Article
Psychiatry
O. Cunat, B. del Hoyo-Buxo, R. Vila-Badia, C. Serra-Arumi, A. Butjosa, N. Del Cacho, A. Colomer-Salvans, M. Dolz, J. Cuevas-Esteban, M. Iglesias-Gonzalez, J. Usall
Summary: This study aimed to examine the relationship between negative symptoms and demographic and clinical variables in patients with first-episode psychosis, as well as explore differences in association when divided into experiential and expressive deficits. The results showed that worse PSP score, higher CDSS score, higher disorganized factor score, and lower excited factor score were all associated with negative symptoms. Furthermore, a longer DUP was only associated with the experiential deficit subdomain.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Martin Lepage, Michael Bodnar, Delphine Raucher-Chene, Katie M. Lavigne, Carolina Makowski, Ridha Joober, Ashok K. Malla
Summary: This study found that persistent negative symptoms (PNS) or secondary PNS (sPNS) significantly affect patients' psychosocial functioning and quality of life, with PNS patients showing more severe impairments in certain cognitive functions. The sPNS group was more likely to experience higher levels of depressive and positive symptoms, as well as requiring higher doses of medication.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Lindsay A. Bornheimer, Jessica A. Wojtalik, Juliann Li, Derin Cobia, Matthew J. Smith
Summary: This study found that during the initial episode of psychosis, positive symptoms and depression were significantly associated with an increased likelihood of experiencing suicidal ideation, while impaired clinical insight and stronger working memory were significantly associated with a decreased likelihood.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Joseph Ghanem, Massimiliano Orri, Laura Moro, Katie M. Lavigne, Delphine Raucher-Chene, Ashok Malla, Ridha Joober, Martin Lepage
Summary: The study found that in first-episode psychosis patients, there was no significant difference in suicidality between those with Persistent Negative Symptoms (PNS) and non-PNS patients, but secondary PNS (sPNS) patients had a higher risk of suicidality compared to PNS and non-PNS patients. This suggests that sPNS patients may benefit from targeted interventions to address their elevated risk of suicidality beyond depression.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Medicine, General & Internal
Antonio Melillo, Edoardo Caporusso, Giulia Maria Giordano, Luigi Giuliani, Pasquale Pezzella, Andrea Perrottelli, Paola Bucci, Armida Mucci, Silvana Galderisi, Jean-Arthur Micoulaud Franchi
Summary: This review aims to explore the correlations between negative symptoms and deficits in neurocognition and social cognition in individuals with first-episode psychosis and at-risk populations. The available evidence suggests that negative symptoms are associated with executive functioning and theory of mind deficits in first-episode psychosis subjects, and with deficits in processing speed, attention, vigilance, and working memory in at-risk populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Alba Toll, Laura Blanco-Hinojo, Daniel Berge, Xavier Duran, Irene Canosa, Teresa Legido, Federico Marmol, Victor Perez-Sola, Emilio Fernandez-Egea, Anna Mane
Summary: This study suggests that low baseline BDNF levels, smaller left amygdala relative volume, and score on the PANSS negative subscale are significant predictors of outcomes in first-episode psychosis. These findings could help tailor treatments for individuals with first-episode psychosis.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Hanaa Tarek El-Zawawy, Aliaa Aly El-Aghoury, Khaled Mohamed Katri, Eman Mohamed El-Sharkawy, Samar Mohamed Samy Gad
Summary: It was found that following bariatric surgery, the Cortisol/DHEA ratio can serve as a surrogate marker for improved blood glucose levels and resolution of inflammation, and is an independent predictor of diastolic function improvement post surgery.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Psychiatry
Maria Garcia-Lopez, Miguel Alonso-Sanchez, Itziar Leal, David Martin-Hernandez, Javier R. Caso, Covadonga M. Diaz-Caneja, Alvaro Andreu-Bernabeu, Celso Arango, Roberto Rodriguez-Jimenez, Luis Sanchez-Pastor, Marina Diaz-Marsa, Blanca Mellor-Marsa, Angela Ibanez, Norberto Malpica, Maria-Fe Bravo-Ortiz, Enrique Baca-Garcia, Jose Luis Ayuso-Mateos, Ana Izquierdo
Summary: This study examines the relationships between social cognition, social functioning, and negative symptoms in first-episode psychosis patients. The findings suggest a direct relationship between social cognition and social functioning, with an indirect connection mediated by the experiential factor of negative symptoms.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Delphine Raucher-Chene, Michael Bodnar, Katie M. Lavigne, Ashok Malla, Ridha Joober, Martin Lepage
Summary: Persistent negative symptoms have a significant impact on clinical insight in first episode psychosis patients, affecting long-term functional outcomes. Patients with PNS or sPNS showed poorer insight over a 24-month period compared to those without negative symptoms, highlighting the strong relationship between poor insight and negative symptoms early in the course of the disorder.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychology, Clinical
Arsime Demjaha, Silvana Galderisi, Birthe Glenthoj, Celso Arango, Armida Mucci, Andrew Lawrence, Owen O'Daly, Matthew Kempton, Simone Ciufolini, Lone Baandrup, Bjorn H. Ebdrup, Roberto Rodriguez-Jimenez, Maria Diaz-Marsa, Covadonga Martinez Diaz-Caneja, Inge Winter van Rossum, Rene Kahn, Paola Dazzan, Philip McGuire
Summary: This study found that the orbitofrontal and temporal cortices play an important role in the pathogenesis of negative symptoms in schizophrenia. These findings were evident in generally untreated FEP patients and are unlikely to be related to effects of previous treatment or illness chronicity.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Claudia Aymerich, Borja Pedruzo, Malein Pacho, Marta Laborda, Jon Herrero, Toby Pillinger, Robert A. McCutcheon, Daniel Alonso-Alconada, Marta Bordenave, Maria Martinez-Querol, Ainara Arnaiz, Javier Labad, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres, Ana Catalan
Summary: Alterations in prolactin and cortisol levels have been found in antipsychotic naive patients with first episode psychosis. This study aims to provide estimates for the standardized mean differences and inter-group variability of these hormone levels in this patient group compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Arsime Demjaha, Eduardo Iacoponi, Lars Hansen, Pradeep Peddu, Philip McGuire
Summary: Negative psychotic symptoms are debilitating and associated with poor outcomes in schizophrenia, but effective treatments are lacking. Recent research suggests that these symptoms may be present from the early stages of the disorder.
