explore novel potential lead compounds for its treatment. Research suggests that various piperidine and piperazine derivatives have shown promising activity against dopamine and serotonin receptors involved in schizophrenia.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yangsik Kim, Esther Yang, Hyun Kim
Summary: The study found that deletion of IRSp53 in mice leads to a decrease in prepulse inhibition (PPI), indicating that dysfunction of various modulatory neurons may result in PPI impairment. This suggests that PPI could be broadly affected by changes in various types of modulatory neurons.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Jin Zhang, Xiaobing Wang, Rick E. Bernardi, Jun Ju, Shoupeng Wei, Zhiting Gong
Summary: This study found that activation of AMPA receptors in the lateral habenula can reduce anxiety-like behaviors and increase dopamine and serotonin levels in the basolateral amygdala. Conversely, blocking AMPA receptors in the LHb may induce anxiety-like effects and decrease dopamine and serotonin levels in the BLA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Pei Shang, Ada Man-Choi Ho, Maximilian Tufvesson-Alm, Daniel R. Lindberg, Caroline W. Grant, Funda Orhan, Feride Eren, Maria Bhat, Goran Engberg, Lilly Schwieler, Helena Fatouros-Bergman, Sophie Imbeault, Ryan M. Iverson, Surendra Dasari, Fredrik Piehl, Simon Cervenka, Carl M. Sellgren, Sophie Erhardt, Doo-Sup Choi
Summary: This study utilized metabolomics analysis to identify psychosis-associated metabolites in CSF and serum samples, revealing increased levels of CSF serotonin (5-HT) and potential biomarkers for psychosis. Most metabolites remained stable at the 18-month follow-up, indicating improvement in positive symptoms and cognitive functions. Changes in CSF and serum metabolites between baseline and follow-up provided insights into psychosis pathogenesis and progression.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Cell Biology
D. Kavindi Weerasinghe, Jason M. Hodge, Julie A. Pasco, Rasika M. Samarasinghe, Behnaz Azimi Manavi, Lana J. Williams
Summary: This article provides an overview of the mechanisms of action of antipsychotics and the expression profiles of dopamine, serotonin, and adrenergic receptors during osteoclastogenesis and osteoblastogenesis, aiming to elucidate the effects of antipsychotic use on bone.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Rina Kwag, Jieon Lee, Doyoung Kim, Haeun Lee, Miyoung Yeom, Jiwan Woo, Yakdol Cho, Hak Joong Kim, Jeongjin Kim, Gyochang Keum, Byungsun Jeon, Hyunah Choo
Summary: By designing and synthesizing a series of compounds and evaluating their activities and selectivities, it was found that one compound showed good binding affinity and selectivity for 5-HT7R, exhibiting a G protein-biased antagonistic effect. The compound demonstrated inhibitory effects on self-grooming behavior in transgenic mice, indicating that 5-HT7R may be a potential therapeutic target for treating stereotypical behaviors in autism spectrum disorder.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimaraes Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcilia Aparecida Silva
Summary: This systematic review examined the potential association between anxiety and depression and chemo/radiotherapy-induced oral mucositis. The results showed that there is a connection between anxiety and depression and the severity of oral mucositis in a significant number of participants. However, the limited number of cases and heterogeneity in the data hindered a conclusive conclusion about this association.
Article
Clinical Neurology
Kelly Santana, Eduardo Franca, Joao Sato, Ana Silva, Maria Queiroz, Julia de Farias, Danniely Rodrigues, Iara Souza, Vanessa Ribeiro, Egas Caparelli-Daquer, Antonio L. Teixeira, Leigh Charvet, Abhishek Datta, Marom Bikson, Suellen Andrade
Summary: This study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCs) combined with a rehabilitation program for the management of PASC-related fatigue. The results showed that active HD-tDCS significantly reduced fatigue, decreased anxiety, and improved quality of life compared to sham HD-tDCS.
Article
Neurosciences
Haitham Salem, Robert Suchting, Mitzi M. Gonzales, Sudha Seshadri, Antonio L. Teixeira
Summary: This study aimed to detect conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and determine the effect of apathy on the progression to AD in patients with MCI. The study found that 17.3% of individuals had conversion from MCI to AD over a period of 8.21 years. Patients with apathy had a higher conversion rate and shorter time-to-conversion. Age and cognitive performance were found to moderate the relationship between apathy and time-to-conversion.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Eliana C. B. Toscano, Erica L. M. Vieira, Lea T. Grinberg, Natalia P. Rocha, Joseane A. S. Brant, Regina S. Paradela, Alexandre V. Giannetti, Claudia K. Suemoto, Renata E. P. Leite, Ricardo Nitrini, Milene A. Rachid, Antonio L. Teixeira
Summary: Temporal lobe epilepsy (TLE) is associated with cognitive deficits, and this study investigates the underlying neuronal basis. The researchers found that an increase in p-tau burden is potentially involved in cognitive deficits in mesial TLE, particularly attention impairment and seizure frequency.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Peter M. Bruno, Richard T. Timms, Nouran S. Abdelfattah, Yumei Leng, Felipe J. N. Lelis, Duane R. Wesemann, Xu G. Yu, Stephen J. Elledge
Summary: Identification of CD8(+) T cell epitopes is crucial for immunotherapy development. The EpiScan method, using surface MHC class I levels as a readout for ligand discovery, can screen large-scale MHC class I peptides and predict binding affinities. The EpiScan Predictor performs comparably to other algorithms and overcomes the underrepresentation of cysteine-containing peptides. This targeted immunopeptidomics approach will accelerate individual-specific immunotherapy.