Review
Chemistry, Medicinal
Justine Tang, Li-Ru Chen, Kuo-Hu Chen
Summary: Dehydroepiandrosterone (DHEA) and its metabolite, dehydroepiandrosterone sulfate ester (DHEAS), are circulating steroid hormones that play multiple roles in the human body. While DHEA supplementation may have benefits for postmenopausal women, such as alleviating vasomotor symptoms and preserving immune system integrity, its effects on cardiovascular disease and insulin sensitivity are still uncertain. Further research is needed to determine the physiological role, optimal dosage, and effects on women for DHEA.
Article
Psychiatry
Marta Diago, Regina Vila-Badia, Clara Serra-Arumi, Anna Butjosa, Nuria Del Cacho, Marina Esteban Sanjusto, Alicia Colomer-Salvans, Laura Sanchez, Montserrat Dolz, Daniel Munoz-Samons, Group P. R. O. F. E. P. Grp PROFEP, Judith Usall
Summary: The study found that patients with first-episode psychosis were more likely to exhibit suicidal behavior compared to the healthy control group, with emotional abuse being the most relevant type of childhood trauma in suicide ideation and suicide risk. Additionally, perceived stress was found to play an important role in suicide ideations, suicide attempt, and suicide risk, even after controlling for other relevant variables.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
G. Paul Amminger, Ashleigh Lin, Melissa Kerr, Amber Weller, Jessica Spark, Charlotte Pugh, Sally O'Callaghan, Maximus Berger, Scott R. Clark, James G. Scott, Andrea Baker, Iain McGregor, David Cotter, Zoltan Sarnyai, Andrew Thompson, Alison R. Yung, Brian O'Donoghue, Eoin Killackey, Cathy Mihalopoulos, Hok Pan Yuen, Barnaby Nelson, Patrick D. McGorry
Summary: This study aims to test the efficacy of CBD in treating subthreshold psychotic symptoms in the at-risk stage of psychotic disorder. Through a randomized controlled trial, CBD will be compared to placebo in improving positive psychotic symptoms in UHR patients, with the hypothesis that CBD will be significantly more effective.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Michael Tham, Sarah Bendall, Thomas Carlyon-Stewart, Andrea Polari, Jessica Hartmann, Melissa Kerr, Paul Amminger, Patrick McGorry, Barnaby Nelson, Aswin Ratheesh
Summary: The study found that carers' experiences of their teenagers being identified as at-risk for psychosis varied, with main themes including limited or variable recall of risk information, perceived positive goal of risk disclosure, negative emotions associated with knowledge of risk, relief from uncertainty and helplessness, and effects of risk disclosure mediated by individual circumstance.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Sue M. Cotton, Kate M. Filia, Martin Lambert, Michael Berk, Aswin Ratheesh, Benno G. Schimmelmann, Craig Macneil, Melissa Hasty, Patrick D. McGorry, Philippe Conus
Summary: The study found that NEET status in young people with bipolar disorder and psychotic features is associated with premorbid decline, substance use, and forensic issues. NEET status can change during treatment, suggesting a need to further explore the effectiveness of vocational intervention programs specifically for BD.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Review
Psychiatry
Anna Beneria, Olga Santesteban-Echarri, Constanza Daigre, Hailey Tremain, Josep Antoni Ramos-Quiroga, Patrick D. McGorry, Mario Alvarez-Jimenez
Summary: The study found that online interventions did not significantly reduce cannabis consumption, with high heterogeneity. However, recent studies suggest that structured interventions, daily feedback, AYA centred designs, and peer support specifically targeting cannabis users may have positive effects to address cannabis use in this population.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Sue Cotton, Kate Filia, Amity Watson, Andrew J. Mackinnon, Leanne Hides, John F. M. Gleeson, Michael Berk, Philippe Conus, Martin Lambert, Benno Schimmelmann, Helen Herrman, Victoria Rayner, Aswin Ratheesh, Patrick D. McGorry
Summary: This study aims to provide a comprehensive evaluation of the long-term trajectory of psychotic disorders after treatment for first episode psychosis in a specialist early intervention service.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Cassandra M. J. Wannan, Cali F. Bartholomeusz, Christos Pantelis, Maria A. Di Biase, Warda T. Syeda, M. Mallar Chakravarty, Chad A. Bousman, Ian P. Everall, Patrick D. McGorry, Andrew Zalesky, Vanessa L. Cropley
Summary: Episodic memory ability relies on hippocampal-prefrontal connectivity, with disruptions in white matter microstructure in the hippocampal-prefrontal pathway potentially contributing to memory impairments in individuals with chronic SSDs but not FEP. Abnormal WM microstructure, especially in the hippocampal-thalamic pathway in the right hemisphere, was associated with poorer memory performance in individuals with chronic SSDs, who also exhibited impaired episodic memory performance.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Psychiatry