NATURE BIOTECHNOLOGY
(2023)
Article
Psychiatry
Izabela Guimaraes Barbosa, Flavia da Mata Chiacchio Leite, Maxime Bertoux, Henrique Cerqueira Guimaraes, Luciano Inacio Mariano, Leandro Boson Gambogi, Antonio Lucio Teixeira, Paulo Caramelli, Leonardo Cruz de Souza
Summary: This study found that bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) have similar deficits in social cognition functions. The results of the Facial Emotion Recognition (FER) and Modified Faux-Pas (mFP) tests can be used to differentiate between the two disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Giselle A. Funchal, Jaqueline B. Schuch, Aline Zaparte, Breno Sanvicente-Vieira, Thiago W. Viola, Rodrigo Grassi-Oliveira, Moises E. Bauer
Summary: This study investigated the functional activities of neutrophils and the impact of early life stress on inflammatory responses in female individuals with cocaine-use disorder (CUD). The results showed that CUD subjects had higher levels of childhood trauma and exhibited abnormalities in inflammatory responses, neutrophil function, and cell signaling pathways. This study deepens our understanding of the effects of cocaine abuse and early life stress on neutrophil activation and inflammation.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Neurosciences
Natalia Pessoa Rocha, Eduarda Xavier Carreira, Ana Carolina de Almeida Prado, Fabiola Tavares, Mayra Tavares, Francisco Cardoso, Antonio Jaeger, Leonardo Cruz de Souza, Antonio Lucio Teixeira
Summary: The International Parkinson's Disease and Movement Disorder Society (MDS) developed diagnostic criteria for mild cognitive impairment (MCI) and dementia in Parkinson disease (PD). However, the applicability of these criteria was limited for PD patients with low levels of formal education in Brazil. There is a need for revision of the guidelines to account for differences among populations, especially related to educational level.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Lopes Martins, Rita Carolina Figueiredo Duarte, Erica Leandro Marciano Vieira, Natalia Pessoa Rocha, Estevao Lanna Figueiredo, Francisco Rezende Silveira, Jose Raymundo Sollero Caiaffa, Rodrigo Pinheiro Lanna, Maria das Gracas Carvalho, Andras Palotas, Claudia Natalia Ferreira, Helton Jose Reis
Summary: Elevated levels of inflammatory markers such as IL-6, IL-10, TNF, and IP-10 have been found in patients with nonvalvular atrial fibrillation (NVAF), suggesting their potential involvement in the pathogenesis and development of AF. These findings provide a basis for studying inflammatory markers associated with AF and may contribute to the discovery of clinical markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Multidisciplinary Sciences
Parnian Shobeiri, Sanam Alilou, Mehran Jaberinezhad, Farshad Zare, Nastaran Karimi, Saba Maleki, Antonio L. Teixeira, George Perry, Nima Rezaei
Summary: This systematic review evaluated the accuracy of long non-coding RNAs (lncRNAs) in identifying Alzheimer's disease (AD) through meta-analysis. The results showed that lncRNAs had high accuracy in identifying AD and could be considered a promising diagnostic biomarker for the disease.
Review
Medicine, General & Internal
Lijin Jose, Lais Bhering Martins, Thiago M. Cordeiro, Keya Lee, Alexandre Paim Diaz, Hyochol Ahn, Antonio L. Teixeira
Summary: This systematic review aims to investigate the effectiveness of noninvasive neuromodulation in HD-associated motor, cognitive, and behavioral symptoms. 19 studies were identified, exploring the use of ECT, TMS, and tDCS in the treatment of HD. The results showed improvement in HD symptoms, particularly depression and psychosis after ECT protocols, although the impact on cognitive and motor symptoms is more controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Karina Braga Gomes, Ramon Goncalves Pereira, Alexandre Alberto Braga, Henrique Cerqueira Guimaraes, Elisa de Paula Franca Resende, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Wagner Meira Junior, Maria das Gracas Carvalho, Paulo Caramelli
Summary: This study used machine learning algorithms to assess the ability of routine laboratory variables in predicting cognitive and functional decline in older adults. The random forest model was found to be the most accurate in predicting cognitive decline, including variables such as triglycerides, glucose, and hemoglobin. For functional decline, platelet count, hemoglobin, and cortisol were identified as important features. The findings suggest that routine laboratory variables can be used to predict cognitive and functional decline in older populations using machine learning algorithms.
Article
Geriatrics & Gerontology
Natalia P. Rocha, Antonio L. Teixeira, Gabriela D. Colpo, Michelle A. Babicz, Jennifer L. Thompson, Steven Paul Woods
Summary: This study found a significant association between plasma levels of neurofilament light chain (NfL) and HIV-associated neurocognitive disorders (HANDs), suggesting that NfL may serve as a promising biomarker for assessing cognitive function in people living with HIV.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2023)
Letter
Obstetrics & Gynecology
Juliane C. Albuquerque, Natalia M. C. Luz, Thalles H. O. Ribeiro, Luana B. X. Costa, Ana L. Candido, Fernando M. Reis, Helton J. Reis, Franciele S. Silva, Ieda F. O. Silva, Karina B. Gomes, Claudia N. Ferreira
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)