Holly Sizer, Ellie Brown, Hellen Geros, Alison Yung, Barnaby Nelson, Patrick McGorry, Brian O'Donoghue
Summary: Limited research suggests similar or superior outcomes for individuals with a first episode of psychosis who present initially via an ARMS clinic. The reduced psychiatric admission rate is an important potential benefit of ARMS clinics that requires further validation.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Patrick D. McGorry, Cristina Mei, Andrew Chanen, Craig Hodges, Mario Alvarez-Jimenez, Eoin Killackey
Summary: Mental ill-health is the main threat to young people's health and future potential globally. The COVID-19 pandemic has worsened this trend. Despite the immense need, adolescents and emerging adults have limited access to mental health care. Co-designed strategies and innovations have emerged, including integrated primary youth mental health care services, but these need to be scaled up globally to meet the rising demand.
Article
Psychiatry
Tara Burke, Andrew Thompson, Nathan Mifsud, Alison R. Yung, Barnaby Nelson, Patrick McGorry, Brian O'Donoghue
Summary: This study found that a significant proportion of young people initially attended other specialist youth mental health services, and these individuals had lower rates of hospital admission at the time of transition to first-episode psychosis.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Brian O'Donoghue, Andrea Polari, Patrick McGorry, Barnaby Nelson
Summary: This study aimed to investigate the under-representation of migrants in cohorts of young people at ultra-high risk for psychosis. The study found that migrants were more commonly referred by community health services, while non-migrants were more likely to be referred through other mental health services. The severity of attenuated psychotic symptoms and depressive symptoms did not differ based on migrant status.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
S. Cook, S. Moore, C. Bryant, L. J. Phillips
Summary: Social anxiety disorder (SAD) is commonly associated with fear of negative evaluation (FNE), but fear of positive evaluation (FPE) has also been recognized as an important aspect of SAD. A systematic review and meta-analysis of 147 studies found that considering both FNE and FPE accounted for an additional 9% of variance in social anxiety symptoms compared to considering FNE alone. The mean differences between FPE and FNE were also significant. It is recommended that research and treatment take into account the unique contribution of fear of positive evaluation in addressing social anxiety symptoms.
CLINICAL PSYCHOLOGY-SCIENCE AND PRACTICE
(2022)
Article
Psychology, Clinical
Katie Truss, Jocelyn Liao Siling, Lisa Phillips, Oliver Eastwood, Sarah Bendall
Summary: Young people affected by trauma face internal barriers when seeking help, such as avoidance of trauma memories and lack of trust in others. Service providers can reduce these barriers by providing information about confidentiality processes and psycho-education about the impact of trauma.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Article
Psychiatry
Natasa Borojevic, Midya Dawud, Junhua Xiao, Yang Yun
Summary: This case report describes a 55-year-old man with first-episode delusional disorder who developed an allergic reaction to paliperidone long-acting injection following oral tolerance. It suggests the importance of monitoring allergic reactions in psychiatric patients when switching from oral to injection forms of paliperidone.
Article
Communication
Elise R. Carrotte, Michelle Blanchard, Christopher Groot, Fincina Hopgood, Lisa Phillips
Summary: A survey found that approximately one third of adult Australians had listened to a mental health-themed podcast in the last 12 months. Listeners of these podcasts held fewer stigmatizing attitudes towards mental health issues and had higher levels of mental health knowledge. However, there was no significant relationship between listeners' internalized stigma and mental health-themed podcasts. Further research is needed to determine the impact of these podcasts on attitudes and behaviors, as well as how they can effectively communicate mental health content.
COMMUNICATION STUDIES
(2023)
Article
Health Care Sciences & Services
Elise Carrotte, Fincina Hopgood, Michelle Blanchard, Christopher Groot, Lisa Phillips
Summary: This study aimed to collaborate with target audience members to develop a new podcast that reduces stigma towards people with complex mental health issues. The study involved information gathering and co-design processes, resulting in a podcast design that features lived experience narratives and a focus on stigma and discrimination.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)